University of California San Francisco
Helen Diller Family Comprehensive Cancer Center

Benjamin J. Huang, MD

Assistant Professor of Pediatrics, UCSF
Attending Pediatric Hematologist/Oncologist, UCSF

Cancer Center Program Memberships

Pediatric Malignancies

Research Summary

Dr. Benjamin Huang is a physician-scientist whose research program focuses on mouse cancer modeling, molecular therapeutics, and functional genomics. He is a contributing member within the UCSF Helen Diller Family Comprehensive Cancer Center, the Children's Oncology Group Myeloid Committee, and the Leukemia and Lymphoma Society Pediatric Acute Leukemia Initiative.

Education

University of California, Berkeley, BS, 06/2005, Electrical Engineering and Computer Sciences
University of California, San Francisco, MD, 06/2010, Medicine
University of California, San Francisco, Residency, 06/2013, Pediatrics
University of California, San Francisco, Fellowship, 06/2016, Pediatric Hematology/Oncology


Professional Experience

  • 2002-2005
    Graduate Student Instructor in Electrical Engineering and Computer Sciences, UC Berkeley
  • 2010-2013
    Resident in Pediatrics, UCSF
  • 2013-2016
    Fellow in Pediatric Hematology/Oncology, UCSF
  • 2015-present
    Chair, UCSF (and Northern California) Pediatric Leukemia Tumor Board
  • 2016-2018
    Instructor of Pediatrics, Attending Pediatric Hematologist/Oncologist, UCSF
  • 2018-present 
    Assistant Professor of Pediatrics, Attending Pediatric Hematologist/Oncologist, UCSF
  • 2017-present 
    Member, Children’s Oncology Group Myeloid Committee
  • 2018-present 
    Member, Leukemia and Lymphoma Society Pediatric Acute Leukemia Initiative

Honors & Awards

  • 2006
    UC Berkeley Outstanding Graduate Student Instructor Award
  • 2009
    Alpha Omega Alpha, Medical Honor Society
  • 2010
    UCSF School of Medicine Essential Core Teaching Award
  • 2011
    UCSF Pediatric Residency Ahmad Ghanea Bassiri Award Finalist
  • 2013
    UCSF Pediatric Residency Rudolph Award Finalist
  • 2014
    UCSF School of Medicine Core Clerkship Teaching Award
  • 2016
    St. Baldrick’s Foundation Fellowship Award
  • 2017
    Bleecher Junior Faculty Research Award
  • 2019
    Hyundai Hope on Wheels Scholar Award

Selected Publications

  1. Meyer LK, Huang BJ, Delgado-Martin C, Roy RP, Hechmer A, Wandler AM, Vincent TL, Fortina P, Olshen AB, Wood BL, Horton TM, Shannon KM, Teachey DT, Hermiston ML. Glucocorticoids paradoxically facilitate steroid resistance in T cell acute lymphoblastic leukemias and thymocytes. J Clin Invest. 2020 Jan 13.
    View on PubMed
  2. Huang BJ, Wandler AM, Meyer LK, Dail M, Daemen A, Sampath D, Li Q, Wang X, Wong JC, Nakitandwe J, Downing JR, Zhang J, Taylor BS, Shannon K. Convergent genetic aberrations in murine and human T lineage acute lymphoblastic leukemias. PLoS Genet. 2019 06; 15(6):e1008168.
    View on PubMed
  3. Delgado-Martin C, Meyer LK, Huang BJ, Shimano KA, Zinter MS, Nguyen JV, Smith GA, Taunton J, Winter SS, Roderick JR, Kelliher MA, Horton TM, Wood BL, Teachey DT, Hermiston ML. JAK/STAT pathway inhibition overcomes IL7-induced glucocorticoid resistance in a subset of human T-cell acute lymphoblastic leukemias. Leukemia. 2017 12; 31(12):2568-2576.
    View on PubMed
  4. Burgess MR, Hwang E, Mroue R, Bielski CM, Wandler AM, Huang BJ, Firestone AJ, Young A, Lacap JA, Crocker L, Asthana S, Davis EM, Xu J, Akagi K, Le Beau MM, Li Q, Haley B, Stokoe D, Sampath D, Taylor BS, Evangelista M, Shannon K. KRAS Allelic Imbalance Enhances Fitness and Modulates MAP Kinase Dependence in Cancer. Cell. 2017 02 23; 168(5):817-829.e15.
    View on PubMed
  5. Wandler A, Huang B, Scacchetti A, Craig J, Yan H, Monsalve G, Li Q, Dail M, Wong J, Nakitandwe J, Weinberg O, Hasserjian R, Kogan S, Sampath D, Downing J, Yamamoto K, Taylor B, Aster J, Zhang J, Shannon K. Resistant T-Cell Acute Lymphoblastic Leukemias That Emerge after In Vivo Treatment with Dexamethasone Frequently Down-Regulate Glucocorticoid Receptor Protein Expression. Blood (ASH Annual Meeting Abstracts). 2016; 753(605).
    View on PubMed
  6. Huang B, Hwang E, Wandler A, Powell B, Bollag G, Shannon K. Response and Resistance to Bromodomain Inhibition in AML Driven By Hyperactive Ras Signaling. Blood (ASH Annual Meeting Abstracts). 2016; 1654(616).
    View on PubMed
  7. Dail M, Li Q, McDaniel A, Wong J, Akagi K, Huang B, Kang HC, Kogan SC, Shokat K, Wolff L, Braun BS, Shannon K. Mutant Ikzf1, KrasG12D, and Notch1 cooperate in T lineage leukemogenesis and modulate responses to targeted agents. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):5106-11.
    View on PubMed

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