University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Chiung-Yu Huang, PhD

Chiung-Yu Huang, PhD

Professor, Dept. of Epidemiology and Biostatistics, UCSF

Cancer Center Program Memberships

Hematopoietic Malignancies

Research Summary

Dr. Huang's research interest is in general biostatistics methodology and its application to the biomedical sciences. She has extensive experience in the statistical analysis of survival outcomes, recurrent events, competing risks, longitudinal measurements, missing data, and monitoring of clinical trials. In particular, she has developed novel nonparametric and semiparametric approaches for analyzing recurrent event data and panel count data under informative censoring, where a dependent terminal event, such as death, precludes further occurrence of recurrent events of interest. She also developed efficient estimation procedures to combine auxiliary subgroup survival or covariate effect information in the analysis of survival data, with the goal to improve risk prediction in cancer patients. Recently, she has developed efficient statistical methods for evaluating vaccine efficacy in clinical trials with active surveillance by incorporating information about the number of founder virus.

Dr. Huang has published extensively in peer-reviewed journals in oncology and infectious diseases as a biostatistician. During her service at NIH (2004-2013), Dr. Huang worked closely with both extramural and intramural NIH scientists on the design, conduct, monitoring, analysis, and presentation of preclinical and clinical studies. As a former faculty member in the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (2013-2017), Dr. Huang was involved in the design and analysis of a range of clinical studies. She served as the principal statistician to the Breast and Ovarian Cancer Program and had collaborated on several pancreatic cancer studies.

Education

National Tsing-Hua University, Hsinchu, Taiwan, B.S., 07/1994, Mathematics
National Tsing-Hua University, Hsinchu, Taiwan, M.S., 07/1996, Mathematics
Johns Hopkins University, Baltimore, Maryland, Ph.D., 05/2002, Biostatistics


Professional Experience

  • 2002-2004
    Assistant Professor, Division of Biostatistics, University of Minnesota School of Public Health, Minneapolis, MN 2004-2013 Mathematical Statistician, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD
  • 2013-2017
    Associate Professor, Division of Oncology Biostatistics and Bioinformatics, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD
  • 2014-2017
    Associate Professor, Department of Biostatistics, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD
  • 2017-present
    Professor, Department of Epidemiology and Biostatistics, University of California at San Francisco, San Francisco, CA

Honors & Awards

  • 1991
    Invited Contestant, Asian Pacific Mathematics Olympiad (APMO)
  • 1991
    College admission for gifted students under Taiwan’s Special Education Act
  • 1991-1995
    Four-Year College Scholarship for Gifted Students in Mathematics and Sciences, Taiwanese Ministry of Education
  • 1992, 1993, 1994
    President’s Academic Awards (3 times), National Tsing-Hua University
  • 1994
    Graduated first in class from the Department of Mathematics, National Tsing-Hua University, Taiwan (completed a bachelor's degree in three years and admitted into graduate school without entrance exam)
  • 1997-2002
    Five-year departmental scholarship, Department of Biostatistics, Johns Hopkins University
  • 2002
    Margaret Merrell Award for Excellence in Research, Department of Biostatistics, Johns Hopkins University
  • 2004
    NIH Travel Award, ENAR Young Investigators Meeting
  • 2003-2005
    Grant-in-Aid of Research, Artistry, and Scholarship, University of Minnesota
  • 2005
    Performance Award for special achievement, Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, NIH
  • 2005, 2006, 2007, 2008, 2010, 2011
    Special Act or Service Award, National Institute of Allergy and Infectious Diseases, NIH
  • 2007
    NIAID Merit Award, National Institute of Allergy and Infectious Diseases, NIH

Selected Publications

  1. Sun Y, Qin J, Huang CY. Missing information principle: a unified approach for general truncated and/or censored survival data problems. Statistical Science. 2018; 33:261-276.
    View on PubMed
  2. Chiou S, Huang CY, Xu G, Yan J. Semiparametric regression analysis of panel count data: a practical review. International Statistical Review. 2018.
    View on PubMed
  3. Jose JJM, Brahmadathan KN, Abraham VJ, Huang CY, Morens D, Hoe NP, Follmann DA, Krause RM.. Streptococcal Group A, C, and G pharyngitis in school children: a prospective cohort study in southern India. Epidemiology and Infection. Epidemiology and Infection. 2018.
    View on PubMed
  4. Chiou SH, Xu G, Yan J, Huang CY. Semiparametric estimation of the accelerated mean model with panel count data under informative examination times. Biometrics. 2017 Dec 29.
    View on PubMed
  5. Follmann D, Huang CY. Sieve analysis using the number of infecting pathogens. Biometrics. 2017 Dec 14.
    View on PubMed
  6. Lee CH, Huang CY, DeFor TE, Brunstein CG, Weisdorf DJ, Luo X. Semiparametric regression model for recurrent bacterial infections after umbilical cord blood transplantation. Statistica Sinica. 2017.
    View on PubMed
  7. Lyu T, Luo X, Xu G, Huang CY. Induced smoothing for rank-based regression with recurrent gap time data. Stat Med. 2018 Mar 30; 37(7):1086-1100.
    View on PubMed
  8. Xu G, Sit T, Wang L, Huang CY. Estimation and inference of quantile regression for survival data under biased sampling. J Am Stat Assoc. 2017; 520(112):1571-1586.
    View on PubMed
  9. Lee CH, Huang CY, Xu G, Luo X. Semiparametric regression analysis for alternating recurrent event data. Stat Med. 2018 Mar 15; 37(6):996-1008.
    View on PubMed
  10. Murphy AG, Foley K, Rucki AA, Xia T, Jaffee EM, Huang CY, Zheng L. Stromal Annexin A2 expression is predictive of decreased survival in pancreatic cancer. Oncotarget. 2017 Dec 05; 8(63):106405-106414.
    View on PubMed
  11. Shrestha B, Sun Y, Faisal F, Kim V, Soares K, Blair A, Herman JM, Narang A, Dholakia AS, Rosati L, Hacker-Prietz A, Chen L, Laheru DA, De Jesus-Acosta A, Le DT, Donehower R, Azad N, Diaz LA, Murphy A, Lee V, Fishman EK, Hruban RH, Liang T, Cameron JL, Makary M, Weiss MJ, Ahuja N, He J, Wolfgang CL, Huang CY, Zheng L. Long-term survival benefit of upfront chemotherapy in patients with newly diagnosed borderline resectable pancreatic cancer. Cancer Med. 2017 Jul; 6(7):1552-1562.
    View on PubMed
  12. Sengupta S, Nagalingam A, Muniraj N, Bonner MY, Mistriotis P, Afthinos A, Kuppusamy P, Lanoue D, Cho S, Korangath P, Shriver M, Begum A, Merino VF, Huang CY, Arbiser JL, Matsui W, Gyorffy B, Konstantopoulos K, Sukumar S, Marignani PA, Saxena NK, Sharma D. Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3. Oncogene. 2017 Oct 12; 36(41):5709-5721.
    View on PubMed
  13. Xu G, Chiou SH, Huang CY, Wang MC, Yan J. Joint scale-change models for recurrent events and failure time. J Am Stat Assoc. 2017; 112(518):794-805.
    View on PubMed
  14. Sun Y, Huang CY, Wang MC. Nonparametric benefit-risk assessment using marker process in the presence of a terminal event. J Am Stat Assoc. 2017; 112(518):826-836.
    View on PubMed
  15. Huang CY, Qin J, Tsai HT. Efficient Estimation of the Cox Model With Auxiliary Subgroup Survival Information. J Am Stat Assoc. 2016; 111(514):787-799.
    View on PubMed
  16. Follmann D, Huang CY, Gabriel E. Who really gets strep sore throat? Confounding and effect modification of a time-varying exposure on recurrent events. Stat Med. 2016 10 30; 35(24):4398-4412.
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  17. Huang CY, Wang C, Wang MC. Nonparametric analysis of bivariate gap time with competing risks. Biometrics. 2016 09; 72(3):780-90.
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  18. Avnir Y, Watson CT, Glanville J, Peterson EC, Tallarico AS, Bennett AS, Qin K, Fu Y, Huang CY, Beigel JH, Breden F, Zhu Q, Marasco WA. IGHV1-69 polymorphism modulates anti-influenza antibody repertoires, correlates with IGHV utilization shifts and varies by ethnicity. Sci Rep. 2016 Feb 16; 6:20842.
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  19. Li S, Sun Y, Huang CY, Follmann DA, Krause R. Recurrent event data analysis with intermittently observed time-varying covariates. Stat Med. 2016 08 15; 35(18):3049-65.
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  20. Lee CH, Luo X, Huang CY, DeFor TE, Brunstein CG, Weisdorf DJ. Nonparametric methods for analyzing recurrent gap time data with application to infections after hematopoietic cell transplant. Biometrics. 2016 06; 72(2):535-45.
    View on PubMed

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