Yong Huang, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Yong Huang, PhD

Associate Professor and Director, Drug Studies Unit, Department of Bioengineering and Therapeutic Sciences, UCSF

Yong.Huang@ucsf.edu

Phone: (415) 476-5220
Box 0912, UCSF
San Francisco, CA 94143

UCSF Profiles

Cancer Center Membership

Member ยป Developmental Therapeutics

Research Summary

The Drug Studies Unit, Analytical Division, specializes in the development of methods needed to detect and quantify drug substances in biological fluids. Their methodologies are applied to the testing of drug treatments and therapies of major importance in human health and well-being. They strive to secure and succeed in a variety of educational, pharmaceutical industry and governmental projects, for it is these projects that offer the staff and academic personnel the opportunity to develop their abilities and apply their expertise to advance their understanding of problems in drug research.

Quantification of Drug and Metabolites in Biological Fluids

Endogenous Compound and Biomarker Bioanalysis

LC/MS/MS, HPLC

ADME/PK Studies

Education

Southeast University, China, M.D., 1981-1986, Medicine
Chongqing University of Medical Sciences, China, M.S., 1986-1989, Pharmacology
Chiba University, Japan, Ph.D., 1993-1996, Bioanalytical Chemistry
University of Tokyo, Japan, Postdoc, 1996-1999, Bioanalytical Chemistry


Professional Experience

  • 1985 - 1986
    Intern Beijing General Railroad Hospital, China
  • 1989 - 1991
    Researcher Neijiang Institute for Drug Control, Neijiang, China Division of Pharmacology
  • 1991 - 1993
    Visiting Scholar Faculty of Pharmaceutical Sciences, Chiba University, Japan Dept. of Biopharmaceutics
  • 1999 - 2000
    Researcher Tanabe Seiyaku Co. Ltd, Osaka, Japan Pharmacokinetics Department
  • 2001 - 2002
    Visiting postdoctoral fellow Drug Studies Unit, Department of Biopharmaceutical Sciences, School of Pharmacy, UCSF
  • 2002 - 2005
    Assistant Researcher Drug Studies Unit, Department of Biopharmaceutical Sciences, School of Pharmacy, UCSF
  • 2005 - 2009
    Assistant Adjunct Professor Drug Studies Unit, Department of Biopharmaceutical Sciences, School of Pharmacy, UCSF
  • 2009 - present
    Associate Adjunct Professor Drug Studies Unit, Department of Bioengineering and Therapeutic Sciences, School of Pharmacy, UCSF
  • 2007 - present
    Drug Studies Unit, Director Department of Department of Bioengineering and Therapeutic Sciences, School of Pharmacy, UCSF

Honors & Awards

  • 1991 - 1996
    Japanese Government's Scholarship
  • 1996 - 1997
    The Tokyo Biochemical Research Foundation Scholarship
  • 1997 -1999
    Japanese Society for Promotion of Science Fellowship

Selected Publications

  1. Liquid chromatographic-tandem mass spectrometric assay for the simultaneous determination of didanosine and stavudine in human plasma, bronchoalveolar lavage fluid, alveolar cells, peripheral blood mononuclear cells, seminal plasma, cerebrospinal fluid and tonsil tissue. Huang Y, Zurlinden E, Lin E, Li X, Tokumoto J, Golden J, Murr A, Engstrom J, Conte J Jr. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004; 799(1):51-61. PMID: 14659435
  2. 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone. Scanlan TS, Suchland KL, Hart ME, Chiellini G, Huang Y, Kruzich PJ, Frascarelli S, Crossley DA, Bunzow JR, Ronca-Testoni S, Lin ET, Hatton D, Zucchi R, Grandy DK. Nature medicine. 2004; 10(6):638-42. PMID: 15146179
  3. Pharmacokinetics of quinacrine in the treatment of prion disease. Yung L, Huang Y, Lessard P, Legname G, Lin ET, Baldwin M, Prusiner SB, Ryou C, Guglielmo BJ. BMC infectious diseases. 2004; 4:53. PMID: 15569390 PMCID: PMC535929
  4. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Schwab SR, Pereira JP, Matloubian M, Xu Y, Huang Y, Cyster JG. Science (New York, N.Y.). 2005; 309(5741):1735-9. PMID: 16151014
  5. Liquid chromatographic tandem mass spectrometric assay for the uremic toxin 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid in human plasma. Huang Y, Sun H, Frassetto L, Benet LZ, Lin ET. Rapid communications in mass spectrometry : RCM. 2006; 20(10):1611-4. PMID: 16628600
  6. Induction of renal cytochrome P450 arachidonic acid epoxygenase activity by dietary gamma-linolenic acid. Yu Z, Ng VY, Su P, Engler MM, Engler MB, Huang Y, Lin E, Kroetz DL. The Journal of pharmacology and experimental therapeutics. 2006; 317(2):732-8. PMID: 16421287
  7. Pharmacokinetics of atorvastatin and its hydroxy metabolites in rats and the effects of concomitant rifampicin single doses: relevance of first-pass effect from hepatic uptake transporters, and intestinal and hepatic metabolism. Lau YY, Okochi H, Huang Y, Benet LZ. Drug metabolism and disposition: the biological fate of chemicals. 2006; 34(7):1175-81. PMID: 16624870
  8. Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein. Huang Y, Okochi H, May BC, Legname G, Prusiner SB, Benet LZ, Guglielmo BJ, Lin ET. Drug metabolism and disposition: the biological fate of chemicals. 2006; 34(7):1136-44. PMID: 16581945
  9. Dose-response effect of tetracyclines on cerebral matrix metalloproteinase-9 after vascular endothelial growth factor hyperstimulation. Lee CZ, Yao JS, Huang Y, Zhai W, Liu W, Guglielmo BJ, Lin E, Yang GY, Young WL. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2006; 26(9):1157-64. PMID: 16395286
  10. Role of sphingosine kinase activity in protection of heart against ischemia reperfusion injury. Vessey DA, Kelley M, Li L, Huang Y, Zhou HZ, Zhu BQ, Karliner JS. Medical science monitor : international medical journal of experimental and clinical research. 2006; 12(10):BR318-24. PMID: 17006394
  11. Cytochrome P450 eicosanoids are activators of peroxisome proliferator-activated receptor alpha. Ng VY, Huang Y, Reddy LM, Falck JR, Lin ET, Kroetz DL. Drug metabolism and disposition: the biological fate of chemicals. 2007; 35(7):1126-34. PMID: 17431031
  12. Sensitive analysis of anti-HIV drugs, efavirenz, lopinavir and ritonavir, in human hair by liquid chromatography coupled with tandem mass spectrometry. Huang Y, Gandhi M, Greenblatt RM, Gee W, Lin ET, Messenkoff N. Rapid communications in mass spectrometry : RCM. 2008; 22(21):3401-9. NIHMSID: NIHMS100192 PMID: 18837069 PMCID: PMC2669487
  13. Protease inhibitor levels in hair strongly predict virologic response to treatment. Gandhi M, Ameli N, Bacchetti P, Gange SJ, Anastos K, Levine A, Hyman CL, Cohen M, Young M, Huang Y, Greenblatt RM. AIDS (London, England). 2009; 23(4):471-8. NIHMSID: NIHMS94598 PMID: 19165084 PMCID: PMC2654235
  14. Cannabinoid receptor 2 mediates the retention of immature B cells in bone marrow sinusoids. Pereira JP, An J, Xu Y, Huang Y, Cyster JG. Nature immunology. 2009; 10(4):403-11. NIHMSID: NIHMS151335 PMID: 19252491 PMCID: PMC2768754
  15. Sphingosine protects aging hearts from ischemia/reperfusion injury: Superiority to sphingosine 1-phosphate and ischemic pre- and post-conditioning. Vessey DA, Kelley M, Li L, Huang Y. Oxidative medicine and cellular longevity. 2009; 2(3):146-51. PMID: 20592769 PMCID: PMC2763240
  16. A phase I study of a 2-day lapatinib chemosensitization pulse preceding nanoparticle albumin-bound Paclitaxel for advanced solid malignancies. Chien AJ, Illi JA, Ko AH, Korn WM, Fong L, Chen LM, Kashani-Sabet M, Ryan CJ, Rosenberg JE, Dubey S, Small EJ, Jahan TM, Hylton NM, Yeh BM, Huang Y, Koch KM, Moasser MM. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009; 15(17):5569-75. NIHMSID: NIHMS263170 PMID: 19706807 PMCID: PMC3029022
  17. Y-27632 improves rotarod performance and reduces huntingtin levels in R6/2 mice. Li M, Huang Y, Ma AA, Lin E, Diamond MI. Neurobiology of disease. 2009; 36(3):413-20. PMID: 19591939
  18. Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease. Favre D, Mold J, Hunt PW, Kanwar B, Loke P, Seu L, Barbour JD, Lowe MM, Jayawardene A, Aweeka F, Huang Y, Douek DC, Brenchley JM, Martin JN, Hecht FM, Deeks SG, McCune JM. Science translational medicine. 2010; 2(32):32ra36. NIHMSID: NIHMS255872 PMID: 20484731 PMCID: PMC3034445
  19. Low lopinavir plasma or hair concentrations explain second-line protease inhibitor failures in a resource-limited setting. van Zyl GU, van Mens TE, McIlleron H, Zeier M, Nachega JB, Decloedt E, Malavazzi C, Smith P, Huang Y, van der Merwe L, Gandhi M, Maartens G. Journal of acquired immune deficiency syndromes (1999). 2011; 56(4):333-9. NIHMSID: NIHMS268926 PMID: 21239995 PMCID: PMC3073814
  20. Atazanavir concentration in hair is the strongest predictor of outcomes on antiretroviral therapy. Gandhi M, Ameli N, Bacchetti P, Anastos K, Gange SJ, Minkoff H, Young M, Milam J, Cohen MH, Sharp GB, Huang Y, Greenblatt RM. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2011; 52(10):1267-75. PMID: 21507924 PMCID: PMC3079399