Millie Hughes-Fulford, PhD

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Additional Websites

• Lab Website

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Education

Tarleton State University, Stephenville, TX, B.S., 1968, Chemistry and Biology
Texas Women's University, Denton, TX, Ph.D., 1972, Radiation Chemistry
Woods Hole, Post-Graduate Training, 1987, Summer Physiology courses; 1999, Microscopy course

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Professional Experience

• 1973-1985
  Research Chemist, VAMC San Francisco, CA
• 1977-1984
  Adjunct Assistant Professor; Biochemistry, Department of Medicine; University of California, San Francisco; and San Francisco Extension Faculty, Biochemistry, UC Berkeley
• 1984-1991
  Astronaut Scientist, Spacelab Life Sciences-l, JSC, Houston
• 1984-1994
  Adjunct Associate Professor of Biochemistry, Dept. of Medicine, UCSF, San Francisco
• 1995- 2001
  Deputy Associate Chief of Staff for Education VAMCSF
• 1991-present
  Scientific Advisor to the Undersecretary of the Department of Veteran's Affairs
• 1993-present
  Director, Laboratory of Cell Growth, VAMC/UCSF
• 1993-present
  Scientific Advisor to the UnderSecretary, Dept of Veteran's Affairs, Washington, DC
• 1994-present
  Adjunct Professor in Medicine, Dept. of Medicine, UCSF, San Francisco
• 1996-present
  Research Scientist, NCIRE
• 2001-present
  Principal Medical Investigator, VAMC

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Honors & Awards

• 1965
  National Science Foundation Summer Research Fellow (Undergraduate)
• 1968-1971
  National Science Foundation Fellowship (Graduate)
• 1971-1972
  American Association of University Women's Fellowship
• 1984
  Presidential Award for Federal Employee for Western Region
• 1995
  Woman of the Year Marin county
• 1995
  Named International Zontian, 1995

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Selected Publications

1. Grenon SM, Jeanne M, Aguado-Zuniga J, Conte MS, Hughes-Fulford M. Effects of Gravitational Mechanical Unloading in Endothelial Cells: Association between Caveolins, Inflammation and Adhesion Molecules. Sci Rep. 2013 Mar 20; 3:1494.
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2. Grenon SM, Saary J, Gray G, Vanderploeg JM, Hughes-Fulford M. Can I take a space flight? Considerations for doctors. BMJ. 2012; 345:e8124.
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3. Chang TT, Walther I, Li CF, Boonyaratanakornkit J, Galleri G, Meloni MA, Pippia P, Cogoli A, Hughes-Fulford M. The Rel/NF-?B pathway and transcription of immediate early genes in T cell activation are inhibited by microgravity. J Leukoc Biol. 2012 Dec; 92(6):1133-45.
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4. Grenon SM, Aguado-Zuniga J, Hatton JP, Owens CD, Conte MS, Hughes-Fulford M. Effects of fatty acids on endothelial cells: inflammation and monocyte adhesion. J Surg Res. 2012 Sep; 177(1):e35-43.
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5. Grenon SM, Hughes-Fulford M, Rapp J, Conte MS. Polyunsaturated fatty acids and peripheral artery disease. Vasc Med. 2012 Feb; 17(1):51-63.
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6. Hughes-Fulford M. To infinity ... and beyond! Human spaceflight and life science. FASEB J. 2011 Sep; 25(9):2858-64.
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7. Magbanua MJ, Roy R, Sosa EV, Weinberg V, Federman S, Mattie MD, Hughes-Fulford M, Simko J, Shinohara K, Haqq CM, Carroll PR, Chan JM. Gene expression and biological pathways in tissue of men with prostate cancer in a randomized clinical trial of lycopene and fish oil supplementation. PLoS One. 2011; 6(9):e24004.
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8. Hughes-Fulford M, Li CF. The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization. J Orthop Surg Res. 2011; 6:8.
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9. Chan JM, Weinberg V, Magbanua MJ, Sosa E, Simko J, Shinohara K, Federman S, Mattie M, Hughes-Fulford M, Haqq C, Carroll PR. Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer. Cancer Causes Control. 2011 Jan; 22(1):141-50.
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10. Chang TT, Hughes-Fulford M. Monolayer and spheroid culture of human liver hepatocellular carcinoma cell line cells demonstrate distinct global gene expression patterns and functional phenotypes. Tissue Eng Part A. 2009 Mar; 15(3):559-67.
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11. Sevigny MB, Li CF, Alas M, Hughes-Fulford M. Glycosylation regulates turnover of cyclooxygenase-2. FEBS Lett. 2006 Dec 11; 580(28-29):6533-6.
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12. Hughes-Fulford M, Rodenacker K, Jütting U. Reduction of anabolic signals and alteration of osteoblast nuclear morphology in microgravity. J Cell Biochem. 2006 Oct 1; 99(2):435-49.
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13. Li CF, Hughes-Fulford M. Fibroblast growth factor-2 is an immediate-early gene induced by mechanical stress in osteogenic cells. J Bone Miner Res. 2006 Jun; 21(6):946-55.
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14. Hughes-Fulford M, Li CF, Boonyaratanakornkit J, Sayyah S. Arachidonic acid activates phosphatidylinositol 3-kinase signaling and induces gene expression in prostate cancer. Cancer Res. 2006 Feb 1; 66(3):1427-33.
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15. Boonyaratanakornkit JB, Cogoli A, Li CF, Schopper T, Pippia P, Galleri G, Meloni MA, Hughes-Fulford M. Key gravity-sensitive signaling pathways drive T cell activation. FASEB J. 2005 Dec; 19(14):2020-2.
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16. Hughes-Fulford M, Tjandrawinata RR, Li CF, Sayyah S. Arachidonic acid, an omega-6 fatty acid, induces cytoplasmic phospholipase A2 in prostate carcinoma cells. Carcinogenesis. 2005 Sep; 26(9):1520-6.
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17. Hughes-Fulford M, Sugano E, Schopper T, Li CF, Boonyaratanakornkit JB, Cogoli A. Early immune response and regulation of IL-2 receptor subunits. Cell Signal. 2005 Sep; 17(9):1111-24.
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18. Hughes-Fulford M. Signal transduction and mechanical stress. Sci STKE. 2004 Sep 7; 2004(249):RE12.
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19. Hughes-Fulford M. Lessons learned about spaceflight and cell biology experiments. J Gravit Physiol. 2004 Mar; 11(1):105-9.
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20. Hughes-Fulford M. Function of the cytoskeleton in gravisensing during spaceflight. Adv Space Res. 2003; 32(8):1585-93.
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