Millie Hughes-Fulford, PhD

Millie Hughes-Fulford, PhD

Professor, Department of Biochemistry and Biophysics, UCSF; and Director, Laboratory of Cell Growth, VAMC/UCSF

Phone: 415) 221-4810 x2749 (voice)
VAMC 151F, San Francisco, CA 94143

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Cancer Center Membership

Associate Member » Prostate Cancer» Cancer Genetics


Tarleton State University, Stephenville, TX, B.S., 1968, Chemistry and Biology
Texas Women's University, Denton, TX, Ph.D., 1972, Radiation Chemistry
Woods Hole, Post-Graduate Training, 1987, Summer Physiology courses; 1999, Microscopy course

Professional Experience

  • 1973-1985
    Research Chemist, VAMC San Francisco, CA
  • 1977-1984
    Adjunct Assistant Professor; Biochemistry, Department of Medicine; University of California, San Francisco; and San Francisco Extension Faculty, Biochemistry, UC Berkeley
  • 1984-1991
    Astronaut Scientist, Spacelab Life Sciences-l, JSC, Houston
  • 1984-1994
    Adjunct Associate Professor of Biochemistry, Dept. of Medicine, UCSF, San Francisco
  • 1995- 2001
    Deputy Associate Chief of Staff for Education VAMCSF
  • 1991-present
    Scientific Advisor to the Undersecretary of the Department of Veteran's Affairs
  • 1993-present
    Director, Laboratory of Cell Growth, VAMC/UCSF
  • 1993-present
    Scientific Advisor to the UnderSecretary, Dept of Veteran's Affairs, Washington, DC
  • 1994-present
    Adjunct Professor in Medicine, Dept. of Medicine, UCSF, San Francisco
  • 1996-present
    Research Scientist, NCIRE
  • 2001-present
    Principal Medical Investigator, VAMC

Honors & Awards

  • 1965
    National Science Foundation Summer Research Fellow (Undergraduate)
  • 1968-1971
    National Science Foundation Fellowship (Graduate)
  • 1971-1972
    American Association of University Women's Fellowship
  • 1984
    Presidential Award for Federal Employee for Western Region
  • 1995
    Woman of the Year Marin county
  • 1995
    Named International Zontian, 1995

Selected Publications

  1. Grenon SM, Owens CD, Nosova EV, Hughes-Fulford M, Alley HF, Chong K, Perez S, Yen PK, Boscardin J, Hellmann J, Spite M, Conte MS. Short-Term, High-Dose Fish Oil Supplementation Increases the Production of Omega-3 Fatty Acid-Derived Mediators in Patients With Peripheral Artery Disease (the OMEGA-PAD I Trial). J Am Heart Assoc. 2015; 4(8).
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  2. Chang TT, Spurlock SM, Candelario TL, Grenon SM, Hughes-Fulford M. Spaceflight impairs antigen-specific tolerance induction in vivo and increases inflammatory cytokines. FASEB J. 2015 Oct; 29(10):4122-32.
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  3. Martinez EM, Yoshida MC, Candelario TL, Hughes-Fulford M. Spaceflight and simulated microgravity cause a significant reduction of key gene expression in early T-cell activation. Am J Physiol Regul Integr Comp Physiol. 2015 Mar 15; 308(6):R480-8.
    View on PubMed
  4. Chang TT, Hughes-Fulford M. Molecular mechanisms underlying the enhanced functions of three-dimensional hepatocyte aggregates. Biomaterials. 2014 Feb; 35(7):2162-71.
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  5. Grenon SM, Owens CD, Alley H, Chong K, Yen PK, Harris W, Hughes-Fulford M, Conte MS. n-3 Polyunsaturated fatty acids supplementation in peripheral artery disease: the OMEGA-PAD trial. Vasc Med. 2013 Oct; 18(5):263-74.
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  6. Grenon SM, Jeanne M, Aguado-Zuniga J, Conte MS, Hughes-Fulford M. Effects of gravitational mechanical unloading in endothelial cells: association between caveolins, inflammation and adhesion molecules. Sci Rep. 2013; 3:1494.
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  7. Grenon SM, Saary J, Gray G, Vanderploeg JM, Hughes-Fulford M. Can I take a space flight? Considerations for doctors. BMJ. 2012; 345:e8124.
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  8. Chang TT, Walther I, Li CF, Boonyaratanakornkit J, Galleri G, Meloni MA, Pippia P, Cogoli A, Hughes-Fulford M. The Rel/NF-?B pathway and transcription of immediate early genes in T cell activation are inhibited by microgravity. J Leukoc Biol. 2012 Dec; 92(6):1133-45.
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  9. Grenon SM, Aguado-Zuniga J, Hatton JP, Owens CD, Conte MS, Hughes-Fulford M. Effects of fatty acids on endothelial cells: inflammation and monocyte adhesion. J Surg Res. 2012 Sep; 177(1):e35-43.
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  10. Grenon SM, Hughes-Fulford M, Rapp J, Conte MS. Polyunsaturated fatty acids and peripheral artery disease. Vasc Med. 2012 Feb; 17(1):51-63.
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  11. Magbanua MJ, Roy R, Sosa EV, Weinberg V, Federman S, Mattie MD, Hughes-Fulford M, Simko J, Shinohara K, Haqq CM, Carroll PR, Chan JM. Gene expression and biological pathways in tissue of men with prostate cancer in a randomized clinical trial of lycopene and fish oil supplementation. PLoS One. 2011; 6(9):e24004.
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  12. Hughes-Fulford M. To infinity ... and beyond! Human spaceflight and life science. FASEB J. 2011 Sep; 25(9):2858-64.
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  13. Hughes-Fulford M, Li CF. The role of FGF-2 and BMP-2 in regulation of gene induction, cell proliferation and mineralization. J Orthop Surg Res. 2011; 6:8.
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  14. Chan JM, Weinberg V, Magbanua MJ, Sosa E, Simko J, Shinohara K, Federman S, Mattie M, Hughes-Fulford M, Haqq C, Carroll PR. Nutritional supplements, COX-2 and IGF-1 expression in men on active surveillance for prostate cancer. Cancer Causes Control. 2011 Jan; 22(1):141-50.
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  15. Chang TT, Hughes-Fulford M. Monolayer and spheroid culture of human liver hepatocellular carcinoma cell line cells demonstrate distinct global gene expression patterns and functional phenotypes. Tissue Eng Part A. 2009 Mar; 15(3):559-67.
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  16. Sevigny MB, Li CF, Alas M, Hughes-Fulford M. Glycosylation regulates turnover of cyclooxygenase-2. FEBS Lett. 2006 Dec 11; 580(28-29):6533-6.
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  17. Hughes-Fulford M, Rodenacker K, Jütting U. Reduction of anabolic signals and alteration of osteoblast nuclear morphology in microgravity. J Cell Biochem. 2006 Oct 1; 99(2):435-49.
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  18. Li CF, Hughes-Fulford M. Fibroblast growth factor-2 is an immediate-early gene induced by mechanical stress in osteogenic cells. J Bone Miner Res. 2006 Jun; 21(6):946-55.
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  19. Hughes-Fulford M, Li CF, Boonyaratanakornkit J, Sayyah S. Arachidonic acid activates phosphatidylinositol 3-kinase signaling and induces gene expression in prostate cancer. Cancer Res. 2006 Feb 1; 66(3):1427-33.
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  20. Boonyaratanakornkit JB, Cogoli A, Li CF, Schopper T, Pippia P, Galleri G, Meloni MA, Hughes-Fulford M. Key gravity-sensitive signaling pathways drive T cell activation. FASEB J. 2005 Dec; 19(14):2020-2.
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