Robert B. Jaffe, MD

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Additional Websites

• Physician Referral Directory

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Education

University of Michigan, Ann Arbor, 1950-53
University of Michigan, Ann Arbor, M.D., 1957, Medicine
University of Colorado, Denver, M.S., 1966, Endocrinology
Univ. of Colo. Med. Ctr., Resident, 1959-63, OB/GYN
Unite de Neuroendocrinologie, Paris, 1981, Neuroendocrinology
Peptide Biol. Lab., Salk Institute, La Jolla, CA, 1989, Neuroendocrinology/ Molecular Biology

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Professional Experience

• 1953-54
  Laboratory Assistant, Department of Biochemistry, Univ. of Michigan
• 1958-59
  USPHS Postdoctoral Fellow in Endocrinology, Dept. of Internal Medicine, Univ. of Colorado Medical Center
• 1963-64
  NIH Postdoctoral Fellow in Reproductive Endocrinology, Hormone Laboratory, Karolinska Sjukhuset, Stockholm, Sweden (Egon Diczfalusy, M.D.).
• 1964-71
  Asst and Assoc Professor of Obstetrics and Gynecology, Univ. of Michigan
• 1971-73
  Professor of Obstetrics and Gynecology, Univ. of Michigan
• 1973-present
  Professor of Obstetrics, Gynecology& Reproductive Sciences and Department of Physiology, Univ. of Calif., San Francisco School of Medicine
• 1973-95
  Chairman, Dept. of OB/GYN& Reproductive Sciences.
• 1973-00
  Director, Center for Reproductive Sciences, University of Calif., San Francisco
• 1981
  Macy Foundation Sabbatical Fellowship (C. Kordon, Ph.D.)
• 1989
  Sabbatical, Peptide Biology Laboratory, Salk Institute (W. Vale, Ph.D.)

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Honors & Awards

• Alpha Omega Alpha
• USPHS (NIH) Postdoctoral Fellow in Endocrinology NIH Postdoctoral Fellow in Reproductive Endocrinology
• Josiah Macy Faculty Fellow in Obstetrics
• President, Society for Gynecologic Investigation
• President, Perinatal Research Society
• Human Embryology and Development Study Section
• Natl. Inst. of Child Health and Human Development, Advisory Council
• Josiah Macy Scholar (Neuroendocrinology)
• Assn. of American Physicians
• Reproductive Biology Study Section
• Institute of Medicine
• Fred Gellert Chair in Reproductive Medicine and Biology
• President's Distinguished Scientist Award, SGI
• Fellow, Royal College of Obstetricians and Gynaecologists, Society of Gynecological Investigation President's Mentorship Award
• Distinguished Scientist Award, American Society for Reproductive Medicine, Sidney Ingbar Distinguished Service Award, Endocrine Society

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Selected Publications

1. Coleman RL, Duska LR, Ramirez PT, Heymach JV, Kamat AA, Modesitt SC, Schmeler KM, Iyer RB, Garcia ME, Miller DL, Jackson EF, Ng CS, Kundra V, Jaffe R, Sood AK. Phase 1-2 study of docetaxel plus aflibercept in patients with recurrent ovarian, primary peritoneal, or fallopian tube cancer. Lancet Oncol. 2011 Nov; 12(12):1109-17.
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2. Hu W, Lu C, Dong HH, Huang J, Shen DY, Stone RL, Nick AM, Shahzad MM, Mora E, Jennings NB, Lee SJ, Roh JW, Matsuo K, Nishimura M, Goodman BW, Jaffe RB, Langley RR, Deavers MT, Lopez-Berestein G, Coleman RL, Sood AK. Biological roles of the Delta family Notch ligand Dll4 in tumor and endothelial cells in ovarian cancer. Cancer Res. 2011 Sep 15; 71(18):6030-9.
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3. Ishimoto H, Jaffe RB. Development and function of the human fetal adrenal cortex: a key component in the feto-placental unit. Endocr Rev. 2011 Jun; 32(3):317-55.
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4. Lu C, Han HD, Mangala LS, Ali-Fehmi R, Newton CS, Ozbun L, Armaiz-Pena GN, Hu W, Stone RL, Munkarah A, Ravoori MK, Shahzad MM, Lee JW, Mora E, Langley RR, Carroll AR, Matsuo K, Spannuth WA, Schmandt R, Jennings NB, Goodman BW, Jaffe RB, Nick AM, Kim HS, Guven EO, Chen YH, Li LY, Hsu MC, Coleman RL, Calin GA, Denkbas EB, Lim JY, Lee JS, Kundra V, Birrer MJ, Hung MC, Lopez-Berestein G, Sood AK. Regulation of tumor angiogenesis by EZH2. Cancer Cell. 2010 Aug 9; 18(2):185-97.
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5. Hu L, McArthur C, Jaffe RB. Ovarian cancer stem-like side-population cells are tumourigenic and chemoresistant. Br J Cancer. 2010 Apr 13; 102(8):1276-83.
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6. Lu C, Shahzad MM, Moreno-Smith M, Lin YG, Jennings NB, Allen JK, Landen CN, Mangala LS, Armaiz-Pena GN, Schmandt R, Nick AM, Stone RL, Jaffe RB, Coleman RL, Sood AK. Targeting pericytes with a PDGF-B aptamer in human ovarian carcinoma models. Cancer Biol Ther. 2010 Feb; 9(3):176-82.
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7. Mersereau JE, Khouri C, Jaffe RB. The role of alendronate in mitigating perimenopausal bone loss: a double-blind randomized controlled pilot study. Fertil Steril. 2010 Aug; 94(3):1138-40.
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8. Merritt WM, Danes CG, Shahzad MM, Lin YG, Kamat AA, Han LY, Spannuth WA, Nick AM, Mangala LS, Stone RL, Kim HS, Gershenson DM, Jaffe RB, Coleman RL, Chandra J, Sood AK. Anti-angiogenic properties of metronomic topotecan in ovarian carcinoma. Cancer Biol Ther. 2009 Aug; 8(16):1596-603.
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9. Longo LD, Jaffe RB. A challenge for the 21st century: whither physician-scientists in obstetrics, gynecology, and the reproductive sciences? Am J Obstet Gynecol. 2008 May; 198(5):489-95.
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10. Lu C, Thaker PH, Lin YG, Spannuth W, Landen CN, Merritt WM, Jennings NB, Langley RR, Gershenson DM, Yancopoulos GD, Ellis LM, Jaffe RB, Coleman RL, Sood AK. Impact of vessel maturation on antiangiogenic therapy in ovarian cancer. Am J Obstet Gynecol. 2008 Apr; 198(4):477.e1-9; discussion 477.e9-10.
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11. Ishimoto H, Minegishi K, Higuchi T, Furuya M, Asai S, Kim SH, Tanaka M, Yoshimura Y, Jaffe RB. The periphery of the human fetal adrenal gland is a site of angiogenesis: zonal differential expression and regulation of angiogenic factors. J Clin Endocrinol Metab. 2008 Jun; 93(6):2402-8.
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12. Shelly W, Draper MW, Krishnan V, Wong M, Jaffe RB. Selective estrogen receptor modulators: an update on recent clinical findings. Obstet Gynecol Surv. 2008 Mar; 63(3):163-81.
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13. Lu C, Kamat AA, Lin YG, Merritt WM, Landen CN, Kim TJ, Spannuth W, Arumugam T, Han LY, Jennings NB, Logsdon C, Jaffe RB, Coleman RL, Sood AK. Dual targeting of endothelial cells and pericytes in antivascular therapy for ovarian carcinoma. Clin Cancer Res. 2007 Jul 15; 13(14):4209-17.
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14. Levy N, Zhao X, Tang H, Jaffe RB, Speed TP, Leitman DC. Multiple transcription factor elements collaborate with estrogen receptor alpha to activate an inducible estrogen response element in the NKG2E gene. Endocrinology. 2007 Jul; 148(7):3449-58.
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15. Lu C, Bonome T, Li Y, Kamat AA, Han LY, Schmandt R, Coleman RL, Gershenson DM, Jaffe RB, Birrer MJ, Sood AK. Gene alterations identified by expression profiling in tumor-associated endothelial cells from invasive ovarian carcinoma. Cancer Res. 2007 Feb 15; 67(4):1757-68.
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16. Kamat AA, Kim TJ, Landen CN, Lu C, Han LY, Lin YG, Merritt WM, Thaker PH, Gershenson DM, Bischoff FZ, Heymach JV, Jaffe RB, Coleman RL, Sood AK. Metronomic chemotherapy enhances the efficacy of antivascular therapy in ovarian cancer. Cancer Res. 2007 Jan 1; 67(1):281-8.
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17. Hu L, Ferrara N, Jaffe RB. Paracrine VEGF/VE-cadherin action on ovarian cancer permeability. Exp Biol Med (Maywood). 2006 Nov; 231(10):1646-52.
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18. Ishimoto H, Muench MO, Higuchi T, Minegishi K, Tanaka M, Yoshimura Y, Jaffe RB. Midkine, a heparin-binding growth factor, selectively stimulates proliferation of definitive zone cells of the human fetal adrenal gland. J Clin Endocrinol Metab. 2006 Oct; 91(10):4050-6.
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19. Ishimoto H, Ginzinger DG, Matsumoto T, Hattori Y, Furuya M, Minegishi K, Tanaka M, Yoshimura Y, Jaffe RB. Differential zonal expression and adrenocorticotropin regulation of secreted protein acidic and rich in cysteine (SPARC), a matricellular protein, in the midgestation human fetal adrenal gland: implications for adrenal development. J Clin Endocrinol Metab. 2006 Aug; 91(8):3208-14.
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20. Ishimoto H, Ginzinger DG, Jaffe RB. Adrenocorticotropin preferentially up-regulates angiopoietin 2 in the human fetal adrenal gland: implications for coordinated adrenal organ growth and angiogenesis. J Clin Endocrinol Metab. 2006 May; 91(5):1909-15.
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