University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Lily Jan, PhD

Lily Jan, PhD

Professor of Physiology and Biochemistry, UCSF
Jack and De Loris Lange Endowed Chair of Physiology and Biophysics, UCSF

Cancer Center Program Memberships

Non-aligned

Research Summary

In collaboration with our UCSF colleagues including Sabine Mueller, Marc Shuman, Bill Weiss and David Rowitch, our recent study revealed that EAG2 is upregulated in multiple subgroups of medulloblastoma (MB) and the activity of this potassium channel is crucial for MB growth and metastasis, MB cell proliferation (Huang et al., 2012, Genes & Development 26, 1780-1796) and migration (Huang et al., 2015, Nature Neuroscience 18, 1236-1246). Taken together with our previous collaborative studies of KCNK9 that is upregulated in breast cancer (Mu et al., 2003, Cancer Cell 3, 297-302; Pei et al., 2003 PNAS 100, 7803-7807) and our on-going study of the involvement of another ion channel in pancreatic cancer, these studies support the notion that different types of cancer may upregulate different potassium channels and/or other ion channels in order to undergo rapid proliferation, extensive migration and invasion.

Education

National Taiwan University, Taipei, Taiwan, B.Sc., 06/1968, Physics
California Institute of Technology, Pasadena, CA, M.Sc., 06/1970, Physics
California Institute of Technology, Pasadena, CA, Ph.D., 06/1974, Biophysics & Physics
California Institute of Technology, Pasadena, CA, Postdoc, 06/1977, Neuroscience
Harvard Medical School, Boston, MA, Postdoc, 06/1979, Neuroscience


Professional Experience

  • 1979–1983
    Assistant Professor of Physiology, University of California, San Francisco
  • 1983–1985
    Associate Professor of Physiology and Biochemistry, University of California, San Francisco
  • 1985–present
    Professor of Physiology and Biochemistry, University of California, San Francisco

Honors & Awards

  • 1977-1982
    Established Investigator of the American Heart Association
  • 1977-1979
    Alfred P. Sloan Research Fellowship
  • 1983-1986
    Klingenstein Fellowship Award
  • 1988
    W. Alden Spencer Award and Lecture, Columbia University
  • 1988-2001
    NINDS Javits Neuroscience Investigator Award
  • 1995
    Faculty Lecturer at University of California, San Francisco
  • 1996-present
    Member, National Academy of Sciences
  • 1998–present
    Member, Academia Sinica
  • 1998
    Harvey Lecture
  • 1999
    Stephen W. Kuffler Lecture, Harvard Medical School
  • 2004
    K.S. Cole Award, Biophysical Society
  • 2004
    NIH Margaret Pittman Lecture
  • 2006
    Distinguished Alumni Award, California Institute of Technology
  • 2006
    NIMH MERIT Award
  • 2006
    Society of Chinese Bioscientists in America (SCBA) Presidential Award
  • 2007-present
    Member, American Academy of Arts and Sciences
  • 2007
    Outstanding Mentorship Award form the Postdoctoral Scholar’s Association of UCSF
  • 2009
    Ralph W. Gerard Prize, Society for Neuroscience
  • 2010
    Edward M. Scolnick Prize in Neuroscience
  • 2010
    Grass Lecture at Society for Neuroscience Annual Meeting
  • 2011
    Wiley Prize in Biomedical Research
  • 2012
    Gruber Prize in Neuroscience

Selected Publications

  1. Zhou W, Cheung K, Kyu S, Wang L, Guan Z, Kurien PA, Bickler PE, Jan LY. Activation of orexin system facilitates anesthesia emergence and pain control. Proc Natl Acad Sci U S A. 2018 Oct 22.
    View on PubMed
  2. Jan LY, Jan YN. Influences: Cold Spring Harbor summer courses and Drosophila melanogaster neurogenetics. J Gen Physiol. 2018 May 16.
    View on PubMed
  3. DeVault L, Li T, Izabel S, Thompson-Peer KL, Jan LY, Jan YN. Dendrite regeneration of adult Drosophila sensory neurons diminishes with aging and is inhibited by epidermal-derived matrix metalloproteinase 2. Genes Dev. 2018 Mar 01; 32(5-6):402-414.
    View on PubMed
  4. Jan YN, Jan LY. Force-activated ion channels in close-up. Nature. 2018 Feb 22; 554(7693):469-470.
    View on PubMed
  5. Peters CJ, Gilchrist JM, Tien J, Bethel NP, Qi L, Chen T, Wang L, Jan YN, Grabe M, Jan LY. The Sixth Transmembrane Segment Is a Major Gating Component of the TMEM16A Calcium-Activated Chloride Channel. Neuron. 2018 Mar 07; 97(5):1063-1077.e4.
    View on PubMed
  6. Ye W, Han TW, Nassar LM, Zubia M, Jan YN, Jan LY. Phosphatidylinositol-(4, 5)-bisphosphate regulates calcium gating of small-conductance cation channel TMEM16F. Proc Natl Acad Sci U S A. 2018 Feb 13; 115(7):E1667-E1674.
    View on PubMed
  7. Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbühler K, Ye W, Qi L, Chen T, Craik CS, Jan YN, Minor DL, Cheng Y, Jan LY. Cryo-EM structures of the TMEM16A calcium-activated chloride channel. Nature. 2017 12 21; 552(7685):426-429.
    View on PubMed
  8. He M, Ye W, Wang WJ, Sison ES, Jan YN, Jan LY. Cytoplasmic Cl- couples membrane remodeling to epithelial morphogenesis. Proc Natl Acad Sci U S A. 2017 Dec 26; 114(52):E11161-E11169.
    View on PubMed
  9. Meltzer S, Bagley JA, Perez GL, O'Brien CE, DeVault L, Guo Y, Jan LY, Jan YN. Phospholipid Homeostasis Regulates Dendrite Morphogenesis in Drosophila Sensory Neurons. Cell Rep. 2017 Oct 24; 21(4):859-866.
    View on PubMed
  10. Zhang Y, Zhang Z, Xiao S, Tien J, Le S, Le T, Jan LY, Yang H. Inferior Olivary TMEM16B Mediates Cerebellar Motor Learning. Neuron. 2017 Aug 30; 95(5):1103-1111.e4.
    View on PubMed
  11. Orr BO, Gorczyca D, Younger MA, Jan LY, Jan YN, Davis GW. Composition and Control of a Deg/ENaC Channel during Presynaptic Homeostatic Plasticity. Cell Rep. 2017 Aug 22; 20(8):1855-1866.
    View on PubMed
  12. Jin P, Bulkley D, Guo Y, Zhang W, Guo Z, Huynh W, Wu S, Meltzer S, Cheng T, Jan LY, Jan YN, Cheng Y. Electron cryo-microscopy structure of the mechanotransduction channel NOMPC. Nature. 2017 07 06; 547(7661):118-122.
    View on PubMed
  13. Klassen MP, Peters CJ, Zhou S, Williams HH, Jan LY, Jan YN. Age-dependent diastolic heart failure in an in vivo Drosophila model. Elife. 2017 03 22; 6.
    View on PubMed
  14. Yadav S, Oses-Prieto JA, Peters CJ, Zhou J, Pleasure SJ, Burlingame AL, Jan LY, Jan YN. TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine Maturation through Septin7 Phosphorylation. Neuron. 2017 Jan 18; 93(2):379-393.
    View on PubMed
  15. Li J, Zhang W, Guo Z, Wu S, Jan LY, Jan YN. A Defensive Kicking Behavior in Response to Mechanical Stimuli Mediated by Drosophila Wing Margin Bristles. J Neurosci. 2016 Nov 02; 36(44):11275-11282.
    View on PubMed
  16. Thayer DA, Yang SB, Jan YN, Jan LY. N-linked glycosylation of Kv1.2 voltage-gated potassium channel facilitates cell surface expression and enhances the stability of internalized channels. J Physiol. 2016 11 15; 594(22):6701-6713.
    View on PubMed
  17. Thompson-Peer KL, DeVault L, Li T, Jan LY, Jan YN. In vivo dendrite regeneration after injury is different from dendrite development. Genes Dev. 2016 08 01; 30(15):1776-89.
    View on PubMed
  18. Guo Y, Wang Y, Zhang W, Meltzer S, Zanini D, Yu Y, Li J, Cheng T, Guo Z, Wang Q, Jacobs JS, Sharma Y, Eberl DF, Göpfert MC, Jan LY, Jan YN, Wang Z. Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion. Proc Natl Acad Sci U S A. 2016 06 28; 113(26):7243-8.
    View on PubMed
  19. Ori-McKenney KM, McKenney RJ, Huang HH, Li T, Meltzer S, Jan LY, Vale RD, Wiita AP, Jan YN. Phosphorylation of ß-Tubulin by the Down Syndrome Kinase, Minibrain/DYRK1a, Regulates Microtubule Dynamics and Dendrite Morphogenesis. Neuron. 2016 05 04; 90(3):551-63.
    View on PubMed
  20. Meltzer S, Yadav S, Lee J, Soba P, Younger SH, Jin P, Zhang W, Parrish J, Jan LY, Jan YN. Epidermis-Derived Semaphorin Promotes Dendrite Self-Avoidance by Regulating Dendrite-Substrate Adhesion in Drosophila Sensory Neurons. Neuron. 2016 Feb 17; 89(4):741-55.
    View on PubMed

Go to UCSF Profiles, powered by CTSI