Robert Judson, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Robert Judson, PhD

Assistant Researcher, Sandler Faculty Fellow, UCSF

Robert.Judson@ucsf.edu

Phone: (415) 476-7290
Box 3111, UCSF
San Francisco, CA 94143

UCSF Profiles | Lab website

Cancer Center Membership

Member » Cancer Genetics

Research Summary

Melanoma is the most deadly skin cancer, and the incidence of the disease has been increasing steadily for about three decades. In 2016, we expect over 75,000 new diagnoses and about 10,000 deaths in the United States. Metastasized melanomas are notorious for their ability to acquire resistance to even the most promising treatments, usually resulting in a fatal recurrence. Perhaps most tragic, melanoma is among the most common cancers in young adults, ages 20 to 39. Better methods of predicting and preventing this disease would have significant impact on the lives of these patients and the economic burden of treatment.

At the root of melanoma is a cell state transition – the reprogramming of a melanocyte functioning under one specific set of operations into a different cell type that has lost some of its cellular programs and acquired others. What causes this transition to occur? Melanoma, like many cancers, has traditionally been viewed as a strictly genetic disease - progression is driven though the accumulation of genetic mutations that confer survival advantages and oncogenic phenotypes. One consequence of this progressive hit model is that treatment is reactionary – no individual cell is at greater or less risk of progression, but rather a cancer cell is only identified after it has obtained the causal mutation.

This progressive hit model is almost certainly over-simplified. Much of previous research has focused on “surviving cells” – for example, the few cells that progressed to form a tumor in a patient or mouse model, or cells that successfully transform into lines in culture. The interests of my research group can be generalized by the inverse question: “If one in ten (or more accurately, ten thousand) mutated melanocytes successfully form a melanoma – what prevented the rest from doing so and why?” Answering this question will flesh out the progressive hit model by providing both an understanding of the diversity of phenotypic consequences established oncogenic mutations can have on individual cells and by identifying the non-genetic factors that result in cells being permissive to transformation. With the goal of developing novel strategies for early diagnostics and prevention, my research group uses a combination of primary tumor sequencing, microRNA-based network dissection, CRISPR/Cas9-based engineering of melanomas from primary melanocytes, and digital holographic quantitative cytometry to study the networks of genes that prevent normal melanocytes and primary melanomas from acquiring oncogenic programs.

For more information please visit: http://judsonlab.ucsf.edu.

Education

Wesleyan University, B.A., 05/05, Mol. Biology & Biochemistry
National Institutes of Health, 09/07, Biochemistry
University of California, San Francisco, Ph.D., 12/12, Biomedical Sciences


Professional Experience

  • 2004 – 2005
    Research Assistant, Georgetown University
  • 2005 – 2007
    Postbaccalaureate Fellow, National Institutes of Health, NICHD
  • 2007 – 2012
    Graduate Student Researcher, University of California, San Francisco
  • 2013 – 2014
    Postdoctoral Fellow, University of California, San Francisco
  • 2014 – present
    Sandler Faculty Fellow, University of California, San Francisco

Honors & Awards

  • 2004
    Goldwater Scholarship, Barry Goldwater Excellence in Education Foundation
  • 2005
    Graduated University Honors: Wesleyan’s highest honor awarded to 0-2 graduating seniors a year.
  • 2005
    Graham Prize for Excellence in Natural Sciences, Wesleyan University
  • 2005
    Hawk Prize for Excellence in Biochemistry, Wesleyan University
  • 2007 – 2010
    National Sciences Foundation Graduate Research Fellowship
  • 2010
    UC Cancer Research Coordinating Committee Fellowship, UCSF
  • 2011
    Julius R. and Patricia A. Krevans Fellowship, UCSF
  • 2012
    Northern California Association of Phi Beta Kappa Graduate Fellowship
  • 2013
    UCSF Faculty Fellow, University of California, San Francisco
  • 2014
    NIH Common Fund DP5 Early Independence Award

Selected Publications

robert.judson