University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Young-wook Jun, PhD

Young-wook Jun, PhD

Associate Professor, Dept. of Otolaryngology - Head and Neck Surgery (OHNS), UCSF

Cancer Center Program Memberships

Non-aligned

Research Summary

Young-Wook Jun, PhD, is an Associate Professor and he is the Director of the Nano-Probing Single Biomolecule Dynamics Laboratory in the Department of Otolaryngology - Head and Neck Surgery (OHNS) at the University of California, San Francisco. He received his PhD from the Korea Advanced Institute of Science and Technology in Seoul, South Korea, and he completed a postdoctoral from Yonsei University, Seoul, South Korea, followed by a postdoctoral from the University of California, Berkeley.

Dr. Jun's research interests include nanoprobing systems to investigate the single molecule dynamics of biomolecules involved in cellular developments such as gene regulation, cell-to-cell communications, and neuron circuit formation. His research on "Nanocrystal-Molecules as Probes for Monitoring the Dynamics of Biomolecular Machineries at the Single Molecule Level" will contribute to a foundation of a new field by providing a comprehensive understanding of the nanocrystal molecules including the fabrication, surface chemistry, scaling laws of magnetic, plasmonic, and charge coupling, and their behaviors in cells.

Dr. Jun has been invited to speak both national and internationally. He has contributed to over 40 articles, and 5 book chapters.

Education

University of California, Berkeley, CA, Postdoc, 06/2010, Nanoscience
Yonsei University, Seoul, Korea, Postdoc, 06/2007, Nanochemistry
Korea Adv. Inst. Sci. & Tech., Daejeon, Korea, Ph.D., 02/2005, Materials Chemistry
Yonsei University, Seoul, Korea, B.A., 02/1999, Chemistry


Professional Experience

  • 2016-present
    Associate Professor, Dept. of Otolaryngology, Univ. of California, San Francisco, CA
  • 2017-present
    Associate Professor, Dept. of Pharmaceutical Chemistry, Univ. of California, San Francisco, CA
  • 2010-2016
    Assistant Professor, Dept. of Otolaryngology, Univ. of California, San Francisco, CA
  • 2016-present
    Affiliated faculty, Yonsei Institute of Basic Science (IBS)
  • 2014-present
    Core faculty, UCSF-UCB Bioengineering program
  • 2010-present
    Core faculty, Programs in Chemistry & Chemical Biology, Univ. of California, San Francisco, CA

Honors & Awards

  • 2005
    IUPAC Prize for Young Chemist: The Honorable Mention Award
  • 2010
    The Sandler Foundation New Innovator Research Award
  • 2011
    The Endowed Hemming Fellow
  • 2014
    The World’s Most Influential Scientific Minds
  • 2014
    Thomson Reuters Highly Cited Researchers
  • 2014
    BayBRAIN Initiative Award
  • 2016
    The Sandler Foundation New Frontier Research Award

Selected Publications

  1. Lee M, Moon Y, Lee S, Lee C, Jun Y. Ergosterol interacts with Sey1p to promote atlastin-mediated endoplasmic reticulum membrane fusion in Saccharomyces cerevisiae. FASEB J. 2018 Nov 21; fj201800779RR.
    View on PubMed
  2. Kim MA, Kim DK, Yang HJ, Yoo Y, Ahn Y, Park HS, Lee HJ, Jeong YY, Kim BS, Bae WY, Jang AS, Park Y, Koh YI, Lee J, Lim DH, Kim JH, Lee SM, Kim YM, Jun YJ, Kim HY, Kim Y, Choi JH. Pollen-Food Allergy Syndrome in Korean Pollinosis Patients: A Nationwide Survey. Allergy Asthma Immunol Res. 2018 Nov; 10(6):648-661.
    View on PubMed
  3. Min Y, Kim D, Jun YS. Effects of Na+ and K+ Exchange in Interlayers on Biotite Dissolution under High Temperature and High CO2 Pressure Conditions. Environ Sci Technol. 2018 Oct 22.
    View on PubMed
  4. Jiang Q, Ghim D, Cao S, Tadepalli S, Liu KK, Kwon H, Luan J, Min Y, Jun YS, Singamaneni S. Photothermally Active Reduced Graphene Oxide/Bacterial Nanocellulose Composites as Biofouling-Resistant Ultrafiltration Membranes. Environ Sci Technol. 2018 Oct 05.
    View on PubMed
  5. Kim HR, Mun Y, Lee KS, Park YJ, Park JS, Park JH, Jeon BN, Kim CH, Jun Y, Hyun YM, Kim M, Lee SM, Park CS, Im SH, Jun CD. T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells. Nat Commun. 2018 Sep 07; 9(1):3630.
    View on PubMed
  6. Zhang L, Jun YS. The Role of Fe-Bearing Phyllosilicates in DTPMP Degradation under High-Temperature and High-Pressure Conditions. Environ Sci Technol. 2018 Aug 10.
    View on PubMed
  7. Kim JW, Jeong HK, Southard KM, Jun YW, Cheon J. Magnetic Nanotweezers for Interrogating Biological Processes in Space and Time. Acc Chem Res. 2018 Mar 28.
    View on PubMed
  8. Kim JW, Seo D, Lee JU, Southard KM, Lim Y, Kim D, Gartner ZJ, Jun YW, Cheon J. Single-cell mechanogenetics using monovalent magnetoplasmonic nanoparticles. Nat Protoc. 2017 Sep; 12(9):1871-1889.
    View on PubMed
  9. Seo D, Southard KM, Kim JW, Lee HJ, Farlow J, Lee JU, Litt DB, Haas T, Alivisatos AP, Cheon J, Gartner ZJ, Jun YW. A Mechanogenetic Toolkit for Interrogating Cell Signaling in Space and Time. Cell. 2016 Jun 02; 165(6):1507-1518.
    View on PubMed
  10. Daeha Seo, Hyunjung Lee, Jung-uk Lee, Thomas Haas, Young-wook Jun. Monovalent plasmonic nanoparticles for biological applications. Proceedings of SPIE--the International Society for Optical Engineering. 2016; 9722:972201.
    View on PubMed
  11. Mabray MC, Lillaney P, Sze CH, Losey AD, Yang J, Kondapavulur S, Liu D, Saeed M, Patel A, Cooke D, Jun YW, El-Sayed I, Wilson M, Hetts SW. In Vitro Capture of Small Ferrous Particles with a Magnetic Filtration Device Designed for Intravascular Use with Intraarterial Chemotherapy: Proof-of-Concept Study. J Vasc Interv Radiol. 2016 Mar; 27(3):426-32.e1.
    View on PubMed
  12. Seo D, Farlow J, Southard K, Jun YW, Gartner ZJ. Production and targeting of monovalent quantum dots. J Vis Exp. 2014 Oct 23; (92):e52198.
    View on PubMed
  13. Tajon CA, Seo D, Asmussen J, Shah N, Jun YW, Craik CS. Sensitive and selective plasmon ruler nanosensors for monitoring the apoptotic drug response in leukemia. ACS Nano. 2014 Sep 23; 8(9):9199-208.
    View on PubMed
  14. Tajon C, Jun YW, Craik CS. Single-molecule sensing of caspase activation in live cells via plasmon coupling nanotechnology. Methods Enzymol. 2014; 544:271-97.
    View on PubMed
  15. Asmussen J, Lasater EA, Tajon C, Oses-Prieto J, Jun YW, Taylor BS, Burlingame A, Craik CS, Shah NP. MEK-dependent negative feedback underlies BCR-ABL-mediated oncogene addiction. Cancer Discov. 2014 Feb; 4(2):200-15.
    View on PubMed
  16. Farlow J, Seo D, Broaders KE, Taylor MJ, Gartner ZJ, Jun YW. Formation of targeted monovalent quantum dots by steric exclusion. Nat Methods. 2013 Dec; 10(12):1203-5.
    View on PubMed
  17. Hu Y, Jun YS. Biotite dissolution in brine at varied temperatures and CO2 pressures: its activation energy and potential CO2 intercalation. Langmuir. 2012 Oct 16; 28(41):14633-41.
    View on PubMed
  18. Sheikholeslami S, Jun YW, Jain PK, Alivisatos AP. Coupling of optical resonances in a compositionally asymmetric plasmonic nanoparticle dimer. Nano Lett. 2010 Jul 14; 10(7):2655-60.
    View on PubMed
  19. Park J, Zheng H, Jun YW, Alivisatos AP. Hetero-epitaxial anion exchange yields single-crystalline hollow nanoparticles. J Am Chem Soc. 2009 Oct 07; 131(39):13943-5.
    View on PubMed
  20. Jun YW, Sheikholeslami S, Hostetter DR, Tajon C, Craik CS, Alivisatos AP. Continuous imaging of plasmon rulers in live cells reveals early-stage caspase-3 activation at the single-molecule level. Proc Natl Acad Sci U S A. 2009 Oct 20; 106(42):17735-40.
    View on PubMed

Go to UCSF Profiles, powered by CTSI