Ophir D. Klein, MD, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Ophir D. Klein, MD, PhD

Professor, Departments of Orofacial Sciences and Pediatrics, and Institutes for Human Genetics and Regeneration Medicine, UCSF

ophir.klein@ucsf.edu

Phone: (415) 476-4719
Box 0422, UCSF
San Francisco, CA 94143-0422

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Cancer Center Membership

Program Member » Pediatric Malignancies

Research Summary

I am a developmental biologist, as well as a pediatrician and clinical geneticist, and I am interested in translating an understanding of developmental mechanisms into advances for regenerative medicine. After completing the MD/PhD degrees and a pediatric residency, I trained in Medical Genetics, and I became interested in syndromes. As a physician scientist, I treat patients with various syndromes, including those that predispose patients to cancer. As the Larry L. Hillblom Distinguished Professor in Craniofacial Anomalies, Chair of the Divisions of Craniofacial Anomalies and Orthodontics at UCSF, Medical Director of the UCSF Craniofacial Center, and Director of the UCSF Program in Craniofacial Biology, I take a strong interest in integrating clinical and research activities. Work in my research group centers on organ development and regeneration, with a major focus on understanding the processes underlying stem cell-based renewal and on integrating evolutionary and developmental approaches.

Education

University of California, Berkeley, B.A., 1993, Spanish
Yale University, New Haven, CT, Ph.D., 1999, Genetics
Yale University, New Haven, CT, M.D., 2000
Yale-New Haven Hospital, New Haven, CT, 2000-2003, Pediatrics
University of California, San Francisco, 2003-2007, Clinical Genetics


Professional Experience

  • 2007-2013
    Assistant Professor, Departments of Orofacial Sciences and Pediatrics, and Institutes for Human Genetics and Regeneration Medicine, UCSF
  • 2009-present
    Director, UCSF Program in Craniofacial and Mesenchymal Biology
  • 2013-2015
    Associate Professor, Departments of Orofacial Sciences and Pediatrics, and Institutes for Human Genetics and Regeneration Medicine, UCSF
  • 2015-present
    Professor, Departments of Orofacial Sciences and Pediatrics, and Institutes for Human Genetics and Regeneration Medicine, UCSF

 

Honors & Awards

  • 1989-1993
    Chancellor's Scholarship, University of California, Berkeley
  • 1993-2000
    NIH Medical Scientist Training Program
  • 1999
    Dean's Distinguished Thesis Commendation, Yale University Graduate School
  • 2004
    Fellow, American Academy of Pediatrics
  • 2004-2007
    Fellow, Pediatric Scientist Development Program, NICHD/NIH
  • 2005
    David W. Smith Trainee Research Award, Western Society for Pediatric Research
  • 2005
    Fellow (Basic) Research Award, Society for Pediatric Research
  • 2005
    American Academy of Pediatrics Young Investigator Research Grant
  • 2008
    Fellow, American College of Medical Genetics
  • 2008-2010
    Culpeper Scholar
  • 2008
    United States Bone and Joint Decade Young Investigator
  • 2008-2013
    California Institute of Regenerative Medicine New Faculty Award
  • 2008
    Elected to Society for Pediatric Research
  • 2009-2011
    March of Dimes Basil O'Connor Award
  • 2009
    Elected to Western Society for Pediatric Research
  • 2009
    ASBMR Harold M. Frost Young Investigator Award

Selected Publications

  1. Human iPS Cell-Derived Neurons Uncover the Impact of Increased Ras Signaling in Costello Syndrome. J Neurosci. 2016 Jan 6; 36(1):142-52.
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  2. Migration of Founder Epithelial Cells Drives Proper Molar Tooth Positioning and Morphogenesis. Dev Cell. 2015 Dec 21; 35(6):713-24.
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  3. Craniofacial Stem Cells in Health and Disease. J Dent Res. 2015 Nov; 94(11):1485-6.
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  4. From Bench to Bedside and Back: Improving Diagnosis and Treatment of Craniofacial Malformations Utilizing Animal Models. Curr Top Dev Biol. 2015; 115:459-92.
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  5. Phenotypic and evolutionary implications of modulating the ERK-MAPK cascade using the dentition as a model. Sci Rep. 2015; 5:11658.
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  6. Identification of novel Fgf enhancers and their role in dental evolution. Evol Dev. 2015 Jun 18.
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  7. Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In Vivo. Stem Cell Reports. 2015 Jun 3.
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  8. DLX4 is associated with orofacial clefting and abnormal jaw development. Hum Mol Genet. 2015 Aug 1; 24(15):4340-52.
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  9. Further supporting evidence for the SATB2-associated syndrome found through whole exome sequencing. Am J Med Genet A. 2015 May; 167(5):1026-32.
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  10. Hyperplasia of interstitial cells of cajal in sprouty homolog 4 deficient mice. PLoS One. 2015; 10(4):e0124861.
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  11. Continuously Growing Rodent Molars Result from a Predictable Quantitative Evolutionary Change over 50 Million Years. Cell Rep. 2015 May 5; 11(5):673-80.
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  12. Opposing activities of notch and wnt signaling regulate intestinal stem cells and gut homeostasis. Cell Rep. 2015 Apr 7; 11(1):33-42.
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  13. In vitro generation of human pluripotent stem cell derived lung organoids. Elife. 2015; 4.
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  14. Spontaneous emergence of overgrown molar teeth in a colony of Prairie voles (Microtus ochrogaster). Int J Oral Sci. 2015 Mar; 7(1):23-6.
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  15. Developing and regenerating a sense of taste. Curr Top Dev Biol. 2015; 111:401-19.
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  16. Replaying evolutionary transitions from the dental fossil record. Nature. 2014 Aug 7; 512(7512):44-8.
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  17. Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium. Development. 2014 Aug; 141(15):2993-3002.
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  18. Nuclear to cytoplasmic shuttling of ERK promotes differentiation of muscle stem/progenitor cells. Development. 2014 Jul; 141(13):2611-20.
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  19. Craniofacial morphometric analysis of individuals with X-linked hypohidrotic ectodermal dysplasia. Mol Genet Genomic Med. 2014 Sep; 2(5):422-9.
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  20. Isolation and culture of dental epithelial stem cells from the adult mouse incisor. J Vis Exp. 2014; (87).
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