University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Ophir D. Klein, MD, PhD

Ophir D. Klein, MD, PhD

Professor, Departments of Orofacial Sciences and Pediatrics, and Institutes for Human Genetics and Regeneration Medicine, UCSF
Larry L. Hillblom Distinguished Professorship in Craniofacial Anomalies, UCSF

Cancer Center Program Memberships

Pediatric Malignancies

Research Summary

I am a developmental biologist as well as a pediatrician and clinical geneticist, and I am interested in translating an understanding of developmental mechanisms into advances for regenerative medicine. After completing the MD/PhD degrees and a pediatric residency, I trained in Medical Genetics. As a physician scientist, I treat patients with various syndromes, including those that predispose patients to cancer. As the Chief of the Division of Genetics at UCSF and Chair of the Division of Craniofacial Anomalies at UCSF, I take a strong interest in integrating clinical and research activities. Work in my research group centers on organ development and regeneration, with a major focus on understanding the processes underlying stem cell-based renewal and on integrating evolutionary and developmental approaches.

Education

University of California, Berkeley, B.A., 1993, Spanish
Yale University, New Haven, CT, Ph.D., 1999, Genetics
Yale University, New Haven, CT, M.D., 2000
Yale-New Haven Hospital, New Haven, CT, 2000-2003, Pediatrics
University of California, San Francisco, 2003-2007, Clinical Genetics


Professional Experience

  • 2007-2011
    Assistant Professor, Departments of Orofacial Sciences and Pediatrics, and Institutes for Human Genetics and Regeneration Medicine
  • 2009-present
    Director, UCSF Program in Craniofacial and Mesenchymal Biology
  • 2011-2015
    Associate Professor, Departments of Orofacial Sciences and Pediatrics, and Institutes for Human Genetics and Regeneration Medicine
  • 2013-present
    Chair, Division of Craniofacial Anomalies
  • 2013-present
    Medical Director, Craniofacial Anomalies Clinic
  • 2014-2016
    Chair, Division of Orthodontics
  • 2015-present
    Professor, Departments of Orofacial Sciences and Pediatrics, and Institutes for Human Genetics and Regeneration Medicine
  • 2016-present
    Chief, Division of Genetics

Honors & Awards

  • 1989-1993
    Chancellor's Scholarship, University of California, Berkeley
  • 1993-2000
    NIH Medical Scientist Training Program
  • 1999
    Dean's Distinguished Thesis Commendation, Yale University Graduate School
  • 2004
    Fellow, American Academy of Pediatrics
  • 2004-2007
    Fellow, Pediatric Scientist Development Program, NICHD/NIH
  • 2005
    David W. Smith Trainee Research Award, Western Society for Pediatric Research
  • 2005
    Fellow (Basic) Research Award, Society for Pediatric Research
  • 2005
    American Academy of Pediatrics Young Investigator Research Grant
  • 2008
    Fellow, American College of Medical Genetics
  • 2008-2010
    Culpeper Scholar
  • 2008
    United States Bone and Joint Decade Young Investigator
  • 2008-2013
    California Institute of Regenerative Medicine New Faculty Award
  • 2008
    Elected to Society for Pediatric Research
  • 2009-2011
    March of Dimes Basil O'Connor Award
  • 2009
    Elected to Western Society for Pediatric Research
  • 2009
    ASBMR Harold M. Frost Young Investigator Award

Selected Publications

  1. Calamari ZT, Hu JK, Klein OD. Tissue Mechanical Forces and Evolutionary Developmental Changes Act Through Space and Time to Shape Tooth Morphology and Function. Bioessays. 2018 Nov 02; e1800140.
    View on PubMed
  2. Ransom RC, Carter AC, Salhotra A, Leavitt T, Marecic O, Murphy MP, Lopez ML, Wei Y, Marshall CD, Shen EZ, Jones RE, Sharir A, Klein OD, Chan CKF, Wan DC, Chang HY, Longaker MT. Mechanoresponsive stem cells acquire neural crest fate in jaw regeneration. Nature. 2018 Oct 24.
    View on PubMed
  3. May AJ, Cruz-Pacheco N, Emmerson E, Gaylord EA, Seidel K, Nathan S, Muench MO, Klein O, Knox SM. Diverse progenitor cells preserve salivary gland ductal architecture after radiation induced damage. Development. 2018 Oct 10.
    View on PubMed
  4. Bayrer JR, Wang H, Nattiv R, Suzawa M, Escusa HS, Fletterick RJ, Klein OD, Moore DD, Ingraham HA. LRH-1 mitigates intestinal inflammatory disease by maintaining epithelial homeostasis and cell survival. Nat Commun. 2018 Oct 10; 9(1):4055.
    View on PubMed
  5. Weichselbaum L, Klein OD. The intestinal epithelial response to damage. Sci China Life Sci. 2018 Sep 04.
    View on PubMed
  6. Haghighi A, Krier JB, Toth-Petroczy A, Cassa CA, Frank NY, Carmichael N, Fieg E, Bjonnes A, Mohanty A, Briere LC, Lincoln S, Lucia S, Gupta VA, Söylemez O, Sutti S, Kooshesh K, Qiu H, Fay CJ, Perroni V, Valerius J, Hanna M, Frank A, Ouahed J, Snapper SB, Pantazi A, Chopra SS, Leshchiner I, Stitziel NO, Feldweg A, Mannstadt M, Loscalzo J, Sweetser DA, Liao E, Stoler JM, Nowak CB, Sanchez-Lara PA, Klein OD, Perry H, Patsopoulos NA, Raychaudhuri S, Goessling W, Green RC, Seidman CE, MacRae CA, Sunyaev SR, Maas RL, Vuzman D. An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery. NPJ Genom Med. 2018; 3:21.
    View on PubMed
  7. Nguyen MB, Cohen I, Kumar V, Xu Z, Bar C, Dauber-Decker KL, Tsai PC, Marangoni P, Klein OD, Hsu YC, Chen T, Mikkola ML, Ezhkova E. Publisher Correction: FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells. Nat Commun. 2018 Jul 17; 9(1):2854.
    View on PubMed
  8. Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD. Publisher Correction: Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche. Nature. 2018 Jul 16.
    View on PubMed
  9. Zhao H, Feng J, Seidel K, Shi S, Klein O, Sharpe P, Chai Y. Secretion of Shh by a Neurovascular Bundle Niche Supports Mesenchymal Stem Cell Homeostasis in the Adult Mouse Incisor. Cell Stem Cell. 2018 Jul 05; 23(1):147.
    View on PubMed
  10. Nusse YM, Savage AK, Marangoni P, Rosendahl-Huber AKM, Landman TA, de Sauvage FJ, Locksley RM, Klein OD. Parasitic helminths induce fetal-like reversion in the intestinal stem cell niche. Nature. 2018 Jun 27.
    View on PubMed
  11. Castillo-Azofeifa D, Seidel K, Gross L, Golden EJ, Jacquez B, Klein OD, Barlow LA. SOX2 Regulation by hedgehog signaling controls adult lingual epithelium homeostasis. Development. 2018 Jun 26.
    View on PubMed
  12. Herrero D, Cañón S, Pelacho B, Salvador-Bernáldez M, Aguilar S, Pogontke C, Carmona RM, Salvador JM, Perez-Pomares JM, Klein OD, Prósper F, Jimenez-Borreguero LJ, Bernad A. Bmi1-Progenitor Cell Ablation Impairs the Angiogenic Response to Myocardial Infarction. Arterioscler Thromb Vasc Biol. 2018 Jun 21.
    View on PubMed
  13. McKinley KL, Stuurman N, Royer LA, Schartner C, Castillo-Azofeifa D, Delling M, Klein OD, Vale RD. Cellular aspect ratio and cell division mechanics underlie the patterning of cell progeny in diverse mammalian epithelia. Elife. 2018 Jun 13; 7.
    View on PubMed
  14. Nguyen MB, Cohen I, Kumar V, Xu Z, Bar C, Dauber-Decker KL, Tsai PC, Marangoni P, Klein OD, Hsu YC, Chen T, Mikkola ML, Ezhkova E. FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells. Nat Commun. 2018 Jun 13; 9(1):2333.
    View on PubMed
  15. Zou WY, Blutt SE, Zeng XL, Chen MS, Lo YH, Castillo-Azofeifa D, Klein OD, Shroyer NF, Donowitz M, Estes MK. Epithelial WNT Ligands Are Essential Drivers of Intestinal Stem Cell Activation. Cell Rep. 2018 Jan 23; 22(4):1003-1015.
    View on PubMed
  16. Kalha S, Shrestha B, Sanz Navarro M, Jones KB, Klein OD, Michon F. Bmi1+ Progenitor Cell Dynamics in Murine Cornea During Homeostasis and Wound Healing. Stem Cells. 2018 Apr; 36(4):562-573.
    View on PubMed
  17. Sanz-Navarro M, Seidel K, Sun Z, Bertonnier-Brouty L, Amendt BA, Klein OD, Michon F. Plasticity within the niche ensures the maintenance of a Sox2+ stem cell population in the mouse incisor. Development. 2018 01 08; 145(1).
    View on PubMed
  18. Ching ST, Infante CR, Du W, Sharir A, Park S, Menke DB, Klein OD. Isl1 mediates mesenchymal expansion in the developing external genitalia via regulation of Bmp4, Fgf10 and Wnt5a. Hum Mol Genet. 2018 Jan 01; 27(1):107-119.
    View on PubMed
  19. Hughes AJ, Miyazaki H, Coyle MC, Zhang J, Laurie MT, Chu D, Vavrušová Z, Schneider RA, Klein OD, Gartner ZJ. Engineered Tissue Folding by Mechanical Compaction of the Mesenchyme. Dev Cell. 2018 Jan 22; 44(2):165-178.e6.
    View on PubMed
  20. Larson JR, Manyama MF, Cole JB, Gonzalez PN, Percival CJ, Liberton DK, Ferrara TM, Riccardi SL, Kimwaga EA, Mathayo J, Spitzmacher JA, Rolian C, Jamniczky HA, Weinberg SM, Roseman CC, Klein O, Lukowiak K, Spritz RA, Hallgrimsson B. Body size and allometric variation in facial shape in children. Am J Phys Anthropol. 2018 02; 165(2):327-342.
    View on PubMed

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