University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Ophir D. Klein, MD, PhD

Ophir D. Klein, MD, PhD

Professor, Departments of Orofacial Sciences and Pediatrics, and Institutes for Human Genetics and Regeneration Medicine, UCSF

Cancer Center Program Memberships

Pediatric Malignancies

Research Summary

I am a developmental biologist as well as a pediatrician and clinical geneticist, and I am interested in translating an understanding of developmental mechanisms into advances for regenerative medicine. After completing the MD/PhD degrees and a pediatric residency, I trained in Medical Genetics. As a physician scientist, I treat patients with various syndromes, including those that predispose patients to cancer. As the Chief of the Division of Genetics at UCSF and Chair of the Division of Craniofacial Anomalies at UCSF, I take a strong interest in integrating clinical and research activities. Work in my research group centers on organ development and regeneration, with a major focus on understanding the processes underlying stem cell-based renewal and on integrating evolutionary and developmental approaches.

Education

University of California, Berkeley, B.A., 1993, Spanish
Yale University, New Haven, CT, Ph.D., 1999, Genetics
Yale University, New Haven, CT, M.D., 2000
Yale-New Haven Hospital, New Haven, CT, 2000-2003, Pediatrics
University of California, San Francisco, 2003-2007, Clinical Genetics


Professional Experience

  • 2007-2011
    Assistant Professor, Departments of Orofacial Sciences and Pediatrics, and Institutes for Human Genetics and Regeneration Medicine
  • 2009-present
    Director, UCSF Program in Craniofacial and Mesenchymal Biology
  • 2011-2015
    Associate Professor, Departments of Orofacial Sciences and Pediatrics, and Institutes for Human Genetics and Regeneration Medicine
  • 2013-present
    Chair, Division of Craniofacial Anomalies
  • 2013-present
    Medical Director, Craniofacial Anomalies Clinic
  • 2014-2016
    Chair, Division of Orthodontics
  • 2015-present
    Professor, Departments of Orofacial Sciences and Pediatrics, and Institutes for Human Genetics and Regeneration Medicine
  • 2016-present
    Chief, Division of Genetics

Honors & Awards

  • 1989-1993
    Chancellor's Scholarship, University of California, Berkeley
  • 1993-2000
    NIH Medical Scientist Training Program
  • 1999
    Dean's Distinguished Thesis Commendation, Yale University Graduate School
  • 2004
    Fellow, American Academy of Pediatrics
  • 2004-2007
    Fellow, Pediatric Scientist Development Program, NICHD/NIH
  • 2005
    David W. Smith Trainee Research Award, Western Society for Pediatric Research
  • 2005
    Fellow (Basic) Research Award, Society for Pediatric Research
  • 2005
    American Academy of Pediatrics Young Investigator Research Grant
  • 2008
    Fellow, American College of Medical Genetics
  • 2008-2010
    Culpeper Scholar
  • 2008
    United States Bone and Joint Decade Young Investigator
  • 2008-2013
    California Institute of Regenerative Medicine New Faculty Award
  • 2008
    Elected to Society for Pediatric Research
  • 2009-2011
    March of Dimes Basil O'Connor Award
  • 2009
    Elected to Western Society for Pediatric Research
  • 2009
    ASBMR Harold M. Frost Young Investigator Award

Selected Publications

  1. Du W, Hu JK, Du W, Klein OD. Lineage tracing of epithelial cells in developing teeth reveals two strategies for building signaling centers. J Biol Chem. 2017 Sep 08; 292(36):15062-15069.
    View on PubMed
  2. Kousa YA, Roushangar R, Patel N, Walter A, Marangoni P, Krumlauf R, Klein OD, Schutte BC. IRF6 and SPRY4 Signaling Interact in Periderm Development. J Dent Res. 2017 Oct; 96(11):1306-1313.
    View on PubMed
  3. El Shahawy M, Reibring CG, Neben CL, Hallberg K, Marangoni P, Harfe BD, Klein OD, Linde A, Gritli-Linde A. Cell fate specification in the lingual epithelium is controlled by antagonistic activities of Sonic hedgehog and retinoic acid. PLoS Genet. 2017 Jul; 13(7):e1006914.
    View on PubMed
  4. Hadj-Rabia S, Schneider H, Navarro E, Klein O, Kirby N, Huttner K, Wolf L, Orin M, Wohlfart S, Bodemer C, Grange DK. Automatic recognition of the XLHED phenotype from facial images. Am J Med Genet A. 2017 Sep; 173(9):2408-2414.
    View on PubMed
  5. Naveau A, Zhang B, Meng B, Sutherland MT, Prochazkova M, Wen T, Marangoni P, Jones KB, Cox TC, Ganss B, Jheon AH, Klein OD. Isl1 Controls Patterning and Mineralization of Enamel in the Continuously Renewing Mouse Incisor. J Bone Miner Res. 2017 Jun 26.
    View on PubMed
  6. Cao H, Alrejaye N, Klein OD, Goodwin AF, Oberoi S. A review of craniofacial and dental findings of the RASopathies. Orthod Craniofac Res. 2017 Jun; 20 Suppl 1:32-38.
    View on PubMed
  7. Zheng X, Goodwin AF, Tian H, Jheon AH, Klein OD. Ras Signaling Regulates Stem Cells and Amelogenesis in the Mouse Incisor. J Dent Res. 2017 Jun 01; 22034517717255.
    View on PubMed
  8. Prochazkova M, Häkkinen TJ, Prochazka J, Spoutil F, Jheon AH, Ahn Y, Krumlauf R, Jernvall J, Klein OD. FGF signaling refines Wnt gradients to regulate the patterning of taste papillae. Development. 2017 Jun 15; 144(12):2212-2221.
    View on PubMed
  9. Percival CJ, Marangoni P, Tapaltsyan V, Klein O, Hallgrímsson B. The Interaction of Genetic Background and Mutational Effects in Regulation of Mouse Craniofacial Shape. G3 (Bethesda). 2017 May 05; 7(5):1439-1450.
    View on PubMed
  10. Hu JK, Du W, Shelton SJ, Oldham MC, DiPersio CM, Klein OD. An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice. Cell Stem Cell. 2017 Jul 06; 21(1):91-106.e6.
    View on PubMed
  11. Kim R, Green JBA, Klein OD. From snapshots to movies: Understanding early tooth development in four dimensions. Dev Dyn. 2017 Jun; 246(6):442-450.
    View on PubMed
  12. Niethamer TK, Larson AR, O'Neill AK, Bershteyn M, Hsiao EC, Klein OD, Pomerantz JH, Bush JO. EPHRIN-B1 Mosaicism Drives Cell Segregation in Craniofrontonasal Syndrome hiPSC-Derived Neuroepithelial Cells. Stem Cell Reports. 2017 Mar 14; 8(3):529-537.
    View on PubMed
  13. Wald T, Spoutil F, Osickova A, Prochazkova M, Benada O, Kasparek P, Bumba L, Klein OD, Sedlacek R, Sebo P, Prochazka J, Osicka R. Intrinsically disordered proteins drive enamel formation via an evolutionarily conserved self-assembly motif. Proc Natl Acad Sci U S A. 2017 Feb 28; 114(9):E1641-E1650.
    View on PubMed
  14. Cole JB, Manyama M, Larson JR, Liberton DK, Ferrara TM, Riccardi SL, Li M, Mio W, Klein OD, Santorico SA, Hallgrímsson B, Spritz RA. Human Facial Shape and Size Heritability and Genetic Correlations. Genetics. 2017 Feb; 205(2):967-978.
    View on PubMed
  15. Tsai YH, Nattiv R, Dedhia PH, Nagy MS, Chin AM, Thomson M, Klein OD, Spence JR. In vitro patterning of pluripotent stem cell-derived intestine recapitulates in vivo human development. Development. 2017 Mar 15; 144(6):1045-1055.
    View on PubMed
  16. Sun Z, Yu W, Sanz Navarro M, Sweat M, Eliason S, Sharp T, Liu H, Seidel K, Zhang L, Moreno M, Lynch T, Holton NE, Rogers L, Neff T, Goodheart MJ, Michon F, Klein OD, Chai Y, Dupuy A, Engelhardt JF, Chen Z, Amendt BA. Sox2 and Lef-1 interact with Pitx2 to regulate incisor development and stem cell renewal. Development. 2016 Nov 15; 143(22):4115-4126.
    View on PubMed
  17. Sharir A, Klein OD. Watching a deep dive: Live imaging provides lessons about tooth invagination. J Cell Biol. 2016 Sep 12; 214(6):645-7.
    View on PubMed
  18. Koledova Z, Zhang X, Streuli C, Clarke RB, Klein OD, Werb Z, Lu P. SPRY1 regulates mammary epithelial morphogenesis by modulating EGFR-dependent stromal paracrine signaling and ECM remodeling. Proc Natl Acad Sci U S A. 2016 Sep 27; 113(39):E5731-40.
    View on PubMed
  19. Cole JB, Manyama M, Kimwaga E, Mathayo J, Larson JR, Liberton DK, Lukowiak K, Ferrara TM, Riccardi SL, Li M, Mio W, Prochazkova M, Williams T, Li H, Jones KL, Klein OD, Santorico SA, Hallgrimsson B, Spritz RA. Genomewide Association Study of African Children Identifies Association of SCHIP1 and PDE8A with Facial Size and Shape. PLoS Genet. 2016 Aug; 12(8):e1006174.
    View on PubMed
  20. Shaffer JR, Orlova E, Lee MK, Leslie EJ, Raffensperger ZD, Heike CL, Cunningham ML, Hecht JT, Kau CH, Nidey NL, Moreno LM, Wehby GL, Murray JC, Laurie CA, Laurie CC, Cole J, Ferrara T, Santorico S, Klein O, Mio W, Feingold E, Hallgrimsson B, Spritz RA, Marazita ML, Weinberg SM. Genome-Wide Association Study Reveals Multiple Loci Influencing Normal Human Facial Morphology. PLoS Genet. 2016 Aug; 12(8):e1006149.
    View on PubMed

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