Ophir D. Klein, MD, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Ophir D. Klein, MD, PhD

Associate Professor, Departments of Orofacial Sciences and Pediatrics, and Institutes for Human Genetics and Regeneration Medicine, UCSF

ophir.klein@ucsf.edu

Phone: (415) 476-4719
Box 0442, UCSF
San Francisco, CA 94143-0442

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Additional Websites


Education

University of California, Berkeley, B.A., 1993, Spanish
Yale University, New Haven, CT, Ph.D., 1999, Genetics
Yale University, New Haven, CT, M.D., 2000
Yale-New Haven Hospital, New Haven, CT, 2000-2003, Pediatrics
University of California, San Francisco, 2003-2007, Clinical Genetics


Professional Experience

  • 2007-2013
    Assistant Professor, Departments of Orofacial Sciences and Pediatrics, and Institutes for Human Genetics and Regeneration Medicine, UCSF
  • 2009-present
    Director, UCSF Program in Craniofacial and Mesenchymal Biology
  • 2013-present
    Associate Professor, Departments of Orofacial Sciences and Pediatrics, and Institutes for Human Genetics and Regeneration Medicine, UCSF

Honors & Awards

  • 1989-1993
    Chancellor's Scholarship, University of California, Berkeley
  • 1993-2000
    NIH Medical Scientist Training Program
  • 1999
    Dean's Distinguished Thesis Commendation, Yale University Graduate School
  • 2004
    Fellow, American Academy of Pediatrics
  • 2004-2007
    Fellow, Pediatric Scientist Development Program, NICHD/NIH
  • 2005
    David W. Smith Trainee Research Award, Western Society for Pediatric Research
  • 2005
    Fellow (Basic) Research Award, Society for Pediatric Research
  • 2005
    American Academy of Pediatrics Young Investigator Research Grant
  • 2008
    Fellow, American College of Medical Genetics
  • 2008-2010
    Culpeper Scholar
  • 2008
    United States Bone and Joint Decade Young Investigator
  • 2008-2013
    California Institute of Regenerative Medicine New Faculty Award
  • 2008
    Elected to Society for Pediatric Research
  • 2009-2011
    March of Dimes Basil O'Connor Award
  • 2009
    Elected to Western Society for Pediatric Research
  • 2009
    ASBMR Harold M. Frost Young Investigator Award

    • Selected Publications

      1. Zarate YA, Perry H, Ben-Omran T, Sellars EA, Stein Q, Almureikhi M, Simmons K, Klein O, Fish J, Feingold M, Douglas J, Kruer MC, Si Y, Mao R, McKnight D, Gibellini F, Retterer K, Slavotinek A. Further supporting evidence for the SATB2-associated syndrome found through whole exome sequencing. Am J Med Genet A. 2015 May; 167(5):1026-32.
        View on PubMed
      2. Thys A, Vandenberghe P, Hague P, Klein OD, Erneux C, Vanderwinden JM. Hyperplasia of interstitial cells of cajal in sprouty homolog 4 deficient mice. PLoS One. 2015; 10(4):e0124861.
        View on PubMed
      3. Tian H, Biehs B, Chiu C, Siebel CW, Wu Y, Costa M, de Sauvage FJ, Klein OD. Opposing activities of notch and wnt signaling regulate intestinal stem cells and gut homeostasis. Cell Rep. 2015 Apr 7; 11(1):33-42.
        View on PubMed
      4. Dye BR, Hill DR, Ferguson MA, Tsai YH, Nagy MS, Dyal R, Wells JM, Mayhew CN, Nattiv R, Klein OD, White ES, Deutsch GH, Spence JR. In vitro generation of human pluripotent stem cell derived lung organoids. Elife. 2015; 4.
        View on PubMed
      5. Jheon AH, Prochazkova M, Sherman M, Manoli DS, Shah NM, Carbone L, Klein O. Spontaneous emergence of overgrown molar teeth in a colony of Prairie voles (Microtus ochrogaster). Int J Oral Sci. 2015 Mar; 7(1):23-6.
        View on PubMed
      6. Barlow LA, Klein OD. Developing and regenerating a sense of taste. Curr Top Dev Biol. 2015; 111:401-19.
        View on PubMed
      7. Harjunmaa E, Seidel K, Häkkinen T, Renvoisé E, Corfe IJ, Kallonen A, Zhang ZQ, Evans AR, Mikkola ML, Salazar-Ciudad I, Klein OD, Jernvall J. Replaying evolutionary transitions from the dental fossil record. Nature. 2014 Aug 7; 512(7512):44-8.
        View on PubMed
      8. Castillo D, Seidel K, Salcedo E, Ahn C, de Sauvage FJ, Klein OD, Barlow LA. Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium. Development. 2014 Aug; 141(15):2993-3002.
        View on PubMed
      9. Michailovici I, Harrington HA, Azogui HH, Yahalom-Ronen Y, Plotnikov A, Ching S, Stumpf MP, Klein OD, Seger R, Tzahor E. Nuclear to cytoplasmic shuttling of ERK promotes differentiation of muscle stem/progenitor cells. Development. 2014 Jul; 141(13):2611-20.
        View on PubMed
      10. Goodwin AF, Larson JR, Jones KB, Liberton DK, Landan M, Wang Z, Boekelheide A, Langham M, Mushegyan V, Oberoi S, Brao R, Wen T, Johnson R, Huttner K, Grange DK, Spritz RA, Hallgrímsson B, Jheon AH, Klein OD. Craniofacial morphometric analysis of individuals with X-linked hypohidrotic ectodermal dysplasia. Mol Genet Genomic Med. 2014 Sep; 2(5):422-9.
        View on PubMed
      11. Chavez MG, Hu J, Seidel K, Li C, Jheon A, Naveau A, Horst O, Klein OD. Isolation and culture of dental epithelial stem cells from the adult mouse incisor. J Vis Exp. 2014; (87).
        View on PubMed
      12. Sun F, Wan M, Xu X, Gao B, Zhou Y, Sun J, Cheng L, Klein OD, Zhou X, Zheng L. Crosstalk between miR-34a and Notch Signaling Promotes Differentiation in Apical Papilla Stem Cells (SCAPs). J Dent Res. 2014 Apr 7; 93(6):589-595.
        View on PubMed
      13. Mues G, Bonds J, Xiang L, Vieira AR, Seymen F, Klein O, D'Souza RN. The WNT10A gene in ectodermal dysplasias and selective tooth agenesis. Am J Med Genet A. 2014 Oct; 164A(10):2455-60.
        View on PubMed
      14. Mendelsohn BA, Jeng LL, Oberoi S, Klein OD. Dental findings in 14q terminal deletion syndrome. Clin Dysmorphol. 2014 Apr; 23(2):60-2.
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      15. Goodwin AF, Oberoi S, Landan M, Charles C, Massie JC, Fairley C, Rauen KA, Klein OD. Craniofacial and dental development in Costello syndrome. Am J Med Genet A. 2014 Jun; 164A(6):1425-30.
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      16. Naveau A, Seidel K, Klein OD. Tooth, hair and claw: comparing epithelial stem cell niches of ectodermal appendages. Exp Cell Res. 2014 Jul 15; 325(2):96-103.
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      17. Zhao H, Feng J, Seidel K, Shi S, Klein O, Sharpe P, Chai Y. Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor. Cell Stem Cell. 2014 Feb 6; 14(2):160-73.
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      18. Ching ST, Cunha GR, Baskin LS, Basson MA, Klein OD. Coordinated activity of Spry1 and Spry2 is required for normal development of the external genitalia. Dev Biol. 2014 Feb 1; 386(1):1-11.
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      19. Li CY, Prochazka J, Goodwin AF, Klein OD. Fibroblast growth factor signaling in mammalian tooth development. Odontology. 2014 Jan; 102(1):1-13.
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      20. Kuang-Hsien Hu J, Mushegyan V, Klein OD. On the cutting edge of organ renewal: Identification, regulation, and evolution of incisor stem cells. Genesis. 2014 Feb; 52(2):79-92.
        View on PubMed

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