W. Michael Korn, MD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
W. Michael Korn, MD

Professor of Medicine, Divisions of Gastroenterology and Medical Oncology; Leader, HDFCCC Molecular Oncology Initiative, UCSF

Phone: (415) 353-9888 (appts)
Box 1705, UCSF
San Francisco, CA 94143-1705

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Cancer Center Membership

Program Member » Developmental Therapeutics

Research Summary

Dr. Korn's is an expert on gastrointestinal cancers, with focus on esophageal, gastric, and pancreatic, and colon cancers. He initiated and chairs the UCSF Molecular Tumor Board and has a strong clinical as well as research interest in precision oncology. He is principal investigator on clinical trials of novel anti-cancer agents as part of the Phase-I Clinical Trials program and leads trials in esophageal and gastric cancers., Dr. Korn's laboratory research focuses on systems biology and computational models of signal transduction in cancer, as well as design of rational combination therapies targeting receptor tyrosine kinase signaling, and the MAPK and PI3K pathways.

Education

Philipps University of Marburg, Germany, Continuing Education, 1981 - 1984, Medicine
Heinrich-Heine University of Düsseldorf, Germany, Approbation as Physician, 1984 - 1988, Medicine
Philipps University of Marburg, Germany, Medical Doctorate, 1993
University of Bern, Switzerland, Internship, 1997, Medicine


Professional Experience

  • 1988-1992
    Physician in Training, Ev. Krankenhaus Dinslaken, Germany
  • 1992-1996
    Physician in Training, West German Cancer Center, University of Essen, Medical School, Essen, Germany
  • 1996
    Certified Internist, West German Cancer Center, University of Essen, Medical School, Essen, Germany
  • 1996
    Interim Head, Laboratory of Tumor Cytogenetics, West German Cancer Center, University of Essen, Medical School, Essen Germany
  • 1996-1997
    Postdoctoral Fellow, Laboratory Medicine (F. Waldman), UCSF Cancer Center, UCSF
  • 1997
    Postdoctoral Fellow, Cancer Research Institute (F. McCormick), UCSF Cancer Center, UCSF
  • 1997-1999
    Assistant Research Biochemist, Cancer Research Institute, UCSF Cancer Center, UCSF
  • 1999-2004
    Assistant Adjunct Professor of Medicine, Division of Gastroenterology, UCSF
  • 2004-2006
    Assistant Adjunct Professor of Medicine, UCSF
  • 2006-2015
    Associate Professor of Medicine in Residence, Divisions of Gastroenterology and Medical Oncology, UCSF
  • 2008-2011
    Co-Director, Center of Molecular Oncology, UCSF
  • 2015-present
    Professor of Medicine, Divisions of Gastroenterology and Medical Oncology, UCSF
  • 2016-present
    Leader, HDFCCC Molecular Oncology Initiative

Honors & Awards

  • 1996
    Mildred-Scheel Research Fellowship, Mildred Scheel Stiftung e.V., Germany
  • 2000
    UCSF REAC Award
  • 2000
    American Cancer Society Individual Research Award
  • 2001, 2002
    Hellman Family Award
  • 2005
    UCSF THANKS Star Award
  • 2008
    Cancer League Award
  • 2008
    Tip Your Heart Foundation Award
  • 2009
    Helen Diller Family Quality Award

Selected Publications

  1. Chien AJ, Cockerill A, Fancourt C, Schmidt E, Moasser MM, Rugo HS, Melisko ME, Ko AH, Kelley RK, Korn WM, Esserman LJ, Van't Veer L, Yau C, Wolf DM, Munster PN. A phase 1b study of the Akt-inhibitor MK-2206 in combination with weekly paclitaxel and trastuzumab in patients with advanced HER2-amplified solid tumor malignancies. Breast Cancer Res Treat. 2016 Feb; 155(3):521-30.
    View on PubMed
  2. Ko AH, Bekaii-Saab T, Van Ziffle J, Mirzoeva OM, Joseph NM, Talasaz A, Kuhn P, Tempero MA, Collisson EA, Kelley RK, Venook AP, Dito E, Ong A, Ziyeh S, Courtin R, Linetskaya R, Tahiri S, Korn WM. A Multicenter, Open-Label Phase II Clinical Trial of Combined MEK plus EGFR Inhibition for Chemotherapy-Refractory Advanced Pancreatic Adenocarcinoma. Clin Cancer Res. 2016 Jan 1; 22(1):61-8.
    View on PubMed
  3. Ajani JA, D'Amico TA, Almhanna K, Bentrem DJ, Besh S, Chao J, Das P, Denlinger C, Fanta P, Fuchs CS, Gerdes H, Glasgow RE, Hayman JA, Hochwald S, Hofstetter WL, Ilson DH, Jaroszewski D, Jasperson K, Keswani RN, Kleinberg LR, Korn WM, Leong S, Lockhart AC, Mulcahy MF, Orringer MB, Posey JA, Poultsides GA, Sasson AR, Scott WJ, Strong VE, Varghese TK, Washington MK, Willett CG, Wright CD, Zelman D, McMillian N, Sundar H. Esophageal and esophagogastric junction cancers, version 1.2015. J Natl Compr Canc Netw. 2015 Feb; 13(2):194-227.
    View on PubMed
  4. Fidelman N, Kerlan RK, Hawkins RA, Taylor AG, Kohi MP, Kolli KP, Bergsland EK, Kelley RK, Ko AH, Korn WM, McWhirter RM, Luan J, Venook AP. 90Y glass microspheres for the treatment of unresectable metastatic liver disease from chemotherapy-refractory gastrointestinal cancers: a pilot study. J Gastrointest Cancer. 2014 Jun; 45(2):168-80.
    View on PubMed
  5. Kelley RK, Hwang J, Magbanua MJ, Watt L, Beumer JH, Christner SM, Baruchel S, Wu B, Fong L, Yeh BM, Moore AP, Ko AH, Korn WM, Rajpal S, Park JW, Tempero MA, Venook AP, Bergsland EK. A phase 1 trial of imatinib, bevacizumab, and metronomic cyclophosphamide in advanced colorectal cancer. Br J Cancer. 2013 Oct 1; 109(7):1725-34.
    View on PubMed
  6. Mirzoeva OK, Collisson EA, Schaefer PM, Hann B, Hom YK, Ko AH, Korn WM. Subtype-specific MEK-PI3 kinase feedback as a therapeutic target in pancreatic adenocarcinoma. Mol Cancer Ther. 2013 Oct; 12(10):2213-25.
    View on PubMed
  7. Ajani JA, Bentrem DJ, Besh S, D'Amico TA, Das P, Denlinger C, Fakih MG, Fuchs CS, Gerdes H, Glasgow RE, Hayman JA, Hofstetter WL, Ilson DH, Keswani RN, Kleinberg LR, Korn WM, Lockhart AC, Meredith K, Mulcahy MF, Orringer MB, Posey JA, Sasson AR, Scott WJ, Strong VE, Varghese TK, Warren G, Washington MK, Willett C, Wright CD, McMillian NR, Sundar H. Gastric cancer, version 2.2013: featured updates to the NCCN Guidelines. J Natl Compr Canc Netw. 2013 May 1; 11(5):531-46.
    View on PubMed
  8. Kelley RK, Nimeiri HS, Munster PN, Vergo MT, Huang Y, Li CM, Hwang J, Mulcahy MF, Yeh BM, Kuhn P, Luttgen MS, Grabowsky JA, Stucky-Marshall L, Korn WM, Ko AH, Bergsland EK, Benson AB, Venook AP. Temsirolimus combined with sorafenib in hepatocellular carcinoma: a phase I dose-finding trial with pharmacokinetic and biomarker correlates. Ann Oncol. 2013 Jul; 24(7):1900-7.
    View on PubMed
  9. Marrinucci D, Bethel K, Kolatkar A, Luttgen MS, Malchiodi M, Baehring F, Voigt K, Lazar D, Nieva J, Bazhenova L, Ko AH, Korn WM, Schram E, Coward M, Yang X, Metzner T, Lamy R, Honnatti M, Yoshioka C, Kunken J, Petrova Y, Sok D, Nelson D, Kuhn P. Fluid biopsy in patients with metastatic prostate, pancreatic and breast cancers. Phys Biol. 2012 Feb; 9(1):016003.
    View on PubMed
  10. Cho EH, Wendel M, Luttgen M, Yoshioka C, Marrinucci D, Lazar D, Schram E, Nieva J, Bazhenova L, Morgan A, Ko AH, Korn WM, Kolatkar A, Bethel K, Kuhn P. Characterization of circulating tumor cell aggregates identified in patients with epithelial tumors. Phys Biol. 2012 Feb; 9(1):016001.
    View on PubMed
  11. Ajani JA, Barthel JS, Bentrem DJ, D'Amico TA, Das P, Denlinger CS, Fuchs CS, Gerdes H, Glasgow RE, Hayman JA, Hofstetter WL, Ilson DH, Keswani RN, Kleinberg LR, Korn WM, Lockhart AC, Mulcahy MF, Orringer MB, Osarogiagbon RU, Posey JA, Sasson AR, Scott WJ, Shibata S, Strong VE, Varghese TK, Warren G, Washington MK, Willett C, Wright CD. Esophageal and esophagogastric junction cancers. J Natl Compr Canc Netw. 2011 Aug 1; 9(8):830-87.
    View on PubMed
  12. Lacher MD, Shiina M, Chang P, Keller D, Tiirikainen MI, Korn WM. ZEB1 limits adenoviral infectability by transcriptionally repressing the coxsackie virus and adenovirus receptor. Mol Cancer. 2011; 10:91.
    View on PubMed
  13. Mirzoeva OK, Hann B, Hom YK, Debnath J, Aftab D, Shokat K, Korn WM. Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K-mTOR pathway in pancreatic adenocarcinoma. J Mol Med (Berl). 2011 Sep; 89(9):877-89.
    View on PubMed
  14. Bagheri N, Shiina M, Lauffenburger DA, Korn WM. A dynamical systems model for combinatorial cancer therapy enhances oncolytic adenovirus efficacy by MEK-inhibition. PLoS Comput Biol. 2011 Feb; 7(2):e1001085.
    View on PubMed
  15. Ajani JA, Barthel JS, Bekaii-Saab T, Bentrem DJ, D'Amico TA, Das P, Denlinger C, Fuchs CS, Gerdes H, Hayman JA, Hazard L, Hofstetter WL, Ilson DH, Keswani RN, Kleinberg LR, Korn M, Meredith K, Mulcahy MF, Orringer MB, Osarogiagbon RU, Posey JA, Sasson AR, Scott WJ, Shibata S, Strong VE, Washington MK, Willett C, Wood DE, Wright CD, Yang G. Gastric cancer. J Natl Compr Canc Netw. 2010 Apr; 8(4):378-409.
    View on PubMed
  16. Ko AH, Venook AP, Bergsland EK, Kelley RK, Korn WM, Dito E, Schillinger B, Scott J, Hwang J, Tempero MA. A phase II study of bevacizumab plus erlotinib for gemcitabine-refractory metastatic pancreatic cancer. Cancer Chemother Pharmacol. 2010 Nov; 66(6):1051-7.
    View on PubMed
  17. Chien AJ, Illi JA, Ko AH, Korn WM, Fong L, Chen LM, Kashani-Sabet M, Ryan CJ, Rosenberg JE, Dubey S, Small EJ, Jahan TM, Hylton NM, Yeh BM, Huang Y, Koch KM, Moasser MM. A phase I study of a 2-day lapatinib chemosensitization pulse preceding nanoparticle albumin-bound Paclitaxel for advanced solid malignancies. Clin Cancer Res. 2009 Sep 1; 15(17):5569-75.
    View on PubMed
  18. Shiina M, Lacher MD, Christian C, Korn WM. RNA interference-mediated knockdown of p21(WAF1) enhances anti-tumor cell activity of oncolytic adenoviruses. Cancer Gene Ther. 2009 Nov; 16(11):810-9.
    View on PubMed
  19. Mirzoeva OK, Das D, Heiser LM, Bhattacharya S, Siwak D, Gendelman R, Bayani N, Wang NJ, Neve RM, Guan Y, Hu Z, Knight Z, Feiler HS, Gascard P, Parvin B, Spellman PT, Shokat KM, Wyrobek AJ, Bissell MJ, McCormick F, Kuo WL, Mills GB, Gray JW, Korn WM. Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. Cancer Res. 2009 Jan 15; 69(2):565-72.
    View on PubMed
  20. Lu DC, Theodore P, Korn WM, Chou D. Esophageal erosion 9 years after anterior cervical plate implantation. Surg Neurol. 2008 Mar; 69(3):310-2; discussion 312-3.
    View on PubMed

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