Randall H. Kramer, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
kramer_randall

Professor, Department of Cell and Tissue Biology, UCSF

randall.kramer@ucsf.edu

Phone: (415) 476-3275, 476-3274 (voice)
Box 0422, UCSF
San Francisco, CA 94143-0422

View on UCSF Profiles


Education

University of California, Berkeley, B.A., 1971, Biochemistry
Yale University School of Medicine, M.S., 1974, Pharmacology
Yale University School of Medicine, Ph.D., 1977, Pharmacology
University of California, Irvine, Postdoc., 1977-80, Cell Biology

Professional Experience

  • 1977-80
    UC Irvine, Department of Cell and Molecular Biology, American Cancer Society Postdoctoral Fellow
  • 1980-85
    UC San Francisco, Department of Stomatology and Anatomy, Assistant Professor
  • 1985-91
    UC San Francisco, Department of Stomatology and Anatomy, Associate Professor
  • 1991-present
    UC San Francisco, Cardiovascular Research Institute
  • 1996-present
    UC San Francisco, Oral Cancer Research Center, Director
  • 1997-present
    UC San Francisco Cancer Center, Program Leader in Head and Neck Oncology
  • 2005-present
    UC San Francisco, Departments of Cell and Tissue Biology, and Anatomy, Professor

Honors & Awards

  • 1983, 1988
    National Institutes of Health, Ad Hoc Reviewer, Pathology B Study Section
  • 1984
    International Institute for Microcirculation, Cambridge, England, Research Award
  • 1985
    Veterans1 Administration, Career Development Program, Reviewer
  • 1986
    National Cancer Institute, Cancer Therapeutics Review Committee, Consultant
  • 1987-1989
    National Cancer Institute of Canada, Ad Hoc Reviewer, Panel B
  • 1987-1996
    National Science Foundation, Research Grant Program, Reviewer
  • 1989
    National Institutes of Health, Pathobiochemistry Study Section, Ad Hoc Reviewer
  • 1990, 1994
    National Cancer Institute, Program Project, Ad Hoc Reviewer
  • 1990-1993
    Gordon Conference, Basement Membranes, Cell Contact and Adhesion, Invited Speaker
  • 1991, 1993
    American Cancer Institute, Advisory Committee on Cell and Developmental Biology
  • 1995, 1996, 1999
    Oral Biology and Medicine Study Section, Ad Hoc Reviewer
  • 1999, 2004
    NCI Workshop, Head and Neck Cancer
  • 2000
    NIDCR Review Panel, Genetic Basis of Oral Cancer
  • 2001, 2003
    NIDCR Special Review Panel on Oral Cancer
  • 2002, 2004
    NCI Head and Neck SPORE Panel Review
  • 2005, 2006
    NIH Tumor Microenvironment Study Section
  • 2006
    NIDCR Special Review Panel

Selected Publications

  1. Ozeki N, Mogi M, Yamaguchi H, Hiyama T, Kawai R, Hase N, Nakata K, Nakamura H, Kramer RH. Differentiation of Human Skeletal Muscle Stem Cells into Odontoblasts Is Dependent on Induction of a1 Integrin Expression. J Biol Chem. 2014 May 16; 289(20):14380-91.
    View on PubMed
  2. Yang F, Liu R, Kramer R, Xiao W, Jordan R, Lam KS. Discovery of specific ligands for oral squamous carcinoma to develop anti-cancer drug loaded precise targeting nanotherapeutics. J Calif Dent Assoc. 2012 Dec; 40(12):939-43.
    View on PubMed
  3. Humtsoe JO, Koya E, Pham E, Aramoto T, Zuo J, Ishikawa T, Kramer RH. Transcriptional profiling identifies upregulated genes following induction of epithelial-mesenchymal transition in squamous carcinoma cells. Exp Cell Res. 2012 Feb 15; 318(4):379-90.
    View on PubMed
  4. Zuo J, Ishikawa T, Boutros S, Xiao Z, Humtsoe JO, Kramer RH. Bcl-2 overexpression induces a partial epithelial to mesenchymal transition and promotes squamous carcinoma cell invasion and metastasis. Mol Cancer Res. 2010 Feb; 8(2):170-82.
    View on PubMed
  5. Ishikawa T, Kramer RH. Sdc1 negatively modulates carcinoma cell motility and invasion. Exp Cell Res. 2010 Apr 1; 316(6):951-65.
    View on PubMed
  6. Humtsoe JO, Kramer RH. Differential epidermal growth factor receptor signaling regulates anchorage-independent growth by modulation of the PI3K/AKT pathway. Oncogene. 2010 Feb 25; 29(8):1214-26.
    View on PubMed
  7. Pawlikowski B, Lee L, Zuo J, Kramer RH. Analysis of human muscle stem cells reveals a differentiation-resistant progenitor cell population expressing Pax7 capable of self-renewal. Dev Dyn. 2009 Jan; 238(1):138-49.
    View on PubMed
  8. Gorfu G, Virtanen I, Hukkanen M, Lehto VP, Rousselle P, Kenne E, Lindbom L, Kramer R, Tryggvason K, Patarroyo M. Laminin isoforms of lymph nodes and predominant role of alpha5-laminin(s) in adhesion and migration of blood lymphocytes. J Leukoc Biol. 2008 Sep; 84(3):701-12.
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  9. El-Sayed I, Huang X, Macheret F, Humstoe JO, Kramer R, El-Sayed M. Effect of plasmonic gold nanoparticles on benign and malignant cellular autofluorescence: a novel probe for fluorescence based detection of cancer. Technol Cancer Res Treat. 2007 Oct; 6(5):403-12.
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  10. Onishi A, Chen Q, Humtsoe JO, Kramer RH. STAT3 signaling is induced by intercellular adhesion in squamous cell carcinoma cells. Exp Cell Res. 2008 Jan 15; 314(2):377-86.
    View on PubMed
  11. Ozeki N, Jethanandani P, Nakamura H, Ziober BL, Kramer RH. Modulation of satellite cell adhesion and motility following BMP2-induced differentiation to osteoblast lineage. Biochem Biophys Res Commun. 2007 Feb 2; 353(1):54-9.
    View on PubMed
  12. Ozeki N, Lim M, Yao CC, Tolar M, Kramer RH. alpha7 integrin expressing human fetal myogenic progenitors have stem cell-like properties and are capable of osteogenic differentiation. Exp Cell Res. 2006 Dec 10; 312(20):4162-80.
    View on PubMed
  13. Jethanandani P, Kramer RH. Alpha7 integrin expression is negatively regulated by deltaEF1 during skeletal myogenesis. J Biol Chem. 2005 Oct 28; 280(43):36037-46.
    View on PubMed
  14. Kramer RH, Shen X, Zhou H. Tumor cell invasion and survival in head and neck cancer. Cancer Metastasis Rev. 2005 Jan; 24(1):35-45.
    View on PubMed
  15. Zhou H, Kramer RH. Integrin engagement differentially modulates epithelial cell motility by RhoA/ROCK and PAK1. J Biol Chem. 2005 Mar 18; 280(11):10624-35.
    View on PubMed
  16. Murai M, Shen X, Huang L, Carpenter WM, Lin CS, Silverman S, Regezi J, Kramer RH. Overexpression of c-met in oral SCC promotes hepatocyte growth factor-induced disruption of cadherin junctions and invasion. Int J Oncol. 2004 Oct; 25(4):831-40.
    View on PubMed
  17. Shen X, Kramer RH. Adhesion-mediated squamous cell carcinoma survival through ligand-independent activation of epidermal growth factor receptor. Am J Pathol. 2004 Oct; 165(4):1315-29.
    View on PubMed
  18. Chen Q, Lipkina G, Song Q, Kramer RH. Promoter methylation regulates cadherin switching in squamous cell carcinoma. Biochem Biophys Res Commun. 2004 Mar 19; 315(4):850-6.
    View on PubMed
  19. Xiao J, Jethanandani P, Ziober BL, Kramer RH. Regulation of alpha7 integrin expression during muscle differentiation. J Biol Chem. 2003 Dec 12; 278(50):49780-8.
    View on PubMed
  20. Ferguson JW, Thoma BS, Mikesh MF, Kramer RH, Bennett KL, Purchio A, Bellard BJ, LeBaron RG. The extracellular matrix protein betaIG-H3 is expressed at myotendinous junctions and supports muscle cell adhesion. Cell Tissue Res. 2003 Jul; 313(1):93-105.
    View on PubMed

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