Randall H. Kramer, PhD

Randall H. Kramer, PhD

Professor, Department of Cell and Tissue Biology, UCSF


Phone: (415) 476-3275, 476-3274 (voice)
Box 0422, UCSF
San Francisco, CA 94143-0422

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Cancer Center Membership

Associate Member ยป Non-aligned


University of California, Berkeley, B.A., 1971, Biochemistry
Yale University School of Medicine, M.S., 1974, Pharmacology
Yale University School of Medicine, Ph.D., 1977, Pharmacology
University of California, Irvine, Postdoc., 1977-80, Cell Biology

Professional Experience

  • 1977-80
    UC Irvine, Department of Cell and Molecular Biology, American Cancer Society Postdoctoral Fellow
  • 1980-85
    UC San Francisco, Department of Stomatology and Anatomy, Assistant Professor
  • 1985-91
    UC San Francisco, Department of Stomatology and Anatomy, Associate Professor
  • 1991-present
    UC San Francisco, Cardiovascular Research Institute
  • 1996-present
    UC San Francisco, Oral Cancer Research Center, Director
  • 1997-present
    UC San Francisco Cancer Center, Program Leader in Head and Neck Oncology
  • 2005-present
    UC San Francisco, Departments of Cell and Tissue Biology, and Anatomy, Professor

Honors & Awards

  • 1983, 1988
    National Institutes of Health, Ad Hoc Reviewer, Pathology B Study Section
  • 1984
    International Institute for Microcirculation, Cambridge, England, Research Award
  • 1985
    Veterans1 Administration, Career Development Program, Reviewer
  • 1986
    National Cancer Institute, Cancer Therapeutics Review Committee, Consultant
  • 1987-1989
    National Cancer Institute of Canada, Ad Hoc Reviewer, Panel B
  • 1987-1996
    National Science Foundation, Research Grant Program, Reviewer
  • 1989
    National Institutes of Health, Pathobiochemistry Study Section, Ad Hoc Reviewer
  • 1990, 1994
    National Cancer Institute, Program Project, Ad Hoc Reviewer
  • 1990-1993
    Gordon Conference, Basement Membranes, Cell Contact and Adhesion, Invited Speaker
  • 1991, 1993
    American Cancer Institute, Advisory Committee on Cell and Developmental Biology
  • 1995, 1996, 1999
    Oral Biology and Medicine Study Section, Ad Hoc Reviewer
  • 1999, 2004
    NCI Workshop, Head and Neck Cancer
  • 2000
    NIDCR Review Panel, Genetic Basis of Oral Cancer
  • 2001, 2003
    NIDCR Special Review Panel on Oral Cancer
  • 2002, 2004
    NCI Head and Neck SPORE Panel Review
  • 2005, 2006
    NIH Tumor Microenvironment Study Section
  • 2006
    NIDCR Special Review Panel

Selected Publications

  1. ErbB3 upregulation by the HNSCC 3D microenvironment modulates cell survival and growth. Oncogene. 2015; 34(32):1-11.
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  2. Differentiation of human skeletal muscle stem cells into odontoblasts is dependent on induction of a1 integrin expression. J Biol Chem. 2014 May 16; 289(20):14380-91.
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  3. Discovery of specific ligands for oral squamous carcinoma to develop anti-cancer drug loaded precise targeting nanotherapeutics. J Calif Dent Assoc. 2012 Dec; 40(12):939-43.
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  4. Transcriptional profiling identifies upregulated genes following induction of epithelial-mesenchymal transition in squamous carcinoma cells. Exp Cell Res. 2012 Feb 15; 318(4):379-90.
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  5. Bcl-2 overexpression induces a partial epithelial to mesenchymal transition and promotes squamous carcinoma cell invasion and metastasis. Mol Cancer Res. 2010 Feb; 8(2):170-82.
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  6. Sdc1 negatively modulates carcinoma cell motility and invasion. Exp Cell Res. 2010 Apr 1; 316(6):951-65.
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  7. Differential epidermal growth factor receptor signaling regulates anchorage-independent growth by modulation of the PI3K/AKT pathway. Oncogene. 2010 Feb 25; 29(8):1214-26.
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  8. Analysis of human muscle stem cells reveals a differentiation-resistant progenitor cell population expressing Pax7 capable of self-renewal. Dev Dyn. 2009 Jan; 238(1):138-49.
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  9. Laminin isoforms of lymph nodes and predominant role of alpha5-laminin(s) in adhesion and migration of blood lymphocytes. J Leukoc Biol. 2008 Sep; 84(3):701-12.
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  10. Effect of plasmonic gold nanoparticles on benign and malignant cellular autofluorescence: a novel probe for fluorescence based detection of cancer. Technol Cancer Res Treat. 2007 Oct; 6(5):403-12.
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  11. STAT3 signaling is induced by intercellular adhesion in squamous cell carcinoma cells. Exp Cell Res. 2008 Jan 15; 314(2):377-86.
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  12. Modulation of satellite cell adhesion and motility following BMP2-induced differentiation to osteoblast lineage. Biochem Biophys Res Commun. 2007 Feb 2; 353(1):54-9.
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  13. alpha7 integrin expressing human fetal myogenic progenitors have stem cell-like properties and are capable of osteogenic differentiation. Exp Cell Res. 2006 Dec 10; 312(20):4162-80.
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  14. Alpha7 integrin expression is negatively regulated by deltaEF1 during skeletal myogenesis. J Biol Chem. 2005 Oct 28; 280(43):36037-46.
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  15. Tumor cell invasion and survival in head and neck cancer. Cancer Metastasis Rev. 2005 Jan; 24(1):35-45.
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  16. Integrin engagement differentially modulates epithelial cell motility by RhoA/ROCK and PAK1. J Biol Chem. 2005 Mar 18; 280(11):10624-35.
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  17. Overexpression of c-met in oral SCC promotes hepatocyte growth factor-induced disruption of cadherin junctions and invasion. Int J Oncol. 2004 Oct; 25(4):831-40.
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  18. Adhesion-mediated squamous cell carcinoma survival through ligand-independent activation of epidermal growth factor receptor. Am J Pathol. 2004 Oct; 165(4):1315-29.
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  19. Promoter methylation regulates cadherin switching in squamous cell carcinoma. Biochem Biophys Res Commun. 2004 Mar 19; 315(4):850-6.
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  20. Regulation of alpha7 integrin expression during muscle differentiation. J Biol Chem. 2003 Dec 12; 278(50):49780-8.
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