John Kurhanewicz, PhD

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Education

New College, Sarasota, FL, B.S., 1976-1982, Chemistry
University of South Florida, Tampa, FL, Ph.D., 1982-1987, Chemistry
University of California San Francisco, CA, Post-Doc., 1987-1990, In vivo Spectroscopy

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Professional Experience

• 1993-2000
  Assistant Professor of Radiology, Bioengineering and Pharmaceutical Chemistry, University of California, San Francisco
• 2000-2006
  Associate Professor of Radiology, Bioengineering and Pharmaceutical Chemistry, UCSF
• 2006-present
  Professor of Radiology, Bioengineering and Pharmaceutical Chemistry, UCSF

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Honors & Awards

• Phi Beta Kappa (scholastic honorary)
• Outstanding Chemistry Alumnus, University of South Florida

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Selected Publications

1. Koelsch BL, Keshari KR, Peeters TH, Larson PE, Wilson DM, Kurhanewicz J. Diffusion MR of hyperpolarized (13)C molecules in solution. Analyst. 2013 Jan 22; 138(4):1011-4.
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2. Larson PE, Hurd RE, Kerr AB, Pauly JM, Bok RA, Kurhanewicz J, Vigneron DB. Perfusion and diffusion sensitive (13)C stimulated-echo MRSI for metabolic imaging of cancer. Magn Reson Imaging. 2012 Dec 20.
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3. Lebeau AM, Lee M, Murphy ST, Hann BC, Warren RS, Delos Santos R, Kurhanewicz J, Hanash SM, Vanbrocklin HF, Craik CS. Imaging a functional tumorigenic biomarker in the transformed epithelium. Proc Natl Acad Sci U S A. 2013 Jan 2; 110(1):93-8.
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4. Tiwari P, Kurhanewicz J, Madabhushi A. Multi-kernel graph embedding for detection, Gleason grading of prostate cancer via MRI/MRS. Med Image Anal. 2013 Feb; 17(2):219-35.
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5. Keshari KR, Sriram R, Koelsch BL, Van Criekinge M, Wilson DM, Kurhanewicz J, Wang ZJ. Hyperpolarized 13C-Pyruvate Magnetic Resonance Reveals Rapid Lactate Export in Metastatic Renal Cell Carcinomas. Cancer Res. 2013 Jan 15; 73(2):529-38.
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6. Gulley JL, Emberton M, Kurhanewicz J, Choyke P. Progress in prostate cancer imaging. Urol Oncol. 2012 Nov; 30(6):938-9.
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7. Hu S, Larson PE, Vancriekinge M, Leach AM, Park I, Leon C, Zhou J, Shin PJ, Reed G, Keselman P, von Morze C, Yoshihara H, Bok RA, Nelson SJ, Kurhanewicz J, Vigneron DB. Rapid sequential injections of hyperpolarized [1-(13)C]pyruvate in vivo using a sub-kelvin, multi-sample DNP polarizer. Magn Reson Imaging. 2012 Oct 26.
   View on PubMed
8. von Morze C, Sukumar S, Reed GD, Larson PE, Bok RA, Kurhanewicz J, Vigneron DB. Frequency-specific SSFP for hyperpolarized (13)C metabolic imaging at 14.1 T. Magn Reson Imaging. 2013 Feb; 31(2):163-70.
   View on PubMed
9. Hu S, Yoshihara HA, Bok R, Zhou J, Zhu M, Kurhanewicz J, Vigneron DB. Use of hyperpolarized [1-(13)C]pyruvate and [2-(13)C]pyruvate to probe the effects of the anticancer agent dichloroacetate on mitochondrial metabolism in vivo in the normal rat. Magn Reson Imaging. 2012 Dec; 30(10):1367-72.
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10. Créhange G, Chen CP, Hsu CC, Kased N, Coakley FV, Kurhanewicz J, Roach M. Management of prostate cancer patients with lymph node involvement: a rapidly evolving paradigm. Cancer Treat Rev. 2012 Dec; 38(8):956-67.
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11. Jung AJ, Coakley FV, Shinohara K, Carroll PR, Kurhanewicz J, Cowan JE, Westphalen AC. Local staging of prostate cancer: comparative accuracy of T2-weighted endorectal MR imaging and transrectal ultrasound. Clin Imaging. 2012 Sep-Oct; 36(5):547-52.
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12. Hsu CC, Hsu H, Pickett B, Crehange G, Hsu IC, Dea R, Weinberg V, Gottschalk AR, Kurhanewicz J, Shinohara K, Roach M. Feasibility of MR Imaging/MR Spectroscopy-Planned Focal Partial Salvage Permanent Prostate Implant (PPI) for Localized Recurrence After Initial PPI for Prostate Cancer. Int J Radiat Oncol Biol Phys. 2013 Feb 1; 85(2):370-7.
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13. Keshari KR, Kurhanewicz J, Macdonald JM, Wilson DM. Generating contrast in hyperpolarized 13C MRI using ligand-receptor interactions. Analyst. 2012 Aug 7; 137(15):3427-9.
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14. Westphalen AC, Reed GD, Vinh PP, Sotto C, Vigneron DB, Kurhanewicz J. Multiparametric 3T endorectal mri after external beam radiation therapy for prostate cancer. J Magn Reson Imaging. 2012 Aug; 36(2):430-7.
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15. von Morze C, Bok RA, Sands JM, Kurhanewicz J, Vigneron DB. Monitoring urea transport in rat kidney in vivo using hyperpolarized ¹³C magnetic resonance imaging. Am J Physiol Renal Physiol. 2012 Jun 15; 302(12):F1658-62.
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16. Reed GD, Larson PE, Morze Cv, Bok R, Lustig M, Kerr AB, Pauly JM, Kurhanewicz J, Vigneron DB. A method for simultaneous echo planar imaging of hyperpolarized ¹³C pyruvate and ¹³C lactate. J Magn Reson. 2012 Apr; 217:41-7.
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17. Arrayeh E, Westphalen AC, Kurhanewicz J, Roach M, Jung AJ, Carroll PR, Coakley FV. Does local recurrence of prostate cancer after radiation therapy occur at the site of primary tumor? Results of a longitudinal MRI and MRSI study. Int J Radiat Oncol Biol Phys. 2012 Apr 1; 82(5):e787-93.
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18. Costello LC, Franklin RB, Zou J, Feng P, Bok R, Swanson MG, Kurhanewicz J. Human prostate cancer ZIP1/zinc/citrate genetic/metabolic relationship in the TRAMP prostate cancer animal model. Cancer Biol Ther. 2011 Dec 15; 12(12):1078-84.
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19. Muglia VF, Westphalen AC, Wang ZJ, Kurhanewicz J, Carroll PR, Coakley FV. Endorectal MRI of prostate cancer: incremental prognostic importance of gross locally advanced disease. AJR Am J Roentgenol. 2011 Dec; 197(6):1369-74.
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20. Ahmed HU, Akin O, Coleman JA, Crane S, Emberton M, Goldenberg L, Hricak H, Kattan MW, Kurhanewicz J, Moore CM, Parker C, Polascik TJ, Scardino P, van As N, Villers A. Transatlantic Consensus Group on active surveillance and focal therapy for prostate cancer. BJU Int. 2012 Jun; 109(11):1636-47.
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