Peter Jay Kushner, PhD

Peter Jay Kushner, PhD

Adjunct Professor, Department of Medicine, UCSF

Phone: (415) 476-6790 (voice)
Box 0540, UCSF
San Francisco, CA 94143-0540

Cancer Center Membership

Associate Member ยป Breast Oncology


University of Oregon; Eugene OR, Ph.D., 1979, Molecular Biology
University of California San Francisco, Postdoc., 1979-83, Molecular Biology

Professional Experience

  • 1981 - 1983
    Associate Howard Hughes Med. Inst., University of California at San Francisco, San Francisco, CA
  • 1983 - 1988
    Scientist, Senior Scientist, Staff Scientist, California Biotechnology, Inc., Mountain View, CA
  • 1988 - 1990
    Visiting Assist. Res. Biochem, University of California at San Francisco, San Francisco, CA
  • 1990 - 1995
    Assistant Research Biochemist, University of California at San Francisco, San Francisco, CA
  • 1995 - 1998
    Associate Research Biochemist, University of California at San Francisco, San Francisco, CA
  • 1998 - 2004
    Research Biochemist, University of California at San Francisco, San Francisco, CA
  • 2004-present
    Adjunct Professor, Department of Medicine, University of California, San Francisco,CA

Selected Publications

  • (last 7 years from a total of 62)
  • Ding X F, Anderson CM, Ma H, Hong H, Uht R, Kushner PJ, Stallcup, MR. Nuclear Receptor Binding Sites of Coactivators GRIP1 and SRC-1: Multiple Motifs with Different Binding Specificities. Molecular Endocrinology 12:302-313. 1998.
  • Feng W, Ribeiro R,Wagner RL, Nguyen H, Apriletti JW, Fletterick RJ, Baxter JD, Kushner PJ, West BL. Hormone-Dependent Coactivator Binding to a Hydrophobic Cleft on Nuclear Receptors. Science 280:1747-1749. 1998
  • Webb P, Nguyen P, Shinsako J, Anderson CM, Nguyen MP, Feng W-J, Chen D, Huang S-M, Subramanian S, McKinerney E, Katzenellenbogen BS, Stallcup M, and Kushner PJ*. Estrogen Receptor Activation Function 1 Works by Binding to p160 Coactivator Proteins. Molecular Endocrinology, 14:3741-51, 1998
  • Darimont B, Wagner R, Apriletti J, Stallcup M, Kushner PJ, Baxter JD, Fletterick R, Yamamoto KR. Structure and Specificity of Nuclear Receptor Interactions with Coactivator. Genes and Development 12:3343-3356 1998
  • Schiau AK, Barstad D, Loria PM, Cheng L, Kushner PJ, Agaard D, Greene GL. Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of this Interaction by Tamoxifen. Cell, 95:927-37 1998
  • Johnston SRD, Lu B, Scott GK, Kushner PJ, Smith IE, Dowsett M, Benz CC. Increased AP-1 DNA Binding and Jun N-terminal Kinase (JNK) Activity in Human Breast Tumors with Acquired Tamoxifen Resistance. Clinical Cancer Research, 5:251-256 1999
  • Lopez G, Shinsako J, Webb P, Baxter JD, Green GL, Kushner PJ. A Target Distal To Coactivators That Is Titrated By The Estrogen Receptor AF-2 Function Molecular Endocrinology, 13:897-909 1999
  • Webb P, Nguyen P, Valentine C, Lopez GN, Kwok GR, McInerney E, Katzenellenbogen BS, Enmark E, Gustafsson J-A, Nilsson S, Kushner PJ. The Estrogen Receptor Enhances AP-1 Activity by Two Distinct Mechanisms With Different Requirements for Receptor Transactivation Functions. Molecular Endocrinology, 12,: 1605-1618 1999
  • Ma H, Hong H, Huang S-M, Irvine RA, Webb P, Kushner PJ, Coetzee GA, Stallcup MR. Multiple Signal Input and Output Domains of the 160KDa Nuclear Receptor Coactivator Proteins. Molecular and Cellular Biology, 19:6164-6173 1999
  • An J, Ribeiro RCJ,Webb P, Gustafsson J-A, Lomri N, Kushner PJ, Baxter JD,Leitman DC. Estradiol repression of tumor necrosis factor-alpha transcription requires estrogen receptor activation function-2 and is enhanced by coactivators. PNAS 26:15161-15166 1999
  • Kushner PJ, Agard D, Feng W J, Lopez G, Shiau A, Uht R, Webb P, Greene G. Estrogen receptor function at classical and alternative response elements. In "Neuronal and cognitive effects of oestrogens" Wiley, Chichester (Novartis Foundation Symposium 230) p20-32 2000
  • Kushner PJ, Agard D, Greene G, Scanlan T, Shiau A, Uht RM, Webb P. Estrogen Receptor Pathways to AP-1. Journal of Steroid Biochemistry and Molecular Biology 74:311 2000
  • Pissios P, Tzameli I, Kushner PJ, Moore DD. Dynamic Stabilization of Nuclear Receptor Ligand Binding Domains by Hormone or Corepressor Binding. Molecular Cell 6:1-20 2000
  • Webb P, Anderson CM, Valentine C, Nguyen P, Marimuthu A, West BL, Baxter JD, Kushner PJ. The nuclear receptor corepressor (N-CoR) contains three isoleucine motifs (I/LXXII) that serve as receptor interaction domains (IDs). Molecular Endocrinology 14:1976-1985 2000
  • Webb P, Nguyen P, Valentine C, Weatherman RV, Scanlan TS, Kushner PJ. An antiestrogen responsive estrogen receptor alpha mutant (D351Y) shows weak AF-2 activity in the presence of tamoxifen. Journal of Biological Chemistry 275 N48:37552-37558 2000
  • Feng W, Webb P, Nguyen P, Liu X H, Li J, Karin M, Kushner PJ. Potentiation Of Estrogen Receptor AF-1 by Src/JNK Through a Serine 118 Independent pathway. Molecular Endocrinology 15:32-45 2001
  • Fan S, Ma YX, Wang C, Yuan R-Q, Meng Q,Wang J-A, Erdos MR, Goldberg ID, Webb P, Kushner PJ, Pestell RG, Rosen EM. Role of direct interaction in BRCA1 inhibition of estrogen receptor activity. Oncogene 20:77 2001
  • Price RH Jr, Butler CA, Webb P, Uht R, Kushner P, Handa RJ. A splice variant of estrogen receptor beta missing exon 3 displays altered subnuclear localization and capacity for transcriptional activation. Endocrinology. 142(5):2039-49 2001
  • Lopez GN, Turck CW, Schaufele F, Stallcup MR, Kushner PJ. Growth factors signal to steroid receptors through MAP kinase regulation of p160 coactivator activity. Journal of Biological Chemistry 276(25):22177-22182 2001
  • Wang C, Fu M, Angeletti RH, Siconolfi-Baez L, Reutens AT, Albanese C, Lisanti MP, Katzenellenbogen BS, Kato S, Hopp T, Fuqua SA, Lopez GN, Kushner PJ, Pestell RG. Direct Acetylation of the Estrogen Receptor alpha Hinge Region by p300 Regulates Transactivation and Hormone Sensitivity. J Biol Chem. 276(21):18375-18383 2001
  • Fan S, Ma YX, Wang C, Yuan RQ, Meng Q, Wang JA, Erdos M, Goldberg ID, Webb P, Kushner PJ, Pestell RG, Rosen EM p300 Modulates the BRCA1 inhibition of estrogen receptor activity.Cancer Res.1;62(1):141-51 2002
  • Baxter JD, Goede P, Apriletti JW, West BL, Feng W, Mellstrom K, Fletterick RJ, Wagner RL, Kushner PJ, Ribeiro RC, Webb P, Scanlan TS, Nilsson S. Structure-based design and synthesis of a thyroid hormone receptor (TR) antagonist. Endocrinology143(2):517-24 2002
  • Liu MM, Albanese C, Anderson CM, Hilty K, Webb P, Uht RM, Price RH Jr, Pestell RG, Kushner PJ. Opposing action of estrogen receptors alpha and beta on cyclin D1 gene expression.J Biol Chem. 5;277(27):24353-60 2002
  • Webb P, Nguyen P, Kushner PJ. Differential SERM effects on corepressor binding dictate ER alpha activity in vivo.J Biol Chem. 2003 Feb 28;278(9):6912-20
  • Uht RM, Webb P, Nguyen P, Price Jr RH Jr, Valentine C, Favre H, Kushner PJ. A conserved lysine in the estrogen receptor DNA binding domain regulates ligand activation profiles at AP-1 sites, possibly by controlling interactions with a modulating repressor.Nucl Recept. 2004 May 7;2(1):2.
  • Wang C, Fan S, Li Z, Fu M, Rao M, Ma Y, Lisanti MP, Albanese C,Katzenellenbogen BS, Kushner PJ, Weber B, Rosen EM, Pestell RG. Cyclin D1 antagonizes BRCA1 repression of estrogen receptor alpha activity. Cancer Res. 2005 Aug 1;65(15):6557-67.
  • Frigo DE, Basu A, Nierth-Simpson EN, Weldon CB, Dugan CM, Elliott S,Collins-Burow BM, Salvo VA, Zhu Y, Melnik LI, Lopez GN, Kushner PJ, Curiel TJ,Rowan BG, McLachlan JA, Burow ME. p38 Mitogen-Activated Protein Kinase Stimulates Estrogen-Mediated Transcriptionand Proliferation through the Phosphorylation and Potentiation of the p160 Coactivator Glucocorticoid Receptor-Interacting Protein 1.Mol Endocrinol. 2006 May;20(5):971-83. Epub 2006 Jan 12.