University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Diana Laird, PhD

Diana Laird, PhD

Associate Professor, Department of Obstetrics, Gynecology and Reproductive Sciences, UCSF

Cancer Center Program Memberships

Pediatric Malignancies

Research Summary

Our research focuses on the development of germ cells in mammalian embryos. We are working toward understanding the causes of infertility, enhancing our understanding of the fundamental process of gamete selection in evolution, and unlocking the potential of stem cells to generate gametes for research, human reproduction and agriculture.

Education

Stanford University, Stanford, CA, Ph.D., 03/2003, Biological Sciences
Sloan Kettering Institute, New York, NY, Postdoc, 12/2007, Developmental Genetics


Professional Experience

  • 2003 - 2007
    Postdoctoral Fellow, Sloan Kettering Institute, Developmental Genetics Program
  • 2008 - 2015
    Assistant Professor in Residence, Step 5 UCSF Department of Obstetrics, Gynecology and Reproductive Sciences Eli and Edythe Broad Center for Regeneration Medicine and Stem Cell Research
  • 2015 - present
    Associate Professor in Residence, Step 1
  • 2015 - present
    Co-director UCSF Environmental Health Initiative

Honors & Awards

  • 1990
    Tektronix Scholarship for undergraduates Tektronix Corporation (Beaverton, Oregon)
  • 1997
    NSF Predoctoral Fellowship in Biology National Science Foundation
  • 2002
    Keystone Symposium Scholarship Keystone Foundation
  • 2004
    Jane Coffin Childs Memorial Fellowship Jane Coffin Childs Foundation
  • 2008
    Junior Faculty Startup Award Sandler Foundation
  • 2010
    Early Career Award Hellman Foundation
  • 2010
    New Innovator Award (DP2) NIH
  • 2016
    Deleage Prize for Young Investigators Deleage Foundation, UCSF

Selected Publications

  1. Susman MW, Karuna EP, Kunz RC, Gujral TS, Cantú AV, Choi SS, Jong BY, Okada K, Scales MK, Hum J, Hu LS, Kirschner MW, Nishinakamura R, Yamada S, Laird DJ, Jao LE, Gygi SP, Greenberg ME, Ho HH. Kinesin superfamily protein Kif26b links Wnt5a-Ror signaling to the control of cell and tissue behaviors in vertebrates. Elife. 2017 Sep 08; 6.
    View on PubMed
  2. Cantú AV, Laird DJ. A pilgrim's progress: Seeking meaning in primordial germ cell migration. Stem Cell Res. 2017 Jul 18.
    View on PubMed
  3. Whitaker AT, Berthet E, Cantu A, Laird DJ, Alliston T. Smad4 regulates growth plate matrix production and chondrocyte polarity. Biol Open. 2017 Mar 15; 6(3):358-364.
    View on PubMed
  4. Curtis A, Li DJ, DeVeale B, Onishi K, Kim MY, Blelloch R, Laird DJ, Hui EE. Patterning of sharp cellular interfaces with a reconfigurable elastic substrate. Integr Biol (Camb). 2017 Jan 23; 9(1):50-57.
    View on PubMed
  5. Arora R, Fries A, Oelerich K, Marchuk K, Sabeur K, Giudice LC, Laird DJ. Insights from imaging the implanting embryo and the uterine environment in three dimensions. Development. 2016 Dec 15; 143(24):4749-4754.
    View on PubMed
  6. Cantú AV, Altshuler-Keylin S, Laird DJ. Discrete somatic niches coordinate proliferation and migration of primordial germ cells via Wnt signaling. J Cell Biol. 2016 Jul 18; 214(2):215-29.
    View on PubMed
  7. Arora R, Abby E, Ross AD, Cantu AV, Kissner MD, Castro V, Ho HY, Livera G, Laird DJ. Meiotic onset is reliant on spatial distribution but independent of germ cell number in the mouse ovary. J Cell Sci. 2016 Jul 01; 129(13):2493-9.
    View on PubMed
  8. Tran ND, Kissner M, Subramanyam D, Parchem RJ, Laird DJ, Blelloch RH. A miR-372/let-7 Axis Regulates Human Germ Versus Somatic Cell Fates. Stem Cells. 2016 Jul; 34(7):1985-91.
    View on PubMed
  9. Sousa Martins JP, Liu X, Oke A, Arora R, Franciosi F, Viville S, Laird DJ, Fung JC, Conti M. DAZL and CPEB1 regulate mRNA translation synergistically during oocyte maturation. J Cell Sci. 2016 Mar 15; 129(6):1271-82.
    View on PubMed
  10. Chen JC, Hoffman JR, Arora R, Perrone LA, Gonzalez-Gomez CJ, Vo KC, Laird DJ, Irwin JC, Giudice LC. Cryopreservation and recovery of human endometrial epithelial cells with high viability, purity, and functional fidelity. Fertil Steril. 2016 Feb; 105(2):501-10.e1.
    View on PubMed
  11. Faire M, Skillern A, Arora R, Nguyen DH, Wang J, Chamberlain C, German MS, Fung JC, Laird DJ. Follicle dynamics and global organization in the intact mouse ovary. Dev Biol. 2015 Jul 01; 403(1):69-79.
    View on PubMed
  12. Arora R, Altman E, Tran ND, Laird DJ. Novel domains of expression for orphan receptor tyrosine kinase Ror2 in the human and mouse reproductive system. Dev Dyn. 2014 Aug; 243(8):1037-45.
    View on PubMed
  13. Cantú AV, Laird DJ. Wnt and Bmp fit germ cells to a T. Dev Cell. 2013 Dec 09; 27(5):485-7.
    View on PubMed
  14. Blaschke K, Ebata KT, Karimi MM, Zepeda-Martínez JA, Goyal P, Mahapatra S, Tam A, Laird DJ, Hirst M, Rao A, Lorincz MC, Ramalho-Santos M. Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells. Nature. 2013 Aug 08; 500(7461):222-6.
    View on PubMed
  15. Laird DJ. Humans put their eggs in more than one basket. Nat Cell Biol. 2013 Jan; 15(1):13-5.
    View on PubMed
  16. Chen L, Faire M, Kissner MD, Laird DJ. Primordial germ cells and gastrointestinal stromal tumors respond distinctly to a cKit overactivating allele. Hum Mol Genet. 2013 Jan 15; 22(2):313-27.
    View on PubMed
  17. Laird DJ, Altshuler-Keylin S, Kissner MD, Zhou X, Anderson KV. Ror2 enhances polarity and directional migration of primordial germ cells. PLoS Genet. 2011 Dec; 7(12):e1002428.
    View on PubMed
  18. Espejel S, Roll GR, McLaughlin KJ, Lee AY, Zhang JY, Laird DJ, Okita K, Yamanaka S, Willenbring H. Induced pluripotent stem cell-derived hepatocytes have the functional and proliferative capabilities needed for liver regeneration in mice. J Clin Invest. 2010 Sep; 120(9):3120-6.
    View on PubMed
  19. Laird DJ, von Andrian UH, Wagers AJ. Stem cell trafficking in tissue development, growth, and disease. Cell. 2008 Feb 22; 132(4):612-30.
    View on PubMed
  20. Laird DJ, De Tomaso AW, Weissman IL. Stem cells are units of natural selection in a colonial ascidian. Cell. 2005 Dec 29; 123(7):1351-60.
    View on PubMed

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