University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Lewis L. Lanier, PhD

Lewis L. Lanier, PhD

American Cancer Society Professor; and Chair, Department of Microbiology and Immunology, UCSF
Leader, Cancer Immunology Program, UCSF Helen Diller Family Comprehensive Cancer Center
J. Michael Bishop, MD, Distinguished Professor in Microbiology and Immunology, UCSF

Cancer Center Program Memberships

Cancer Immunology

Research Summary

I have studied natural killer (NK) cells in humans and mice since 1981. My lab has identified many of the activating and inhibitory NK receptors, their ligands, and signaling pathways and defined their role in innate and adaptive immune responses to pathogens and cancer.

Education

Virginia Polytechnic Institute & State U., Blacksburg, VA, B.S. (honors), 1975, Microbiology
Univ. North Carolina - Chapel Hill, NC, Ph.D., 1978, Immunology
Univ. North Carolina - Chapel Hill, NC, Postdoc, 1978-79, Immunology
Univ. New Mexico Med Sch, Albuquerque, NM, Postdoc, 1979-81, Immunology


Professional Experience

  • 1981-1988
    Senior Research Scientist, Becton Dickinson Monoclonal Center, Inc.
  • 1988-1990
    Associate Research Director, Becton Dickinson Immunocytometry Systems
  • 1991-1992
    Senior Scientific Staff, Department of Immunology, DNAX Research Institute
  • 1993-1996
    Associate Director, Department of Human Immunology, DNAX Research Institute
  • 1997-1999
    Director, Department of Immunobiology, DNAX Research Institute
  • 1999-present
    Professor, Department of Microbiology & Immunology and Cancer Research Institute, University of California, San Francisco
  • 2003-2010
    Vice Chair, Department of Microbiology & Immunology, University of California, San Francisco
  • 2010
    Chair, Department of Microbiology & Immunology, University of California, San Francisco

Honors & Awards

  • 1971
    Virginia Polytechnic Institute and State University Freshman Science Scholarship
  • 1978-1979
    National Research Service Award Fellowship, University of North Carolina School of Medicine at Chapel Hill Cancer Research Center
  • 1979-1981
    Damon Runyon - Walter Winchell Cancer Fund Postdoctoral Fellowship
  • 2001
    American Association of Immunologists Distinguished Service Award
  • 2002
    William B Coley Award for Distinguished Research in Basic and Tumor Immunology, Cancer Research Institute, New York
  • 2003
    American Cancer Society Research Professorship
  • 2005
    American Society for Histocompatibility and Immunogenetics Rose Payne Award
  • 2006
    NIH Merit Grant Award
  • 2010
    Member, National Academy of Sciences
  • 2011
    Member, National Academy of Arts and Sciences
  • 2011
    Fellow, American Academy of Microbiology

Selected Publications

  1. Mukherjee S, Stewart D, Stewart W, Lanier LL, Das J. Connecting the dots across time: reconstruction of single-cell signalling trajectories using time-stamped data. R Soc Open Sci. 2017 Aug; 4(8):170811.
    View on PubMed
  2. Jensen H, Potempa M, Gotthardt D, Lanier LL. Cutting Edge: IL-2-Induced Expression of the Amino Acid Transporters SLC1A5 and CD98 Is a Prerequisite for NKG2D-Mediated Activation of Human NK Cells. J Immunol. 2017 Sep 15; 199(6):1967-1972.
    View on PubMed
  3. Nabekura T, Gotthardt D, Niizuma K, Trsan T, Jenus T, Jonjic S, Lanier LL. Cutting Edge: NKG2D Signaling Enhances NK Cell Responses but Alone Is Insufficient To Drive Expansion during Mouse Cytomegalovirus Infection. J Immunol. 2017 Sep 01; 199(5):1567-1571.
    View on PubMed
  4. Hosomi S, Grootjans J, Tschurtschenthaler M, Krupka N, Matute JD, Flak MB, Martinez-Naves E, Gomez Del Moral M, Glickman JN, Ohira M, Lanier LL, Kaser A, Blumberg R. Intestinal epithelial cell endoplasmic reticulum stress promotes MULT1 up-regulation and NKG2D-mediated inflammation. J Exp Med. 2017 Jul 26.
    View on PubMed
  5. Vadstrup K, Galsgaard ED, Jensen H, Lanier LL, Ryan JC, Chen SY, Nolan GP, Vester-Andersen MK, Pedersen JS, Gerwien J, Jensen T, Bendtsen F. NKG2D ligand expression in Crohn's disease and NKG2D-dependent stimulation of CD8+ T cell migration. Exp Mol Pathol. 2017 Aug; 103(1):56-70.
    View on PubMed
  6. Mukherjee S, Jensen H, Stewart W, Stewart D, Ray WC, Chen SY, Nolan GP, Lanier LL, Das J. In silico modeling identifies CD45 as a regulator of IL-2 synergy in the NKG2D-mediated activation of immature human NK cells. Sci Signal. 2017 Jun 27; 10(485).
    View on PubMed
  7. Morvan MG, Champsaur M, Reizis B, Lanier LL. Chronic In Vivo Interaction of Dendritic Cells Expressing the Ligand Rae-1e with NK Cells Impacts NKG2D Expression and Function. Immunohorizons. 2017 May 01; 1(3):10-19.
    View on PubMed
  8. Crome SQ, Nguyen LT, Lopez-Verges S, Yang SY, Martin B, Yam JY, Johnson DJ, Nie J, Pniak M, Yen PH, Milea A, Sowamber R, Katz SR, Bernardini MQ, Clarke BA, Shaw PA, Lang PA, Berman HK, Pugh TJ, Lanier LL, Ohashi PS. A distinct innate lymphoid cell population regulates tumor-associated T cells. Nat Med. 2017 Mar; 23(3):368-375.
    View on PubMed
  9. Jensen H, Chen SY, Folkersen L, Nolan GP, Lanier LL. EBI3 regulates the NK cell response to mouse cytomegalovirus infection. Proc Natl Acad Sci U S A. 2017 Feb 14; 114(7):1625-1630.
    View on PubMed
  10. Lam VC, Lanier LL. NK cells in host responses to viral infections. Curr Opin Immunol. 2017 Feb; 44:43-51.
    View on PubMed
  11. Nabekura T, Lanier LL. Tracking the fate of antigen-specific versus cytokine-activated natural killer cells after cytomegalovirus infection. J Exp Med. 2016 Nov 14; 213(12):2745-2758.
    View on PubMed
  12. Nabekura T, Lanier LL. Activating Receptors for Self-MHC Class I Enhance Effector Functions and Memory Differentiation of NK Cells during Mouse Cytomegalovirus Infection. Immunity. 2016 Jul 19; 45(1):74-82.
    View on PubMed
  13. Spits H, Bernink JH, Lanier L. NK cells and type 1 innate lymphoid cells: partners in host defense. Nat Immunol. 2016 Jun 21; 17(7):758-64.
    View on PubMed
  14. Cerwenka A, Lanier LL. Natural killer cell memory in infection, inflammation and cancer. Nat Rev Immunol. 2016 Feb; 16(2):112-23.
    View on PubMed
  15. Madera S, Rapp M, Firth MA, Beilke JN, Lanier LL, Sun JC. Type I IFN promotes NK cell expansion during viral infection by protecting NK cells against fratricide. J Exp Med. 2016 Feb 08; 213(2):225-33.
    View on PubMed
  16. Hendricks DW, Min-Oo G, Lanier LL. Sweet Is the Memory of Past Troubles: NK Cells Remember. Curr Top Microbiol Immunol. 2016; 395:147-71.
    View on PubMed
  17. Morvan MG, Lanier LL. NK cells and cancer: you can teach innate cells new tricks. Nat Rev Cancer. 2016 Jan; 16(1):7-19.
    View on PubMed
  18. Guan Z, Kuhn JA, Wang X, Colquitt B, Solorzano C, Vaman S, Guan AK, Evans-Reinsch Z, Braz J, Devor M, Abboud-Werner SL, Lanier LL, Lomvardas S, Basbaum AI. Injured sensory neuron-derived CSF1 induces microglial proliferation and DAP12-dependent pain. Nat Neurosci. 2016 Jan; 19(1):94-101.
    View on PubMed
  19. O'Sullivan TE, Sun JC, Lanier LL. Natural Killer Cell Memory. Immunity. 2015 Oct 20; 43(4):634-45.
    View on PubMed
  20. Huang X, Li J, Dorta-Estremera S, Di Domizio J, Anthony SM, Watowich SS, Popkin D, Liu Z, Brohawn P, Yao Y, Schluns KS, Lanier LL, Cao W. Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-? Production via the Generation of Reactive Oxygen Species. Cell Rep. 2015 Aug 18; 12(7):1120-32.
    View on PubMed

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