Lewis L. Lanier, PhD

American Cancer Society Professor; and Chair, Department of Microbiology and Immunology, UCSF
Leader, Cancer, Immunity, and Microenvironment Program, UCSF Helen Diller Family Comprehensive Cancer Center

Lewis.Lanier@ucsf.edu

Phone: (415) 514-0829 (voice)
Box 0414, UCSF
San Francisco, CA 94143-0414

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Additional Websites

• Lab Website

Education

Virginia Polytechnic Institute & State U., Blacksburg, VA, B.S. (honors), 1975, Microbiology
Univ. North Carolina - Chapel Hill, NC, Ph.D., 1978, Immunology
Univ. North Carolina - Chapel Hill, NC, Postdoc, 1978-79, Immunology
Univ. New Mexico Med Sch, Albuquerque, NM, Postdoc, 1979-81, Immunology

Professional Experience

• 1981-1988
  Senior Research Scientist, Becton Dickinson Monoclonal Center, Inc.
• 1988-1990
  Associate Research Director, Becton Dickinson Immunocytometry Systems
• 1991-1992
  Senior Scientific Staff, Department of Immunology, DNAX Research Institute
• 1993-1996
  Associate Director, Department of Human Immunology, DNAX Research Institute
• 1997-1999
  Director, Department of Immunobiology, DNAX Research Institute
• 1999-present
  Professor, Department of Microbiology & Immunology and Cancer Research Institute, University of California, San Francisco
• 2003-2010
  Vice Chair, Department of Microbiology & Immunology, University of California, San Francisco
• 2010
  Chair, Department of Microbiology & Immunology, University of California, San Francisco

Honors & Awards

• 1971
  Virginia Polytechnic Institute and State University Freshman Science Scholarship
• 1978-1979
  National Research Service Award Fellowship, University of North Carolina School of Medicine at Chapel Hill Cancer Research Center
• 1979-1981
  Damon Runyon - Walter Winchell Cancer Fund Postdoctoral Fellowship
• 2001
  American Association of Immunologists Distinguished Service Award
• 2002
  William B Coley Award for Distinguished Research in Basic and Tumor Immunology, Cancer Research Institute, New York
• 2003
  American Cancer Society Research Professorship
• 2005
  American Society for Histocompatibility and Immunogenetics Rose Payne Award
• 2006
  NIH Merit Grant Award
• 2010
  Member, National Academy of Sciences
• 2011
  Member, National Academy of Arts and Sciences
• 2011
  Fellow, American Academy of Microbiology

Selected Publications

1. Beaulieu AM, Bezman NA, Lee JE, Matloubian M, Sun JC, Lanier LL. MicroRNA function in NK-cell biology. Immunol Rev. 2013 May; 253(1):40-52.
   View on PubMed
2. Zawislak CL, Beaulieu AM, Loeb GB, Karo J, Canner D, Bezman NA, Lanier LL, Rudensky AY, Sun JC. Stage-specific regulation of natural killer cell homeostasis and response against viral infection by microRNA-155. Proc Natl Acad Sci U S A. 2013 Apr 23; 110(17):6967-72.
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3. Best JA, Blair DA, Knell J, Yang E, Mayya V, Doedens A, Dustin ML, Goldrath AW. Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation. Nat Immunol. 2013 Apr; 14(4):404-12.
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4. Lanier LL. Shades of grey--the blurring view of innate and adaptive immunity. Nat Rev Immunol. 2013 Feb; 13(2):73-4.
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5. Jiang Y, Arase N, Kohyama M, Hirayasu K, Suenaga T, Jin H, Matsumoto M, Shida K, Lanier LL, Saito T, Arase H. Transport of misfolded endoplasmic reticulum proteins to the cell surface by MHC class II molecules. Int Immunol. 2013 Apr; 25(4):235-46.
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6. Batista MD, Ho EL, Kuebler PJ, Milush JM, Lanier LL, Kallas EG, York VA, Chang D, Liao W, Unemori P, Leslie KS, Maurer T, Nixon DF. Skewed distribution of natural killer cells in psoriasis skin lesions. Exp Dermatol. 2013 Jan; 22(1):64-6.
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7. Cohen NR, Brennan PJ, Shay T, Watts GF, Brigl M, Kang J, Brenner MB. Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells. Nat Immunol. 2013 Jan; 14(1):90-9.
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8. Benoist C, Lanier L, Merad M, Mathis D. Consortium biology in immunology: the perspective from the Immunological Genome Project. Nat Rev Immunol. 2012 Oct; 12(10):734-40.
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9. Bezman NA, Kim CC, Sun JC, Min-Oo G, Hendricks DW, Kamimura Y, Best JA, Goldrath AW, Lanier LL. Molecular definition of the identity and activation of natural killer cells. Nat Immunol. 2012 Oct; 13(10):1000-9.
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10. Thomas MF, Abdul-Wajid S, Panduro M, Babiarz JE, Rajaram M, Woodruff P, Lanier LL, Heissmeyer V, Ansel KM. Eri1 regulates microRNA homeostasis and mouse lymphocyte development and antiviral function. Blood. 2012 Jul 5; 120(1):130-42.
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11. Beilke JN, Meagher CT, Hosiawa K, Champsaur M, Bluestone JA, Lanier LL. NK cells are not required for spontaneous autoimmune diabetes in NOD mice. PLoS One. 2012; 7(4):e36011.
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12. Park CY, Jeker LT, Carver-Moore K, Oh A, Liu HJ, Cameron R, Richards H, Li Z, Adler D, Yoshinaga Y, Martinez M, Nefadov M, Abbas AK, Weiss A, Lanier LL, de Jong PJ, Bluestone JA, Srivastava D, McManus MT. A resource for the conditional ablation of microRNAs in the mouse. Cell Rep. 2012 Apr 19; 1(4):385-91.
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13. Sun JC, Madera S, Bezman NA, Beilke JN, Kaplan MH, Lanier LL. Proinflammatory cytokine signaling required for the generation of natural killer cell memory. J Exp Med. 2012 May 7; 209(5):947-54.
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14. Ndhlovu LC, Lopez-Vergès S, Barbour JD, Jones RB, Jha AR, Long BR, Schoeffler EC, Fujita T, Nixon DF, Lanier LL. Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity. Blood. 2012 Apr 19; 119(16):3734-43.
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15. Nielsen N, Ødum N, Ursø B, Lanier LL, Spee P. Cytotoxicity of CD56(bright) NK cells towards autologous activated CD4+ T cells is mediated through NKG2D, LFA-1 and TRAIL and dampened via CD94/NKG2A. PLoS One. 2012; 7(2):e31959.
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16. Tietze JK, Wilkins DE, Sckisel GD, Bouchlaka MN, Alderson KL, Weiss JM, Ames E, Bruhn KW, Craft N, Wiltrout RH, Longo DL, Lanier LL, Blazar BR, Redelman D, Murphy WJ. Delineation of antigen-specific and antigen-nonspecific CD8(+) memory T-cell responses after cytokine-based cancer immunotherapy. Blood. 2012 Mar 29; 119(13):3073-83.
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17. Foley B, Cooley S, Verneris MR, Pitt M, Curtsinger J, Luo X, Lopez-Vergès S, Lanier LL, Weisdorf D, Miller JS. Cytomegalovirus reactivation after allogeneic transplantation promotes a lasting increase in educated NKG2C+ natural killer cells with potent function. Blood. 2012 Mar 15; 119(11):2665-74.
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18. Chen Z, Chen L, Baker K, Olszak T, Zeissig S, Huang YH, Kuo TT, Mandelboim O, Beauchemin N, Lanier LL, Blumberg RS. CEACAM1 dampens antitumor immunity by down-regulating NKG2D ligand expression on tumor cells. J Exp Med. 2011 Dec 19; 208(13):2633-40.
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19. Bezman NA, Chakraborty T, Bender T, Lanier LL. miR-150 regulates the development of NK and iNKT cells. J Exp Med. 2011 Dec 19; 208(13):2717-31.
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20. Sun JC, Lanier LL. NK cell development, homeostasis and function: parallels with CD8? T cells. Nat Rev Immunol. 2011 Oct; 11(10):645-57.
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