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Lewis L. Lanier, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
lanier_lewis

American Cancer Society Professor; and Chair, Department of Microbiology and Immunology, UCSF
Leader, Cancer, Immunity, and Microenvironment Program, UCSF Helen Diller Family Comprehensive Cancer Center

J. Michael Bishop MD Distinguished Professor, UCSF

Lewis.Lanier@ucsf.edu

Phone: (415) 514-0829 (voice)
Box 0414, UCSF
San Francisco, CA 94143-0414

View on UCSF Profiles


Additional Websites


Education

Virginia Polytechnic Institute & State U., Blacksburg, VA, B.S. (honors), 1975, Microbiology
Univ. North Carolina - Chapel Hill, NC, Ph.D., 1978, Immunology
Univ. North Carolina - Chapel Hill, NC, Postdoc, 1978-79, Immunology
Univ. New Mexico Med Sch, Albuquerque, NM, Postdoc, 1979-81, Immunology


Professional Experience

  • 1981-1988
    Senior Research Scientist, Becton Dickinson Monoclonal Center, Inc.
  • 1988-1990
    Associate Research Director, Becton Dickinson Immunocytometry Systems
  • 1991-1992
    Senior Scientific Staff, Department of Immunology, DNAX Research Institute
  • 1993-1996
    Associate Director, Department of Human Immunology, DNAX Research Institute
  • 1997-1999
    Director, Department of Immunobiology, DNAX Research Institute
  • 1999-present
    Professor, Department of Microbiology & Immunology and Cancer Research Institute, University of California, San Francisco
  • 2003-2010
    Vice Chair, Department of Microbiology & Immunology, University of California, San Francisco
  • 2010
    Chair, Department of Microbiology & Immunology, University of California, San Francisco

Honors & Awards

  • 1971
    Virginia Polytechnic Institute and State University Freshman Science Scholarship
  • 1978-1979
    National Research Service Award Fellowship, University of North Carolina School of Medicine at Chapel Hill Cancer Research Center
  • 1979-1981
    Damon Runyon - Walter Winchell Cancer Fund Postdoctoral Fellowship
  • 2001
    American Association of Immunologists Distinguished Service Award
  • 2002
    William B Coley Award for Distinguished Research in Basic and Tumor Immunology, Cancer Research Institute, New York
  • 2003
    American Cancer Society Research Professorship
  • 2005
    American Society for Histocompatibility and Immunogenetics Rose Payne Award
  • 2006
    NIH Merit Grant Award
  • 2010
    Member, National Academy of Sciences
  • 2011
    Member, National Academy of Arts and Sciences
  • 2011
    Fellow, American Academy of Microbiology

Selected Publications

  1. Lanier LL. Just the FACS. J Immunol. 2014 Sep 1; 193(5):2043-4.
    View on PubMed
  2. Crane CA, Austgen K, Haberthur K, Hofmann C, Moyes KW, Avanesyan L, Fong L, Campbell MJ, Cooper S, Oakes SA, Parsa AT, Lanier LL. Immune evasion mediated by tumor-derived lactate dehydrogenase induction of NKG2D ligands on myeloid cells in glioblastoma patients. Proc Natl Acad Sci U S A. 2014 Sep 2; 111(35):12823-8.
    View on PubMed
  3. Min-Oo G, Bezman NA, Madera S, Sun JC, Lanier LL. Proapoptotic Bim regulates antigen-specific NK cell contraction and the generation of the memory NK cell pool after cytomegalovirus infection. J Exp Med. 2014 Jun 30; 211(7):1289-96.
    View on PubMed
  4. Du J, Lopez-Verges S, Pitcher BN, Johnson J, Jung SH, Zhou L, Hsu K, Czuczman MS, Cheson B, Kaplan L, Lanier LL, Venstrom JM. CALGB 150905 (Alliance): Rituximab Broadens the Antilymphoma Response by Activating Unlicensed NK Cells. Cancer Immunol Res. 2014 Sep; 2(9):878-89.
    View on PubMed
  5. Orbelyan GA, Tang F, Sally B, Solus J, Meresse B, Ciszewski C, Grenier JC, Barreiro LB, Lanier LL, Jabri B. Human NKG2E Is Expressed and Forms an Intracytoplasmic Complex with CD94 and DAP12. J Immunol. 2014 Jul 15; 193(2):610-6.
    View on PubMed
  6. Kalinowski A, Ueki I, Min-Oo G, Ballon-Landa E, Knoff D, Galen B, Lanier LL, Nadel JA, Koff JL. EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production. Am J Physiol Lung Cell Mol Physiol. 2014 Jul 15; 307(2):L186-96.
    View on PubMed
  7. Hendricks DW, Balfour HH, Dunmire SK, Schmeling DO, Hogquist KA, Lanier LL. Cutting Edge: NKG2ChiCD57+ NK Cells Respond Specifically to Acute Infection with Cytomegalovirus and Not Epstein-Barr Virus. J Immunol. 2014 May 15; 192(10):4492-6.
    View on PubMed
  8. Jin H, Arase N, Hirayasu K, Kohyama M, Suenaga T, Saito F, Tanimura K, Matsuoka S, Ebina K, Shi K, Toyama-Sorimachi N, Yasuda S, Horita T, Hiwa R, Takasugi K, Ohmura K, Yoshikawa H, Saito T, Atsumi T, Sasazuki T, Katayama I, Lanier LL, Arase H. Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility. Proc Natl Acad Sci U S A. 2014 Mar 11; 111(10):3787-92.
    View on PubMed
  9. Lanier LL. Of snowflakes and natural killer cell subsets. Nat Biotechnol. 2014 Feb 7; 32(2):140-2.
    View on PubMed
  10. Nabekura T, Kanaya M, Shibuya A, Fu G, Gascoigne NR, Lanier LL. Costimulatory Molecule DNAM-1 Is Essential for Optimal Differentiation of Memory Natural Killer Cells during Mouse Cytomegalovirus Infection. Immunity. 2014 Feb 20; 40(2):225-34.
    View on PubMed
  11. Dangl JL, Lanier LL. Founding father of FACS: Professor Leonard A. Herzenberg (1931–2013). Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):20848-9.
    View on PubMed
  12. Milush JM, López-Vergès S, York VA, Deeks SG, Martin JN, Hecht FM, Lanier LL, Nixon DF. CD56negCD16+ NK cells are activated mature NK cells with impaired effector function during HIV-1 infection. Retrovirology. 2013; 10(1):158.
    View on PubMed
  13. Hartigan-O'Connor DJ, Lin D, Ryan JC, Shvachko VA, Cozen ML, Segal MR, Terrault NA, Lanier LL, Manos MM, McCune JM. Monocyte Activation by Interferon a Is Associated With Failure to Achieve a Sustained Virologic Response After Treatment for Hepatitis C Virus Infection. J Infect Dis. 2014 May; 209(10):1602-12.
    View on PubMed
  14. Kim CC, Lanier LL. Beyond the transcriptome: completion of act one of the Immunological Genome Project. Curr Opin Immunol. 2013 Oct; 25(5):593-7.
    View on PubMed
  15. Ueki IF, Min-Oo G, Kalinowski A, Ballon-Landa E, Lanier LL, Nadel JA, Koff JL. Respiratory virus-induced EGFR activation suppresses IRF1-dependent interferon ? and antiviral defense in airway epithelium. J Exp Med. 2013 Sep 23; 210(10):1929-36.
    View on PubMed
  16. Co EC, Gormley M, Kapidzic M, Rosen DB, Scott MA, Stolp HA, McMaster M, Lanier LL, Bárcena A, Fisher SJ. Maternal decidual macrophages inhibit NK cell killing of invasive cytotrophoblasts during human pregnancy. Biol Reprod. 2013 Jun; 88(6):155.
    View on PubMed
  17. Hosomi S, Chen Z, Baker K, Chen L, Huang YH, Olszak T, Zeissig S, Wang JH, Mandelboim O, Beauchemin N, Lanier LL, Blumberg RS. CEACAM1 on activated NK cells inhibits NKG2D-mediated cytolytic function and signaling. Eur J Immunol. 2013 Sep; 43(9):2473-83.
    View on PubMed
  18. Mingueneau M, Kreslavsky T, Gray D, Heng T, Cruse R, Ericson J, Bendall S, Spitzer MH, Nolan GP, Kobayashi K, von Boehmer H, Mathis D, Benoist C. The transcriptional landscape of aß T cell differentiation. Nat Immunol. 2013 Jun; 14(6):619-32.
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  19. Beaulieu AM, Bezman NA, Lee JE, Matloubian M, Sun JC, Lanier LL. MicroRNA function in NK-cell biology. Immunol Rev. 2013 May; 253(1):40-52.
    View on PubMed
  20. Jojic V, Shay T, Sylvia K, Zuk O, Sun X, Kang J, Regev A, Koller D. Identification of transcriptional regulators in the mouse immune system. Nat Immunol. 2013 Jun; 14(6):633-43.
    View on PubMed

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