University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Peder Larson, PhD

Peder Larson, PhD

Assistant Professor-in-Residence, Department of Radiology and Biomedical Imaging, UCSF

Cancer Center Program Memberships

Experimental Therapeutics

Research Summary

I am an Assistant Professor in the Department of Radiology and Biomedical Imaging at UCSF focused on developing MRI methods that provide novel information about tissue structure and function that are not accessible by other clinical imaging modalities. My background is primarily in MR pulse sequence development, including MR physics, RF pulse design, acquisition strategies, and reconstruction techniques, beginning in 2003 under the advising of Profs. Dwight Nishimura and John Pauly at Stanford University. I came to UCSF as a post-doc in 2007 under Prof. Daniel Vigneron and joined the faculty in 2011.
A major focus of my research program is hyperpolarized carbon-13 metabolic magnetic resonance imaging (MRI) methods, and I am part of the team at UCSF translating this modality into human studies of cancer. The technology has the potential to improve staging of cancer and monitoring treatment response by measuring real-time conversion in key metabolic pathways. I develop the MRI data acquisition and image reconstruction methodologies for these studies.

Education

Stanford University, Stanford, CA, B.S., 06/02, Electrical Engineering and Mathematics
Stanford University, Stanford, CA, M.S., 06/03, Electrical Engineering
Stanford University, Stanford, CA, Ph.D., 09/07, Electrical Engineering
University of California – San Francisco, San Francisco, CA, Postdoctoral, 09/07-08/11, Radiology and Biomedical Imaging


Professional Experience

  • 2002-2003
    Teaching Assistant, Department of Electrical Engineering, Stanford University, Stanford, CA
  • 2003-2007
    Research Assistant, Department of Electrical Engineering, Stanford University, Stanford, CA
  • 2007-2011
    Postdoctoral Scholar, Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA
  • 2011-present
    Assistant Professor-in-Residence, Department of Radiology and Biomedical Imaging, UCSF, San Francisco, CA

Honors & Awards


  • 1998
    IEEE Wescon Scholarship - 2nd Place
  • 1998
    RC Byrd Honors Scholarship
  • 2003
    National Science Foundation Graduate Fellowship - Honorable Mention
  • 2005
    International Society for Magnetic Resonance in Medicine Annual Meeting Poster Award – 2nd place, Pulse sequences category
  • 2006
    Myelin Imaging Conference Poster Award – Accompanied by proffered talk
  • 2009
    Surbeck Scholar Award – 2nd place
  • 2009
    Outstanding Poster Award – UCSF Dept. of Radiology and Biomedical Imaging Research Symposium
  • 2010
    Surbeck Scholar Award – 1st place
  • 2011
    Surbeck Scholar Award – 1st place
  • 2011
    International Society for Magnetic Resonance in Medicine (ISMRM) Junior Fellow
  • 2010,2011,2012
    Magnetic Resonance in Medicine (MRM) Distinguished Reviewer

Selected Publications

  1. Larson PEZ, Chen HY, Gordon JW, Korn N, Maidens J, Arcak M, Tang S, Criekinge M, Carvajal L, Mammoli D, Bok R, Aggarwal R, Ferrone M, Slater JB, Nelson SJ, Kurhanewicz J, Vigneron DB. Investigation of analysis methods for hyperpolarized 13C-pyruvate metabolic MRI in prostate cancer patients. NMR Biomed. 2018 Sep 19; e3997.
    View on PubMed
  2. Tang S, Milshteyn E, Reed G, Gordon J, Bok R, Zhu X, Zhu Z, Vigneron DB, Larson PEZ. A regional bolus tracking and real-time B1 calibration method for hyperpolarized 13C MRI. Magn Reson Med. 2018 Sep 18.
    View on PubMed
  3. Sriram R, Gordon J, Baligand C, Ahamed F, Delos Santos J, Qin H, Bok RA, Vigneron DB, Kurhanewicz J, Larson PEZ, Wang ZJ. Non-Invasive Assessment of Lactate Production and Compartmentalization in Renal Cell Carcinomas Using Hyperpolarized 13C Pyruvate MRI. Cancers (Basel). 2018 Sep 05; 10(9).
    View on PubMed
  4. Vareth M, Lupo J, Larson P, Nelson S. A comparison of coil combination strategies in 3D multi-channel MRSI reconstruction for patients with brain tumors. NMR Biomed. 2018 Aug 31; e3929.
    View on PubMed
  5. Yang J, Liu J, Wiesinger F, Menini A, Zhu X, Hope TA, Seo Y, Larson PEZ. Developing an efficient phase-matched attenuation correction method for quiescent period PET in abdominal PET/MRI. Phys Med Biol. 2018 Aug 14.
    View on PubMed
  6. Autry AW, Hashizume R, James CD, Larson PEZ, Vigneron DB, Park I. Measuring Tumor Metabolism in Pediatric Diffuse Intrinsic Pontine Glioma Using Hyperpolarized Carbon-13 MR Metabolic Imaging. Contrast Media Mol Imaging. 2018; 2018:3215658.
    View on PubMed
  7. Coello E, Noeske R, Burns BL, Gordon JW, Jakary A, Menze B, Haase A, Larson PEZ, Li Y, Schulte RF. High-resolution echo-planar spectroscopic imaging at ultra-high field. NMR Biomed. 2018 Jul 27; e3950.
    View on PubMed
  8. Maidens J, Gordon JW, Chen HY, Park I, Van Criekinge M, Milshteyn E, Bok R, Aggarwal R, Ferrone M, Slater JB, Kurhanewicz J, Vigneron DB, Arcak M, Larson PEZ. Spatio-temporally constrained reconstruction for hyperpolarized carbon-13 MRI using kinetic models. IEEE Trans Med Imaging. 2018 Jun 05.
    View on PubMed
  9. Berg-Johansen B, Han M, Fields AJ, Liebenberg EC, Lim BJ, Larson PE, Gunduz-Demir C, Kazakia GJ, Krug R, Lotz JC. Cartilage Endplate Thickness Variation Measured by Ultrashort Echo-Time MRI Is Associated With Adjacent Disc Degeneration. Spine (Phila Pa 1976). 2018 May 15; 43(10):E592-E600.
    View on PubMed
  10. Jordan CD, Han M, Kondapavulur S, Vera DB, Neumann KD, Moore T, Stillson C, Krug R, Behr S, Seo Y, VanBrocklin HF, Larson PEZ, Wilson M, Martin AJ, Hetts SW. Quantification of 89 Zr-Iron oxide nanoparticle biodistribution using PET-MR and ultrashort TE sequences. J Magn Reson Imaging. 2018 May 14.
    View on PubMed
  11. Wei H, Cao P, Bischof A, Henry RG, Larson PEZ, Liu C. MRI gradient-echo phase contrast of the brain at ultra-short TE with off-resonance saturation. Neuroimage. 2018 Mar 29; 175:1-11.
    View on PubMed
  12. Chen HY, Larson PEZ, Gordon JW, Bok RA, Ferrone M, van Criekinge M, Carvajal L, Cao P, Pauly JM, Kerr AB, Park I, Slater JB, Nelson SJ, Munster PN, Aggarwal R, Kurhanewicz J, Vigneron DB. Technique development of 3D dynamic CS-EPSI for hyperpolarized 13 C pyruvate MR molecular imaging of human prostate cancer. Magn Reson Med. 2018 Mar 25.
    View on PubMed
  13. Milshteyn E, von Morze C, Reed GD, Shang H, Shin PJ, Larson PEZ, Vigneron DB. Using a local low rank plus sparse reconstruction to accelerate dynamic hyperpolarized 13C imaging using the bSSFP sequence. J Magn Reson. 2018 May; 290:46-59.
    View on PubMed
  14. Jiang W, Larson PEZ, Lustig M. Simultaneous auto-calibration and gradient delays estimation (SAGE) in non-Cartesian parallel MRI using low-rank constraints. Magn Reson Med. 2018 Mar 09.
    View on PubMed
  15. von Morze C, Reed GD, Larson PE, Mammoli D, Chen AP, Tropp J, Van Criekinge M, Ohliger MA, Kurhanewicz J, Vigneron DB, Merritt ME. In vivo hyperpolarization transfer in a clinical MRI scanner. Magn Reson Med. 2018 Feb 27.
    View on PubMed
  16. Wiesinger F, Bylund M, Yang J, Kaushik S, Shanbhag D, Ahn S, Jonsson JH, Lundman JA, Hope T, Nyholm T, Larson P, Cozzini C. Zero TE-based pseudo-CT image conversion in the head and its application in PET/MR attenuation correction and MR-guided radiation therapy planning. Magn Reson Med. 2018 Feb 18.
    View on PubMed
  17. Milshteyn E, von Morze C, Gordon JW, Zhu Z, Larson PEZ, Vigneron DB. High spatiotemporal resolution bSSFP imaging of hyperpolarized [1-13 C]pyruvate and [1-13 C]lactate with spectral suppression of alanine and pyruvate-hydrate. Magn Reson Med. 2018 Feb 16.
    View on PubMed
  18. Gordon JW, Hansen RB, Shin PJ, Feng Y, Vigneron DB, Larson PEZ. 3D hyperpolarized C-13 EPI with calibrationless parallel imaging. J Magn Reson. 2018 Apr; 289:92-99.
    View on PubMed
  19. Park I, Larson PEZ, Gordon JW, Carvajal L, Chen HY, Bok R, Van Criekinge M, Ferrone M, Slater JB, Xu D, Kurhanewicz J, Vigneron DB, Chang S, Nelson SJ. Development of methods and feasibility of using hyperpolarized carbon-13 imaging data for evaluating brain metabolism in patient studies. Magn Reson Med. 2018 Jan 10.
    View on PubMed
  20. Boucneau T, Cao P, Tang S, Han M, Xu D, Henry RG, Larson PEZ. In vivo characterization of brain ultrashort-T2 components. Magn Reson Med. 2018 Aug; 80(2):726-735.
    View on PubMed

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