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Hassan Lemjabbar-Alaoui, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
lemjabbar-alaoui_hassan

Assistant Adjunct Professor, Department of Surgery

Phone: (415) 476-9303


Additional Websites


Education

University of Paris VII, B.S., Biology, 1988-1989
University of Paris VII, M.S., Molecular Biology and Immunology, 1989-1991
University of Paris VI, M.S., Biochemistry, 1991-1992
University of Paris VI, Post-Master University Diploma (DU), Clinical Pharmacokinetics and Therapeutics, 1992-1993
University of Paris XIII, Post-Master DE.A of Science, Medical and Biological Engineering, 1993-1994
University of Paris XII, Ph.D., Molecular and Cell Biology, 1994-1997


Professional Experience

  • 2001-2005
    Assistant Research Anatomist, Department of Anatomy, University of California, San Francisco, CA. Laboratory of Dr. Carol Basbaum.
  • 2005-2006
    Scientist III, Immunologic Diseases: In Silico R&D, Entelos, Inc.
  • 2005-2007
    Scientific Advisory Consultant, BiPar Sciences, Inc.
  • 2007-2007-Nov
    Research Specialist, Department of Anatomy, University of California, San Francisco, CA. Laboratory of Dr. Steven Rosen.
  • 2007-Nov -2008
    Associate Research Anatomist, Department of Anatomy, University of California, San Francisco, CA. Laboratory of Dr. Steven Rosen.
  • 2008-Present
    Assistant Adjunct Professor, Department of Anatomy, University of California, San Francisco, CA.
  • Sep 2010-Present
    Assistant Adjunct Professor, Thoracic Oncology Program, Dept of Surgery, University of California, San Francisco.

Honors & Awards

  • 2002
    Exceptional rating by Faculty of 1000 Biology, (Lemjabbar and Basbaum. 2002 Nat Med article)*

  • 1999
    Cover page: American Journal of Respiratory Cell and Molecular Biology, (Lemjabbar H., et al. Am J Respir Cell Mol Biol, 1999)

  • 1995-1997
    Research Student travel grant: French Respiratory Society;.

  • 1997
    Travel award from the European Connective Tissue Association;.

  • 1994-1998
    French DEBIOPHARM Association Scholarship;

  • 1996
    Graduate Student Association Award, University of Paris XII, Faculte de Medecine, Creteil, France

  • 1995
    Travel award from the French connective tissue society;

  • 1992-1994
    Students and trainees international center Scholarship. France;

  • 1986-1991
    Scholarship from the Moroccan Ministry of Research and Higher Education


Selected Publications


  • 1. Lui NS, van Zante A, Rosen SD, Jablons DM, Lemjabbar-Alaoui H. SULF2 expression by immunohistochemistry is a prognostic indicator in esophageal cancer Journal of Clinical Pathology. BMJ Open 2012;2:e001624. doi:10.1136/bmjopen-2012-001624

  • 2. Lemjabbar-Alaoui H, Sidhu SS, Mengistab A, Gallup M, Basbaum C. TACE/ADAM-17 phosphorylation by PKC-epsilon mediates premalignant changes in tobacco smoke-exposed lung cells. PLoS One. 2011; 6(3):e17489.

  • 3. Rosen SD, Lemjabbar-Alaoui H. Sulf-2: an extracellular modulator of cell signaling and a cancer target candidate. Expert Opin Ther Targets. 2010 Sep; 14(9):935-49.

  • 4. Sidhu SS, Nawroth R, Retz M, Lemjabbar-Alaoui H, Dasari V, Basbaum C. EMMPRIN regulates the canonical Wnt/beta-catenin signaling pathway, a potential role in accelerating lung tumorigenesis. Oncogene. 2010 Jul 22; 29(29):4145-56.

  • 5. Uchimura K, Lemjabbar-Alaoui H, van Kuppevelt TH, Rosen SD. Use of a phage display antibody to measure the enzymatic activity of the Sulfs. Methods Enzymol. 2010; 480:51-64.

  • 6. Lemjabbar-Alaoui H, van Zante A, Singer MS, Xue Q, Wang YQ, Tsay D, He B, Jablons DM, Rosen SD. Sulf-2, a heparan sulfate endosulfatase, promotes human lung carcinogenesis. Oncogene. 2010 Feb 4; 29(5):635-46.

  • 7. Lemjabbar-Alaoui H, Dasari V, Sidhu SS, Mengistab A, Finkbeiner W, Gallup M, Basbaum C. Wnt and Hedgehog are critical mediators of cigarette smoke-induced lung cancer. PLoS One. 2006; 1:e93.

  • 8. Dasari V, Gallup M, Lemjabbar H, Maltseva I, McNamara N. Epithelial-mesenchymal transition in lung cancer: is tobacco the "smoking gun"? Am J Respir Cell Mol Biol. 2006 Jul; 35(1):3-9.

  • 9. Gensch E, Gallup M, Sucher A, Li D, Gebremichael A, Lemjabbar H, Mengistab A, Dasari V, Hotchkiss J, Harkema J, Basbaum C. Tobacco smoke control of mucin production in lung cells requires oxygen radicals AP-1 and JNK. J Biol Chem. 2004 Sep 10; 279(37):39085-93.

  • 10. Londhe V, McNamara N, Lemjabbar H, Basbaum C. Viral dsRNA activates mucin transcription in airway epithelial cells. FEBS Lett. 2003 Oct 9; 553(1-2):33-8.

  • 11. Lemjabbar H, Li D, Gallup M, Sidhu S, Drori E, Basbaum C. Tobacco smoke-induced lung cell proliferation mediated by tumor necrosis factor alpha-converting enzyme and amphiregulin. J Biol Chem. 2003 Jul 11; 278(28):26202-7.

  • 11. Lemjabbar H, Basbaum C. Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells. Nat Med. 2002 Jan; 8(1):41-6.

  • 13. Basbaum C, Li D, Gensch E, Gallup M, Lemjabbar H. Mechanisms by which gram-positive bacteria and tobacco smoke stimulate mucin induction through the epidermal growth factor receptor (EGFR). Novartis Found Symp. 2002; 248:171-6; discussion 176-80, 277-82.

  • 14. Belcher CE, Drenkow J, Kehoe B, Gingeras TR, McNamara N, Lemjabbar H, Basbaum C, Relman DA. The transcriptional responses of respiratory epithelial cells to Bordetella pertussis reveal host defensive and pathogen counter-defensive strategies. Proc Natl Acad Sci U S A. 2000 Dec 5; 97(25):13847-52.

  • 15. Basbaum C, Lemjabbar H, Longphre M, Li D, Gensch E, McNamara N. Control of mucin transcription by diverse injury-induced signaling pathways. Am J Respir Crit Care Med. 1999 Nov; 160(5 Pt 2):S44-8.

  • 16. Yao PM, Lemjabbar H, D'Ortho MP, Maitre B, Gossett P, Wallaert B, Lafuma C. Balance between MMP-9 and TIMP-1 expressed by human bronchial epithelial cells: relevance to asthma. Ann N Y Acad Sci. 1999 Jun 30; 878:512-4.

  • 17. Lemjabbar H, Gosset P, Lechapt-Zalcman E, Franco-Montoya ML, Wallaert B, Harf A, Lafuma C. Overexpression of alveolar macrophage gelatinase B (MMP-9) in patients with idiopathic pulmonary fibrosis: effects of steroid and immunosuppressive treatment. Am J Respir Cell Mol Biol. 1999 May; 20(5):903-13.

  • 18. Lemjabbar H, Gosset P, Lamblin C, Tillie I, Hartmann D, Wallaert B, Tonnel AB, Lafuma C. Contribution of 92 kDa gelatinase/type IV collagenase in bronchial inflammation during status asthmaticus. Am J Respir Crit Care Med. 1999 Apr; 159(4 Pt 1):1298-307.

  • 19. Meddahi A, Lemjabbar H, Caruelle JP, Barritault D, Hornebeck W. FGF protection and inhibition of human neutrophil elastase by carboxymethyl benzylamide sulfonate dextran derivatives. Int J Biol Macromol. 1996 Feb; 18(1-2):141-5.

  • 20. Meddahi A, Lemjabbar H, Caruelle JP, Barritault D, Hornebeck W. Inhibition by dextran derivatives of FGF-2 plasmin-mediated degradation. Biochimie. 1995; 77(9):703