Joachim J. Li, MD, PhD

Education

Professional Experience

• 1980-1982, 1987-1988
  Medical Student, Johns Hopkins University School of Medicine, Baltimore, MD
• 1982-1987
  Graduate Student (Thomas J. Kelly), Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD
• 1988
  Postdoctoral Fellow,Yeast Genetics (Phil Hieter), Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD
• 1989-1993
  Postdoctoral Fellow, Yeast Genetics/Molecular Biology (Ira Herskowitz), Department of Biochemistry and Biophysics, University of California-San Francisco, San Francisco, CA
• 1993-2000
  Assistant Professor, Department of Microbiology and Immunology, University of California-San Francisco, San Francisco, CA
• 2000-present
  Associate Professor, Department of Microbiology and Immunology, University of California-San Francisco, San Francisco, CA

Honors & Awards

• 1977
  United States Presidential Scholar
• 1979
  Phi Beta Kappa
• 1979-1980
  National Science Foundation Graduate Fellow
• 1987
  Michael A. Shanoff Research Award for Ph.D. Thesis, Johns Hopkins University School of Medicine
• 1989-1990
  Squibb Fellow, Life Sciences Research Foundation
• 1990-1997
  Markey Scholar Award
• 1994-1999
  Rita Allen Scholar
• 1995-1998
  Searle Scholar
• 1998
  Distinction in Teaching Award, UCSF

Selected Publications

1. Hanlon SL, Li JJ. Re-replication of a centromere induces chromosomal instability and aneuploidy. PLoS Genet. 2015 Apr; 11(4):e1005039.
   View on PubMed
2. Richardson CD, Li JJ. Regulatory mechanisms that prevent re-initiation of DNA replication can be locally modulated at origins by nearby sequence elements. PLoS Genet. 2014 Jun; 10(6):e1004358.
   View on PubMed
3. Finn KJ, Li JJ. Single-stranded annealing induced by re-initiation of replication origins provides a novel and efficient mechanism for generating copy number expansion via non-allelic homologous recombination. PLoS Genet. 2013; 9(1):e1003192.
   View on PubMed
4. Green BM, Finn KJ, Li JJ. Loss of DNA replication control is a potent inducer of gene amplification. Science. 2010 Aug 20; 329(5994):943-6.
   View on PubMed
5. Moses AM, Liku ME, Li JJ, Durbin R. Regulatory evolution in proteins by turnover and lineage-specific changes of cyclin-dependent kinase consensus sites. Proc Natl Acad Sci U S A. 2007 Nov 6; 104(45):17713-8.
   View on PubMed
6. Green BM, Morreale RJ, Ozaydin B, Derisi JL, Li JJ. Genome-wide mapping of DNA synthesis in Saccharomyces cerevisiae reveals that mechanisms preventing reinitiation of DNA replication are not redundant. Mol Biol Cell. 2006 May; 17(5):2401-14.
   View on PubMed
7. Liku ME, Nguyen VQ, Rosales AW, Irie K, Li JJ. CDK phosphorylation of a novel NLS-NES module distributed between two subunits of the Mcm2-7 complex prevents chromosomal rereplication. Mol Biol Cell. 2005 Oct; 16(10):5026-39.
   View on PubMed
8. Green BM, Li JJ. Loss of rereplication control in Saccharomyces cerevisiae results in extensive DNA damage. Mol Biol Cell. 2005 Jan; 16(1):421-32.
   View on PubMed

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