Wendell Lim, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Wendell Lim, PhD

Professor of Cellular and Molecular Pharmacology
Biochemistry & Biophysics and Pharm. Chem
Investigator, Howard Hughes Medical Institute

lim@cmp.ucsf.edu

Phone: (415) 502-8080
Box 2240, UCSF
San Francisco, CA 94143-2240

View on UCSF Profiles

Cancer Center Membership

Program Member » Cancer, Immunity, and Microenvironment

Additional Websites


Education

Harvard University, Cambridge, MA, AB, 1986, Chemistry
Mass. Institute of Technology, Cambridge, MA, PhD, 1991, Biochem & Biophysics
Yale University, New Haven, CT, Postdoc, 1992-1996, Biophysics & Biochem


Professional Experience

  • 1996-2000
    Assistant Professor, Department of Cellular & Molecular Pharmacology, UCSF
  • 2000-2003
    Associate Professor, Department of Cellular & Molecular Pharmacology, UCSF
  • 2003-present Professor, Department of Cellular & Molecular Pharmacology, UCSF
  • 2006-present
    Deputy Director, NSF Synthetic Biology Engineering Research Center
  • 2006-present
    Director, UCSF/UCB NIH Nanomedicine Development Center
  • 2008-present
    Investigator, Howard Hughes Medical Institute, San Francisco, CA
  • 2010-present
    Director, UCSF Center for Systems & Synthetic Biology (NIH Natl. SysBio Center)

Honors & Awards

  • 1982
    Westinghouse Science Talent Search
  • 1986
    Blumberg Creative Science Award, Harvard College
  • 1988-1991
    Howard Hughes Medical Institute Predoctoral Fellowship
  • 1992-1994
    Helen Hay Whitney Foundation Postdoctoral Fellowship
  • 1994-1996
    Patrick & Catherine W. Donaghue Foundation Postdoctoral Fellowship
  • 1997
    Burroughs Wellcome Fund New Investigator in the Pharmacological Sciences
  • 1997
    Searle Foundation Scholar
  • 1997
    David and Lucille Packard Fellow in Science and Engineering
  • 2001
    Kirsch Foundation Medical Investigator
  • 2005-present
    Board of Advisors, Burroughs Wellcome Fund Scientific Interfaces Program
  • 2005
    Plenary Lecturer, Proteins Gordon Conference
  • 2006
    Rogers Family Foundation Award
  • 2006-present
    Board of Scientific Counselors, National Cancer Institute
  • 2009
    Keynote Speaker, National Academies Keck Futures Initiative, Synthetic Biology Conf.
  • 2009
    National Academies Committee, “A New Biology for the 21st Century”
  • 2010
    Hans Neurath Award, Protein Society
  • 2011
    NSF Synthetic Aesthetics Fellow, exchange between scientists and artists/designers
  • 2012
    Wired SmartList: 50 people who will change the world
  • 2012
    Frederic M. Richards Memorial Lecture

Selected Publications

  1. Martin H, Shales M, Fernandez-Piñar P, Wei P, Molina M, Fiedler D, Shokat KM, Beltrao P, Lim W, Krogan NJ. Differential genetic interactions of yeast stress response MAPK pathways. Mol Syst Biol. 2015; 11(4):800.
    View on PubMed
  2. Zalatan JG, Lee ME, Almeida R, Gilbert LA, Whitehead EH, La Russa M, Tsai JC, Weissman JS, Dueber JE, Qi LS, Lim WA. Engineering Complex Synthetic Transcriptional Programs with CRISPR RNA Scaffolds. Cell. 2015 Jan 15; 160(1-2):339-50.
    View on PubMed
  3. Ji W, Lee D, Wong E, Dadlani P, Dinh D, Huang V, Kearns K, Teng S, Chen S, Haliburton J, Heimberg G, Heineike B, Ramasubramanian A, Stevens T, Helmke KJ, Zepeda V, Qi LS, Lim WA. Specific Gene Repression by CRISPRi System Transferred through Bacterial Conjugation. ACS Synth Biol. 2014 Dec 19; 3(12):929-31.
    View on PubMed
  4. Youk H, Lim WA. Sending mixed messages for cell population control. Cell. 2014 Aug 28; 158(5):973-5.
    View on PubMed
  5. Park JS, Rhau B, Hermann A, McNally KA, Zhou C, Gong D, Weiner OD, Conklin BR, Onuffer J, Lim WA. Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal. Proc Natl Acad Sci U S A. 2014 Apr 22; 111(16):5896-901.
    View on PubMed
  6. Youk H, Lim WA. Secreting and sensing the same molecule allows cells to achieve versatile social behaviors. Science. 2014 Feb 7; 343(6171):1242782.
    View on PubMed
  7. Toettcher JE, Weiner OD, Lim WA. Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module. Cell. 2013 Dec 5; 155(6):1422-34.
    View on PubMed
  8. Jagirdar K, Yin K, Harrison M, Lim W, Muscat GE, Sturm RA, Smith AG. The NR4A2 nuclear receptor is recruited to novel nuclear foci in response to UV irradiation and participates in nucleotide excision repair. PLoS One. 2013; 8(11):e78075.
    View on PubMed
  9. Moser F, Horwitz A, Chen J, Lim W, Voigt CA. Genetic sensor for strong methylating compounds. ACS Synth Biol. 2013 Oct 18; 2(10):614-24.
    View on PubMed
  10. Larson MH, Gilbert LA, Wang X, Lim WA, Weissman JS, Qi LS. CRISPR interference (CRISPRi) for sequence-specific control of gene expression. Nat Protoc. 2013 Nov; 8(11):2180-96.
    View on PubMed
  11. Dandekar SN, Park JS, Peng GE, Onuffer JJ, Lim WA, Weiner OD. Actin dynamics rapidly reset chemoattractant receptor sensitivity following adaptation in neutrophils. Philos Trans R Soc Lond B Biol Sci. 2013; 368(1629):20130008.
    View on PubMed
  12. Puchner EM, Walter JM, Kasper R, Huang B, Lim WA. Counting molecules in single organelles with superresolution microscopy allows tracking of the endosome maturation trajectory. Proc Natl Acad Sci U S A. 2013 Oct 1; 110(40):16015-20.
    View on PubMed
  13. Coyle SM, Flores J, Lim WA. Exploitation of latent allostery enables the evolution of new modes of MAP kinase regulation. Cell. 2013 Aug 15; 154(4):875-87.
    View on PubMed
  14. Gilbert LA, Larson MH, Morsut L, Liu Z, Brar GA, Torres SE, Stern-Ginossar N, Brandman O, Whitehead EH, Doudna JA, Lim WA, Weissman JS, Qi LS. CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes. Cell. 2013 Jul 18; 154(2):442-51.
    View on PubMed
  15. Lee S, Lim WA, Thorn KS. Improved blue, green, and red fluorescent protein tagging vectors for S. cerevisiae. PLoS One. 2013; 8(7):e67902.
    View on PubMed
  16. Hynes NE, Ingham PW, Lim WA, Marshall CJ, Massagué J, Pawson T. Signalling change: signal transduction through the decades. Nat Rev Mol Cell Biol. 2013 Jun; 14(6):393-8.
    View on PubMed
  17. Fischbach MA, Bluestone JA, Lim WA. Cell-based therapeutics: the next pillar of medicine. Sci Transl Med. 2013 Apr 3; 5(179):179ps7.
    View on PubMed
  18. Qi LS, Larson MH, Gilbert LA, Doudna JA, Weissman JS, Arkin AP, Lim WA. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell. 2013 Feb 28; 152(5):1173-83.
    View on PubMed
  19. Lim WA, Lee CM, Tang C. Design principles of regulatory networks: searching for the molecular algorithms of the cell. Mol Cell. 2013 Jan 24; 49(2):202-12.
    View on PubMed
  20. Lim WA, Alvania R, Marshall WF. Cell biology 2.0. Trends Cell Biol. 2012 Dec; 22(12):611-2.
    View on PubMed

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