About UCSF Search UCSF UCSF Medical Center

Carlo C. Maley, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
maley_carlo

Associate Professor, Department of Surgery, UCSF; Director, Center for Evolution and Cancer

carlo.maley@ucsf.edu

Phone: (415) 514-0592
2340 Sutter Street S-341, Box 0128
University of California, San Francisco San Francisco, CA 94143-0128

View on UCSF Profiles


Additional Websites


Education

Oberlin College, Oberlin, OH B.A., 1991, Computer Science/Psychology
Oxford University, Oxford, UK, M.S., 1993, Zoology
MIT, Cambridge, MA, Ph.D., 1998, Computer Science
Harvard University, Cambridge, MA, Postdoc, 1998, Evolutionary Biology
University of New Mexico, Albuquerque, NM Postdoc, 1998-2000, Computational Biology


Professional Experience

  • 2000-2005
    Staff scientist and member of the Program in GI Oncology, working with Brian Reid, Fred Hutchinson Cancer Research Center, Seattle, WA
  • 2005-2010
    Assistant Professor, The Wistar Institute
  • 2005-2010
    Genomics and Computational Biology Graduate Program, University of Pennsylvania
  • 2007-2010
    Cell and Molecular Biology Graduate Program, University of Pennsylvania
  • 2010-present
    Associate Professor, Dept. of Surgery, University of California San Francisco
  • 2011-present
    Director, Center for Evolution and Cancer, University of California San Francisco

Honors & Awards

  • 1990
    Award for best GPA in social sciences, Oberlin College
  • 1990
    Inducted into Phi Beta Kappa, Junior year
  • 1991
    Inducted into Sigma Xi
  • 1991
    Graduated Oberlin College, Summa Cum Laude
  • 1991
    Summer Student Fellowship at Woods Hole Oceanographic Institute
  • 1991-1993
    Marshall Scholarship
  • 1995-1998
    National Defense Science and Engineering Graduate Fellowship
  • 2000-2002
    Alfred P. Sloan/Department of Energy Postdoctoral Fellowship in Computational Molecular Biology
  • 2001
    NIGMS Fellowship in Quantitative Biology, declined.
  • 2001-2006
    NCI Howard Temin Award (K01 Research Career Award)
  • 2003
    AACR Rodger C. Haggitt Award
  • 2008
    First winner of the Landon AACR Innovator Award for Cancer Prevention Research
  • 2013-2014
    Fellow of the Berlin Institute for Advanced Study (Wissenschaftskolleg)

Selected Publications

  1. Alcock J, Maley CC, Aktipis CA. Is eating behavior manipulated by the gastrointestinal microbiota? Evolutionary pressures and potential mechanisms. Bioessays. 2014 Oct; 36(10):940-9.
    View on PubMed
  2. Li X, Galipeau PC, Paulson TG, Sanchez CA, Arnaudo J, Liu K, Sather CL, Kostadinov RL, Odze RD, Kuhner MK, Maley CC, Self SG, Vaughan TL, Blount PL, Reid BJ. Temporal and Spatial Evolution of Somatic Chromosomal Alterations: A Case-Cohort Study of Barrett's Esophagus. Cancer Prev Res (Phila). 2014 Jan; 7(1):114-27.
    View on PubMed
  3. Aktipis CA, Boddy AM, Gatenby RA, Brown JS, Maley CC. Life history trade-offs in cancer evolution. Nat Rev Cancer. 2013 Dec; 13(12):883-92.
    View on PubMed
  4. Kostadinov RL, Kuhner MK, Li X, Sanchez CA, Galipeau PC, Paulson TG, Sather CL, Srivastava A, Odze RD, Blount PL, Vaughan TL, Reid BJ, Maley CC. NSAIDs modulate clonal evolution in Barrett's esophagus. PLoS Genet. 2013 Jun; 9(6):e1003553.
    View on PubMed
  5. S Datta R, Gutteridge A, Swanton C, Maley CC, Graham TA. Modelling the evolution of genetic instability during tumour progression. Evol Appl. 2013 Jan; 6(1):20-33.
    View on PubMed
  6. Sprouffske K, Athena Aktipis C, Radich JP, Carroll M, Nedelcu AM, Maley CC. An evolutionary explanation for the presence of cancer nonstem cells in neoplasms. Evol Appl. 2013 Jan; 6(1):92-101.
    View on PubMed
  7. Sprouffske K, Merlo LM, Gerrish PJ, Maley CC, Sniegowski PD. Cancer in light of experimental evolution. Curr Biol. 2012 Sep 11; 22(17):R762-71.
    View on PubMed
  8. Roche B, Hochberg ME, Caulin AF, Maley CC, Gatenby RA, Misse D, Thomas F. Natural resistance to cancers: a Darwinian hypothesis to explain Peto's paradox. BMC Cancer. 2012; 12:387.
    View on PubMed
  9. Kosoff RE, Gardiner KL, Merlo LM, Pavlov K, Rustgi AK, Maley CC. Development and characterization of an organotypic model of Barrett's esophagus. J Cell Physiol. 2012 Jun; 227(6):2654-9.
    View on PubMed
  10. Greaves M, Maley CC. Clonal evolution in cancer. Nature. 2012 Jan 19; 481(7381):306-13.
    View on PubMed
  11. Aktipis CA, Kwan VS, Johnson KA, Neuberg SL, Maley CC. Overlooking evolution: a systematic analysis of cancer relapse and therapeutic resistance research. PLoS One. 2011; 6(11):e26100.
    View on PubMed
  12. Merlo LM, Kosoff RE, Gardiner KL, Maley CC. An in vitro co-culture model of esophageal cells identifies ascorbic acid as a modulator of cell competition. BMC Cancer. 2011; 11:461.
    View on PubMed
  13. Aktipis CA, Maley CC, Pepper JW. Dispersal evolution in neoplasms: the role of disregulated metabolism in the evolution of cell motility. Cancer Prev Res (Phila). 2012 Feb; 5(2):266-75.
    View on PubMed
  14. Chen J, Sprouffske K, Huang Q, Maley CC. Solving the puzzle of metastasis: the evolution of cell migration in neoplasms. PLoS One. 2011; 6(4):e17933.
    View on PubMed
  15. Reid BJ, Kostadinov R, Maley CC. New strategies in Barrett's esophagus: integrating clonal evolutionary theory with clinical management. Clin Cancer Res. 2011 Jun 1; 17(11):3512-9.
    View on PubMed
  16. Sprouffske K, Pepper JW, Maley CC. Accurate reconstruction of the temporal order of mutations in neoplastic progression. Cancer Prev Res (Phila). 2011 Jul; 4(7):1135-44.
    View on PubMed
  17. Caulin AF, Maley CC. Peto's Paradox: evolution's prescription for cancer prevention. Trends Ecol Evol. 2011 Apr; 26(4):175-82.
    View on PubMed
  18. Merlo LM, Shah NA, Li X, Blount PL, Vaughan TL, Reid BJ, Maley CC. A comprehensive survey of clonal diversity measures in Barrett's esophagus as biomarkers of progression to esophageal adenocarcinoma. Cancer Prev Res (Phila). 2010 Nov; 3(11):1388-97.
    View on PubMed
  19. Lai LA, Kostadinov R, Barrett MT, Peiffer DA, Pokholok D, Odze R, Sanchez CA, Maley CC, Reid BJ, Gunderson KL, Rabinovitch PS. Deletion at fragile sites is a common and early event in Barrett's esophagus. Mol Cancer Res. 2010 Aug; 8(8):1084-94.
    View on PubMed
  20. Odze RD, Maley CC. Neoplasia without dysplasia: lessons from Barrett esophagus and other tubal gut neoplasms. Arch Pathol Lab Med. 2010 Jun; 134(6):896-906.
    View on PubMed

Go to UCSF Profiles, powered by CTSI