Carlo C. Maley, PhD

Associate Professor, Department of Surgery, UCSF; Director, Center for Evolution and Cancer

carlo.maley@ucsf.edu

Phone: (415) 514-0592
2340 Sutter Street S-341, Box 0128
University of California, San Francisco San Francisco, CA 94143-0128

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Additional Websites

• Center for Cancer and Evolution
• Maley Lab

Education

Oberlin College, Oberlin, OH B.A., 1991, Computer Science/Psychology
Oxford University, Oxford, UK, M.S., 1993, Zoology
MIT, Cambridge, MA, Ph.D., 1998, Computer Science
Harvard University, Cambridge, MA, Postdoc, 1998, Evolutionary Biology
University of New Mexico, Albuquerque, NM Postdoc, 1998-2000, Computational Biology

Professional Experience

• 2000-2005
  Staff scientist and member of the Program in GI Oncology, working with Brian Reid, Fred Hutchinson Cancer Research Center, Seattle, WA
• 2005-2010
  Assistant Professor, The Wistar Institute
• 2005-2010
  Genomics and Computational Biology Graduate Program, University of Pennsylvania
• 2007-2010
  Cell and Molecular Biology Graduate Program, University of Pennsylvania
• 2010-present
  Associate Professor, Dept. of Surgery, University of California San Francisco

Honors & Awards

• 1990
  Award for best GPA in social sciences, Oberlin College
• 1990
  Inducted into Phi Beta Kappa, Junior year
• 1991
  Inducted into Sigma Xi
• 1991
  Graduated Oberlin College, Summa Cum Laude
• 1991
  Summer Student Fellowship at Woods Hole Oceanographic Institute
• 1991-1993
  Marshall Scholarship
• 1995-1998
  National Defense Science and Engineering Graduate Fellowship
• 2000-2002
  Alfred P. Sloan/Department of Energy Postdoctoral Fellowship in Computational Molecular Biology
• 2001
  NIGMS Fellowship in Quantitative Biology, declined.
• 2001-2006
  NCI Howard Temin Award (K01 Research Career Award)
• 2003
  AACR Rodger C. Haggitt Award
• 2008
  First winner of the Landon AACR Innovator Award for Cancer Prevention Research

Selected Publications

1. S Datta R, Gutteridge A, Swanton C, Maley CC, Graham TA. Modelling the evolution of genetic instability during tumour progression. Evol Appl. 2013 Jan; 6(1):20-33.
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2. Sprouffske K, Athena Aktipis C, Radich JP, Carroll M, Nedelcu AM, Maley CC. An evolutionary explanation for the presence of cancer nonstem cells in neoplasms. Evol Appl. 2013 Jan; 6(1):92-101.
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3. Sprouffske K, Merlo LM, Gerrish PJ, Maley CC, Sniegowski PD. Cancer in light of experimental evolution. Curr Biol. 2012 Sep 11; 22(17):R762-71.
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4. Roche B, Hochberg ME, Caulin AF, Maley CC, Gatenby RA, Misse D, Thomas F. Natural resistance to cancers: a Darwinian hypothesis to explain Peto's paradox. BMC Cancer. 2012; 12:387.
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5. Kosoff RE, Gardiner KL, Merlo LM, Pavlov K, Rustgi AK, Maley CC. Development and characterization of an organotypic model of Barrett's esophagus. J Cell Physiol. 2012 Jun; 227(6):2654-9.
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6. Greaves M, Maley CC. Clonal evolution in cancer. Nature. 2012 Jan 19; 481(7381):306-13.
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7. Aktipis CA, Kwan VS, Johnson KA, Neuberg SL, Maley CC. Overlooking evolution: a systematic analysis of cancer relapse and therapeutic resistance research. PLoS One. 2011; 6(11):e26100.
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8. Merlo LM, Kosoff RE, Gardiner KL, Maley CC. An in vitro co-culture model of esophageal cells identifies ascorbic acid as a modulator of cell competition. BMC Cancer. 2011; 11:461.
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9. Aktipis CA, Maley CC, Pepper JW. Dispersal evolution in neoplasms: the role of disregulated metabolism in the evolution of cell motility. Cancer Prev Res (Phila). 2012 Feb; 5(2):266-75.
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10. Chen J, Sprouffske K, Huang Q, Maley CC. Solving the puzzle of metastasis: the evolution of cell migration in neoplasms. PLoS One. 2011; 6(4):e17933.
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11. Reid BJ, Kostadinov R, Maley CC. New strategies in Barrett's esophagus: integrating clonal evolutionary theory with clinical management. Clin Cancer Res. 2011 Jun 1; 17(11):3512-9.
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12. Sprouffske K, Pepper JW, Maley CC. Accurate reconstruction of the temporal order of mutations in neoplastic progression. Cancer Prev Res (Phila). 2011 Jul; 4(7):1135-44.
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13. Caulin AF, Maley CC. Peto's Paradox: evolution's prescription for cancer prevention. Trends Ecol Evol. 2011 Apr; 26(4):175-82.
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14. Merlo LM, Shah NA, Li X, Blount PL, Vaughan TL, Reid BJ, Maley CC. A comprehensive survey of clonal diversity measures in Barrett's esophagus as biomarkers of progression to esophageal adenocarcinoma. Cancer Prev Res (Phila). 2010 Nov; 3(11):1388-97.
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15. Lai LA, Kostadinov R, Barrett MT, Peiffer DA, Pokholok D, Odze R, Sanchez CA, Maley CC, Reid BJ, Gunderson KL, Rabinovitch PS. Deletion at fragile sites is a common and early event in Barrett's esophagus. Mol Cancer Res. 2010 Aug; 8(8):1084-94.
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16. Odze RD, Maley CC. Neoplasia without dysplasia: lessons from Barrett esophagus and other tubal gut neoplasms. Arch Pathol Lab Med. 2010 Jun; 134(6):896-906.
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17. Pavlov K, Maley CC. New models of neoplastic progression in Barrett's oesophagus. Biochem Soc Trans. 2010 Apr; 38(2):331-6.
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18. Cairo MS, Jordan CT, Maley CC, Chao C, Melnick A, Armstrong SA, Shlomchik W, Molldrem J, Ferrone S, Mackall C, Zitvogel L, Bishop MR, Giralt SA, June CH. NCI first International Workshop on the biology, prevention, and treatment of relapse after allogeneic hematopoietic stem cell transplantation: report from the committee on the biological considerations of hematological relapse following allogeneic stem cell transplantation unrelated to graft-versus-tumor effects: state of the science. Biol Blood Marrow Transplant. 2010 Jun; 16(6):709-28.
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19. Merlo LM, Maley CC. The role of genetic diversity in cancer. J Clin Invest. 2010 Feb; 120(2):401-3.
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20. Merlo LM, Wang LS, Pepper JW, Rabinovitch PS, Maley CC. Polyploidy, aneuploidy and the evolution of cancer. Adv Exp Med Biol. 2010; 676:1-13.
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