Carlo C. Maley, PhD

Carlo C. Maley, PhD

Director, Center for Evolution and Cancer, UCSF; Adjunct Associate Professor, Surgery, UCSF; Associate Professor, School of Life Sciences, Arizona State University


Oberlin College, Oberlin, OH B.A., 1991, Computer Science/Psychology
Oxford University, Oxford, UK, M.S., 1993, Zoology
MIT, Cambridge, MA, Ph.D., 1998, Computer Science
Harvard University, Cambridge, MA, Postdoc, 1998, Evolutionary Biology
University of New Mexico, Albuquerque, NM Postdoc, 1998-2000, Computational Biology

Professional Experience

  • 2000-2005
    Staff scientist and member of the Program in GI Oncology, working with Brian Reid, Fred Hutchinson Cancer Research Center, Seattle, WA
  • 2005-2010
    Assistant Professor, The Wistar Institute
  • 2005-2010
    Genomics and Computational Biology Graduate Program, University of Pennsylvania
  • 2007-2010
    Cell and Molecular Biology Graduate Program, University of Pennsylvania
  • 2010-present
    Adjunct Associate Professor, Dept. of Surgery, University of California San Francisco
  • 2011-present
    Director, Center for Evolution and Cancer, University of California San Francisco
  • 2015-present
    Associate Professor, School of Life Sciences, Arizona State University

Honors & Awards

  • 1990
    Award for best GPA in social sciences, Oberlin College
  • 1990
    Inducted into Phi Beta Kappa, Junior year
  • 1991
    Inducted into Sigma Xi
  • 1991
    Graduated Oberlin College, Summa Cum Laude
  • 1991
    Summer Student Fellowship at Woods Hole Oceanographic Institute
  • 1991-1993
    Marshall Scholarship
  • 1995-1998
    National Defense Science and Engineering Graduate Fellowship
  • 2000-2002
    Alfred P. Sloan/Department of Energy Postdoctoral Fellowship in Computational Molecular Biology
  • 2001
    NIGMS Fellowship in Quantitative Biology, declined.
  • 2001-2006
    NCI Howard Temin Award (K01 Research Career Award)
  • 2003
    AACR Rodger C. Haggitt Award
  • 2008
    First winner of the Landon AACR Innovator Award for Cancer Prevention Research
  • 2013-2014
    Fellow of the Berlin Institute for Advanced Study (Wissenschaftskolleg)

Selected Publications

  • Maley, C.C., Galipeau, P.C., Li, X., Sanchez, C.A., Paulson, T.G., Reid, B.J.: Selectively advantageous mutations and hitchhikers in neoplasms: p16 lesions are selected in Barrett's esophagus. Cancer Res 64:3414-3427, 2004.
  • Maley, C.C., Galipeau, P.C., Li, X., Sanchez, C.A., Paulson, T.G., Blount, P.L., Reid, B.J.: The combination of genetic instability and clonal expansion predicts progression to esophageal adenocarcinoma. Cancer Res 64:7629-7633, 2004.
  • Hornick, J.L., Blount, P.L., Sanchez, C.A., Cowan, D.S., Ayub, K., Maley, C.C., Reid, B.J., Odze, R.D.: Biologic properties of columnar epithelium underneath reepithelialized squamous mucosa in Barrett's esophagus. Am J Surg Pathol 29:372-380, 2005.
  • Maley, C.C., Galipeau, P.C., Finley, J.C., Wongsurawat, V.J., Li, X., Sanchez, C.A., Paulson, T.G., Blount, P.L., Risques, R., Rabinovitch, P.S. and Reid, B.J.: Genetic clonal diversity predicts progression to esophageal adenocarcinoma. Nature Genetics, 38:468-473, 2006.
  • Chao, D.L., Maley, C.C., Wu, X., Farrow, D.C., Galipeau, P.C., Sanchez, C.A., Paulson, T.G., Rabinovitch, P.S., Reid, B.J., Spitz, M.R., and Vaughan, T.L.: Mutagen sensitivity and neoplastic progression in patients with Barrett's esophagus: A prospective analysis. Cancer Epidemiology, Biomarkers and Prevention, 15:1935--40, 2006.
  • Merlo L., Pepper, J, Reid B.J., Maley, C.C.: Cancer as an evolutionary and ecological process. Nature Reviews Cancer, 6:924-35, 2006.
  • Lai, L.A., Paulson T.G., Li X., Sanchez C.A., Maley C., Odze R.D., Reid B.J., Rabinovitch, P.S.: Increasing genomic instability during premalignant neoplastic progression revealed through high resolution array-CGH. Genes, Chromosomes and Cancer, 46:532-542, 2007.
  • Galipeau, P.C. Li X, Blount, P.L., Maley, C.C. Sanchez, C.A. Odze, R.D., Ayub, K. Rabinovitch, P.S., Vaughan, T.V. Reid, B.J.: NSAIDs modulate CDKN2A, TP53, and DNA content risk for progression to esophageal adenocarcinoma. PLoS Medicine, 4:e67, 2007.
  • Pepper, J., Sprouffske, K., Maley, C.C.: Cell Differentiation Patterns Suppress Somatic Evolution. PLoS Computational Biology, 3:e250, 2007. PMCID: PMC2134960
  • Chao. D.L., Eck, T., Brash, D., Maley, C.C., Luebeck, E.G.: Pre-neoplastic lesion growth driven by the death of adjacent normal stem cells. PNAS, 105:15034-15039, 2008. PMCID: PMC2567488
  • Li X., Galipeau, P.C., Sanchez, C.A., Blount, P.L., Maley, C.C., Arnaudo, J., Peiffer, D.A., Pokholok, D., Gunderson, K.L., Reid, B.J.: SNP-based Genome-wide Chromosome Copy Change, LOH, and Aneuploidy in Barrett's Esophagus Neoplastic Progression. Cancer Prevention Research 1:413-423, 2008.
  • Pepper, J.W., Findlay, C.S., Kassen, R., Spencer, S.L., Maley, C.C.: Cancer Research Meets Evolutionary Biology. Evolutionary Applications 2:62-70, 2009.
  • Paulson, T.G., Maley, C.C., Li, X., Li, H., Sanchez, C.A., Chao, D.L., Odze, R.D., Vaughan, T.L., Blount, P.L., Reid, B.J.: Chromosomal instability and copy number alterations in Barrett's esophagus and esophageal adenocarcinoma. Clinical Cancer Research 15:3305-3314, 2009. PMCID: PMC2684570
  • Merlo, L.M.F., Maley, C.C.: The role of genetic diversity in cancer. J Clin Invest 120, 401-3, 2010. PMCID: PMC2810093
  • Merlo, L.M.F., Shah, N.A., Li, X., Blount, P., Vaughan, T.L., Reid, B.J., Maley, C.C.: A comprehensive survey of clonal diversity measures in Barrett's esophagus as biomarkers of progression to esophageal adenocarcinoma. Cancer Prevention Research, 3(11); OF1-10, 2010.