University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Jeffrey N. Martin, MD, MPH

Jeffrey N. Martin, MD, MPH

Professor of Epidemiology and Biostatistics, UCSF; Attending Physician, San Francisco General Hospital

Cancer Center Program Memberships

Cancer Control

Research Summary

My cancer-related research centers around Kaposi sarcoma (KS) and its etiologic agent, Kaposi’s sarcoma-associated herpesvirus (KSHV), with work both in the US and in Africa.
My qualifications for research include both theoretical background and practical experience. I am Director of the UCSF Training in Clinical Research (TICR) Program, which provides graduate-level didactic training in clinical, epidemiologic, and translational research methods to graduate students, post-doctoral fellows, and junior faculty members at UCSF. The TICR Program, which is supported by the UCSF NIH-sponsored Clinical and Translational Science Award (CTSA), includes 33 different courses spanning “laboratory to human subjects” translational research, traditional clinical and epidemiologic research, and “evidence to practice” implementation science research. In direct teaching, I am the course director of “Epidemiologic Methods,” the program’s foundational course in research methods, and the “Master’s Program Seminar Series.” On a practical level, I have extensive experience in both observational and experimental research in both the US and Africa. In the US, I am Co-Director of the Population and Clinical Sciences Core of the UCSF NIH-sponsored Center for AIDS Research (CFAR), which manages the 1800-subject UCSF SCOPE cohort, a vehicle that has supported collaborative research leading to over 200 publications since 2000. In Africa, I am the Principal Investigator (PI) for U54 CA190153 (a project which focuses on the early detection and prevention of KS in Uganda); PI for the UCSF component of the East Africa International Epidemiologic Databases to Evaluate AIDS (IeDEA) Consortium (U01 AI069911), in which I direct the working group on cancer; PI for the recently completed R01 CA119903 (a randomized trial for the therapy of KS in Africa); PI for the recently completed D43 CA153717 (a training grant related to KS in Uganda); and Director of the Data Coordinating Center for the 750-subject Mbarara-based Uganda AIDS Rural Treatment Outcomes (UARTO) Cohort. UARTO, which has spun off over 50 publications from collaborative projects since 2006, is a microscopic complement of IeDEA. In all of this work, I have had broad experience with study design, instrument development, study recruitment/ retention, data collection, quality enhancement, data reporting, biostatistical analysis, manuscript preparation, and financial management.

Education

Johns Hopkins University; Baltimore, Maryland, BA, 1979-83, Biology
University of Pennsylvania; Philadelphia, MD, 1983-88, Medicine
UC, San Francisco, 1988-89, Medicine - Internship
UC, San Francisco, 1989-91, Medicine - Residency 
UC, San Francisco, 1991-92, Medicine - Chief Residency
UC, Berkeley, MPH, 1992-93, Epidemiology
UC, San Francisco, 1993-97, Infectious Diseases - Fellowship
UC, San Francisco, 1993-97, AIDS Prevention - Fellowship
 

Professional Experience

  • 1997-2003
    Assistant Professor of Epidemiology and Biostatistics, UCSF
  • 2003-2009
    Associate Professor of Epidemiology and Biostatistics, UCSF
  • 2009-present
    Professor of Epidemiology and Biostatistics, UCSF
  • 1997-present
    Attending Physician, San Francisco General Hospital
  • 1997-1999
    Co-Director, Advanced Training in Clinical Research (ATCR) Program, UCSF
  • 2000-2006
    Co-Director, NIH K30-sponsored Training in Clinical Research (TICR) Program, UCSF
  • 2000-present
    Director, Advanced Training in Clinical Research (ATCR) Certificate Program, UCSF
  • 2001-present
    Director, Master’s Degree Graduate Program in Clinical Research, UCSF
  • 2006-present
    Director, NIH CTSA-sponsored Training in Clinical Research (TICR) Graduate Program, UCSF

Honors & Awards


  • 1982
    Phi Beta Kappa
  • 1988
    Alpha Omega Alpha
  • 1988
    Merck Manual Award, University of Pennsylvania School of Medicine
  • 1989
    Diplomate, National Board of Medical Examiners
  • 1991
    Diplomate, American Board of Internal Medicine
  • 1996
    Diplomate, American Board of Internal Medicine, Subspecialty in Infectious Diseases
  • 1998
    New Investigator Award, UCSF Center for AIDS Research (CFAR)
  • 2009
    Stephen B. Hulley Award for Excellence in Instruction in Methods of Clinical Research at UCSF

Selected Publications

  1. Bachtel ND, Umviligihozo G, Pickering S, Mota T, Liang H, Del Prete GQ, Chatterjee P, Lee GQ, Thomas R, Brockman MA, Neil S, Carrington M, Bwana B, Bangsberg DR, Martin JN, Kallas EG, Donini CS, Cerqueira NB, O'Doherty UT, Hahn BH, Jones RB, Brumme ZL, Nixon DF, Apps R. HLA-C downregulation by HIV-1 adapts to host HLA genotype. PLoS Pathog. 2018 Sep 04; 14(9):e1007257.
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  2. Young CR, Kaida A, Kabakyenga J, Muyindike W, Musinguzi N, Martin JN, Hunt PW, Bangsberg DR, Haberer JE, Matthews LT. Prevalence and correlates of physical and sexual intimate partner violence among women living with HIV in Uganda. PLoS One. 2018; 13(8):e0202992.
    View on PubMed
  3. Ayers LW, Barbachano-Guerrero A, McAllister SC, Ritchie JA, Asiago-Reddy E, Bartlett LC, Cesarman E, Wang D, Rochford R, Martin JN, King CA. Mast cell activation and KSHV infection in Kaposi sarcoma. Clin Cancer Res. 2018 Jul 03.
    View on PubMed
  4. Hosseinipour MC, Kang M, Krown SE, Bukuru A, Umbleja T, Martin JN, Orem J, Godfrey C, Hoagland B, Mwelase N, Langat D, Nyirenda M, MacRae J, Borok M, Samaneka W, Moses A, Mngqbisa R, Busakhala N, Martínez-Maza O, Ambinder R, Dittmer DP, Nokta M, Campbell TB. As-Needed Vs Immediate Etoposide Chemotherapy in Combination With Antiretroviral Therapy for Mild-to-Moderate AIDS-Associated Kaposi Sarcoma in Resource-Limited Settings: A5264/AMC-067 Randomized Clinical Trial. Clin Infect Dis. 2018 Jul 02; 67(2):251-260.
    View on PubMed
  5. McCluskey SM, Lee GQ, Kamelian K, Kembabazi A, Musinguzi N, Bwana MB, Muzoora C, Haberer JE, Hunt PW, Martin JN, Boum Y, Bangsberg DR, Harrigan PR, Siedner MJ. Increasing Prevalence of HIV Pretreatment Drug Resistance in Women But Not Men in Rural Uganda During 2005-2013. AIDS Patient Care STDS. 2018 Jul; 32(7):257-264.
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  6. Chang JL, Tsai AC, Musinguzi N, Haberer JE, Boum Y, Muzoora C, Bwana M, Martin JN, Hunt PW, Bangsberg DR, Siedner MJ. Depression and Suicidal Ideation Among HIV-Infected Adults Receiving Efavirenz Versus Nevirapine in Uganda: A Prospective Cohort Study. Ann Intern Med. 2018 Jun 26.
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  7. Castillo-Mancilla JR, Morrow M, Boum Y, Byakwaga H, Haberer JE, Martin JN, Bangsberg D, Mawhinney S, Musinguzi N, Huang Y, Tracy RP, Burdo TH, Williams K, Muzzora C, Hunt PW, Siedner MJ. Brief Report: Higher ART Adherence Is Associated With Lower Systemic Inflammation in Treatment-Naive Ugandans Who Achieve Virologic Suppression. J Acquir Immune Defic Syndr. 2018 Apr 15; 77(5):507-513.
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  8. Muiru AN, Bibangambah P, Hemphill L, Sentongo R, Kim JH, Triant VA, Bangsberg DR, Tsai AC, Martin JN, Haberer JE, Boum Y, Plutzky J, Hunt PW, Okello S, Siedner MJ. Distribution and performance of cardiovascular risk scores in a mixed population of HIV-infected and community-based HIV-uninfected individuals in Uganda. J Acquir Immune Defic Syndr. 2018 Apr 11.
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  9. Wong C, Gange SJ, Moore RD, Justice AC, Buchacz K, Abraham AG, Rebeiro PF, Koethe JR, Martin JN, Horberg MA, Boyd CM, Kitahata MM, Crane HM, Gebo KA, Gill MJ, Silverberg MJ, Palella FJ, Patel P, Samji H, Thorne J, Rabkin CS, Mayor A, Althoff KN. Multimorbidity Among Persons Living with Human Immunodeficiency Virus in the United States. Clin Infect Dis. 2018 Apr 03; 66(8):1230-1238.
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  10. Ferdin J, Goricar K, Dolžan V, Plemenitaš A, Martin JN, Peterlin BM, Deeks SG, Lenassi M. Viral protein Nef is detected in plasma of half of HIV-infected adults with undetectable plasma HIV RNA. PLoS One. 2018; 13(1):e0191613.
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  11. Ramsuran V, Naranbhai V, Horowitz A, Qi Y, Martin MP, Yuki Y, Gao X, Walker-Sperling V, Del Prete GQ, Schneider DK, Lifson JD, Fellay J, Deeks SG, Martin JN, Goedert JJ, Wolinsky SM, Michael NL, Kirk GD, Buchbinder S, Haas D, Ndung'u T, Goulder P, Parham P, Walker BD, Carlson JM, Carrington M. Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells. Science. 2018 01 05; 359(6371):86-90.
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  12. Grebe E, Welte A, Hall J, Keating SM, Facente SN, Marson K, Martin JN, Little SJ, Price MA, Kallas EG, Busch MP, Pilcher CD, Murphy G. Infection Staging and Incidence Surveillance Applications of High Dynamic Range Diagnostic Immuno-Assay Platforms. J Acquir Immune Defic Syndr. 2017 12 15; 76(5):547-555.
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  13. Mwimanzi F, Toyoda M, Mahiti M, Mann JK, Martin JN, Bangsberg D, Brockman MA, Goulder P, Kirchhoff F, Brumme ZL, Ndung'u T, Ueno T. Resistance of Major Histocompatibility Complex Class B (MHC-B) to Nef-Mediated Downregulation Relative to that of MHC-A Is Conserved among Primate Lentiviruses and Influences Antiviral T Cell Responses in HIV-1-Infected Individuals. J Virol. 2018 01 01; 92(1).
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  14. Teigler JE, Zelinskyy G, Eller MA, Bolton DL, Marovich M, Gordon AD, Alrubayyi A, Alter G, Robb ML, Martin JN, Deeks SG, Michael NL, Dittmer U, Streeck H. Differential Inhibitory Receptor Expression on T Cells Delineates Functional Capacities in Chronic Viral Infection. J Virol. 2017 12 01; 91(23).
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  15. Lee GQ, Bangsberg DR, Mo T, Lachowski C, Brumme CJ, Zhang W, Lima VD, Boum Y, Mwebesa BB, Muzoora C, Andia I, Mbalibulha Y, Kembabazi A, Carroll R, Siedner MJ, Haberer JE, Mocello AR, Kigozi SH, Hunt PW, Martin JN, Harrigan PR. Prevalence and clinical impacts of HIV-1 intersubtype recombinants in Uganda revealed by near-full-genome population and deep sequencing approaches. AIDS. 2017 Nov 13; 31(17):2345-2354.
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  16. Tjiam MC, Morshidi MA, Sariputra L, Martin JN, Deeks SG, Tan DBA, Lee S, Fernandez S, French MA. Association of HIV-1 Gag-Specific IgG Antibodies With Natural Control of HIV-1 Infection in Individuals Not Carrying HLA-B*57: 01 Is Only Observed in Viremic Controllers. J Acquir Immune Defic Syndr. 2017 11 01; 76(3):e90-e92.
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  17. McCluskey SM, Boum Y, Musinguzi N, Haberer JE, Martin JN, Hunt PW, Marconi VC, Bangsberg DR, Siedner MJ. Brief Report: Appraising Viral Load Thresholds and Adherence Support Recommendations in the World Health Organization Guidelines for Detection and Management of Virologic Failure. J Acquir Immune Defic Syndr. 2017 10 01; 76(2):183-187.
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  18. Lee GQ, McCluskey S, Boum Y, Hunt PW, Martin JN, Bangsberg DR, Gao X, Harrigan PR, Haberer JE, Siedner MJ. Brief Report: Should Abacavir Be a First-Line Alternative for Adults With HIV in Sub-Saharan Africa? J Acquir Immune Defic Syndr. 2017 10 01; 76(2):188-192.
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  19. Gatanaga H, Brumme ZL, Adland E, Reyes-Terán G, Avila-Rios S, Mejía-Villatoro CR, Hayashida T, Chikata T, Van Tran G, Van Nguyen K, Meza RI, Palou EY, Valenzuela-Ponce H, Pascale JM, Porras-Cortés G, Manzanero M, Lee GQ, Martin JN, Carrington MN, John M, Mallal S, Poon AFY, Goulder P, Takiguchi M, Oka S. Potential for immune-driven viral polymorphisms to compromise antiretroviral-based preexposure prophylaxis for prevention of HIV-1 infection. AIDS. 2017 Sep 10; 31(14):1935-1943.
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  20. de Mulder M, SenGupta D, Deeks SG, Martin JN, Pilcher CD, Hecht FM, Sacha JB, Nixon DF, Michaud HA. Anti-HERV-K (HML-2) capsid antibody responses in HIV elite controllers. Retrovirology. 2017 Aug 22; 14(1):41.
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