University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Jeffrey N. Martin, MD, MPH

Jeffrey N. Martin, MD, MPH

Professor of Epidemiology and Biostatistics, UCSF; Attending Physician, San Francisco General Hospital

Cancer Center Program Memberships

Cancer Control

Research Summary

My cancer-related research centers around Kaposi sarcoma (KS) and its etiologic agent, Kaposi’s sarcoma-associated herpesvirus (KSHV), with work both in the US and in Africa.
My qualifications for research include both theoretical background and practical experience. I am Director of the UCSF Training in Clinical Research (TICR) Program, which provides graduate-level didactic training in clinical, epidemiologic, and translational research methods to graduate students, post-doctoral fellows, and junior faculty members at UCSF. The TICR Program, which is supported by the UCSF NIH-sponsored Clinical and Translational Science Award (CTSA), includes 33 different courses spanning “laboratory to human subjects” translational research, traditional clinical and epidemiologic research, and “evidence to practice” implementation science research. In direct teaching, I am the course director of “Epidemiologic Methods,” the program’s foundational course in research methods, and the “Master’s Program Seminar Series.” On a practical level, I have extensive experience in both observational and experimental research in both the US and Africa. In the US, I am Co-Director of the Population and Clinical Sciences Core of the UCSF NIH-sponsored Center for AIDS Research (CFAR), which manages the 1800-subject UCSF SCOPE cohort, a vehicle that has supported collaborative research leading to over 200 publications since 2000. In Africa, I am the Principal Investigator (PI) for U54 CA190153 (a project which focuses on the early detection and prevention of KS in Uganda); PI for the UCSF component of the East Africa International Epidemiologic Databases to Evaluate AIDS (IeDEA) Consortium (U01 AI069911), in which I direct the working group on cancer; PI for the recently completed R01 CA119903 (a randomized trial for the therapy of KS in Africa); PI for the recently completed D43 CA153717 (a training grant related to KS in Uganda); and Director of the Data Coordinating Center for the 750-subject Mbarara-based Uganda AIDS Rural Treatment Outcomes (UARTO) Cohort. UARTO, which has spun off over 50 publications from collaborative projects since 2006, is a microscopic complement of IeDEA. In all of this work, I have had broad experience with study design, instrument development, study recruitment/ retention, data collection, quality enhancement, data reporting, biostatistical analysis, manuscript preparation, and financial management.

Education

Johns Hopkins University; Baltimore, Maryland, BA, 1979-83, Biology
University of Pennsylvania; Philadelphia, MD, 1983-88, Medicine
UC, San Francisco, 1988-89, Medicine - Internship
UC, San Francisco, 1989-91, Medicine - Residency 
UC, San Francisco, 1991-92, Medicine - Chief Residency
UC, Berkeley, MPH, 1992-93, Epidemiology
UC, San Francisco, 1993-97, Infectious Diseases - Fellowship
UC, San Francisco, 1993-97, AIDS Prevention - Fellowship
 

Professional Experience

  • 1997-2003
    Assistant Professor of Epidemiology and Biostatistics, UCSF
  • 2003-2009
    Associate Professor of Epidemiology and Biostatistics, UCSF
  • 2009-present
    Professor of Epidemiology and Biostatistics, UCSF
  • 1997-present
    Attending Physician, San Francisco General Hospital
  • 1997-1999
    Co-Director, Advanced Training in Clinical Research (ATCR) Program, UCSF
  • 2000-2006
    Co-Director, NIH K30-sponsored Training in Clinical Research (TICR) Program, UCSF
  • 2000-present
    Director, Advanced Training in Clinical Research (ATCR) Certificate Program, UCSF
  • 2001-present
    Director, Master’s Degree Graduate Program in Clinical Research, UCSF
  • 2006-present
    Director, NIH CTSA-sponsored Training in Clinical Research (TICR) Graduate Program, UCSF

Honors & Awards


  • 1982
    Phi Beta Kappa
  • 1988
    Alpha Omega Alpha
  • 1988
    Merck Manual Award, University of Pennsylvania School of Medicine
  • 1989
    Diplomate, National Board of Medical Examiners
  • 1991
    Diplomate, American Board of Internal Medicine
  • 1996
    Diplomate, American Board of Internal Medicine, Subspecialty in Infectious Diseases
  • 1998
    New Investigator Award, UCSF Center for AIDS Research (CFAR)
  • 2009
    Stephen B. Hulley Award for Excellence in Instruction in Methods of Clinical Research at UCSF

Selected Publications

  1. McCluskey SM, Boum Y, Musinguzi N, Haberer JE, Martin JN, Hunt PW, Marconi VC, Bangsberg DR, Siedner MJ. Brief Report: Appraising Viral Load Thresholds and Adherence Support Recommendations in the World Health Organization Guidelines for Detection and Management of Virologic Failure. J Acquir Immune Defic Syndr. 2017 Oct 01; 76(2):183-187.
    View on PubMed
  2. Lee GQ, McCluskey S, Boum Y, Hunt PW, Martin JN, Bangsberg DR, Gao X, Harrigan PR, Haberer JE, Siedner MJ. Brief Report: Should Abacavir Be a First-Line Alternative for Adults With HIV in Sub-Saharan Africa? J Acquir Immune Defic Syndr. 2017 Oct 01; 76(2):188-192.
    View on PubMed
  3. Teigler JE, Zelinskyy G, Eller MA, Bolton DL, Marovich M, Gordon AD, Alrubayyi A, Alter G, Robb ML, Martin JN, Deeks SG, Michael NL, Dittmer U, Streeck H. Differential Inhibitory Receptor Expression on T Cells Delineates Functional Capacities in Chronic Viral Infection. J Virol. 2017 Sep 13.
    View on PubMed
  4. Gatanaga H, Brumme ZL, Adland E, Reyes-Terán G, Avila-Rios S, Mejía-Villatoro CR, Hayashida T, Chikata T, Van Tran G, Van Nguyen K, Meza RI, Palou EY, Valenzuela-Ponce H, Pascale JM, Porras-Cortés G, Manzanero M, Lee GQ, Martin JN, Carrington MN, John M, Mallal S, Poon AFY, Goulder P, Takiguchi M, Oka S. Potential for immune-driven viral polymorphisms to compromise antiretroviral-based preexposure prophylaxis for prevention of HIV-1 infection. AIDS. 2017 Sep 10; 31(14):1935-1943.
    View on PubMed
  5. Grebe E, Welte A, Hall J, Keating SM, Facente SN, Marson K, Martin JN, Little SJ, Price MA, Kallas EG, Busch MP, Pilcher CD, Murphy G. Infection Staging and Incidence Surveillance Applications of High Dynamic Range Diagnostic Immuno-Assay Platforms. J Acquir Immune Defic Syndr. 2017 Sep 07.
    View on PubMed
  6. de Mulder M, SenGupta D, Deeks SG, Martin JN, Pilcher CD, Hecht FM, Sacha JB, Nixon DF, Michaud HA. Anti-HERV-K (HML-2) capsid antibody responses in HIV elite controllers. Retrovirology. 2017 Aug 22; 14(1):41.
    View on PubMed
  7. Lee GQ, Bangsberg DR, Mo T, Lachowski C, Brumme CJ, Zhang W, Lima VD, Boum Y, Mwebesa BB, Muzoora C, Andia I, Mbalibulha Y, Kembabazi A, Carroll R, Siedner MJ, Haberer JE, Mocello AR, Kigozi SH, Hunt PW, Martin JN, Harrigan PR. Prevalence and clinical impacts of HIV-1 intersubtype recombinants in Uganda revealed by near-full-genome population and deep sequencing approaches. AIDS. 2017 08 21.
    View on PubMed
  8. Drozd DR, Kitahata MM, Althoff KN, Zhang J, Gange SJ, Napravnik S, Burkholder GA, Mathews WC, Silverberg MJ, Sterling TR, Heckbert SR, Budoff MJ, Van Rompaey S, Delaney JAC, Wong C, Tong W, Palella FJ, Elion RA, Martin JN, Brooks JT, Jacobson LP, Eron JJ, Justice AC, Freiberg MS, Klein DB, Post WS, Saag MS, Moore RD, Crane HM. Increased Risk of Myocardial Infarction in HIV-Infected Individuals in North America Compared With the General Population. J Acquir Immune Defic Syndr. 2017 Aug 15; 75(5):568-576.
    View on PubMed
  9. Tjiam MC, Morshidi MA, Sariputra L, Martin JN, Deeks SG, Tan D, Lee S, Fernandez S, French MA. The association of HIV-1 Gag-specific IgG antibodies with natural control of HIV-1 infection in individuals not carrying HLA-B*57: 01 is only observed in viremic controllers. J Acquir Immune Defic Syndr. 2017 Jun 09.
    View on PubMed
  10. Kiguoya MW, Mann JK, Chopera D, Gounder K, Lee GQ, Hunt PW, Martin JN, Ball TB, Kimani J, Brumme ZL, Brockman MA, Ndung'u T. Subtype-Specific Differences in Gag-Protease-Driven Replication Capacity Are Consistent with Intersubtype Differences in HIV-1 Disease Progression. J Virol. 2017 Jul 01; 91(13).
    View on PubMed
  11. Musinguzi N, Mocello RA, Boum Y, Hunt PW, Martin JN, Haberer JE, Bangsberg DR, Siedner MJ. Duration of Viral Suppression and Risk of Rebound Viremia with First-Line Antiretroviral Therapy in Rural Uganda. AIDS Behav. 2017 Jun; 21(6):1735-1740.
    View on PubMed
  12. North CM, Valeri L, Hunt PW, Mocello AR, Martin JN, Boum Y, Haberer JE, Bangsberg DR, Christiani DC, Siedner MJ. Cooking fuel and respiratory symptoms among people living with HIV in rural Uganda. ERJ Open Res. 2017 Apr; 3(2).
    View on PubMed
  13. Lee S, Byakwaga H, Boum Y, Burdo TH, Williams KC, Lederman MM, Huang Y, Tracy RP, Cao H, Haberer JE, Kembabazi A, Bangsberg DR, Martin JN, Hunt PW. Immunologic Pathways That Predict Mortality in HIV-Infected Ugandans Initiating Antiretroviral Therapy. J Infect Dis. 2017 04 15; 215(8):1270-1274.
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  14. Jacobs ES, Keating SM, Abdel-Mohsen M, Gibb SL, Heitman JW, Inglis HC, Martin JN, Zhang J, Kaidarova Z, Deng X, Wu S, Anastos K, Crystal H, Villacres MC, Young M, Greenblatt RM, Landay AL, Gange SJ, Deeks SG, Golub ET, Pillai SK, Norris PJ. Cytokines Elevated in HIV Elite Controllers Reduce HIV Replication In Vitro and Modulate HIV Restriction Factor Expression. J Virol. 2017 Mar 15; 91(6).
    View on PubMed
  15. Haberer JE, Musinguzi N, Tsai AC, Boum Y, Bwana BM, Muzoora C, Hunt PW, Martin JN, Bangsberg DR. Real-time electronic adherence monitoring plus follow-up improves adherence compared with standard electronic adherence monitoring. AIDS. 2017 Jan 02; 31(1):169-171.
    View on PubMed
  16. Keating SM, Kassanjee R, Lebedeva M, Facente SN, MacArthur JC, Grebe E, Murphy G, Welte A, Martin JN, Little S, Price MA, Kallas EG, Busch MP, Pilcher CD. Performance of the Bio-Rad Geenius HIV1/2 Supplemental Assay in Detecting "Recent" HIV Infection and Calculating Population Incidence. J Acquir Immune Defic Syndr. 2016 Dec 15; 73(5):581-588.
    View on PubMed
  17. Okello S, Asiimwe SB, Kanyesigye M, Muyindike WR, Boum Y, Mwebesa BB, Haberer JE, Huang Y, Williams K, Burdo TH, Tracy RP, Bangsberg DR, Mocello AR, Martin JN, Hunt PW, Siedner MJ. D-Dimer Levels and Traditional Risk Factors Are Associated With Incident Hypertension Among HIV-Infected Individuals Initiating Antiretroviral Therapy in Uganda. J Acquir Immune Defic Syndr. 2016 Dec 01; 73(4):396-402.
    View on PubMed
  18. Kassanjee R, Pilcher CD, Busch MP, Murphy G, Facente SN, Keating SM, Mckinney E, Marson K, Price MA, Martin JN, Little SJ, Hecht FM, Kallas EG, Welte A. Viral load criteria and threshold optimization to improve HIV incidence assay characteristics. AIDS. 2016 Sep 24; 30(15):2361-71.
    View on PubMed
  19. Bebell LM, Siedner MJ, Musinguzi N, Boum Y, Bwana BM, Muyindike W, Hunt PW, Martin JN, Bangsberg DR. Trends in one-year cumulative incidence of death between 2005 and 2013 among patients initiating antiretroviral therapy in Uganda. Int J STD AIDS. 2017 Jul; 28(8):800-807.
    View on PubMed
  20. Feinstein MJ, Kim JH, Bibangambah P, Sentongo R, Martin JN, Tsai AC, Bangsberg DR, Hemphill L, Triant VA, Boum Y, Hunt PW, Okello S, Siedner MJ. Ideal Cardiovascular Health and Carotid Atherosclerosis in a Mixed Cohort of HIV-Infected and Uninfected Ugandans. AIDS Res Hum Retroviruses. 2017 Jan; 33(1):49-56.
    View on PubMed

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