University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Lisa McConlogue, PhD

Lisa McConlogue, PhD

Adjunct Professor of Biochemistry and Biophysics, UCSF

Cancer Center Program Memberships

Experimental Therapeutics

Research Summary

The McConlogue laboratory focuses on both understanding the mechanisms involved in neurodegeneration driven by misfolding-prone proteins and in developing therapeutic approaches to treat neurological diseases such as Alzheimer’s and Parkinson’s diseases (AD and PD). We are particularly interested in understanding the pathogenic role and functional perturbation of intrinsically disordered proteins (IDP) that, due to their unique structural characteristics and key functional roles, lead to diseases of amyloid-type misfolding including cancer and neurodegenerative diseases.

Our current focus is on understanding and blocking the pathogenic processes of a-Synuclein (a-Syn), an IDP that plays a central role in PD and also contributes to AD. We are developing small molecules that act as chaperones restoring the native structure and function of a-Syn under disease conditions to both probe the pathogenic mechanisms of a-Syn misfolding and malfunction, and to develop therapies to treat PD, AD and related diseases.

Education

University of California, Los Angeles, B.A., 1973, Mathematics
University of California, Los Angeles, M.S., 1975, Medical Physics
University of California, Los Angeles, Ph.D., 1978, Medical Physics
University of California, San Francisco, Postdoctoral, 1985, Somatic Cell Genetics


Professional Experience

  • 2015-present
    Visiting Investigator, Gladstone Institute of Neurological Disease (GIND)
  • 2014-present
    Adjunct Professor of Biochemistry and Biophysics, UCSF
  • 2012-2013
    Distinguished Research Fellow, Elan Pharmaceuticals (Vice President level research position) Steering Committee, Cambridge Elan Centre for Research Excellence and Drug Discovery, Cambridge Elan Alliance project leader.
  • 2010-2012
    Research Fellow, Parkinson’s Disease Strategic and Synuclein Stabilization Project leader, Elan.
  • 2006-2011
    Research Fellow, Group Leader of Molecular Genetics, Parkinson’s Disease Project Leader, Elan
  • 2002-2006
    Senior Scientist, Group Leader of Molecular Genetics, Parkinson’s Disease Discovery Project Leader. Elan Pharmaceuticals
  • 2000-2002
    Senior Scientist, Group Leader of Molecular Biology, Project leader, Digital Gene Technologies/Elan AD Joint Venture, Elan Pharmaceuticals
  • 1998-2000
    Principal Scientist, Group Leader of Molecular Biology Elan Pharmaceuticals
  • 1997-1998
    Staff Scientist, Group Leader of Molecular Biology, Elan Pharmaceuticals
  • 1993-1997
    Staff Scientist, Associate Director of Molecular Biology, Project Leader Dyax/Elan phage display collaboration. Athena Neurosciences
  • 1988-1992
    Scientist, Molecular Biology, Athena Neurosciences
  • 1985-1988
    Scientist, Molecular Biology, Project Manager Mammalian Expression, Cetus Corporation

Selected Publications

  1. Roberds SL, Anderson J, Basi G, Bienkowski MJ, Branstetter DG, Chen KS, Freedman SB, Frigon NL, Games D, Hu K, Johnson-Wood K, Kappenman KE, Kawabe TT, Kola I, Kuehn R, Lee M, Liu W, Motter R, Nichols NF, Power M, Robertson DW, Schenk D, Schoor M, Shopp GM, Shuck ME, Sinha S, Svensson KA, Tatsuno G, Tintrup H, Wijsman J, Wright S, McConlogue L. BACE knockout mice are healthy despite lacking the primary beta-secretase activity in brain: implications for Alzheimer's disease therapeutics. Hum Mol Genet. 2001 Jun 01; 10(12):1317-24.
    View on PubMed
  2. Maltese WA, Wilson S, Tan Y, Suomensaari S, Sinha S, Barbour R, McConlogue L. Retention of the Alzheimer's amyloid precursor fragment C99 in the endoplasmic reticulum prevents formation of amyloid beta-peptide. J Biol Chem. 2001 Jun 08; 276(23):20267-79.
    View on PubMed
  3. 41 Gwen Tatsuno, John Anderson , Jin Hong, David A. Agard, Nobuyuki Ota, Sukanto Sinha, Guriqbal Basi, Lisa McConlogue . Alzheimer’s Disease:Advances in Etiology, Pathogenesis and Therapeutics. Functional analysis of ß-secretase using mutagenesis and structural homology modeling. 2001; Chapter 74:799-808. .
    View on PubMed
  4. Chen G, Chen KS, Knox J, Inglis J, Bernard A, Martin SJ, Justice A, McConlogue L, Games D, Freedman SB, Morris RG. A learning deficit related to age and beta-amyloid plaques in a mouse model of Alzheimer's disease. Nature. 2000 Dec 21-28; 408(6815):975-9.
    View on PubMed
  5. Sinha S, Anderson J, John V, McConlogue L, Basi G, Thorsett E, Schenk D. Recent advances in the understanding of the processing of APP to beta amyloid peptide. Ann N Y Acad Sci. 2000; 920:206-8.
    View on PubMed
  6. Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, Doan M, Dovey HF, Frigon N, Hong J, Jacobson-Croak K, Jewett N, Keim P, Knops J, Lieberburg I, Power M, Tan H, Tatsuno G, Tung J, Schenk D, Seubert P, Suomensaari SM, Wang S, Walker D, Zhao J, McConlogue L, John V. Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature. 1999 Dec 02; 402(6761):537-40.
    View on PubMed
  7. Tan Y, Hong J, Doan T, McConlogue L, Maltese WA. Presenilin-1 mutations associated with familial Alzheimer's disease do not disrupt protein transport from the endoplasmic reticulum to the Golgi apparatus. Biochim Biophys Acta. 1998 Jul 01; 1407(1):69-78.
    View on PubMed
  8. Gillian AM, McFarlane I, Lucy FM, Overly C, McConlogue L, Breen KC. Individual isoforms of the amyloid beta precursor protein demonstrate differential adhesive potentials to constituents of the extracellular matrix. J Neurosci Res. 1997 Jul 15; 49(2):154-60.
    View on PubMed
  9. Johnson-Wood K, Lee M, Motter R, Hu K, Gordon G, Barbour R, Khan K, Gordon M, Tan H, Games D, Lieberburg I, Schenk D, Seubert P, McConlogue L. Amyloid precursor protein processing and A beta42 deposition in a transgenic mouse model of Alzheimer disease. Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1550-5.
    View on PubMed
  10. Zhao J, Paganini L, Mucke L, Gordon M, Refolo L, Carman M, Sinha S, Oltersdorf T, Lieberburg I, McConlogue L. Beta-secretase processing of the beta-amyloid precursor protein in transgenic mice is efficient in neurons but inefficient in astrocytes. J Biol Chem. 1996 Dec 06; 271(49):31407-11.
    View on PubMed
  11. McConlogue L, Castellano F, deWit C, Schenk D, Maltese WA. Differential effects of a Rab6 mutant on secretory versus amyloidogenic processing of Alzheimer's beta-amyloid precursor protein. J Biol Chem. 1996 Jan 19; 271(3):1343-8.
    View on PubMed
  12. Rockenstein EM, McConlogue L, Tan H, Power M, Masliah E, Mucke L. Levels and alternative splicing of amyloid beta protein precursor (APP) transcripts in brains of APP transgenic mice and humans with Alzheimer's disease. J Biol Chem. 1995 Nov 24; 270(47):28257-67.
    View on PubMed
  13. Schenk D, Games KD, McConlogue L. The potential utility of transgenic mice harboring beta-amyloid precursor protein. Neurobiol Aging. 1995 Jul-Aug; 16(4):711-3; discussion 715-8.
    View on PubMed
  14. Dugan JM, deWit C, McConlogue L, Maltese WA. The Ras-related GTP-binding protein, Rab1B, regulates early steps in exocytic transport and processing of beta-amyloid precursor protein. J Biol Chem. 1995 May 05; 270(18):10982-9.
    View on PubMed
  15. Knops J, Suomensaari S, Lee M, McConlogue L, Seubert P, Sinha S. Cell-type and amyloid precursor protein-type specific inhibition of A beta release by bafilomycin A1, a selective inhibitor of vacuolar ATPases. J Biol Chem. 1995 Feb 10; 270(6):2419-22.
    View on PubMed
  16. Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C, Carr T, Clemens J, Donaldson T, Gillespie F. Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature. 1995 Feb 09; 373(6514):523-7.
    View on PubMed
  17. Kosik KS, McConlogue L. Microtubule-associated protein function: lessons from expression in Spodoptera frugiperda cells. Cell Motil Cytoskeleton. 1994; 28(3):195-8.
    View on PubMed
  18. Citron M, Oltersdorf T, Haass C, McConlogue L, Hung AY, Seubert P, Vigo-Pelfrey C, Lieberburg I, Selkoe DJ. Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production. Nature. 1992 Dec 17; 360(6405):672-4.
    View on PubMed
  19. Overly CC, Fritz LC, Lieberburg I, McConlogue L. The beta-amyloid precursor protein is not processed by the regulated secretory pathway. Biochem Biophys Res Commun. 1991 Dec 16; 181(2):513-9.
    View on PubMed
  20. Knops J, Kosik KS, Lee G, Pardee JD, Cohen-Gould L, McConlogue L. Overexpression of tau in a nonneuronal cell induces long cellular processes. J Cell Biol. 1991 Aug; 114(4):725-33.
    View on PubMed

Go to UCSF Profiles, powered by CTSI