Tracy R. McKnight, PhD

Tracy R. McKnight, PhD

Associate Professor, Department of Radiology and Biomedical Imaging, UCSF

Phone: (415) 353-9467 (voice)
Box 0946, UCSF
San Francisco, CA 94143-0946

Cancer Center Membership

Program Member » Non-aligned


Spelman College, Atlanta, GA, B.S., 1988, Physics
Polytechnic University, Brooklyn, NY, M.S., 1990, Physics
University of California, Davis, CA, Ph.D., 1998, Biomedical Engineering
University of California, San Francisco, CA, Postdoc, 2001, Radiology (MRI/MRS)

Professional Experience

  • 1988-1989
    Teaching Assistant, Department of Physics, Polytechnic University, Brooklyn, NY.
  • 1990-1991
    Research Associate, Materials Science Research Center, Howard University, Washington, DC.
  • 1991-1998
    Graduate Student, Department of Human Physiology, University of California, Davis, CA.
  • 1991-1997
    Technical Consultant, Confocal Microscopy Laboratory, Department of Human Physiology, University of California, Davis, CA.
  • 1991-1994
    NIH Initiative for Underrepresented Minorities in Biomedical Research grant supplement
  • 1994-1997
    NIH Trainee in Cardiovascular and Neurophysiology, Department of Human Physiology, University of California, Davis, CA.
  • 1997-1999
    Confocal Microscopy Course Instructor, Biotechnology Program, University of California, Davis, CA
  • 1998-2001
    Postdoctoral Fellow, Magnetic Resonance Science Center, University of California, San Francisco, CA.
  • 1998-2001
    NIH Trainee in Diagnostic Oncology, Magnetic Resonance Science Center, University of California, San Francisco, CA.
  • 2001-present
    Assistant Professor, Department of Radiology, University of California, San Francisco, CA.
  • 2004-present
    Supervisor, Tissue Culture Laboratory, Center for Molecular and Functional Imaging, University of California, San Francisco, CA

Selected Publications

  • McKnight TR, Curry FE. Cell-cell communication of calcium in single, perfused frog microvessels. Microcirc 1996;3(1):M115.
  • McKnight TR, Curry FE. Imaging of calcium transients after exposure to ATP in single perfused venular microvessels. Microcirc 1997;4(1):M164.
  • McKnight TR, Noworolski SM, Vigneron DB, Nelson, SJ. An automated technique for the quantitative assessment of 3D-MRSI data from patients with glioma. J Magn Reson Imaging 2001;13:167-177.
  • Pirzkall A, McKnight TR, Graves EE, Carol MP, Sneed PK, Wara WW, Nelson SJ, Verhey LJ, Larson DA. MR-spectroscopy guided target delineation for high-grade gliomas, Int J Radiation Oncology Biol Phys 2001;50:4:915-928.
  • McKnight TR, Curry, FE. Mechanisms of heterogeneous endothelial cytoplasmic calcium increases in venular microvessels. Microcirculation 2002;9:537-550.
  • McKnight TR, von dem Bussche M, Vigneron DB, Berger MS, McDermott MW, Dillon WP, Nelson SJ. Validation of a Cho-NAA index of likelihood of tumor presence: a comparison of 1H-MRSI data and histopathology from patients with untreated glioma. J Neurosurgery 2002;97:794-802.
  • McKnight, TR, Vigneron DB, Berger MS., McDermott MW, Lu Y, Nellson SJ. Evaluation of a novel Cho-NAA index as a tool for guiding biopsies of untreated glioma. Neuro-oncology 2002;4(1):59.
  • Pirzkall A, Nelson SJ, McKnight TR, Takahashi MM, Li XJ, Graves EE, Verhey LJ, Wara WW, Larson DA, Sneed PK. Metabolic Imaging of Low-Grade Gliomas with 3D MR-Spectroscopy. Int J Rad Onc Biol Phys, 2002;53:1254-1264.
  • Li X, Lu Y, Pirzkall A, McKnight T, Nelson S. Analysis of Spatial Characteristics of the Metabolic Abnormalities for Newly Diagnosed Glioma Patients. JMRI 2002;16:229-237.
  • Nelson SJ, Graves E, Pirzkall A, Li X, Chan AA, Vigneron D, McKnight TR. In vivo molecular imaging for planning radiation therapy of gliomas: and application of 1H MRSI. J Magn Reson Imaging 2002;16(4):464-476.
  • Nelson SJ, McKnight TR, Henry RG. Characterization of untreated gliomas by MR spectroscopic imaging. Neuroimaging Clinics of North America 2002;12(4):484.
  • Mamot C, Nguyen J, Pourdehnad M, Hadaczek P, Saito R, Bringas J, Drummond D, Hong K, Kirpotin DB, McKnight TR, Berger MS, Park JW, Bankiewicz KS. Extensive distribution of liposomes in rodent brains and brain tumors following CED. J Neuro-oncol 2004;68:1-9.
  • Saito R, Bringas JR, McKnight TR, Mamot C, Drummond DC, Kirpotin DB, Park JW, Berger MS, Bankiewicz, KS. Effective distribution of liposomes into the central nervous system and brain tumor models by convection-enhanced delivery monitored with magnetic resonance imaging. Canc Res 2004;(64):2572-2579.
  • Lee MC, Pirzkall A, McKnight TR, Nelson SJ. 1H-MRSI of radiation effects in normal-appearing white matter: Dose-dependence and impact on automated spectral classification. J Magn Reson Imaging 2004;19(4):379-388.
  • Graves EE, Pirzkall A, McKnight TR, Vigneron DB, Larson DA, Verhey LJ, McDermott M, Chang S, Nelson SJ. Use of proton magnetic resonance spectroscopic imaging data in planning focal radiation therapies for brain tumors. Image Analysis and Stereology 2004;21:69-76.
  • McKnight TR. Proton magnetic resonance spectroscopic evaluation of brain tumor metabolism. Ed J Buckner. Seminars in Oncology 2004;31(5):605-617.
  • Laprie A, Pirzkall A, Haas-Kogen D, Cha S, Banerjee A, Le T, Lu Y, Nelson S, McKnight T. Longitudinal Multivoxel MR Spectroscopy Study of Pediatric Diffuse Brainstem Gliomas Treated with Radiotherapy. Int J Rad Onc Biol Phys 2005;62:20-31.
  • Saito R, Krauze MT, Bringas JR, Noble C, McKnight TR, Jackson P, Wendland MF, Mamot C, Drummond DC, Kirpotin DB, Hong K, Berger MS, Park JW, Bankiewicz KS. Gadolinium-loaded liposomes allow for real-time magnetic resonance imaging of convection-enhanced delivery in the primate brain. Exp Neurol 2005;196:381-389.
  • Krauze MT, McKnight TR, Yamashita Y, Bringas J, Noble CO, Saito R, Geletneky K, Forsayeth J, Berger MS, Jackson P, Park JW, Bankiewicz KS. Real-time visualization and characterization of liposomal delivery into the monkey brain by magnetic resonance imaging. Brain Res Brain Res Protoc 2005;16(1-3):20-26.
  • Krauze MT, Saito R, Noble C, Bringas J, Forsayeth J, McKnight TR, Park J, Bankiewicz KS. Effects of the perivascular space on convection-enhanced delivery of liposomes in primate putamen. Exp Neurol 2005;196(1):104-111.
  • Catalaa I, Henry RG, Dillon WP, Graves EE, McKnight TR, Lu Y, Vigneron DB, Nelson SJ. Perfusion, diffusion and spectroscopy values in newly diagnosed cerebral Gliomas. NMR Biomed 2006;19(4):463-475.