Director of Professional Education; and Co-Leader, Developmental Therapeutics Program, UCSF Helen Diller Family Comprehensive Cancer Center
Efim Guzik Distinguished Professorship in Cancer Biology, UCSF
Additional Websites
Education
University of Glasgow, Glasgow, Scotland, B.Sc., 1981, Biochemistry
University of London, London, England, Ph.D., 1985, Biochemistry
Professional Experience
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1989-1991
Assistant Specialist, Hooper Foundation, University of California, San Francisco, CA.
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1991-1997
Staff Scientist, Dept of Cell Signaling, DNAX Research Institute, Palo Alto, CA
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1997-1998
Senior Staff Scientist, Dept. of Cell Signaling, DNAX Research Institute, Palo Alto, CA
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1998
Associate Professor, University of California San Francisco, CA
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2001-present
Efim Guzik Distinguished Professor of Cancer Biology, UCSF Helen Diller Family Comprehensive Cancer Center
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2001-2007
Co-Director, UCSF Biomedical Sciences Graduate Program
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2004-2006
Co-Leader, UCSF Comprehensive Cancer Center Program in Liver Cancer
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2006-present
Professor-In-Residence, UCSF Helen Diller Family Comprehensive Cancer Center
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2007-2011
Leader, UCSF Helen Diller Family Comprehensive Cancer Center Program in Pancreas Cancer
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2007-present
Director of Professional Education, UCSF Helen Diller Family Comprehensive Cancer Center
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2011-present
Co-Leader, UCSF Helen Diller Family Comprehensive Cancer Center Program in Developmental Therapeutics
Honors & Awards
- 1977-1981
Imperial Chemical Industries (ICI) Undergraduate Educational Scholarship - 1981
J. N. Davidson Memorial Prize in Biochemistry - 1981-1985
ICI Graduate Student Bursary and Postgraduate Educational Scholarship - 1985-1987
Imperial Cancer Research Fund Postdoctoral Traveling Fellowship - 1988-1990
American Cancer Society (California Division) Senior Postdoctoral Fellowship - 2001
NIH/NCI Pancreatic Cancer Progress Review Group (Panc CA PRG) - 2001
Served on the National Cancer Legislative Action Committee - 2006
Diana Ashby Award of the Melanoma Research Foundation - 2009-present
Charter member of NIH BMCT study section
Selected Publications
- Maertens O, Johnson B, Hollstein P, Frederick DT, Cooper ZA, Messiaen L, Bronson RT, McMahon M, Granter S, Flaherty K, Wargo JA, Marais R, Cichowski K. Elucidating distinct roles for NF1 in melanomagenesis. Cancer Discov. 2013 Mar; 3(3):338-49.
View on PubMed - Mito JK, Min HD, Ma Y, Carter JE, Brigman BE, Dodd L, Dankort D, McMahon M, Kirsch DG. Oncogene-dependent control of miRNA biogenesis and metastatic progression in a model of undifferentiated pleomorphic sarcoma. J Pathol. 2013 Jan; 229(1):132-40.
View on PubMed - Mitra D, Luo X, Morgan A, Wang J, Hoang MP, Lo J, Guerrero CR, Lennerz JK, Mihm MC, Wargo JA, Robinson KC, Devi SP, Vanover JC, D'Orazio JA, McMahon M, Bosenberg MW, Haigis KM, Haber DA, Wang Y, Fisher DE. An ultraviolet-radiation-independent pathway to melanoma carcinogenesis in the red hair/fair skin background. Nature. 2012 Nov 15; 491(7424):449-53.
View on PubMed - Andreadi C, Cheung LK, Giblett S, Patel B, Jin H, Mercer K, Kamata T, Lee P, Williams A, McMahon M, Marais R, Pritchard C. The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway. Genes Dev. 2012 Sep 1; 26(17):1945-58.
View on PubMed - Gysin S, Paquette J, McMahon M. Analysis of mRNA Profiles after MEK1/2 Inhibition in Human Pancreatic Cancer Cell Lines Reveals Pathways Involved in Drug Sensitivity. Mol Cancer Res. 2012 Dec; 10(12):1607-19.
View on PubMed - Wang J, Kobayashi T, Floc'h N, Kinkade CW, Aytes A, Dankort D, Lefebvre C, Mitrofanova A, Cardiff RD, McMahon M, Califano A, Shen MM, Abate-Shen C. B-Raf activation cooperates with PTEN loss to drive c-Myc expression in advanced prostate cancer. Cancer Res. 2012 Sep 15; 72(18):4765-76.
View on PubMed - Tien AC, Tsai HH, Molofsky AV, McMahon M, Foo LC, Kaul A, Dougherty JD, Heintz N, Gutmann DH, Barres BA, Rowitch DH. Regulated temporal-spatial astrocyte precursor cell proliferation involves BRAF signalling in mammalian spinal cord. Development. 2012 Jul; 139(14):2477-87.
View on PubMed - Collisson EA, Trejo CL, Silva JM, Gu S, Korkola JE, Heiser LM, Charles RP, Rabinovich BA, Hann B, Dankort D, Spellman PT, Phillips WA, Gray JW, McMahon M. A central role for RAF?MEK?ERK signaling in the genesis of pancreatic ductal adenocarcinoma. Cancer Discov. 2012 Aug; 2(8):685-93.
View on PubMed - Huillard E, Hashizume R, Phillips JJ, Griveau A, Ihrie RA, Aoki Y, Nicolaides T, Perry A, Waldman T, McMahon M, Weiss WA, Petritsch C, James CD, Rowitch DH. Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8710-5.
View on PubMed - Vredeveld LC, Possik PA, Smit MA, Meissl K, Michaloglou C, Horlings HM, Ajouaou A, Kortman PC, Dankort D, McMahon M, Mooi WJ, Peeper DS. Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis. Genes Dev. 2012 May 15; 26(10):1055-69.
View on PubMed - Trejo CL, Juan J, Vicent S, Sweet-Cordero A, McMahon M. MEK1/2 inhibition elicits regression of autochthonous lung tumors induced by KRASG12D or BRAFV600E. Cancer Res. 2012 Jun 15; 72(12):3048-59.
View on PubMed - Damsky WE, Curley DP, Santhanakrishnan M, Rosenbaum LE, Platt JT, Gould Rothberg BE, Taketo MM, Dankort D, Rimm DL, McMahon M, Bosenberg M. ß-catenin signaling controls metastasis in Braf-activated Pten-deficient melanomas. Cancer Cell. 2011 Dec 13; 20(6):741-54.
View on PubMed - Tang N, Marshall WF, McMahon M, Metzger RJ, Martin GR. Control of mitotic spindle angle by the RAS-regulated ERK1/2 pathway determines lung tube shape. Science. 2011 Jul 15; 333(6040):342-5.
View on PubMed - Charles RP, Iezza G, Amendola E, Dankort D, McMahon M. Mutationally activated BRAF(V600E) elicits papillary thyroid cancer in the adult mouse. Cancer Res. 2011 Jun 1; 71(11):3863-71.
View on PubMed - Rauen KA, Banerjee A, Bishop WR, Lauchle JO, McCormick F, McMahon M, Melese T, Munster PN, Nadaf S, Packer RJ, Sebolt-Leopold J, Viskochil DH. Costello and cardio-facio-cutaneous syndromes: Moving toward clinical trials in RASopathies. Am J Med Genet C Semin Med Genet. 2011 May 15; 157(2):136-46.
View on PubMed - McMahon M. Parsing out the complexity of RAF inhibitor resistance. Pigment Cell Melanoma Res. 2011 Apr; 24(2):361-5.
View on PubMed - McMahon M. RAF translocations expand cancer targets. Nat Med. 2010 Jul; 16(7):749-50.
View on PubMed - Amin DN, Sergina N, Ahuja D, McMahon M, Blair JA, Wang D, Hann B, Koch KM, Shokat KM, Moasser MM. Resiliency and vulnerability in the HER2-HER3 tumorigenic driver. Sci Transl Med. 2010 Jan 27; 2(16):16ra7.
View on PubMed - Held MA, Curley DP, Dankort D, McMahon M, Muthusamy V, Bosenberg MW. Characterization of melanoma cells capable of propagating tumors from a single cell. Cancer Res. 2010 Jan 1; 70(1):388-97.
View on PubMed - Rauen KA, Schoyer L, McCormick F, Lin AE, Allanson JE, Stevenson DA, Gripp KW, Neri G, Carey JC, Legius E, Tartaglia M, Schubbert S, Roberts AE, Gelb BD, Shannon K, Gutmann DH, McMahon M, Guerra C, Fagin JA, Yu B, Aoki Y, Neel BG, Balmain A, Drake RR, Nolan GP, Zenker M, Bollag G, Sebolt-Leopold J, Gibbs JB, Silva AJ, Patton EE, Viskochil DH, Kieran MW, Korf BR, Hagerman RJ, Packer RJ, Melese T. Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back. Am J Med Genet A. 2010 Jan; 152A(1):4-24.
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