Nancy A. McNamara, PhD, OD

Associate Adjunct Professor, University of California, San Francisco; Associate Professor of Clinical Optometry, University of California, Berkeley

Nancy.McNamara@ucsf.edu

Phone: (415) 476-8132

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Education

Michigan State University, E. Lansing, MI,        1985-1987,    Biology
Michigan College of Optometry, Big Rapids, MI,         O.D.,    1987-1991    Optometry
University of California, Berkeley, CA,        1991-1992,    Cornea Residency
Mayo Graduate School, Rochester, MN,        1995,    Clinical Trials
University of California, Berkeley, CA,         Ph.D.,    1992-1996    Vision Science
 

Professional Experience

• 1987-1990
  Ocular Research Assistant, Ferris State University, Big Rapids, MI
• 1989-1990
  Ophthalmic Technician, Vanderbilt University Medical Center, Nashville, TN
• 1991-1992
  Contact Lens/Cornea Residency, University of California, Berkeley, CA
• 1992-1996
  Doctoral Candidate in Vision Science, University of California, Berkeley, CA
• 1992-1995
  Staff Research Optometrist, California Pacific Medical Center, San Francisco, CA
• 1996-1998
  Ciba Vision Corporation Postdoctoral Fellowship
• 1995-2000
  Research Optometrist, Morton D. Sarver Laboratory, University of California, Berkeley, CA
• 1996-1998
  Assistant Research Biologist, University of California, Berkeley, CA
• 1998-2006
  Associate Research Biologist, University of California, San Francisco, CA
• 2006-2011
  Assistant Adjunct Professor, University of California, San Francisco, CA
• 2011-
  Co-Director, University of California, Berkeley, School of Optometry, Dry Eye Clinic
• 2011-
  Associate Adjunct Professor, University of California, San Francisco, CA (50%)
• 2012-
  Associate Professor of Clinical Optometry, University of California, Berkeley (50%)

Honors & Awards

• 1990-1991
  Medivision Scholarship


• 1991
  Beta Sigma Kappa Silver Medal Award


• 1991
  George N. Holcomb Memorial Scholarship


• 1991
  Michigan College of Optometry Academic Recognition Award


• 1992
  Polymer Technology Travel Award


• 1992-1994
  American Academy of Optometry Travel Fellowship


• 1992-1995
  Morton D. Sarver Fellowship


• 1995-1996
  National Institute of Health Training Grant


• 1995-1996
  American Optometric Foundation Ezell Fellowship


• 1995-1997
  International Society for Contact Lens Research Student Travel Grant


• 1998-2003
  National Eye Institute, Mentored Clinical Scientist Award


• 2006
  U.S. Patent - UC Case No.: B98-040-3


• 2007
  Irvin M. and Beatrice Borish Award – American Academy of Optometry


• 2009
  American Cancer Society Research Scholar


• 2009
  Best Poster Award – American Academy of Ophthalmology


• 2012
  Ezell Research Symposium – Women on the Front Lines of Ocular Surface Research - American Academy of Optometry


• 2012
  Ocular Surface: Application of Cutting Edge Research - American Academy of Optometry

Selected Publications

1. Zhang L, Gallup M, Zlock L, Finkbeiner WE, McNamara NA. Rac1 and Cdc42 Differentially Modulate Cigarette Smoke-Induced Airway Cell Migration through p120-Catenin-Dependent and -Independent Pathways. Am J Pathol. 2013 Jun; 182(6):1986-95.
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2. Zhang L, Gallup M, Zlock L, Basbaum C, Finkbeiner WE, McNamara NA. Cigarette smoke disrupts the integrity of airway adherens junctions through the aberrant interaction of p120-catenin with the cytoplasmic tail of MUC1. J Pathol. 2013 Jan; 229(1):74-86.
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3. Zhou D, Chen YT, Chen F, Gallup M, Vijmasi T, Bahrami AF, Noble LB, van Rooijen N, McNamara NA. Critical involvement of macrophage infiltration in the development of Sjögren's syndrome-associated dry eye. Am J Pathol. 2012 Sep; 181(3):753-60.
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4. Shiboski SC, Shiboski CH, Criswell L, Baer A, Challacombe S, Lanfranchi H, Schiødt M, Umehara H, Vivino F, Zhao Y, Dong Y, Greenspan D, Heidenreich AM, Helin P, Kirkham B, Kitagawa K, Larkin G, Li M, Lietman T, Lindegaard J, McNamara N, Sack K, Shirlaw P, Sugai S, Vollenweider C, Whitcher J, Wu A, Zhang S, Zhang W, Greenspan J, Daniels T. American College of Rheumatology classification criteria for Sjögren's syndrome: a data-driven, expert consensus approach in the Sjögren's International Collaborative Clinical Alliance cohort. Arthritis Care Res (Hoboken). 2012 Apr; 64(4):475-87.
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5. Zhang L, Gallup M, Zlock L, Finkbeiner W, McNamara NA. p120-catenin modulates airway epithelial cell migration induced by cigarette smoke. Biochem Biophys Res Commun. 2012 Jan 6; 417(1):49-55.
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6. Chan MF, Sack R, Quigley DA, Sathe S, Vijmasi T, Li S, Holsclaw D, Strauss EC, McNamara NA. Membrane array analysis of tear proteins in ocular cicatricial pemphigoid. Optom Vis Sci. 2011 Aug; 88(8):1005-9.
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7. Chen YT, Nikulina K, Lazarev S, Bahrami AF, Noble LB, Gallup M, McNamara NA. Interleukin-1 as a phenotypic immunomodulator in keratinizing squamous metaplasia of the ocular surface in Sjögren's syndrome. Am J Pathol. 2010 Sep; 177(3):1333-43.
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8. Chen YT, Gallup M, Nikulina K, Lazarev S, Zlock L, Finkbeiner W, McNamara N. Cigarette smoke induces epidermal growth factor receptor-dependent redistribution of apical MUC1 and junctional beta-catenin in polarized human airway epithelial cells. Am J Pathol. 2010 Sep; 177(3):1255-64.
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9. McNamara NA. Molecular mechanisms of keratinizing ocular surface disease. Optom Vis Sci. 2010 Apr; 87(4):233-8.
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10. Li S, Gallup M, Chen YT, McNamara NA. Molecular mechanism of proinflammatory cytokine-mediated squamous metaplasia in human corneal epithelial cells. Invest Ophthalmol Vis Sci. 2010 May; 51(5):2466-75.
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11. Whitcher JP, Shiboski CH, Shiboski SC, Heidenreich AM, Kitagawa K, Zhang S, Hamann S, Larkin G, McNamara NA, Greenspan JS, Daniels TE. A simplified quantitative method for assessing keratoconjunctivitis sicca from the Sjögren's Syndrome International Registry. Am J Ophthalmol. 2010 Mar; 149(3):405-15.
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12. Liu H, Begley C, Chen M, Bradley A, Bonanno J, McNamara NA, Nelson JD, Simpson T. A link between tear instability and hyperosmolarity in dry eye. Invest Ophthalmol Vis Sci. 2009 Aug; 50(8):3671-9.
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13. Chen YT, Li S, Nikulina K, Porco T, Gallup M, McNamara N. Immune profile of squamous metaplasia development in autoimmune regulator-deficient dry eye. Mol Vis. 2009; 15:563-76.
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14. Sack R, Sathe S, Beaton AR, McNamara N, Fleiszig S, Ni M. Protein array characterization of bioactive proteins secreted by immortalized human corneal epithelium in response to pseudomonas constituents. Curr Eye Res. 2009 Feb; 34(2):92-8.
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15. Li S, Sack R, Vijmasi T, Sathe S, Beaton A, Quigley D, Gallup M, McNamara NA. Antibody protein array analysis of the tear film cytokines. Optom Vis Sci. 2008 Aug; 85(8):653-60.
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16. Li S, Nikulina K, DeVoss J, Wu AJ, Strauss EC, Anderson MS, McNamara NA. Small proline-rich protein 1B (SPRR1B) is a biomarker for squamous metaplasia in dry eye disease. Invest Ophthalmol Vis Sci. 2008 Jan; 49(1):34-41.
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17. Sack R, Conradi L, Beaton A, Sathe S, McNamara N, Leonardi A. Antibody array characterization of inflammatory mediators in allergic and normal tears in the open and closed eye environments. Exp Eye Res. 2007 Oct; 85(4):528-38.
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18. Evans DJ, McNamara NA, Fleiszig SM. Life at the front: dissecting bacterial-host interactions at the ocular surface. Ocul Surf. 2007 Jul; 5(3):213-27.
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19. Maltseva IA, Fleiszig SM, Evans DJ, Kerr S, Sidhu SS, McNamara NA, Basbaum C. Exposure of human corneal epithelial cells to contact lenses in vitro suppresses the upregulation of human beta-defensin-2 in response to antigens of Pseudomonas aeruginosa. Exp Eye Res. 2007 Jul; 85(1):142-53.
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20. Dasari V, Gallup M, Lemjabbar H, Maltseva I, McNamara N. Epithelial-mesenchymal transition in lung cancer: is tobacco the "smoking gun"? Am J Respir Cell Mol Biol. 2006 Jul; 35(1):3-9.
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