John P. Murnane, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
murnane_john

Professor, Department of Radiation Oncology, UCSF
Wun-Kon Fu Endowed Chair in Radiation Oncology, UCSF

jmurnane@radonc.ucsf.edu

Phone: (415) 476-9083 (voice)
Box 0806, UCSF
San Francisco, CA 94143-0806

View on UCSF Profiles


Education

California State University, Northridge, B.S., 1971, Chemistry
University of California, Los Angeles, Ph.D., 1980, Microbiology and Immunology


Professional Experience

  • 1980-1983
    Postdoctoral Fellow, Laboratory of Radiobiology & Environmental Health, University of California, San Francisco
  • 1983-1984
    Asst. Research Biochemist, Laboratory of Radiobiology & Environmental Health, University of California, San Francisco
  • 1991-1995
    Associate Professor, Laboratory of Radiobiology & Environmental Health, University of California, San Francisco
  • 1995-1998
    Associate Professor, Department of Radiation Oncology, University of California, San Francisco
  • 2000-2004
    Assistant Professor, Laboratory of Radiobiology & Environmental Health, University of California, San Francisco
  • 1998-present
    Professor, Department of Radiation Oncology, University of California, San Francisco
  • 2007-present
    Vice Chairman, Department of Radiation Oncology, UCSF

Honors & Awards

  • 2007
    Margolis Lifetime Teaching Award, Department of Radiation Oncology, UCSF
  • 2009
    Wun-Kon Fu Endowed Chair in Radiation Oncology, Dept. of Radiation Oncology, UCSF

Selected Publications

  1. Bakhoum SF, Kabeche L, Murnane JP, Zaki BI, Compton DA. DNA-Damage Response during Mitosis Induces Whole-Chromosome Missegregation. Cancer Discov. 2014 Nov; 4(11):1281-9.
    View on PubMed
  2. Li Z, Hudson FZ, Wang H, Wang Y, Bian Z, Murnane JP, Dynan WS. Increased mutagenic joining of enzymatically-induced DNA double-strand breaks in high-charge and energy particle irradiated human cells. Radiat Res. 2013 Jul; 180(1):17-24.
    View on PubMed
  3. Muraki K, Han L, Miller D, Murnane JP. The role of ATM in the deficiency in nonhomologous end-joining near telomeres in a human cancer cell line. PLoS Genet. 2013 Mar; 9(3):e1003386.
    View on PubMed
  4. Muraki K, Nyhan K, Han L, Murnane JP. Mechanisms of telomere loss and their consequences for chromosome instability. Front Oncol. 2012; 2:135.
    View on PubMed
  5. Reynolds GE, Gao Q, Miller D, Snow BE, Harrington LA, Murnane JP. PIF1 disruption or NBS1 hypomorphism does not affect chromosome healing or fusion resulting from double-strand breaks near telomeres in murine embryonic stem cells. DNA Repair (Amst). 2011 Nov 10; 10(11):1164-73.
    View on PubMed
  6. Murnane JP. Telomere dysfunction and chromosome instability. Mutat Res. 2012 Feb 1; 730(1-2):28-36.
    View on PubMed
  7. Miller D, Reynolds GE, Mejia R, Stark JM, Murnane JP. Subtelomeric regions in mammalian cells are deficient in DNA double-strand break repair. DNA Repair (Amst). 2011 May 5; 10(5):536-44.
    View on PubMed
  8. Murnane JP. Telomere loss as a mechanism for chromosome instability in human cancer. Cancer Res. 2010 Jun 1; 70(11):4255-9.
    View on PubMed
  9. Kulkarni A, Zschenker O, Reynolds G, Miller D, Murnane JP. Effect of telomere proximity on telomere position effect, chromosome healing, and sensitivity to DNA double-strand breaks in a human tumor cell line. Mol Cell Biol. 2010 Feb; 30(3):578-89.
    View on PubMed
  10. Zschenker O, Kulkarni A, Miller D, Reynolds GE, Granger-Locatelli M, Pottier G, Sabatier L, Murnane JP. Increased sensitivity of subtelomeric regions to DNA double-strand breaks in a human cancer cell line. DNA Repair (Amst). 2009 Aug 6; 8(8):886-900.
    View on PubMed
  11. Gao Q, Reynolds GE, Wilcox A, Miller D, Cheung P, Artandi SE, Murnane JP. Telomerase-dependent and -independent chromosome healing in mouse embryonic stem cells. DNA Repair (Amst). 2008 Aug 2; 7(8):1233-49.
    View on PubMed
  12. Ho CY, Murnane JP, Yeung AK, Ng HK, Lo AW. Telomeres acquire distinct heterochromatin characteristics during siRNA-induced RNA interference in mouse cells. Curr Biol. 2008 Feb 12; 18(3):183-7.
    View on PubMed
  13. Gao Q, Reynolds GE, Innes L, Pedram M, Jones E, Junabi M, Gao DW, Ricoul M, Sabatier L, Van Brocklin H, Franc BL, Murnane JP. Telomeric transgenes are silenced in adult mouse tissues and embryo fibroblasts but are expressed in embryonic stem cells. Stem Cells. 2007 Dec; 25(12):3085-92.
    View on PubMed
  14. Hosoi Y, Kapp LN, Murnane JP, Matsumoto Y, Enomoto A, Ono T, Miyagawa K. Suppression of anchorage-independent growth by expression of the ataxia-telangiectasia group D complementing gene, ATDC. Biochem Biophys Res Commun. 2006 Sep 22; 348(2):728-34.
    View on PubMed
  15. Murnane JP. Telomeres and chromosome instability. DNA Repair (Amst). 2006 Sep 8; 5(9-10):1082-92.
    View on PubMed
  16. Bailey SM, Murnane JP. Telomeres, chromosome instability and cancer. Nucleic Acids Res. 2006; 34(8):2408-17.
    View on PubMed
  17. Pedram M, Sprung CN, Gao Q, Lo AW, Reynolds GE, Murnane JP. Telomere position effect and silencing of transgenes near telomeres in the mouse. Mol Cell Biol. 2006 Mar; 26(5):1865-78.
    View on PubMed
  18. Volik S, Raphael BJ, Huang G, Stratton MR, Bignel G, Murnane J, Brebner JH, Bajsarowicz K, Paris PL, Tao Q, Kowbel D, Lapuk A, Shagin DA, Shagina IA, Gray JW, Cheng JF, de Jong PJ, Pevzner P, Collins C. Decoding the fine-scale structure of a breast cancer genome and transcriptome. Genome Res. 2006 Mar; 16(3):394-404.
    View on PubMed
  19. Sabatier L, Ricoul M, Pottier G, Murnane JP. The loss of a single telomere can result in instability of multiple chromosomes in a human tumor cell line. Mol Cancer Res. 2005 Mar; 3(3):139-50.
    View on PubMed
  20. Murnane JP, Sabatier L. Chromosome rearrangements resulting from telomere dysfunction and their role in cancer. Bioessays. 2004 Nov; 26(11):1164-74.
    View on PubMed

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