Sorena Nadaf, MS, MMI

Sorena Nadaf, MS, MMI

Associate Director, Translational Informatics, and Chief Informatics Officer, UCSF Helen Diller Family Comprehensive Cancer Center

Phone: (415) 502-0119 (phone)
Box 0875, UCSF
2340 Sutter St., N315, San Francisco, CA 94143-0875


University of Texas, B.S. Summa Cum Laude, 1990, Molecular Biology
St. Georges School of Medicine N/D 1990 - 1992
University of Texas, M.S. 1996, Computer Science
AMIA NU Medical Informatics, M.MI, 2006, Medical Informatics

Professional Experience

  • 1996- 2008
    Associate Director of Cancer Informatics; CIO, Vanderbilt Ingram Cancer Center
  • 2003 - 2010
    NCI caBIG Program Principle Investigator
  • 2006 - Present
    Editorial Board, Journal of Experimental Biology and Medicine, Interdisciplinary Categories in Genomics, Proteomics, and Bioinformatics
  • 2008 - Present
    Chief Information Officer, UCSF Helen Diller Family Comprehensive Cancer Center (HDFCCC)
  • 2008 - Present
    Associate Director, Translational Bioinformatics, UCSF HDFCCC
  • 2008 - Present
    Director, Translational Informatics Shared Resource, UCSF HDFCCC
  • May 2008-Present
    Investigational Trials Resource Steering Committee
  • June 2009-Present
    HDFCCC Director Data Coordinating Center
  • June 2011-Present
    UCSF Clinical Research Infrastructure Advisory Committee
  • Jan 2012-Present
    UCSF Enterprise Data Warehouse Committee
  • Jan 2012-Present
    Chair, UCSF Clinical Research Informatics Infrastructure - OE CRT

Honors & Awards

  • 2007 - 20011
    Chair NCI CTMS Steering Committee
  • 2007 - present
    Leadership Committee, Association of American Medical Colleges Group on Information Resources (AAMC GIR)
  • 2009-2010
    UCSF Biospecimens Task Force Committee
  • 2010
    NCI Advancing Innovation Award – PI NCI Transcend Informatics Project
  • 2011
    UCSF Bioinformatics Task Force Committee
  • 2012
    National Cancer Informatics Program Committee

Selected Publications

  • Almand, B., Resser, J. R., Lindman, B., Nadaf, S., English, N., Clark, J. I., Kwon, E. D., Knight, S. C., Carbone, D. P. and Gabrilovich, D. I. Clinical significance of dendritic cell dysfunction in patients with cancer. Clinical Cancer Research. 6: 1755-66. 2000.
  • Dikov, M. M., Oyama, T., Cheng, P., Takahashi, T., Takahashi, K., Sepetavec, T., Edwards, B., Adachi, Y., Nadaf, S., Daniel, T., Gabrilovich, D. I. and Carbone, D. P. Vascular endothelial growth factor effects on nuclear factor-kappaB activation in hematopoietic progenitor cells. Cancer Research. 61: 2015-21., 2001.
  • Adachi, J., Lee, C-T, Coffee, K., Yamagata, N., Ohm, J., Park, K-H, Dikov, M., Nadaf, S., Arteaga, C., and Carbone, D. P. Effects of genetic blockade of the insulin-like growth factor in human colon cancer cell lines. Gastroenterology. 123(4):1191-204, 2002.
  • Gabrilovich, D. I., Cheng, P., Fan, Y., Yu, B., Nikitina, E., Sirotkin, A., Shurin, M., Oyama, T., Adachi, Y., Nadaf, S., Carbone, D. P. and Skoultchi, A. I. H1(0) histone and differentiation of dendritic cells. A molecular target for tumor-derived factors. J Leukoc Biol. 72:285-96, 2002.
  • Yanagisawa, K., Shyr, Y., Xu, B. J., Massion, P. P., Larsen, P. H., White, B. C., Roberts, J. R., Edgerton, M., Gonzalez, A., Nadaf, S., Moore, J. H., Caprioli, R. M., and Carbone, D. P. Proteomic patterns of tumour subsets in non-small-cell lung cancer. Lancet. 362: 433-439, 2003.
  • Ohm, J. E., Gabrilovich, D. I., Sempowski, G. D., Kisseleva, E., Parman, K. S., Nadaf, S. and Carbone, D. P. VEGF inhibits T-cell development and may contribute to tumor-induced immune suppression. Blood. 101:4878-86, 2003.
  • Yamagata, N., Shyr, Y., Yanagisawa, K., Edgerton, M., Dang, T. P., Gonzalez, A., Nadaf, S., Larsen, P. H., Roberts, J. R., Nesbitt, J. C., Jensen, R., Levy, S., Moore, J. H., Minna, J. D., and Carbone, D. A trainingtesting approach to the molecular classification of resected non-small cell lung cancer. Clinical Cancer Research. 9:4695-4704, 2003
  • Lee, C. T., Park, K. H., Yanagisawa, K., Adachi, Y., Ohm, J. E., Nadaf, S., Dikov, M. M., Curiel, D. T., and Carbone, D. P. Combination therapy with conditionally replicating adenovirus and replication defective adenovirus. Cancer Research. 64: 6660-6665, 2004.
  • Amann, J., Kalyankrishna, S., Massion, P. P., Ohm, J.E., Nadaf, S, Girard, L., Shigematsu, H., Peyton, M, Juroske, D., Huang, Y., Kim, Y.H., Pollack, Yanagisawa, K., J.R., Gazdar, A.F., Minna, J.D., Kurie, J.M., and Carbone, D.P. Aberrant EGFR Signaling and Enhanced Sensitivity to EGFR Inhibitors in Lung Cancer. Cancer Research. 65: 226-35, 2005.
  • Dikov, MM, Ohm, JE, Ray, N, Tchekneva, EE, Burlison, J, Moghanaki, D, Nadaf, S and Carbone, DP. Differential roles of vascular endothelial growth factor receptors 1 and 2 in dendritic cell differentiation. Journal of Immunology. 174: 215-22, 2005.
  • Min, Y., Adachi, Y., Yamamoto, H., Imsumran, A., Arimura, Y., Endo, T., Hinoda, Y., Lee, C.T., Nadaf, S., Carbone, D.P., et al. 2005. Insulin-like growth factor I receptor blockade enhances chemotherapy and radiation responses and inhibits tumour growth in human gastric cancer xenografts. Gut. 54:591-600.
  • Carbone DP, Ciernik IF, Kelley MJ, Smith MC, Nadaf S, Kavanaugh D, Maher VE, Stipanov M, Contois D, Johnson BE, Pendleton CD, Seifert B, Carter C, Read EJ, Greenblatt J, Top LE, Kelsey MI, Minna JD, Berzofsky JA. Immunization with mutant p53- and K-ras derived peptides in cancer patients: immune response and clinical outcome. J Clinical Oncology. 2005 Aug 1:23(22): 5099-107.
  • Csiki I, Yanagisawa K, Haruki N, Nadaf S, Morrow JD, Johnson DH, Carbone DP. Thioredoxin-1 modulates transcription of cyclooxygenase-2 via hypoxia-inducible factor-1alpha in non-small cell lung cancer. Cancer Research. 2006 Jan 1;66(1):143-50
  • Oyama T. Sugio K, Uramato H. Kawamoto T. Kagawa N. Nadaf S. Carbone D. Yasumoto K. Cytochorome p450 expression (CYP) in non-small cell lung cancer. Front Biosci. Epub: 2007 Jan 1;12:2299-308
  • Katherine A. Rauen, Anuradha Banerjee, W. Robert Bishop, Jennifer O Lauchle, Frank McCormick, Martin McMahon, Teri Melese, Pamela N. Munster, Sorena Nadaf, Roger J. Packer, Judith Sebolt-Leopold, and David H. Viskochil. Costello and Cardio-Facio-Cutaneous Syndromes: Moving Toward Clinical Trials in RASopathies. American Journal of Medical Genetics: 2011 Apr 1.