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Jay A. Nadel, MD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
nadel_jay

Professor, Departments of Medicine, Physiology, and Radiology, UCSF

jay.nadel@ucsf.edu

Phone: (415) 476-1105 (voice)
Box 0130, UCSF
San Francisco, CA 94143-0130

View on UCSF Profiles


Education

Temple University, Philadelphia, PA, A.B., 1949, Physiology
Jefferson Medical College, Philadelphia, PA, M.D., 1953, Medicine


Professional Experience

  • 1964-present
    Senior Staff Member, Cardiovascular Research Institute, UCSF
  • 1960-1978
    Chief, Pulmonary Function Laboratory, Cardiovasular Research Institute, UCSF
  • 1970-present
    Professor, Department of Medicine, UCSF
  • 1974-present
    Professor, Department of Radiology, UCSF
  • 1977-present
    Professor, Department of Physiology, UCSF
  • 1977-present
    Director, NIH Multidisciplinary Research Training Program in Pulmonary Diseases, CVRI
  • 1979-1997
    Director, NIH Program Project Grant HL-24136
  • 1983-1996
    Director, UCSF Cystic Fibrosis Research Center
  • 1968-1999
    Chief, Section of Pulmonary Diseases, Department of Medicine, UCSF

Honors & Awards

  • 1960
    Gianninni Award
  • 1984
    Clean Air Award, ALA Calif
  • 1984
    California Medal, American Lung Association Calif
  • 1987
    Honorary Member Cal Thoracic Society
  • 1987
    Distinguished Lecturer in Physiology, American College of Chest Physicians
  • 1990
    Pfizer Visiting Professor, Royal Society of Medicine
  • 1991
    Honorary Degree of Medicine and Surgery, University of Ferrara
  • 1992
    Crocker Clean Air Award, American Lung Association
  • 1992
    Sam J. Sills Honorary Lectureship, University of Southern California
  • 1992
    Distinguished Achievement Award, Ben Gurion University
  • 1992
    Robert F. Johnston, M.D., Honorary Lecturer, Philadelphia
  • 1993
    Amberson Honorary Lecturer, American Thoracic Society
  • 1994
    Medal of The University of Helsinki
  • 1994
    Honorary Member, German Society of Pulmonology
  • 1994
    Honorary Member, Finnish Association of Pulmonary Physicians
  • 1996
    Honorary Doctorate of Medicine, University of Lund, Sweden
  • 1997
    Trudeau Medal, American Thoracic Society
  • 1997
    Honorary Degree in Law: Dickinson Law School, Carlisle, PA
  • 1998
    Alumni Achievement Award, Jefferson Medical College (JH Coley Lectureship)
  • 1998
    Best Doctors of America
  • 1999
    Best Doctors of SF Bay Area

Selected Publications

  1. Nadel JA. The CFTR and EGFR relationship in airway vascular growth, and its importance in cystic fibrosis. Eur Respir J. 2013 Dec; 42(6):1438-40.
    View on PubMed
  2. Gelb AF, Yamamoto A, Mauad T, Kollin J, Schein MJ, Nadel JA. Unsuspected mild emphysema in nonsmoking patients with chronic asthma with persistent airway obstruction. J Allergy Clin Immunol. 2014 Jan; 133(1):263-265.e3.
    View on PubMed
  3. Ueki IF, Min-Oo G, Kalinowski A, Ballon-Landa E, Lanier LL, Nadel JA, Koff JL. Respiratory virus-induced EGFR activation suppresses IRF1-dependent interferon ? and antiviral defense in airway epithelium. J Exp Med. 2013 Sep 23; 210(10):1929-36.
    View on PubMed
  4. Kim S, Beyer BA, Lewis C, Nadel JA. Normal CFTR inhibits epidermal growth factor receptor-dependent pro-inflammatory chemokine production in human airway epithelial cells. PLoS One. 2013; 8(8):e72981.
    View on PubMed
  5. Chung KF, Nadel JA, Fontana G. John Widdicombe's contribution to respiratory physiology and cough: reminiscences. Cough. 2013; 9(1):6.
    View on PubMed
  6. Nadel JA. Mucous hypersecretion and relationship to cough. Pulm Pharmacol Ther. 2013 Oct; 26(5):510-3.
    View on PubMed
  7. Kim S, Lewis C, Nadel JA. Epidermal growth factor receptor reactivation induced by E-prostanoid-3 receptor- and tumor necrosis factor-alpha-converting enzyme-dependent feedback exaggerates interleukin-8 production in airway cancer (NCI-H292) cells. Exp Cell Res. 2011 Nov 1; 317(18):2650-60.
    View on PubMed
  8. Kim S, Lewis C, Nadel JA. CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells. J Immunol. 2011 Mar 15; 186(6):3392-400.
    View on PubMed
  9. Burgel PR, Nadel JA. Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases. Eur Respir J. 2008 Oct; 32(4):1068-81.
    View on PubMed
  10. Koff JL, Shao MX, Ueki IF, Nadel JA. Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium. Am J Physiol Lung Cell Mol Physiol. 2008 Jun; 294(6):L1068-75.
    View on PubMed
  11. Nadel JA. Innate immune mucin production via epithelial cell surface signaling: relationship to allergic disease. Curr Opin Allergy Clin Immunol. 2007 Feb; 7(1):57-62.
    View on PubMed
  12. Koff JL, Shao MX, Kim S, Ueki IF, Nadel JA. Pseudomonas lipopolysaccharide accelerates wound repair via activation of a novel epithelial cell signaling cascade. J Immunol. 2006 Dec 15; 177(12):8693-700.
    View on PubMed
  13. Shao MX, Nadel JA. Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme. J Immunol. 2005 Sep 15; 175(6):4009-16.
    View on PubMed
  14. Shao MX, Nadel JA. Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells. Proc Natl Acad Sci U S A. 2005 Jan 18; 102(3):767-72.
    View on PubMed
  15. Nadel JA. COPD. Role of the Airway Epithelium in Defense Against Inhaled Invaders. 2005; 3:285-287.
    View on PubMed
  16. Shao MX, Nakanaga T, Nadel JA. Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-alpha-converting enzyme in human airway epithelial (NCI-H292) cells. Am J Physiol Lung Cell Mol Physiol. 2004 Aug; 287(2):L420-7.
    View on PubMed
  17. Shao MX, Ueki IF, Nadel JA. Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11618-23.
    View on PubMed
  18. Takeyama K, Dabbagh K, Jeong Shim J, Dao-Pick T, Ueki IF, Nadel JA. Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils. J Immunol. 2000 Feb 1; 164(3):1546-52.
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  19. Takeyama K, Dabbagh K, Lee HM, Agustí C, Lausier JA, Ueki IF, Grattan KM, Nadel JA. Epidermal growth factor system regulates mucin production in airways. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):3081-6.
    View on PubMed
  20. Li JD, Dohrman AF, Gallup M, Miyata S, Gum JR, Kim YS, Nadel JA, Prince A, Basbaum CB. Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease. Proc Natl Acad Sci U S A. 1997 Feb 4; 94(3):967-72.
    View on PubMed

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