Jay A. Nadel, MD

Professor, Departments of Medicine, Physiology, and Radiology, UCSF

jay.nadel@ucsf.edu

Phone: (415) 476-1105 (voice)
Box 0130, UCSF
San Francisco, CA 94143-0130

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Education

Temple University, Philadelphia, PA, A.B., 1949, Physiology
Jefferson Medical College, Philadelphia, PA, M.D., 1953, Medicine

Professional Experience

• 1964-present
  Senior Staff Member, Cardiovascular Research Institute, UCSF
• 1960-1978
  Chief, Pulmonary Function Laboratory, Cardiovasular Research Institute, UCSF
• 1970-present
  Professor, Department of Medicine, UCSF
• 1974-present
  Professor, Department of Radiology, UCSF
• 1977-present
  Professor, Department of Physiology, UCSF
• 1977-present
  Director, NIH Multidisciplinary Research Training Program in Pulmonary Diseases, CVRI
• 1979-1997
  Director, NIH Program Project Grant HL-24136
• 1983-1996
  Director, UCSF Cystic Fibrosis Research Center
• 1968-1999
  Chief, Section of Pulmonary Diseases, Department of Medicine, UCSF

Honors & Awards

• 1960
  Gianninni Award
• 1984
  Clean Air Award, ALA Calif
• 1984
  California Medal, American Lung Association Calif
• 1987
  Honorary Member Cal Thoracic Society
• 1987
  Distinguished Lecturer in Physiology, American College of Chest Physicians
• 1990
  Pfizer Visiting Professor, Royal Society of Medicine
• 1991
  Honorary Degree of Medicine and Surgery, University of Ferrara
• 1992
  Crocker Clean Air Award, American Lung Association
• 1992
  Sam J. Sills Honorary Lectureship, University of Southern California
• 1992
  Distinguished Achievement Award, Ben Gurion University
• 1992
  Robert F. Johnston, M.D., Honorary Lecturer, Philadelphia
• 1993
  Amberson Honorary Lecturer, American Thoracic Society
• 1994
  Medal of The University of Helsinki
• 1994
  Honorary Member, German Society of Pulmonology
• 1994
  Honorary Member, Finnish Association of Pulmonary Physicians
• 1996
  Honorary Doctorate of Medicine, University of Lund, Sweden
• 1997
  Trudeau Medal, American Thoracic Society
• 1997
  Honorary Degree in Law: Dickinson Law School, Carlisle, PA
• 1998
  Alumni Achievement Award, Jefferson Medical College (JH Coley Lectureship)
• 1998
  Best Doctors of America
• 1999
  Best Doctors of SF Bay Area

Selected Publications

1. Chung KF, Nadel JA, Fontana G. John Widdicombe's contribution to respiratory physiology and cough: reminiscences. Cough. 2013; 9(1):6.
   View on PubMed
2. Kim S, Lewis C, Nadel JA. Epidermal growth factor receptor reactivation induced by E-prostanoid-3 receptor- and tumor necrosis factor-alpha-converting enzyme-dependent feedback exaggerates interleukin-8 production in airway cancer (NCI-H292) cells. Exp Cell Res. 2011 Nov 1; 317(18):2650-60.
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3. Kim S, Lewis C, Nadel JA. CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells. J Immunol. 2011 Mar 15; 186(6):3392-400.
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4. Burgel PR, Nadel JA. Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases. Eur Respir J. 2008 Oct; 32(4):1068-81.
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5. Koff JL, Shao MX, Ueki IF, Nadel JA. Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium. Am J Physiol Lung Cell Mol Physiol. 2008 Jun; 294(6):L1068-75.
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6. Nadel JA. Innate immune mucin production via epithelial cell surface signaling: relationship to allergic disease. Curr Opin Allergy Clin Immunol. 2007 Feb; 7(1):57-62.
   View on PubMed
7. Koff JL, Shao MX, Kim S, Ueki IF, Nadel JA. Pseudomonas lipopolysaccharide accelerates wound repair via activation of a novel epithelial cell signaling cascade. J Immunol. 2006 Dec 15; 177(12):8693-700.
   View on PubMed
8. Shao MX, Nadel JA. Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme. J Immunol. 2005 Sep 15; 175(6):4009-16.
   View on PubMed
9. Shao MX, Nadel JA. Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells. Proc Natl Acad Sci U S A. 2005 Jan 18; 102(3):767-72.
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10. Nadel JA. COPD. Role of the Airway Epithelium in Defense Against Inhaled Invaders. 2005; 3:285-287.
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11. Shao MX, Nakanaga T, Nadel JA. Cigarette smoke induces MUC5AC mucin overproduction via tumor necrosis factor-alpha-converting enzyme in human airway epithelial (NCI-H292) cells. Am J Physiol Lung Cell Mol Physiol. 2004 Aug; 287(2):L420-7.
    View on PubMed
12. Shao MX, Ueki IF, Nadel JA. Tumor necrosis factor alpha-converting enzyme mediates MUC5AC mucin expression in cultured human airway epithelial cells. Proc Natl Acad Sci U S A. 2003 Sep 30; 100(20):11618-23.
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13. Takeyama K, Dabbagh K, Jeong Shim J, Dao-Pick T, Ueki IF, Nadel JA. Oxidative stress causes mucin synthesis via transactivation of epidermal growth factor receptor: role of neutrophils. J Immunol. 2000 Feb 1; 164(3):1546-52.
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14. Takeyama K, Dabbagh K, Lee HM, Agustí C, Lausier JA, Ueki IF, Grattan KM, Nadel JA. Epidermal growth factor system regulates mucin production in airways. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):3081-6.
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15. Li JD, Dohrman AF, Gallup M, Miyata S, Gum JR, Kim YS, Nadel JA, Prince A, Basbaum CB. Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease. Proc Natl Acad Sci U S A. 1997 Feb 4; 94(3):967-72.
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16. Rosenecker J, Zhang W, Hong K, Lausier J, Geppetti P, Yoshihara S, Papahadjopoulos D, Nadel JA. Increased liposome extravasation in selected tissues: effect of substance P. Proc Natl Acad Sci U S A. 1996 Jul 9; 93(14):7236-41.
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17. Inoue H, Massion PP, Ueki IF, Grattan KM, Hara M, Dohrman AF, Chan B, Lausier JA, Golden JA, Nadel JA. Pseudomonas stimulates interleukin-8 mRNA expression selectively in airway epithelium, in gland ducts, and in recruited neutrophils. Am J Respir Cell Mol Biol. 1994 Dec; 11(6):651-63.
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18. Richman-Eisenstat JB, Jorens PG, Hébert CA, Ueki I, Nadel JA. Interleukin-8: an important chemoattractant in sputum of patients with chronic inflammatory airway diseases. Am J Physiol. 1993 Apr; 264(4 Pt 1):L413-8.
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19. Jorens PG, Graf PD, Ueki IF, Olesch J, Nadel JA. Interleukin-8 induces neutrophil accumulation in the trachea of allergic dogs. Trans Assoc Am Physicians. 1992; 105:190-6.
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20. Nadel JA, Conrad DJ, Ueki IF, Schuster A, Sigal E. Immunocytochemical localization of arachidonate 15-lipoxygenase in erythrocytes, leukocytes, and airway cells. J Clin Invest. 1991 Apr; 87(4):1139-45.
    View on PubMed

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