Jay A. Nadel, MD

Jay A. Nadel, MD

Professor, Departments of Medicine, Physiology, and Radiology, UCSF


Phone: (415) 476-1105 (voice)
Box 0130, UCSF
San Francisco, CA 94143-0130

UCSF Profiles

Cancer Center Membership

Associate Member » Non-aligned

Research Summary

A. Background

• 1968 appointed the first Chief of the Division of Pulmonary Diseases in the Department of Medicine, UCSF

• Lobbied Congress to rename the National Heart Institute to the National Heart and Lung Institute

• Co-Editor of the Murray/Nadel Textbook of Respiratory Medicine

B. Early Areas of Studies

• Chronic airway diseases, including asthma, COPD, and CF

• Air pollutants (sulfur dioxide and ozone)

• Airway epithelium

• Viruses, bacteria, air pollutants, allergens, cigarette smoke

• Na+, Cl¯ exchange mechanism in the airway epithelium

C. Later Areas of Study

• Cell and molecular biology

• Antimuscarinic Therapy of Bronchospasm

• Signaling pathways for mucin production

D. Recent Areas of Study

• EGFR Signaling Pathways

• Modulation of proinflammatory responses

• Viral infections

• CFTR and its role in inflammatory airway diseases

• Bronchiolitis Obliterans Syndrome following lung transplantation


Temple University, Philadelphia, PA, A.B., 1949, Physiology
Jefferson Medical College, Philadelphia, PA, M.D., 1953, Medicine

Professional Experience

  • 1964-present
    Senior Staff Member, Cardiovascular Research Institute, UCSF
  • 1960-1978
    Chief, Pulmonary Function Laboratory, Cardiovasular Research Institute, UCSF
  • 1970-present
    Professor, Department of Medicine, UCSF
  • 1974-present
    Professor, Department of Radiology, UCSF
  • 1977-present
    Professor, Department of Physiology, UCSF
  • 1977-present
    Director, NIH Multidisciplinary Research Training Program in Pulmonary Diseases, CVRI
  • 1979-1997
    Director, NIH Program Project Grant HL-24136
  • 1983-1996
    Director, UCSF Cystic Fibrosis Research Center
  • 1968-1999
    Chief, Section of Pulmonary Diseases, Department of Medicine, UCSF

Honors & Awards

  • 1960
    Gianninni Award
  • 1984
    Clean Air Award, ALA Calif
  • 1984
    California Medal, American Lung Association Calif
  • 1987
    Honorary Member Cal Thoracic Society
  • 1987
    Distinguished Lecturer in Physiology, American College of Chest Physicians
  • 1990
    Pfizer Visiting Professor, Royal Society of Medicine
  • 1991
    Honorary Degree of Medicine and Surgery, University of Ferrara
  • 1992
    Crocker Clean Air Award, American Lung Association
  • 1992
    Sam J. Sills Honorary Lectureship, University of Southern California
  • 1992
    Distinguished Achievement Award, Ben Gurion University
  • 1992
    Robert F. Johnston, M.D., Honorary Lecturer, Philadelphia
  • 1993
    Amberson Honorary Lecturer, American Thoracic Society
  • 1994
    Medal of The University of Helsinki
  • 1994
    Honorary Member, German Society of Pulmonology
  • 1994
    Honorary Member, Finnish Association of Pulmonary Physicians
  • 1996
    Honorary Doctorate of Medicine, University of Lund, Sweden
  • 1997
    Trudeau Medal, American Thoracic Society
  • 1997
    Honorary Degree in Law: Dickinson Law School, Carlisle, PA
  • 1998
    Alumni Achievement Award, Jefferson Medical College (JH Coley Lectureship)
  • 1998
    Best Doctors of America
  • 1999
    Best Doctors of SF Bay Area

Selected Publications

  1. Gelb AF, Nadel JA. Affirmation of the adoration of the vagi and role of tiotropium in asthmatic patients. J Allergy Clin Immunol. 2016 Oct; 138(4):1011-1013.
    View on PubMed
  2. Gelb AF, Christenson SA, Nadel JA. Understanding the pathophysiology of the asthma-chronic obstructive pulmonary disease overlap syndrome. Curr Opin Pulm Med. 2016 Mar; 22(2):100-5.
    View on PubMed
  3. Gelb AF, Nadel JA. Understanding the pathophysiology of the asthma-chronic obstructive pulmonary disease overlap syndrome. J Allergy Clin Immunol. 2015 Sep; 136(3):553-5.
    View on PubMed
  4. Gelb AF, Yamamoto A, Verbeken EK, Nadel JA. Unraveling the Pathophysiology of the Asthma-COPD Overlap Syndrome: Unsuspected Mild Centrilobular Emphysema Is Responsible for Loss of Lung Elastic Recoil in Never Smokers With Asthma With Persistent Expiratory Airflow Limitation. Chest. 2015 Aug; 148(2):313-20.
    View on PubMed
  5. Kalinowski A, Ueki I, Min-Oo G, Ballon-Landa E, Knoff D, Galen B, Lanier LL, Nadel JA, Koff JL. EGFR activation suppresses respiratory virus-induced IRF1-dependent CXCL10 production. Am J Physiol Lung Cell Mol Physiol. 2014 Jul 15; 307(2):L186-96.
    View on PubMed
  6. Nadel JA. The CFTR and EGFR relationship in airway vascular growth, and its importance in cystic fibrosis. Eur Respir J. 2013 Dec; 42(6):1438-40.
    View on PubMed
  7. Gelb AF, Yamamoto A, Mauad T, Kollin J, Schein MJ, Nadel JA. Unsuspected mild emphysema in nonsmoking patients with chronic asthma with persistent airway obstruction. J Allergy Clin Immunol. 2014 Jan; 133(1):263-5.e1-3.
    View on PubMed
  8. Ueki IF, Min-Oo G, Kalinowski A, Ballon-Landa E, Lanier LL, Nadel JA, Koff JL. Respiratory virus-induced EGFR activation suppresses IRF1-dependent interferon ? and antiviral defense in airway epithelium. J Exp Med. 2013 Sep 23; 210(10):1929-36.
    View on PubMed
  9. Kim S, Beyer BA, Lewis C, Nadel JA. Normal CFTR inhibits epidermal growth factor receptor-dependent pro-inflammatory chemokine production in human airway epithelial cells. PLoS One. 2013; 8(8):e72981.
    View on PubMed
  10. Chung KF, Nadel JA, Fontana G. John Widdicombe's contribution to respiratory physiology and cough: reminiscences. Cough. 2013; 9(1):6.
    View on PubMed
  11. Nadel JA. Mucous hypersecretion and relationship to cough. Pulm Pharmacol Ther. 2013 Oct; 26(5):510-3.
    View on PubMed
  12. Kim S, Lewis C, Nadel JA. Epidermal growth factor receptor reactivation induced by E-prostanoid-3 receptor- and tumor necrosis factor-alpha-converting enzyme-dependent feedback exaggerates interleukin-8 production in airway cancer (NCI-H292) cells. Exp Cell Res. 2011 Nov 1; 317(18):2650-60.
    View on PubMed
  13. Kim S, Lewis C, Nadel JA. CCL20/CCR6 feedback exaggerates epidermal growth factor receptor-dependent MUC5AC mucin production in human airway epithelial (NCI-H292) cells. J Immunol. 2011 Mar 15; 186(6):3392-400.
    View on PubMed
  14. Burgel PR, Nadel JA. Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases. Eur Respir J. 2008 Oct; 32(4):1068-81.
    View on PubMed
  15. Koff JL, Shao MX, Ueki IF, Nadel JA. Multiple TLRs activate EGFR via a signaling cascade to produce innate immune responses in airway epithelium. Am J Physiol Lung Cell Mol Physiol. 2008 Jun; 294(6):L1068-75.
    View on PubMed
  16. Nadel JA. Innate immune mucin production via epithelial cell surface signaling: relationship to allergic disease. Curr Opin Allergy Clin Immunol. 2007 Feb; 7(1):57-62.
    View on PubMed
  17. Koff JL, Shao MX, Kim S, Ueki IF, Nadel JA. Pseudomonas lipopolysaccharide accelerates wound repair via activation of a novel epithelial cell signaling cascade. J Immunol. 2006 Dec 15; 177(12):8693-700.
    View on PubMed
  18. Shao MX, Nadel JA. Neutrophil elastase induces MUC5AC mucin production in human airway epithelial cells via a cascade involving protein kinase C, reactive oxygen species, and TNF-alpha-converting enzyme. J Immunol. 2005 Sep 15; 175(6):4009-16.
    View on PubMed
  19. Shao MX, Nadel JA. Dual oxidase 1-dependent MUC5AC mucin expression in cultured human airway epithelial cells. Proc Natl Acad Sci U S A. 2005 Jan 18; 102(3):767-72.
    View on PubMed
  20. Nadel JA. COPD. Role of the Airway Epithelium in Defense Against Inhaled Invaders. 2005; 3:285-287.
    View on PubMed

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