Stephen L. Nishimura, MD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
nishimura_stephen

Associate Professor, Department of Pathology, UCSF

stephen.nishimura@ucsf.edu

Phone: (415) 206-5906 (voice)
Box 0854, UCSF
San Francisco, CA 94143-0854

View on UCSF Profiles


Education

Wesleyan University, Middletown, CT, B.A., 1981, Chemistry
University of Vermont College of Medicine, M.D., 1988, Medicine
University of California, San Francisco, Resident, 1988-1991, Anatomic and Clinical Pathology
University of California, San Francisco, Fellow, 1991-1995, Molecular Biology

Professional Experience

  • 1981-1983
    Research Asst. in Neuropharmacology, Memorial Sloan-Kettering Cancer Center, NY
  • 1984
    Student Research Fellow in Pharmacology, University of Vermont
  • 1986
    Student Fellowship in Pathology, University of Vermont
  • 1988-1991
    Resident in Anatomic and Clinical Pathology, UCSF
  • 1990
    Chief Resident in Anatomic Pathology, San Francisco General Hospital
  • 1995
    Clinical Instructor in Pathology, San Francisco General Hospital
  • 1995-1999
    Adjunct Assistant Professor in Pathology, University of California, San Francisco
  • 1997-2001
    Consultant, Chiron Corporation, Emeryville, CA
  • 1999-2003
    Assistant Professor in Pathology, in Residence University of California, San Francisco
  • 2003-present
    Associate Professor in Pathology, in Residence, University of California, San Francisco

Honors & Awards

  • 1991
    Research Fellowship, Department of Pathology
  • 1992-93
    College of American Pathologists Foundation Scholar
  • 1993-5
    National Research Service Award (CA09335)
  • 1995-00
    Clinical Investigator Award (KO8 CA63148)
  • 1998
    ACS Institutional Award
  • 1998-00
    American Lung Association, Research Grant
  • 1998
    Edward Livingston Trudeau Scholar
  • 1998
    American Lung Association
  • 1999-01
    American Heart Association, Grant in Aid
  • 2000
    UCSF Academic Senate Award
  • 2000
    UCSF, Research Allocation Committee Award
  • 2001
    Hellman Family Award for Early-Career Faculty

Selected Publications

  1. Minagawa S, Lou J, Seed RI, Cormier A, Wu S, Cheng Y, Murray L, Tsui P, Connor J, Herbst R, Govaerts C, Barker T, Cambier S, Yanagisawa H, Goodsell A, Hashimoto M, Brand OJ, Cheng R, Ma R, McKnelly KJ, Wen W, Hill A, Jablons D, Wolters P, Kitamura H, Araya J, Barczak AJ, Erle DJ, Reichardt LF, Marks JD, Baron JL, Nishimura SL. Selective Targeting of TGF-ß Activation to Treat Fibroinflammatory Airway Disease. Sci Transl Med. 2014 Jun 18; 6(241):241ra79.
    View on PubMed
  2. Lee TH, McKleroy W, Khalifeh-Soltani A, Sakuma S, Lazarev S, Riento K, Nishimura SL, Nichols BJ, Atabai K. Functional genomic screen identifies novel mediators of collagen uptake. Mol Biol Cell. 2014 Mar; 25(5):583-93.
    View on PubMed
  3. Takasaka N, Araya J, Hara H, Ito S, Kobayashi K, Kurita Y, Wakui H, Yoshii Y, Yumino Y, Fujii S, Minagawa S, Tsurushige C, Kojima J, Numata T, Shimizu K, Kawaishi M, Kaneko Y, Kamiya N, Hirano J, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K. Autophagy Induction by SIRT6 through Attenuation of Insulin-like Growth Factor Signaling Is Involved in the Regulation of Human Bronchial Epithelial Cell Senescence. J Immunol. 2014 Feb 1; 192(3):958-68.
    View on PubMed
  4. Publicover J, Gaggar A, Nishimura S, Van Horn CM, Goodsell A, Muench MO, Reinhardt RL, van Rooijen N, Wakil AE, Peters M, Cyster JG, Erle DJ, Rosenthal P, Cooper S, Baron JL. Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B. J Clin Invest. 2013 Sep 3; 123(9):3728-39.
    View on PubMed
  5. Araya J, Kojima J, Takasaka N, Ito S, Fujii S, Hara H, Yanagisawa H, Kobayashi K, Tsurushige C, Kawaishi M, Kamiya N, Hirano J, Odaka M, Morikawa T, Nishimura SL, Kawabata Y, Hano H, Nakayama K, Kuwano K. Insufficient autophagy in idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2013 Jan 1; 304(1):L56-69.
    View on PubMed
  6. Markovics JA, Araya J, Cambier S, Somanath S, Gline S, Jablons D, Hill A, Wolters PJ, Nishimura SL. Interleukin-1beta induces increased transcriptional activation of the transforming growth factor-beta-activating integrin subunit beta8 through altering chromatin architecture. J Biol Chem. 2011 Oct 21; 286(42):36864-74.
    View on PubMed
  7. Numata T, Araya J, Fujii S, Hara H, Takasaka N, Kojima J, Minagawa S, Yumino Y, Kawaishi M, Hirano J, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K. Insulin-dependent phosphatidylinositol 3-kinase/Akt and ERK signaling pathways inhibit TLR3-mediated human bronchial epithelial cell apoptosis. J Immunol. 2011 Jul 1; 187(1):510-9.
    View on PubMed
  8. Kitamura H, Cambier S, Somanath S, Barker T, Minagawa S, Markovics J, Goodsell A, Publicover J, Reichardt L, Jablons D, Wolters P, Hill A, Marks JD, Lou J, Pittet JF, Gauldie J, Baron JL, Nishimura SL. Mouse and human lung fibroblasts regulate dendritic cell trafficking, airway inflammation, and fibrosis through integrin avß8-mediated activation of TGF-ß. J Clin Invest. 2011 Jul; 121(7):2863-75.
    View on PubMed
  9. Publicover J, Goodsell A, Nishimura S, Vilarinho S, Wang ZE, Avanesyan L, Spolski R, Leonard WJ, Cooper S, Baron JL. IL-21 is pivotal in determining age-dependent effectiveness of immune responses in a mouse model of human hepatitis B. J Clin Invest. 2011 Mar; 121(3):1154-62.
    View on PubMed
  10. Minagawa S, Araya J, Numata T, Nojiri S, Hara H, Yumino Y, Kawaishi M, Odaka M, Morikawa T, Nishimura SL, Nakayama K, Kuwano K. Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-ß-induced senescence of human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011 Mar; 300(3):L391-401.
    View on PubMed
  11. Markovics JA, Araya J, Cambier S, Jablons D, Hill A, Wolters PJ, Nishimura SL. Transcription of the transforming growth factor beta activating integrin beta8 subunit is regulated by SP3, AP-1, and the p38 pathway. J Biol Chem. 2010 Aug 6; 285(32):24695-706.
    View on PubMed
  12. Arjomandi M, Seward J, Gotway MB, Nishimura S, Fulton GP, Thundiyil J, King TE, Harber P, Balmes JR. Low prevalence of chronic beryllium disease among workers at a nuclear weapons research and development facility. J Occup Environ Med. 2010 Jun; 52(6):647-52.
    View on PubMed
  13. Araya J, Nishimura SL. Fibrogenic reactions in lung disease. Annu Rev Pathol. 2010; 5:77-98.
    View on PubMed
  14. Su H, Kim H, Pawlikowska L, Kitamura H, Shen F, Cambier S, Markovics J, Lawton MT, Sidney S, Bollen AW, Kwok PY, Reichardt L, Young WL, Yang GY, Nishimura SL. Reduced expression of integrin alphavbeta8 is associated with brain arteriovenous malformation pathogenesis. Am J Pathol. 2010 Feb; 176(2):1018-27.
    View on PubMed
  15. Chesnokova LS, Nishimura SL, Hutt-Fletcher LM. Fusion of epithelial cells by Epstein-Barr virus proteins is triggered by binding of viral glycoproteins gHgL to integrins alphavbeta6 or alphavbeta8. Proc Natl Acad Sci U S A. 2009 Dec 1; 106(48):20464-9.
    View on PubMed
  16. Nishimura SL. Integrin-mediated transforming growth factor-beta activation, a potential therapeutic target in fibrogenic disorders. Am J Pathol. 2009 Oct; 175(4):1362-70.
    View on PubMed
  17. Zhu Y, Cuevas IC, Gabriel RA, Su H, Nishimura S, Gao P, Fields A, Hao Q, Young WL, Yang GY, Boudreau NJ. Restoring transcription factor HoxA5 expression inhibits the growth of experimental hemangiomas in the brain. J Neuropathol Exp Neurol. 2009 Jun; 68(6):626-32.
    View on PubMed
  18. Wilson SM, Barbone D, Yang TM, Jablons DM, Bueno R, Sugarbaker DJ, Nishimura SL, Gordon GJ, Broaddus VC. mTOR mediates survival signals in malignant mesothelioma grown as tumor fragment spheroids. Am J Respir Cell Mol Biol. 2008 Nov; 39(5):576-83.
    View on PubMed
  19. An F, Drummond DC, Wilson S, Kirpotin DB, Nishimura SL, Broaddus VC, Liu B. Targeted drug delivery to mesothelioma cells using functionally selected internalizing human single-chain antibodies. Mol Cancer Ther. 2008 Mar; 7(3):569-78.
    View on PubMed
  20. Vilarinho S, Ogasawara K, Nishimura S, Lanier LL, Baron JL. Blockade of NKG2D on NKT cells prevents hepatitis and the acute immune response to hepatitis B virus. Proc Natl Acad Sci U S A. 2007 Nov 13; 104(46):18187-92.
    View on PubMed

Go to UCSF Profiles, powered by CTSI