Douglas F. Nixon, DPhil

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Education

University College London, University of London, B.Sc. (Hons), 1981, Immunology
Westminster Medical School, London, M.B., B.S., 1984, Medicine and Surgery
University of Oxford, England, M.A., 1991, Immunology
University of Oxford, England, D. Phil., 1992, Immunology

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Professional Experience

• 1989-1993
  Clinical Lecturer, Medicine, University of Oxford, U.K.
• 1993-1995
  Director, Immunotherapy, United Biomedical, Inc., New York
• 1996-1997
  Visiting Scientist, Aaron Diamond AIDS Research Center, New York
• 1997-2000
  Staff Investigator, Aaron Diamond AIDS Research Center, New York
• 1997-2000
  Assistant Professor, The Rockefeller University, New York
• 2000-present
  Associate Investigator, Gladstone Institute of Virology and Immunology, San Francisco
• 2001-2006
  Associate Professor of Medicine (in residence), University of California, San Francisco
• 2006-present
  Professor of Medicine (in residence), University of California, San Francisco

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Selected Publications

1. Sanabani SS, Pessôa R, Soares de Oliveira AC, Martinez VP, Giret MT, de Menezes Succi RC, Carvalho K, Tomiyama CS, Nixon DF, Sabino EC, Kallas EG. Variability of HIV-1 Genomes among Children and Adolescents from São Paulo, Brazil. PLoS One. 2013; 8(5):e62552.
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2. Champiat S, Garrison KE, Raposo RA, Burwitz BJ, Reed J, Tandon R, York VA, Newman LP, Nimityongskul FA, Wilson NA, Almeida RR, Martin JN, Deeks SG, Rosenberg MG, Wiznia AA, Spotts GE, Pilcher CD, Hecht FM, Ostrowski MA, Sacha JB, Nixon DF. T Cells Target APOBEC3 Proteins in Human Immunodeficiency Virus Type 1-Infected Humans and Simian Immunodeficiency Virus-Infected Indian Rhesus Macaques. J Virol. 2013 Jun; 87(11):6073-80.
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3. Batista MD, Tincati C, Milush JM, Ho EL, Ndhlovu LC, York VA, Kallas EG, Kalil J, Keating SM, Norris PJ, Chang D, Unemori P, Leslie KS, Maurer T, Liao W, Nixon DF. CD57 Expression and Cytokine Production by T Cells in Lesional and Unaffected Skin from Patients with Psoriasis. PLoS One. 2013; 8(2):e52144.
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4. Leal FE, Ndhlovu LC, Hasenkrug AM, Bruno FR, Carvalho KI, Wynn-Williams H, Neto WK, Sanabani SS, Segurado AC, Nixon DF, Kallas EG. Expansion in CD39(+) CD4(+) Immunoregulatory T Cells and Rarity of Th17 Cells in HTLV-1 Infected Patients Is Associated with Neurological Complications. PLoS Negl Trop Dis. 2013 Feb; 7(2):e2028.
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5. Jones RB, Leal FE, Hasenkrug AM, Segurado AC, Nixon DF, Ostrowski MA, Kallas EG. Human Endogenous Retrovirus K(HML-2) Gag and Env specific T-cell responses are not detected in HTLV-I-infected subjects using standard peptide screening methods. J Negat Results Biomed. 2013; 12:3.
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6. Perez CL, Milush JM, Buggert M, Eriksson EM, Larsen MV, Liegler T, Hartogensis W, Bacchetti P, Lund O, Hecht FM, Nixon DF, Karlsson AC. Targeting of Conserved Gag-Epitopes in Early HIV Infection Is Associated with Lower Plasma Viral Load and Slower CD4(+) T Cell Depletion. AIDS Res Hum Retroviruses. 2013 Mar; 29(3):602-12.
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7. Batista MD, Ho EL, Kuebler PJ, Milush JM, Lanier LL, Kallas EG, York VA, Chang D, Liao W, Unemori P, Leslie KS, Maurer T, Nixon DF. Skewed distribution of natural killer cells in psoriasis skin lesions. Exp Dermatol. 2013 Jan; 22(1):64-6.
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8. Keh CE, Jha AR, Nzarubara B, Lanar DE, Dutta S, Theisen M, Rosenthal PJ, Dorsey G, Nixon DF, Greenhouse B. Associations between Antibodies to a Panel of Plasmodium falciparum Specific Antigens and Response to Sub-Optimal Antimalarial Therapy in Kampala, Uganda. PLoS One. 2012; 7(12):e52571.
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9. Eriksson EM, Keh CE, Deeks SG, Martin JN, Hecht FM, Nixon DF. Differential Expression of CD96 Surface Molecule Represents CD8(+) T Cells with Dissimilar Effector Function during HIV-1 Infection. PLoS One. 2012; 7(12):e51696.
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10. Jones RB, Garrison KE, Mujib S, Mihajlovic V, Aidarus N, Hunter DV, Martin E, John VM, Zhan W, Faruk NF, Gyenes G, Sheppard NC, Priumboom-Brees IM, Goodwin DA, Chen L, Rieger M, Muscat-King S, Loudon PT, Stanley C, Holditch SJ, Wong JC, Clayton K, Duan E, Song H, Xu Y, Sengupta D, Tandon R, Sacha JB, Brockman MA, Benko E, Kovacs C, Nixon DF, Ostrowski MA. HERV-K-specific T cells eliminate diverse HIV-1/2 and SIV primary isolates. J Clin Invest. 2012 Dec 3; 122(12):4473-89.
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11. Tandon R, Giret MT, Sengupta D, York VA, Wiznia AA, Rosenberg MG, Kallas EG, Ndhlovu LC, Nixon DF. Age-related expansion of Tim-3 expressing T cells in vertically HIV-1 infected children. PLoS One. 2012; 7(9):e45733.
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12. Ormsby CE, Sengupta D, Tandon R, Deeks SG, Martin JN, Jones RB, Ostrowski MA, Garrison KE, Vázquez-Pérez JA, Reyes-Terán G, Nixon DF. Human endogenous retrovirus expression is inversely associated with chronic immune activation in HIV-1 infection. PLoS One. 2012; 7(8):e41021.
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13. Champiat S, Raposo RA, Maness NJ, Lehman JL, Purtell SE, Hasenkrug AM, Miller JC, Dean H, Koff WC, Hong MA, Martin JN, Deeks SG, Spotts GE, Pilcher CD, Hecht FM, Kallas EG, Garrison KE, Nixon DF. Influence of HAART on alternative reading frame immune responses over the course of HIV-1 infection. PLoS One. 2012; 7(6):e39311.
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14. Sacha JB, Kim IJ, Chen L, Ullah JH, Goodwin DA, Simmons HA, Schenkman DI, von Pelchrzim F, Gifford RJ, Nimityongskul FA, Newman LP, Wildeboer S, Lappin PB, Hammond D, Castrovinci P, Piaskowski SM, Reed JS, Beheler KA, Tharmanathan T, Zhang N, Muscat-King S, Rieger M, Fernandes C, Rumpel K, Gardner JP, Gebhard DH, Janies J, Shoieb A, Pierce BG, Trajkovic D, Rakasz E, Rong S, McCluskie M, Christy C, Merson JR, Jones RB, Nixon DF, Ostrowski MA, Loudon PT, Pruimboom-Brees IM, Sheppard NC. Vaccination with cancer- and HIV infection-associated endogenous retrotransposable elements is safe and immunogenic. J Immunol. 2012 Aug 1; 189(3):1467-79.
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15. Sandberg JK, Andersson SK, Bächle SM, Nixon DF, Moll M. HIV-1 Vpu interference with innate cell-mediated immune mechanisms. Curr HIV Res. 2012 Jun; 10(4):327-33.
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16. Gurfein BT, Stamm AW, Bacchetti P, Dallman MF, Nadkarni NA, Milush JM, Touma C, Palme R, Di Borgo CP, Fromentin G, Lown-Hecht R, Konsman JP, Acree M, Premenko-Lanier M, Darcel N, Hecht FM, Nixon DF. The calm mouse: an animal model of stress reduction. Mol Med. 2012; 18:606-17.
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17. Carvalho KI, Bruno FR, Snyder-Cappione JE, Maeda SM, Tomimori J, Xavier MB, Haslett PA, Nixon DF, Kallas EG. Lower numbers of natural killer T cells in HIV-1 and Mycobacterium leprae co-infected patients. Immunology. 2012 May; 136(1):96-102.
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18. Lai OY, Chen H, Michaud HA, Hayashi G, Kuebler PJ, Hultman GK, Ariza ME, Williams MV, Batista MD, Nixon DF, Foerster J, Bowcock AM, Liao W. Protective effect of human endogenous retrovirus K dUTPase variants on psoriasis susceptibility. J Invest Dermatol. 2012 Jul; 132(7):1833-40.
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19. Ndhlovu LC, Lopez-Vergès S, Barbour JD, Jones RB, Jha AR, Long BR, Schoeffler EC, Fujita T, Nixon DF, Lanier LL. Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity. Blood. 2012 Apr 19; 119(16):3734-43.
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20. Chen H, Hayashi G, Lai OY, Dilthey A, Kuebler PJ, Wong TV, Martin MP, Fernandez Vina MA, McVean G, Wabl M, Leslie KS, Maurer T, Martin JN, Deeks SG, Carrington M, Bowcock AM, Nixon DF, Liao W. Psoriasis patients are enriched for genetic variants that protect against HIV-1 disease. PLoS Genet. 2012 Feb; 8(2):e1002514.
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