Scott A. Oakes, MD


Associate Professor of Pathology, UCSF

Phone: (415) 476-1777, 514-3165 (voice)
Box 0511, UCSF
San Francisco, CA 94143-0511

View on UCSF Profiles

Additional Websites


Elmira College, Elmira, NY, B.A., 1993, Biochemistry
University of Connecticut, Farmington, CT, M.D., 1998, Medicine

Professional Experience

  • 1995-1996
    Research Scholar, HHMI, Lymphocyte Cell Biology Section, National Institute of Arthritis, Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD. Advisor: John J. O'Shea, M.D.
  • 1998-2000
    Resident, Anatomic Pathology, Brigham and Women's Hospital, Boston, MA
  • 1998-2002
    Clinical Fellow in Pathology, Harvard Medical School, Boston, MA
  • 2000-2005
    Research Associate, Department of Cancer Immunology & AIDS, Dana-Farber Cancer Institute, Boston, MA. Advisor: Stanley J. Korsmeyer, M.D.
  • 2002-2005
    Instructor in Pathology, Harvard Medical School, Boston, MA.
  • 2005-2012
    Assistant Professor, Department of Pathology, University of California San Francisco
  • 2012-present
    Associate Professor (tenured), Department of Pathology, University of California San Francisco

Honors & Awards

  • 1989
    Salutatorian Scholarship
  • 1990
    Borden Highest Freshman GPA Prize
  • 1991
    Phi Beta Kappa Prize
  • 1992
    Phi Beta Kappa Prize
  • 1992
    Gorman Prize for Most Scholarly Work in Chemistry
  • 1993
    Outstanding Senior Chemistry Award
  • 1993
    Elmira College Valedictorian
  • 1998
    American Endocrine Society Award
  • 1998
    American Endocrine Society Award
  • 2000-2003
    NIH Pathology Training Grant Recipient
  • 2003-2008
    NIH Mentored Clinical Scientist Development Award (K08)
  • 2006-2007
    American Cancer Society Junior Investigator Award
  • 2007-2011
    HHMI Early Career Physician Scientist Award
  • 2012-2015
    American Cancer Society Research Scholar
  • 2013-2015
    Harrington Discovery Institute Scholar-Innovator Award
  • 2013
    Inductee—American Society for Clinical Investigation (ASCI)

Selected Publications

  1. Crane CA, Austgen K, Haberthur K, Hofmann C, Moyes KW, Avanesyan L, Fong L, Campbell MJ, Cooper S, Oakes SA, Parsa AT, Lanier LL. Immune evasion mediated by tumor-derived lactate dehydrogenase induction of NKG2D ligands on myeloid cells in glioblastoma patients. Proc Natl Acad Sci U S A. 2014 Sep 2; 111(35):12823-8.
    View on PubMed
  2. Ghosh R, Wang L, Wang ES, Perera BG, Igbaria A, Morita S, Prado K, Thamsen M, Caswell D, Macias H, Weiberth KF, Gliedt MJ, Alavi MV, Hari SB, Mitra AK, Bhhatarai B, Schürer SC, Snapp EL, Gould DB, German MS, Backes BJ, Maly DJ, Oakes SA, Papa FR. Allosteric Inhibition of the IRE1a RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress. Cell. 2014 Jul 31; 158(3):534-48.
    View on PubMed
  3. van Dis V, Kuijpers M, Haasdijk ED, Teuling E, Oakes SA, Hoogenraad CC, Jaarsma D. Golgi fragmentation precedes neuromuscular denervation and is associated with endosome abnormalities in SOD1-ALS mouse motor neurons. Acta Neuropathol Commun. 2014; 2(1):38.
    View on PubMed
  4. Wang L, Perera BG, Hari SB, Bhhatarai B, Backes BJ, Seeliger MA, Schürer SC, Oakes SA, Papa FR, Maly DJ. Divergent allosteric control of the IRE1a endoribonuclease using kinase inhibitors. Nat Chem Biol. 2012 Dec; 8(12):982-9.
    View on PubMed
  5. Upton JP, Wang L, Han D, Wang ES, Huskey NE, Lim L, Truitt M, McManus MT, Ruggero D, Goga A, Papa FR, Oakes SA. IRE1a cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2. Science. 2012 Nov 9; 338(6108):818-22.
    View on PubMed
  6. Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, Heintz N, Greengard P, Hui S, Tang Q, Trusina A, Oakes SA, Papa FR. IRE1a induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab. 2012 Aug 8; 16(2):250-64.
    View on PubMed
  7. Cheng CK, Gustafson WC, Charron E, Houseman BT, Zunder E, Goga A, Gray NS, Pollok B, Oakes SA, James CD, Shokat KM, Weiss WA, Fan QW. Dual blockade of lipid and cyclin-dependent kinases induces synthetic lethality in malignant glioma. Proc Natl Acad Sci U S A. 2012 Jul 31; 109(31):12722-7.
    View on PubMed
  8. Austgen K, Johnson ET, Park TJ, Curran T, Oakes SA. The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress. Nat Cell Biol. 2012 Jan; 14(1):87-92.
    View on PubMed
  9. Austgen K, Oakes SA, Ganem D. Multiple defects, including premature apoptosis, prevent Kaposi's sarcoma-associated herpesvirus replication in murine cells. J Virol. 2012 Feb; 86(3):1877-82.
    View on PubMed
  10. Shore GC, Papa FR, Oakes SA. Signaling cell death from the endoplasmic reticulum stress response. Curr Opin Cell Biol. 2011 Apr; 23(2):143-9.
    View on PubMed
  11. Fan QW, Cheng C, Hackett C, Feldman M, Houseman BT, Nicolaides T, Haas-Kogan D, James CD, Oakes SA, Debnath J, Shokat KM, Weiss WA. Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci Signal. 2010; 3(147):ra81.
    View on PubMed
  12. Reyes NA, Fisher JK, Austgen K, VandenBerg S, Huang EJ, Oakes SA. Blocking the mitochondrial apoptotic pathway preserves motor neuron viability and function in a mouse model of amyotrophic lateral sclerosis. J Clin Invest. 2010 Oct; 120(10):3673-9.
    View on PubMed
  13. Han D, Lerner AG, Vande Walle L, Upton JP, Xu W, Hagen A, Backes BJ, Oakes SA, Papa FR. IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell. 2009 Aug 7; 138(3):562-75.
    View on PubMed
  14. Upton JP, Austgen K, Nishino M, Coakley KM, Hagen A, Han D, Papa FR, Oakes SA. Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress. Mol Cell Biol. 2008 Jun; 28(12):3943-51.
    View on PubMed
  15. Han D, Upton JP, Hagen A, Callahan J, Oakes SA, Papa FR. A kinase inhibitor activates the IRE1alpha RNase to confer cytoprotection against ER stress. Biochem Biophys Res Commun. 2008 Jan 25; 365(4):777-83.
    View on PubMed
  16. Oakes SA. Mitochondria control calcium entry at the immunological synapse. Proc Natl Acad Sci U S A. 2007 Sep 25; 104(39):15171-2.
    View on PubMed
  17. Oakes SA, Lin SS, Bassik MC. The control of endoplasmic reticulum-initiated apoptosis by the BCL-2 family of proteins. Curr Mol Med. 2006 Feb; 6(1):99-109.
    View on PubMed
  18. Oakes SA, Scorrano L, Opferman JT, Bassik MC, Nishino M, Pozzan T, Korsmeyer SJ. Proapoptotic BAX and BAK regulate the type 1 inositol trisphosphate receptor and calcium leak from the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2005 Jan 4; 102(1):105-10.
    View on PubMed
  19. Oakes SA, Korsmeyer SJ. Untangling the web: mitochondrial fission and apoptosis. Dev Cell. 2004 Oct; 7(4):460-2.
    View on PubMed
  20. Bassik MC, Scorrano L, Oakes SA, Pozzan T, Korsmeyer SJ. Phosphorylation of BCL-2 regulates ER Ca2+ homeostasis and apoptosis. EMBO J. 2004 Mar 10; 23(5):1207-16.
    View on PubMed

Go to UCSF Profiles, powered by CTSI