Charles P. Ordahl, PhD

Charles P. Ordahl, PhD

Professor, Department of Anatomy, UCSF

Phone: (415) 476-4051 (voice)
Box 0452, UCSF
San Francisco, CA 94143-0452

Cancer Center Membership

Associate Member ยป Non-aligned


University of Colorado, Boulder, CO, B.A., 1967, Biology
University of Colorado, Boulder, CO, M.A., 1970, Embryology
Univ. of Colorado Medical School, Denver, CO, Ph.D., 1974, Molecular Biology

Professional Experience

  • 1965-1967
    Undergraduate Student, Department of Biology, University of Colorado, Boulder, Colorado B.A. Zoology, 1967
  • 1967-1969
    Graduate Student, Laboratory of Dr. Bruce Criley, Department of Biology, University of Colorado, Boulder, Colorado M.A. Zoology, 1970
  • 1969-1974
    Predoctoral Student, Laboratory of Dr. William E. Hahn, Department of Anatomy, University of Colorado Medical School, Denver, CO
  • 1974-1977
    Postdoctoral Associate, Laboratory of Dr. Arnold I. Caplan, Department of Biology, Case Western Reserve University, Cleveland, OH
  • 1977-1982
    Assistant Professor, Department of Anatomy, Temple University Medical School, Philadelphia, PA
  • 1982-1988
    Associate Professor, Department of Anatomy, University of California, San Francisco,
  • 1988-present
    Professor, Department of Anatomy, University of California, San Francisco, San Francisco, CA
  • 1990-1991
    Sabbatical visitor with Dr. Nicole Le Douarin, Institut d'Embryologie Cellulaire et Moleculaire, Nogent sur Marne, Paris, France

Honors & Awards

  • NIH Research Career Development Award
  • Basil O'Connor Award March of Dimes
  • Sigma Xi
  • 1991; 1996
    Francois Premier Medallion de College de France
  • 1995; 1998
    Co-Chair and Chair, Myogenesis Gordon Conferences
  • 1997
    Co-Chair Keystone symposium on myogenesis

Selected Publications

  • Long, C.S., C.P. Ordahl, and P.C. Simpson, Alpha 1-adrenergic receptor stimulation of sarcomeric actin isogene transcription in hypertrophy of cultured rat heart muscle cells. J Clin Invest, 1989. 83(3): p. 1078-82.
  • Cooper, T.A. and C.P. Ordahl, Nucleotide substitutions within the cardiac troponin T alternative exon disrupt pre-mRNA alternative splicing. Nucleic Acids Res, 1989. 17(19): p. 7905-21.
  • Mar, J.H. and C.P. Ordahl, M-CAT binding factor, a novel trans-acting factor governing muscle-specific transcription. Mol Cell Biol, 1990. 10(8): p. 4271-83.
  • Antin, P.B., G.C. Karp, and C.P. Ordahl, Transgene expression in the QM myogenic cell line. Dev Biol, 1991. 143(1): p. 122-9.
  • Antin, P.B., J.H. Mar, and C.P. Ordahl, Single cell analysis of transfected gene expression in primary heart cultures containing multiple cell types. Biotechniques, 1988. 6(7): p. 640-2, 645-9.
  • Antin, P.B. and C.P. Ordahl, Isolation and characterization of an avian myogenic cell line. Dev Biol, 1991. 143(1): p. 111-21.
  • Iannello, R.C., J.H. Mar, and C.P. Ordahl, Characterization of a promoter element required for transcription in myocardial cells. J Biol Chem, 1991. 266(5): p. 3309-16.
  • Ordahl, C.P. and N.M. Le Douarin, Two myogenic lineages within the developing somite. Development, 1992. 114(2): p. 339-53.
  • Farrance, I.K., J.H. Mar, and C.P. Ordahl, M-CAT binding factor is related to the SV40 enhancer binding factor, TEF-1. J Biol Chem, 1992. 267(24): p. 17234-40.
  • Farrance, I.K. and C.P. Ordahl, The role of transcription enhancer factor-1 (TEF-1) related proteins in the formation of M-CAT binding complexes in muscle and non-muscle tissues. J Biol Chem, 1996. 271(14): p. 8266-74.
  • Pourquie, O., M. Coltey, M.A. Teillet, C. Ordahl, and N.M. Le Douarin, Control of dorsoventral patterning of somitic derivatives by notochord and floor plate. Proc Natl Acad Sci U S A, 1993. 90(11): p. 5242-6.
  • Stewart, A.F., S.B. Larkin, I.K. Farrance, J.H. Mar, D.E. Hall, and C.P. Ordahl, Muscle-enriched TEF-1 isoforms bind M-CAT elements from muscle-specific promoters and differentially activate transcription. J Biol Chem, 1994. 269(5): p. 3147-50.
  • Williams, B.A. and C.P. Ordahl, Pax-3 expression in segmental mesoderm marks early stages in myogenic cell specification. Development, 1994. 120(4): p. 785-96.
  • Williams, B.A. and C.P. Ordahl, Emergence of determined myotome precursor cells in the somite. Development, 1997. 124(24): p. 4983-97.
  • Williams, B.A. and C.P. Ordahl, Fate restriction in limb muscle precursor cells precedes high-level expression of MyoD family member genes. Development, 2000. 127(12): p. 2523-36.
  • Larkin, S.B., I.K. Farrance, and C.P. Ordahl, Flanking sequences modulate the cell specificity of M-CAT elements. Mol Cell Biol, 1996. 16(7): p. 3742-55.
  • Azakie, A., S.B. Larkin, I.K. Farrance, G. Grenningloh, and C.P. Ordahl, DTEF-1, a novel member of the transcription enhancer factor-1 (TEF-1) multigene family. J Biol Chem, 1996. 271(14): p. 8260-5.
  • Denetclaw, W.F., Jr., B. Christ, and C.P. Ordahl, Location and growth of epaxial myotome precursor cells. Development, 1997. 124(8): p. 1601-10.
  • Denetclaw, W.F. and C.P. Ordahl, The growth of the dermomyotome and formation of early myotome lineages in thoracolumbar somites of chicken embryos. Development, 2000. 127(4): p. 893-905.
  • Denetclaw, W.F., Jr., E. Berdougo, S.J. Venters, and C.P. Ordahl, Morphogenetic cell movements in the middle region of the dermomyotome dorsomedial lip associated with patterning and growth of the primary epaxial myotome. Development, 2001. 128(10): p. 1745-55.
  • Huang, R., Q. Zhi, C.P. Ordahl, and B. Christ, The fate of the first avian somite. Anat Embryol (Berl), 1997. 195(5): p. 435-49.
  • Dockter, J.L. and C.P. Ordahl, Determination of sclerotome to the cartilage fate. Development, 1998. 125(11): p. 2113-24.
  • Dockter, J. and C.P. Ordahl, Dorsoventral axis determination in the somite: a re-examination. Development, 2000. 127(10): p. 2201-6.
  • Butler, A.J. and C.P. Ordahl, Poly(ADP-ribose) polymerase binds with transcription enhancer factor 1 to MCAT1 elements to regulate muscle-specific transcription. Mol Cell Biol, 1999. 19(1): p. 296-306.
  • Ordahl, C.P., E. Berdougo, S.J. Venters, and W.F. Denetclaw, Jr., The dermomyotome dorsomedial lip drives growth and morphogenesis of both the primary myotome and dermomyotome epithelium. Development, 2001. 128(10): p. 1731-44.
  • Venters, S.J. and C.P. Ordahl, Persistent myogenic capacity of the dermomyotome dorsomedial lip and restriction of myogenic competence. Development, 2002. 129(16): p. 3873-85.
  • Tidyman, W.E., A.J. Sehnert, A. Huq, J. Agard, F. Deegan, D.Y. Stainier, and C.P. Ordahl, In vivo regulation of the chicken cardiac troponin T gene promoter in zebrafish embryos. Dev Dyn, 2003. 227(4): p. 484-96.
  • Kun, E., E. Kirsten, and C.P. Ordahl, Coenzymatic activity of randomly broken or intact double-stranded DNAs in auto and histone H1 trans-poly(ADP-ribosylation), catalyzed by poly(ADP-ribose) polymerase (PARP I). J Biol Chem, 2002. 277(42): p. 39066-9.
  • Kun, E., E. Kirsten, J. Mendeleyev, and C.P. Ordahl, Regulation of the enzymatic catalysis of poly(ADP-ribose) polymerase by dsDNA, polyamines, Mg2+, Ca2+, histones H1 and H3, and ATP. Biochemistry, 2004. 43(1): p. 210-6.
  • Huang, K., W.E. Tidyman, K.U. Le, E. Kirsten, E. Kun, and C.P. Ordahl, Analysis of nucleotide sequence-dependent DNA binding of poly(ADP-ribose) polymerase in a purified system. Biochemistry, 2004. 43(1): p. 217-23.
  • Venters, S.J., Argent, R.E., Deegan, F.M., Perez,Baron, G., Wong, T.S., Tidyman, W.E., Denetclaw, Jr., W.F., Marcelle, C., Bronner-Fraser, M., and C.P. Ordahl, Precocious terminal differentiation of premigratory limb muscle precursor cells requires positive signaling. Dev Dyn, 2004, 229: p. 591-99.