University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Charles P. Ordahl, PhD

Charles P. Ordahl, PhD

Professor, Department of Anatomy, UCSF


University of Colorado, Boulder, CO, B.A., 1967, Biology
University of Colorado, Boulder, CO, M.A., 1970, Embryology
Univ. of Colorado Medical School, Denver, CO, Ph.D., 1974, Molecular Biology

Professional Experience

  • 1965-1967
    Undergraduate Student, Department of Biology, University of Colorado, Boulder, Colorado B.A. Zoology, 1967
  • 1967-1969
    Graduate Student, Laboratory of Dr. Bruce Criley, Department of Biology, University of Colorado, Boulder, Colorado M.A. Zoology, 1970
  • 1969-1974
    Predoctoral Student, Laboratory of Dr. William E. Hahn, Department of Anatomy, University of Colorado Medical School, Denver, CO
  • 1974-1977
    Postdoctoral Associate, Laboratory of Dr. Arnold I. Caplan, Department of Biology, Case Western Reserve University, Cleveland, OH
  • 1977-1982
    Assistant Professor, Department of Anatomy, Temple University Medical School, Philadelphia, PA
  • 1982-1988
    Associate Professor, Department of Anatomy, University of California, San Francisco,
  • 1988-present
    Professor, Department of Anatomy, University of California, San Francisco, San Francisco, CA
  • 1990-1991
    Sabbatical visitor with Dr. Nicole Le Douarin, Institut d'Embryologie Cellulaire et Moleculaire, Nogent sur Marne, Paris, France

Honors & Awards

  • NIH Research Career Development Award
  • Basil O'Connor Award March of Dimes
  • Sigma Xi
  • 1991; 1996
    Francois Premier Medallion de College de France
  • 1995; 1998
    Co-Chair and Chair, Myogenesis Gordon Conferences
  • 1997
    Co-Chair Keystone symposium on myogenesis

Selected Publications

  • Long, C.S., C.P. Ordahl, and P.C. Simpson, Alpha 1-adrenergic receptor stimulation of sarcomeric actin isogene transcription in hypertrophy of cultured rat heart muscle cells. J Clin Invest, 1989. 83(3): p. 1078-82.
  • Cooper, T.A. and C.P. Ordahl, Nucleotide substitutions within the cardiac troponin T alternative exon disrupt pre-mRNA alternative splicing. Nucleic Acids Res, 1989. 17(19): p. 7905-21.
  • Mar, J.H. and C.P. Ordahl, M-CAT binding factor, a novel trans-acting factor governing muscle-specific transcription. Mol Cell Biol, 1990. 10(8): p. 4271-83.
  • Antin, P.B., G.C. Karp, and C.P. Ordahl, Transgene expression in the QM myogenic cell line. Dev Biol, 1991. 143(1): p. 122-9.
  • Antin, P.B., J.H. Mar, and C.P. Ordahl, Single cell analysis of transfected gene expression in primary heart cultures containing multiple cell types. Biotechniques, 1988. 6(7): p. 640-2, 645-9.
  • Antin, P.B. and C.P. Ordahl, Isolation and characterization of an avian myogenic cell line. Dev Biol, 1991. 143(1): p. 111-21.
  • Iannello, R.C., J.H. Mar, and C.P. Ordahl, Characterization of a promoter element required for transcription in myocardial cells. J Biol Chem, 1991. 266(5): p. 3309-16.
  • Ordahl, C.P. and N.M. Le Douarin, Two myogenic lineages within the developing somite. Development, 1992. 114(2): p. 339-53.
  • Farrance, I.K., J.H. Mar, and C.P. Ordahl, M-CAT binding factor is related to the SV40 enhancer binding factor, TEF-1. J Biol Chem, 1992. 267(24): p. 17234-40.
  • Farrance, I.K. and C.P. Ordahl, The role of transcription enhancer factor-1 (TEF-1) related proteins in the formation of M-CAT binding complexes in muscle and non-muscle tissues. J Biol Chem, 1996. 271(14): p. 8266-74.
  • Pourquie, O., M. Coltey, M.A. Teillet, C. Ordahl, and N.M. Le Douarin, Control of dorsoventral patterning of somitic derivatives by notochord and floor plate. Proc Natl Acad Sci U S A, 1993. 90(11): p. 5242-6.
  • Stewart, A.F., S.B. Larkin, I.K. Farrance, J.H. Mar, D.E. Hall, and C.P. Ordahl, Muscle-enriched TEF-1 isoforms bind M-CAT elements from muscle-specific promoters and differentially activate transcription. J Biol Chem, 1994. 269(5): p. 3147-50.
  • Williams, B.A. and C.P. Ordahl, Pax-3 expression in segmental mesoderm marks early stages in myogenic cell specification. Development, 1994. 120(4): p. 785-96.
  • Williams, B.A. and C.P. Ordahl, Emergence of determined myotome precursor cells in the somite. Development, 1997. 124(24): p. 4983-97.
  • Williams, B.A. and C.P. Ordahl, Fate restriction in limb muscle precursor cells precedes high-level expression of MyoD family member genes. Development, 2000. 127(12): p. 2523-36.
  • Larkin, S.B., I.K. Farrance, and C.P. Ordahl, Flanking sequences modulate the cell specificity of M-CAT elements. Mol Cell Biol, 1996. 16(7): p. 3742-55.
  • Azakie, A., S.B. Larkin, I.K. Farrance, G. Grenningloh, and C.P. Ordahl, DTEF-1, a novel member of the transcription enhancer factor-1 (TEF-1) multigene family. J Biol Chem, 1996. 271(14): p. 8260-5.
  • Denetclaw, W.F., Jr., B. Christ, and C.P. Ordahl, Location and growth of epaxial myotome precursor cells. Development, 1997. 124(8): p. 1601-10.
  • Denetclaw, W.F. and C.P. Ordahl, The growth of the dermomyotome and formation of early myotome lineages in thoracolumbar somites of chicken embryos. Development, 2000. 127(4): p. 893-905.
  • Denetclaw, W.F., Jr., E. Berdougo, S.J. Venters, and C.P. Ordahl, Morphogenetic cell movements in the middle region of the dermomyotome dorsomedial lip associated with patterning and growth of the primary epaxial myotome. Development, 2001. 128(10): p. 1745-55.
  • Huang, R., Q. Zhi, C.P. Ordahl, and B. Christ, The fate of the first avian somite. Anat Embryol (Berl), 1997. 195(5): p. 435-49.
  • Dockter, J.L. and C.P. Ordahl, Determination of sclerotome to the cartilage fate. Development, 1998. 125(11): p. 2113-24.
  • Dockter, J. and C.P. Ordahl, Dorsoventral axis determination in the somite: a re-examination. Development, 2000. 127(10): p. 2201-6.
  • Butler, A.J. and C.P. Ordahl, Poly(ADP-ribose) polymerase binds with transcription enhancer factor 1 to MCAT1 elements to regulate muscle-specific transcription. Mol Cell Biol, 1999. 19(1): p. 296-306.
  • Ordahl, C.P., E. Berdougo, S.J. Venters, and W.F. Denetclaw, Jr., The dermomyotome dorsomedial lip drives growth and morphogenesis of both the primary myotome and dermomyotome epithelium. Development, 2001. 128(10): p. 1731-44.
  • Venters, S.J. and C.P. Ordahl, Persistent myogenic capacity of the dermomyotome dorsomedial lip and restriction of myogenic competence. Development, 2002. 129(16): p. 3873-85.
  • Tidyman, W.E., A.J. Sehnert, A. Huq, J. Agard, F. Deegan, D.Y. Stainier, and C.P. Ordahl, In vivo regulation of the chicken cardiac troponin T gene promoter in zebrafish embryos. Dev Dyn, 2003. 227(4): p. 484-96.
  • Kun, E., E. Kirsten, and C.P. Ordahl, Coenzymatic activity of randomly broken or intact double-stranded DNAs in auto and histone H1 trans-poly(ADP-ribosylation), catalyzed by poly(ADP-ribose) polymerase (PARP I). J Biol Chem, 2002. 277(42): p. 39066-9.
  • Kun, E., E. Kirsten, J. Mendeleyev, and C.P. Ordahl, Regulation of the enzymatic catalysis of poly(ADP-ribose) polymerase by dsDNA, polyamines, Mg2+, Ca2+, histones H1 and H3, and ATP. Biochemistry, 2004. 43(1): p. 210-6.
  • Huang, K., W.E. Tidyman, K.U. Le, E. Kirsten, E. Kun, and C.P. Ordahl, Analysis of nucleotide sequence-dependent DNA binding of poly(ADP-ribose) polymerase in a purified system. Biochemistry, 2004. 43(1): p. 217-23.
  • Venters, S.J., Argent, R.E., Deegan, F.M., Perez,Baron, G., Wong, T.S., Tidyman, W.E., Denetclaw, Jr., W.F., Marcelle, C., Bronner-Fraser, M., and C.P. Ordahl, Precocious terminal differentiation of premigratory limb muscle precursor cells requires positive signaling. Dev Dyn, 2004, 229: p. 591-99.