Pamela L. Paris, PhD

Associate Adjunct Professor, Department of Urology, UCSF

pparis@cc.ucsf.edu

Phone: (415) 514-2559 (voice)
Box 3110, UCSF
San Francisco, CA 94143-3110

View on UCSF Profiles

Education

John Carroll University, Cleveland, Ohio, B.S., 1992, Chemistry
University of Rochester, Rochester, New York, M.S., 1995, Biophysical Chemistry
University of Rochester, Rochester, New York, Ph.D., 1998, Biophysical Chemistry
Cleveland Clinic Foundation, Cleveland, Ohio, Postdoc, 1998-2001, Prostate cancer genetics
University of California at San Francisco, San Francisco, California, Postdoc, 2001-2003, Prostate cancer genomics

Professional Experience

• 1993-1998
  Graduate Student, University of Rochester, Rochester, New York (Advisor: Eric T. Kool)
• 1998-2001
  Postdoctoral Research Fellow, Cleveland Clinic Foundation, Lerner Research Institute, Cancer Biology Department, Cleveland, Ohio
• 2001-2003
  Translational Research Fellow, Prostate SPORE, Dept of Urology, UCSF, San Francisco, CA
• 2003-2006
  Assistant Researcher, UCSF Comprehensive Cancer Center, San Francisco, California
• 2006-2009
  Associate Researcher, Department of Urology, UCSF, San Francisco, California
• 2009-present
  Associate Adjunct Professor, Department of Urology, UCSF, San Francisco, California
• 2010-present
  Joint Appointment, Division of Hematology-Oncology, Department of Medicine, UCSF

Honors & Awards

• 1990
  Phi Lambda Upsilon, Honorary Chemical Society
• 1992
  Magna cum laude
• 1993-1998
  Sherman Clarke Fellow
• 1995-1996
  Merck Fellow
• 2000
  Society for Basic Urologic Research Travel Award
• 2001-2003
  UCSF Prostate Cancer Research Fellow
• 2003-present
  NCI Cancer Prevention and Epidemiology Review Committee
• 2005
  Gordon Research Conference (New Frontiers: Cancer Detection and Diagnosis) Poster Award
• 2005
  UCSF, Prostate Cancer Annual Retreat, Poster Award
• 2008
  Longevity Consortium Member

Selected Publications

1. Friedlander TW, Roy R, Tomlins SA, Ngo VT, Kobayashi Y, Azameera A, Rubin MA, Pienta KJ, Chinnaiyan A, Ittmann MM, Ryan CJ, Paris PL. Common structural and epigenetic changes in the genome of castration-resistant prostate cancer. Cancer Res. 2012 Feb 1; 72(3):616-25.
   View on PubMed
2. Ritz A, Paris PL, Ittmann MM, Collins C, Raphael BJ. Detection of recurrent rearrangement breakpoints from copy number data. BMC Bioinformatics. 2011; 12:114.
   View on PubMed
3. Paris PL, Weinberg V, Albo G, Roy R, Burke C, Simko J, Carroll P, Collins C. A group of genome-based biomarkers that add to a Kattan nomogram for predicting progression in men with high-risk prostate cancer. Clin Cancer Res. 2010 Jan 1; 16(1):195-202.
   View on PubMed
4. Paris PL, Kobayashi Y, Zhao Q, Zeng W, Sridharan S, Fan T, Adler HL, Yera ER, Zarrabi MH, Zucker S, Simko J, Chen WT, Rosenberg J. Functional phenotyping and genotyping of circulating tumor cells from patients with castration resistant prostate cancer. Cancer Lett. 2009 May 18; 277(2):164-73.
   View on PubMed
5. Paris PL. A whole-genome amplification protocol for a wide variety of DNAs, including those from formalin-fixed and paraffin-embedded tissue. Methods Mol Biol. 2009; 556:89-98.
   View on PubMed
6. Paris PL, Sridharan S, Hittelman AB, Kobayashi Y, Perner S, Huang G, Simko J, Carroll P, Rubin MA, Collins C. An oncogenic role for the multiple endocrine neoplasia type 1 gene in prostate cancer. Prostate Cancer Prostatic Dis. 2009; 12(2):184-91.
   View on PubMed
7. Mosquera JM, Perner S, Genega EM, Sanda M, Hofer MD, Mertz KD, Paris PL, Simko J, Bismar TA, Ayala G, Shah RB, Loda M, Rubin MA. Characterization of TMPRSS2-ERG fusion high-grade prostatic intraepithelial neoplasia and potential clinical implications. Clin Cancer Res. 2008 Jun 1; 14(11):3380-5.
   View on PubMed
8. Raphael BJ, Volik S, Yu P, Wu C, Huang G, Linardopoulou EV, Trask BJ, Waldman F, Costello J, Pienta KJ, Mills GB, Bajsarowicz K, Kobayashi Y, Sridharan S, Paris PL, Tao Q, Aerni SJ, Brown RP, Bashir A, Gray JW, Cheng JF, de Jong P, Nefedov M, Ried T, Padilla-Nash HM, Collins CC. A sequence-based survey of the complex structural organization of tumor genomes. Genome Biol. 2008; 9(3):R59.
   View on PubMed
9. Hittelman A, Sridharan S, Roy R, Fridlyand J, Loda M, Collins C, Paris PL. Evaluation of whole genome amplification protocols for array and oligonucleotide CGH. Diagn Mol Pathol. 2007 Dec; 16(4):198-206.
   View on PubMed
10. Paris PL, Sridharan S, Scheffer A, Tsalenko A, Bruhn L, Collins C. High resolution oligonucleotide CGH using DNA from archived prostate tissue. Prostate. 2007 Sep 15; 67(13):1447-55.
    View on PubMed
11. Perner S, Mosquera JM, Demichelis F, Hofer MD, Paris PL, Simko J, Collins C, Bismar TA, Chinnaiyan AM, De Marzo AM, Rubin MA. TMPRSS2-ERG fusion prostate cancer: an early molecular event associated with invasion. Am J Surg Pathol. 2007 Jun; 31(6):882-8.
    View on PubMed
12. Mosquera JM, Perner S, Demichelis F, Kim R, Hofer MD, Mertz KD, Paris PL, Simko J, Collins C, Bismar TA, Chinnaiyan AM, Rubin MA. Morphological features of TMPRSS2-ERG gene fusion prostate cancer. J Pathol. 2007 May; 212(1):91-101.
    View on PubMed
13. Paris PL, Hofer MD, Albo G, Kuefer R, Gschwend JE, Hautmann RE, Fridyland J, Simko J, Carroll PR, Rubin MA, Collins C. Genomic profiling of hormone-naïve lymph node metastases in patients with prostate cancer. Neoplasia. 2006 Dec; 8(12):1083-9.
    View on PubMed
14. Volik S, Raphael BJ, Huang G, Stratton MR, Bignel G, Murnane J, Brebner JH, Bajsarowicz K, Paris PL, Tao Q, Kowbel D, Lapuk A, Shagin DA, Shagina IA, Gray JW, Cheng JF, de Jong PJ, Pevzner P, Collins C. Decoding the fine-scale structure of a breast cancer genome and transcriptome. Genome Res. 2006 Mar; 16(3):394-404.
    View on PubMed
15. Paris PL, Weinberg V, Simko J, Andaya A, Albo G, Rubin MA, Carroll PR, Collins C. Preliminary evaluation of prostate cancer metastatic risk biomarkers. Int J Biol Markers. 2005 Jul-Sep; 20(3):141-5.
    View on PubMed
16. van Duin M, van Marion R, Watson JE, Paris PL, Lapuk A, Brown N, Oseroff VV, Albertson DG, Pinkel D, de Jong P, Nacheva EP, Dinjens W, van Dekken H, Collins C. Construction and application of a full-coverage, high-resolution, human chromosome 8q genomic microarray for comparative genomic hybridization. Cytometry A. 2005; 63(1):10-9.
    View on PubMed
17. Macoska JA, Paris P, Collins C, Andaya A, Beheshti B, Chaib H, Kant R, Begley L, MacDonald JW, Squire JA. Evolution of 8p loss in transformed human prostate epithelial cells. Cancer Genet Cytogenet. 2004 Oct 1; 154(1):36-43.
    View on PubMed
18. Watson JE, Kamkar S, James K, Kowbel D, Andaya A, Paris PL, Simko J, Carroll P, McAlhany S, Rowley D, Collins C. Molecular analysis of WFDC1/ps20 gene in prostate cancer. Prostate. 2004 Oct 1; 61(2):192-9.
    View on PubMed
19. Zhou Y, Huang D, Paris PL, Sauter CS, Prock KA, Hoffman GS. An analysis of CTLA-4 and proinflammatory cytokine genes in Wegener's granulomatosis. Arthritis Rheum. 2004 Aug; 50(8):2645-50.
    View on PubMed
20. Rubin MA, Varambally S, Beroukhim R, Tomlins SA, Rhodes DR, Paris PL, Hofer MD, Storz-Schweizer M, Kuefer R, Fletcher JA, Hsi BL, Byrne JA, Pienta KJ, Collins C, Sellers WR, Chinnaiyan AM. Overexpression, amplification, and androgen regulation of TPD52 in prostate cancer. Cancer Res. 2004 Jun 1; 64(11):3814-22.
    View on PubMed

View on UCSF Profiles