Anders Persson, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Anders Persson, PhD

Assistant Professor In-Residence, Departments of Neurology and Neurological Surgery, UCSF

anders.persson@ucsf.edu

Phone: (415) 502-7178

UCSF Profiles | Lab Website

Cancer Center Membership

Program Member » Neurologic Oncology» Pediatric Malignancies

Research Summary

With a research background in neural stem cell (NSC) biology, I have dedicated the past eleven years to the study of the cell of origin and biology of gliomas. As a postdoctoral fellow in the laboratory of HDFCCC investigator William Weiss, I co-published three articles in the journal Cancer Cell. We and others found that oligodendrocyte progenitor cells (OPCs) can give rise to oligodendroglioma. We also found that introduction of an identical oncogene in forebrain and hindbrain NSCs produce different types of brain tumors.
As an Associate Member of the HDFCCC, I established a laboratory at the UCSF Sandler Neuroscience Center in 2012. Our group works with HDFCCC members on genetically engineered mouse (GEM) models of glioma and human glioma xenografts to identify the earliest events that drive glioma formation in a cell type-specific manner, and when targeted, can serve as therapies to improve survival in patients. In collaboration with basic scientists and clinicians at the HDFCCC, our translational work has identified dormant GBM cells that share properties with quiescent NSCs, displaying increased resistance to radiation and chemotherapy, the standard treatment in GBM patients. To target dormant GBM cells, we are focusing on priming regimens that sensitize tumors to therapies. We have previously shown that microRNA-124 (miR-124), a small non-coding RNA, induces neuron production in mouse NSCs and NSC-like human GBM cells. We are currently collaborating with Dr. Jakobsson in Lund, Sweden, to test whether miR-124 overexpression inhibits initiation and progression of GBM, and increases sensitivity to radiation in developing tumors. We are working with teams at the HDFCCC to test whether translation control through MAPK-dependent regulation of mRNA recruitment to polyribosomes and the RISC is a critical component for gliomagenesis.
As a PI and co-investigator on several university and NIH-funded grants, I have established national and international collaborations to access reagents and expertise for our ongoing projects. As a co-project leader of the NIH-supported U54 Tumor Microenvironment collaboration at the HDFCCC, we find that elevated compression drives GBM growth and is a barrier to drug uptake. Given the robust regulation of non-coding RNAs during compression-induced proliferation, our laboratory is heavily invested in translational control of tumor biology in glioma. Our work will link the origin of gliomas, non-coding RNAs, translation control, and novel therapeutics.

Education

Fassberg Senior High School (Sweden) 06/92 Natural Science
Gothenburg University (Gothenburg,Sweden) M.S. 06/99 Biochemistry
Gothenburg University (Gothenburg,Sweden) Ph.D. 11/03 Neurobiology
University of California, San Francisco Fellow 08/08 Brain Tumors


Professional Experience

  • 2004 - 2005
    Research Associate, Department of Rehabilitation Medicine, Sahlgrenska Hospital, Sweden
  • 2004 - 2005
    Principal Investigator at Institute of Clinical Neuroscience and Physiology, University of Gothenburg, Sweden
  • 2005 - 2008
    Postdoctoral Fellow, Department of Neurology, UCSF
  • 2008 - 2011
    Assistant Adjunct Professor, Department of Neurology, UCSF
  • 2012-present
    Assistant Professor In-Residence, Departments of Neurology and Neurological Surgery, UCSF

Honors & Awards


  • 2005
    Swedish Society of Medicine
  • 2005
    Swedish Society for Medical Research
  • 2005 - 2006
    Swedish Brain Tumor Foundation
  • 2005 - 2007
    Swedish Society for Medical Research
  • 2008
    Sandler Postdoctoral Fellowship
  • 2008 - 2010
    American Brain Tumor Association Fellowship
  • 2010
    American Brain Tumor Association Translational Award
  • 2010
    Hellman Family Foundation Early-Career Award
  • 2011
    UCSF SPORE - Career Developmental Award
  • 2012
    American Cancer Society Individual Research Award
  • 2013
    National Brain Tumor Society- Oligodendroglioma Award

Selected Publications

  1. Lau J, Ilkhanizadeh S, Wang S, Miroshnikova YA, Salvatierra NA, Wong RA, Schmidt C, Weaver VM, Weiss WA, Persson AI. STAT3 Blockade Inhibits Radiation-Induced Malignant Progression in Glioma. Cancer Res. 2015 Oct 15; 75(20):4302-11.
    View on PubMed
  2. Li N, Maly DJ, Chanthery YH, Sirkis DW, Nakamura JL, Berger MS, James CD, Shokat KM, Weiss WA, Persson AI. Radiotherapy followed by aurora kinase inhibition targets tumor-propagating cells in human glioblastoma. Mol Cancer Ther. 2015 Feb; 14(2):419-28.
    View on PubMed
  3. Swartling FJ, Cancer M, Frantz A, Weishaupt H, Persson AI. Deregulated proliferation and differentiation in brain tumors. Cell Tissue Res. 2015 Jan; 359(1):225-54.
    View on PubMed
  4. Ilkanizadeh S, Lau J, Huang M, Foster DJ, Wong R, Frantz A, Wang S, Weiss WA, Persson AI. Glial progenitors as targets for transformation in glioma. Adv Cancer Res. 2014; 121:1-65.
    View on PubMed
  5. Shchors K, Persson AI, Rostker F, Tihan T, Lyubynska N, Li N, Swigart LB, Berger MS, Hanahan D, Weiss WA, Evan GI. Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):E1480-9.
    View on PubMed
  6. Swartling FJ, Bolin S, Phillips JJ, Persson AI. Signals that regulate the oncogenic fate of neural stem cells and progenitors. Exp Neurol. 2014 Oct; 260:56-68.
    View on PubMed
  7. Swartling FJ, Savov V, Persson AI, Chen J, Hackett CS, Northcott PA, Grimmer MR, Lau J, Chesler L, Perry A, Phillips JJ, Taylor MD, Weiss WA. Distinct neural stem cell populations give rise to disparate brain tumors in response to N-MYC. Cancer Cell. 2012 May 15; 21(5):601-13.
    View on PubMed
  8. Chanthery YH, Gustafson WC, Itsara M, Persson A, Hackett CS, Grimmer M, Charron E, Yakovenko S, Kim G, Matthay KK, Weiss WA. Paracrine signaling through MYCN enhances tumor-vascular interactions in neuroblastoma. Sci Transl Med. 2012 Jan 4; 4(115):115ra3.
    View on PubMed
  9. Sugiarto S, Persson AI, Munoz EG, Waldhuber M, Lamagna C, Andor N, Hanecker P, Ayers-Ringler J, Phillips J, Siu J, Lim DA, Vandenberg S, Stallcup W, Berger MS, Bergers G, Weiss WA, Petritsch C. Asymmetry-defective oligodendrocyte progenitors are glioma precursors. Cancer Cell. 2011 Sep 13; 20(3):328-40.
    View on PubMed
  10. Persson AI, Petritsch C, Swartling FJ, Itsara M, Sim FJ, Auvergne R, Goldenberg DD, Vandenberg SR, Nguyen KN, Yakovenko S, Ayers-Ringler J, Nishiyama A, Stallcup WB, Berger MS, Bergers G, McKnight TR, Goldman SA, Weiss WA. Non-stem cell origin for oligodendroglioma. Cancer Cell. 2010 Dec 14; 18(6):669-82.
    View on PubMed
  11. Persson AI, Weiss WA. The side story of stem-like glioma cells. Cell Stem Cell. 2009 Mar 6; 4(3):191-2.
    View on PubMed
  12. Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M, Vandenberg SR, Ginzinger DG, James CD, Costello JF, Bergers G, Weiss WA, Alvarez-Buylla A, Hodgson JG. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med. 2008; 6:14.
    View on PubMed
  13. Persson AI, Bull C, Eriksson PS. Requirement for Id1 in opioid-induced oligodendrogenesis in cultured adult rat hippocampal progenitors. Eur J Neurosci. 2006 May; 23(9):2277-88.
    View on PubMed
  14. Zarnegar P, Persson AI, Ming Y, Terenius L. Opioid-induced regulation of gene expression in PC12 cells stably transfected with mu-opioid receptor. Neurosci Lett. 2006 Apr 3; 396(3):197-201.
    View on PubMed
  15. Persson AI, Thorlin T, Eriksson PS. Comparison of immunoblotted delta opioid receptor proteins expressed in the adult rat brain and their regulation by growth hormone. Neurosci Res. 2005 May; 52(1):1-9.
    View on PubMed
  16. Naylor AS, Persson AI, Eriksson PS, Jonsdottir IH, Thorlin T. Extended voluntary running inhibits exercise-induced adult hippocampal progenitor proliferation in the spontaneously hypertensive rat. J Neurophysiol. 2005 May; 93(5):2406-14.
    View on PubMed
  17. Dahl A, Eriksson PS, Davidsson P, Persson AI, Ekman R, Westman-Brinkmalm A. Demonstration of multiple novel glycoforms of the stem cell survival factor CCg. J Neurosci Res. 2004 Jul 1; 77(1):9-14.
    View on PubMed
  18. Persson AI, Naylor AS, Jonsdottir IH, Nyberg F, Eriksson PS, Thorlin T. Differential regulation of hippocampal progenitor proliferation by opioid receptor antagonists in running and non-running spontaneously hypertensive rats. Eur J Neurosci. 2004 Apr; 19(7):1847-55.
    View on PubMed
  19. Persson AI, Thorlin T, Bull C, Eriksson PS. Opioid-induced proliferation through the MAPK pathway in cultures of adult hippocampal progenitors. Mol Cell Neurosci. 2003 Jul; 23(3):360-72.
    View on PubMed
  20. Persson AI, Thorlin T, Bull C, Zarnegar P, Ekman R, Terenius L, Eriksson PS. Mu- and delta-opioid receptor antagonists decrease proliferation and increase neurogenesis in cultures of rat adult hippocampal progenitors. Eur J Neurosci. 2003 Mar; 17(6):1159-72.
    View on PubMed

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