Claudia Petritsch, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Claudia Petritsch, PhD

Assistant Professor, Brain Tumor Research Center and Department of Neurological Surgery; and Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, UCSF

claudia.petritsch@ucsf.edu

Phone: (415) 514-9785 (office); (415) 514-4990 (lab)
Box 0520, UCSF
San Francisco, CA 94143-0520

View on UCSF Profiles

Cancer Center Membership

Program Member » Neurologic Oncology» Pediatric Malignancies

Research Summary

Stem and progenitor cells can switch between asymmetric and symmetric cell division modes presumably to respond to micro-environment changes such as those induced by tissue injury and cancer. The Petritsch lab elucidates the regulation of stem and progenitor cell division mode both by intrinsic and extrinsic factors in the context of the healthy and diseased brain. Our findings show that aberrant control of cell division mode carries the risk of cancer progression. In a collaborative effort we translate our basic insights into stem and progenitor biology into improved treatment of brain tumor patients.

Education, Training, and Previous Positions

1996: PhD: Institute for Molecular Pathology (IMP) Vienna, Austria

1997-2002: Postdoctoral Fellow, Howard Hughes Medical Institute, University of California, San Francisco

2002-2003: Postdoctoral Researcher, Department of Physiology, University of California, San Francisco

2003-2005: Group Leader, Gene Center and Department of Biochemistry, Ludwig-Maximilian-University, Munich, Germany

2005-2008: Associate Research Biochemist, Department of Neurological Surgery, University of California, San Francisco

2008-Present: Assistant Adjunct Professor, Department of Neurological Surgery, University of California, San Francisco

Education

University of Vienna BioCenter, Vienna, MS, BA, 1985 -1991, Cell and Molecular Biology and Biochemistry
University of Vienna BioCenter, Vienna, PhD, 1991-1996, Cell & Molecular Biology
Institute of Molecular Pathology, Vienna, Postdoc, 1996-1997
University of California, San Francisco, Dept of Physiology, Postdoc, 1997-2002


Professional Experience

  • 2002-2003
    Postgraduate Researcher, Department of Physiology, University of California, San Francisco
  • 2003-2005
    Investigator, GeneCenter and Institute of Biochemistry at the University of Munich
  • 2005-2008
    Associate Research Biochemist, Department of Neurological Surgery, University of California, San Francisco
  • 2008-present
    Assistant Professor, Brain Tumor Research Center and Department of Neurological Surgery, University of California, San Francisco

Honors & Awards

  • 1990
    Diploma Fellowship, Institute of Molecular Pathology
  • 1991-96
    PhD Fellowship, Institute for Molecular Pathology
  • 1993
    European Molecular Biology Organisation short-term fellowship
  • 1994
    Federation of European Biochemical Societies short-term fellowship
  • 1996
    European Molecular Biology Organisation long-term fellowship
  • 1999
    Human Frontiers Science Program Organization long-term fellowship
  • 2003
    PO 1 Research Grant; German Research Council (DFG) # SFB 413
  • 2004
    PO 1 Research Grant; German Research Council (DFG) # SFB 413
  • 2004-06
    Award for Outstanding Women in Life Sciences (University of Munich)
  • 2005-06
    Bavarian California Technology Award
  • 2006
    California Breast Cancer Research Program/CBRCP, IDEA Award, San Francisco, USA
  • 2007-2008
    National Brain Tumor Foundation, Oligodendroglioma Award, San Francisco, USA
  • 2007-2008
    Brain Tumor SPORE, Career Development Research Award, San Francisco, USA
  • 2010
    American Brain Tumor Association, Discovery Award, Des Plaines, USA

Selected Publications

  1. Pan-cancer analysis of the extent and consequences of intratumor heterogeneity. Nat Med. 2016 Jan; 22(1):105-13.
    View on PubMed
  2. Targeting a Plk1-Controlled Polarity Checkpoint in Therapy-Resistant Glioblastoma-Propagating Cells. Cancer Res. 2015 Dec 15; 75(24):5355-66.
    View on PubMed
  3. Numerical chromosomal instability mediates susceptibility to radiation treatment. Nat Commun. 2015; 6:5990.
    View on PubMed
  4. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nat Med. 2014 Dec; 20(12):1394-6.
    View on PubMed
  5. Heterogeneously expressed fezf2 patterns gradient Notch activity in balancing the quiescence, proliferation, and differentiation of adult neural stem cells. J Neurosci. 2014 Oct 15; 34(42):13911-23.
    View on PubMed
  6. A microRNA-operated switch of asymmetric-to-symmetric cancer stem cell divisions. Nat Cell Biol. 2014 Mar; 16(3):212-4.
    View on PubMed
  7. EXPANDS: expanding ploidy and allele frequency on nested subpopulations. Bioinformatics. 2014 Jan 1; 30(1):50-60.
    View on PubMed
  8. Asymmetric cell division of stem and progenitor cells during homeostasis and cancer. Cell Mol Life Sci. 2014 Feb; 71(4):575-97.
    View on PubMed
  9. Proteoglycans and their roles in brain cancer. FEBS J. 2013 May; 280(10):2399-417.
    View on PubMed
  10. Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8710-5.
    View on PubMed
  11. Asymmetry-defective oligodendrocyte progenitors are glioma precursors. Cancer Cell. 2011 Sep 13; 20(3):328-40.
    View on PubMed
  12. Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila. Development. 2011 Jun; 138(11):2185-96.
    View on PubMed
  13. Non-stem cell origin for oligodendroglioma. Cancer Cell. 2010 Dec 14; 18(6):669-82.
    View on PubMed
  14. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med. 2008; 6:14.
    View on PubMed
  15. Asymmetric localization of the adaptor protein Miranda in neuroblasts is achieved by diffusion and sequential interaction of Myosin II and VI. J Cell Sci. 2008 May 1; 121(Pt 9):1403-14.
    View on PubMed
  16. Matrix metalloproteinase-2 regulates vascular patterning and growth affecting tumor cell survival and invasion in GBM. Neuro Oncol. 2008 Jun; 10(3):254-64.
    View on PubMed
  17. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell. 2008 Mar; 13(3):206-20.
    View on PubMed
  18. The Drosophila caspase DRONC is required for metamorphosis and cell death in response to irradiation and developmental signals. Mech Dev. 2005 Jul; 122(7-8):914-27.
    View on PubMed
  19. Nanos and Pumilio are essential for dendrite morphogenesis in Drosophila peripheral neurons. Curr Biol. 2004 Feb 17; 14(4):314-21.
    View on PubMed
  20. The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts. Dev Cell. 2003 Feb; 4(2):273-81.
    View on PubMed

Go to UCSF Profiles, powered by CTSI