Claudia Petritsch, PhD

Claudia Petritsch, PhD

Assistant Professor, Brain Tumor Research Center and Department of Neurological Surgery; and Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, UCSF

Phone: (415) 514-9785 (office); (415) 514-4990 (lab)
Box 0520, UCSF
San Francisco, CA 94143-0520

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University of Vienna BioCenter, Vienna, MS, BA, 1985 -1991, Cell and Molecular Biology and Biochemistry
University of Vienna BioCenter, Vienna, PhD, 1991-1996, Cell & Molecular Biology
Institute of Molecular Pathology, Vienna, Postdoc, 1996-1997
University of California, San Francisco, Dept of Physiology, Postdoc, 1997-2002

Professional Experience

  • 2002-2003
    Postgraduate Researcher, Department of Physiology, University of California, San Francisco
  • 2003-2005
    Investigator, GeneCenter and Institute of Biochemistry at the University of Munich
  • 2005-2008
    Associate Research Biochemist, Department of Neurological Surgery, University of California, San Francisco
  • 2008-present
    Assistant Professor, Brain Tumor Research Center and Department of Neurological Surgery, University of California, San Francisco

Honors & Awards

  • 1990
    Diploma Fellowship, Institute of Molecular Pathology
  • 1991-96
    PhD Fellowship, Institute for Molecular Pathology
  • 1993
    European Molecular Biology Organisation short-term fellowship
  • 1994
    Federation of European Biochemical Societies short-term fellowship
  • 1996
    European Molecular Biology Organisation long-term fellowship
  • 1999
    Human Frontiers Science Program Organization long-term fellowship
  • 2003
    PO 1 Research Grant; German Research Council (DFG) # SFB 413
  • 2004
    PO 1 Research Grant; German Research Council (DFG) # SFB 413
  • 2004-06
    Award for Outstanding Women in Life Sciences (University of Munich)
  • 2005-06
    Bavarian California Technology Award
  • 2006
    California Breast Cancer Research Program/CBRCP, IDEA Award, San Francisco, USA
  • 2007-2008
    National Brain Tumor Foundation, Oligodendroglioma Award, San Francisco, USA
  • 2007-2008
    Brain Tumor SPORE, Career Development Research Award, San Francisco, USA
  • 2010
    American Brain Tumor Association, Discovery Award, Des Plaines, USA

Selected Publications

  1. Bakhoum SF, Kabeche L, Wood MD, Laucius CD, Qu D, Laughney AM, Reynolds GE, Louie RJ, Phillips J, Chan DA, Zaki BI, Murnane JP, Petritsch C, Compton DA. Numerical chromosomal instability mediates susceptibility to radiation treatment. Nat Commun. 2015; 6:5990.
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  2. Hashizume R, Andor N, Ihara Y, Lerner R, Gan H, Chen X, Fang D, Huang X, Tom MW, Ngo V, Solomon D, Mueller S, Paris PL, Zhang Z, Petritsch C, Gupta N, Waldman TA, James CD. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nat Med. 2014 Nov 17.
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  3. Berberoglu MA, Dong Z, Li G, Zheng J, Trejo Martinez Ldel C, Peng J, Wagle M, Reichholf B, Petritsch C, Li H, Pleasure SJ, Guo S. Heterogeneously Expressed fezf2 Patterns Gradient Notch Activity in Balancing the Quiescence, Proliferation, and Differentiation of Adult Neural Stem Cells. J Neurosci. 2014 Oct 15; 34(42):13911-23.
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  4. Lerner RG, Petritsch C. A microRNA-operated switch of asymmetric-to-symmetric cancer stem cell divisions. Nat Cell Biol. 2014 Feb 28; 16(3):212-4.
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  5. Andor N, Harness JV, Müller S, Mewes HW, Petritsch C. EXPANDS: expanding ploidy and allele frequency on nested subpopulations. Bioinformatics. 2014 Jan 1; 30(1):50-60.
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  6. Gómez-López S, Lerner RG, Petritsch C. Asymmetric cell division of stem and progenitor cells during homeostasis and cancer. Cell Mol Life Sci. 2014 Feb; 71(4):575-97.
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  7. Wade A, Robinson AE, Engler JR, Petritsch C, James CD, Phillips JJ. Proteoglycans and their roles in brain cancer. FEBS J. 2013 May; 280(10):2399-417.
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  8. Huillard E, Hashizume R, Phillips JJ, Griveau A, Ihrie RA, Aoki Y, Nicolaides T, Perry A, Waldman T, McMahon M, Weiss WA, Petritsch C, James CD, Rowitch DH. Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy. Proc Natl Acad Sci U S A. 2012 May 29; 109(22):8710-5.
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  9. Sugiarto S, Persson AI, Munoz EG, Waldhuber M, Lamagna C, Andor N, Hanecker P, Ayers-Ringler J, Phillips J, Siu J, Lim DA, Vandenberg S, Stallcup W, Berger MS, Bergers G, Weiss WA, Petritsch C. Asymmetry-defective oligodendrocyte progenitors are glioma precursors. Cancer Cell. 2011 Sep 13; 20(3):328-40.
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  10. Ouyang Y, Petritsch C, Wen H, Jan L, Jan YN, Lu B. Dronc caspase exerts a non-apoptotic function to restrain phospho-Numb-induced ectopic neuroblast formation in Drosophila. Development. 2011 Jun; 138(11):2185-96.
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  11. Persson AI, Petritsch C, Swartling FJ, Itsara M, Sim FJ, Auvergne R, Goldenberg DD, Vandenberg SR, Nguyen KN, Yakovenko S, Ayers-Ringler J, Nishiyama A, Stallcup WB, Berger MS, Bergers G, McKnight TR, Goldman SA, Weiss WA. Non-stem cell origin for oligodendroglioma. Cancer Cell. 2010 Dec 14; 18(6):669-82.
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  12. Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M, Vandenberg SR, Ginzinger DG, James CD, Costello JF, Bergers G, Weiss WA, Alvarez-Buylla A, Hodgson JG. miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med. 2008; 6:14.
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  13. Erben V, Waldhuber M, Langer D, Fetka I, Jansen RP, Petritsch C. Asymmetric localization of the adaptor protein Miranda in neuroblasts is achieved by diffusion and sequential interaction of Myosin II and VI. J Cell Sci. 2008 May 1; 121(Pt 9):1403-14.
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  14. Du R, Petritsch C, Lu K, Liu P, Haller A, Ganss R, Song H, Vandenberg S, Bergers G. Matrix metalloproteinase-2 regulates vascular patterning and growth affecting tumor cell survival and invasion in GBM. Neuro Oncol. 2008 Jun; 10(3):254-64.
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  15. Du R, Lu KV, Petritsch C, Liu P, Ganss R, Passegué E, Song H, Vandenberg S, Johnson RS, Werb Z, Bergers G. HIF1alpha induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion. Cancer Cell. 2008 Mar; 13(3):206-20.
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  16. Waldhuber M, Emoto K, Petritsch C. The Drosophila caspase DRONC is required for metamorphosis and cell death in response to irradiation and developmental signals. Mech Dev. 2005 Jul; 122(7-8):914-27.
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  17. Ye B, Petritsch C, Clark IE, Gavis ER, Jan LY, Jan YN. Nanos and Pumilio are essential for dendrite morphogenesis in Drosophila peripheral neurons. Curr Biol. 2004 Feb 17; 14(4):314-21.
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  18. Petritsch C, Tavosanis G, Turck CW, Jan LY, Jan YN. The Drosophila myosin VI Jaguar is required for basal protein targeting and correct spindle orientation in mitotic neuroblasts. Dev Cell. 2003 Feb; 4(2):273-81.
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  19. Petritsch C, Beug H, Balmain A, Oft M. TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest. Genes Dev. 2000 Dec 15; 14(24):3093-101.
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