University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
David Raleigh, MD, PhD

David Raleigh, MD, PhD

Assistant Professor in Residence, Dept. of Radiation Oncology, UCSF

Cancer Center Program Memberships

Cancer Genetics

Research Summary

I am an Assistant Professor and Physician Scientist in the Department of Radiation Oncology at the University of California-San Francisco (UCSF), where I specialize in the treatment and investigation of adult and pediatric brain tumors. Eighty percent of my time is protected for laboratory research, and I am also therefore a Principle Investigator in the UCSF Department of Neurological Surgery Brain Tumor Center. My research examines how developmental signaling pathways function in cancer with the overall objectives of shedding light on the fundamental mechanisms of developmental biology, and identifying novel biomarkers and therapeutic targets to improve patient outcomes. To accomplish those goals, my laboratory makes use of biochemistry, molecular biology, cell biology, mouse genetics, genomics, bioinformatics and pharmacology. Our work has identified novel activators and effectors of oncogenic Hedgehog signaling in medulloblastoma, and revealed a FOXM1/WNT signaling axis that underlies meningioma proliferation. Each of these discoveries serves as the foundation for clinical trials of molecular therapy in medulloblastoma and meningioma patients that are currently under development.

Education

University of California-Berkeley, B.A. (Honors), 08/00-05/04, Molecular Cell Biology
University of California-Berkeley B.A. (Honors) 08/00 05/04 Cognitive Science
University of Chicago-Chicago M.D. 05/05 06/12 Medicine
University of Chicago-Chicago Ph.D. 07/07 05/10 Pathology
Kaiser Permanente-Santa Clara, Intern, 07/12-06/13, Internal Medicine
University of California-San Francisco, Resident, 07/13-06/17, Radiation Oncology
University of California-San Francisco, Postdoctoral Fellow, 01/15-06/17, Cancer Biology


Professional Experience

  • 2017-present
    Assistant Professor, Dept. of Radiation Oncology, UCSF
  • 2017-present
    UCSF Principal Investigator Brain Tumor Center
    2017-present
    Children’s Oncology Group Principal Investigator ANBL 1232

Honors & Awards

  • 2009
    FASEB Travel Award, FASEB Gastrointestinal Tract XIII Meeting
  • 2009
    DDW Poster of Distinction, Digestive Disease Week Annual Meeting
  • 2009
    Outstanding Graduate Student Oral Presentation, University of Chicago
  • 2010
    Takeda Travel Award, Experimental Biology Annual Meeting
  • 2011
    Naomi Ragins Goldsmith Career Development Award, University of Chicago
  • 2012
    Outstanding Performance in Radiation and Cellular Oncology, University of Chicago
  • 2013
    Teaching Award in Recognition of Excellent Medical Student Education, Kaiser Permanente
  • 2015
    Clinical & Translational Science Institute Resident Research Travel Program Award, UCSF
  • 2016
    Career Award for Medical Scientists Semifinalist, Burroughs Wellcome Fund
  • 2016
    Radiological Society of North America Roentgen Resident/Fellow Research Award, UCSF
  • 2016
    Biology Abstract Travel Award, American Society for Radiation Oncology Annual Meeting
  • 2016
    Poster Walk Award, Association of Residents in Radiation Oncology
  • 2016
    Top Young Investigator Awardee, ASCO Scientific Career Development Retreat
  • 2017
    Young Oncologist Travel Grant Recipient, American Radium Society Annual Meeting
  • 2017
    Poster of Distinction, American Radium Society Annual Meeting
  • 2017
    Biology Abstract Travel Award, American Society for Radiation Oncology Annual Meeting