University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Mark L. Rubinstein, MD

Mark L. Rubinstein, MD

Assistant Professor, Department of Pediatrics (Adolescent Medicine), UCSF

Cancer Center Program Memberships

Pediatric Malignancies | Tobacco Control

Research Summary

As an Adolescent Medicine physician and researcher, I have extensive experience working with adolescent smokers both in the clinical and research setting. Furthermore, as the PI on several NIH-funded adolescent nicotine addiction studies, I have expertise recruiting and following adolescent smokers over time. I am a member of the UCSF HDFCCC and have demonstrated a record of productive research projects in the area of adolescent smoking, including factors involved with the development of nicotine addiction such as nicotine metabolism, as well as the utilization of biomarkers to study adolescent nicotine exposure behaviors.
Given the rapid uptake of electronic nicotine delivery systems (ENDS) among teens, there is a critical need to understand the safety of these products in adolescents, including (1) how use contributes to toxicant exposure and (2) identification of possible biologic mediators of usage and dependence, such as the nicotine metabolic rate. The goal of my current research is to investigate the presence of toxicants and examine the influence of the rate of nicotine metabolism on ENDS use behaviors and nicotine dependence in adolescent ENDS-only users.

Education

New York University, New York, B.F.A., 1990, Film and Television
Yale University School of Medicine, M.D., 1997, Medicine
Yale New Haven Hospital, New Haven, Residency, 2000, Internal Medicine
University of California, San Francisco, Fellowship, 2003, Adolescent Medicine


Professional Experience

  • 2003-present
    Assistant Professor, Dept. of Adolescent Medicine, University of California, San Francisco

Honors & Awards

  • 1986
    Scholars Program, New York University
  • 1990
    Founders Day Award, New York University
  • 2000-2003
    MCHB Postdoctoral Training Fellowship in Adolescent Health
  • 2002-2004
    Tobacco-Related Disease Research Program Fellowship

Selected Publications

  1. McKelvey KL, Ramo DE, Delucchi K, Rubinstein ML. Polydrug use among urban adolescent cigarette smokers. Addict Behav. 2017 Mar; 66:145-150.
    View on PubMed
  2. Vo M, Lau J, Rubinstein M. Eating Disorders in Adolescent and Young Adult Males: Presenting Characteristics. J Adolesc Health. 2016 Oct; 59(4):397-400.
    View on PubMed
  3. Rait MA, Prochaska JJ, Rubinstein ML. Recruitment of adolescents for a smoking study: use of traditional strategies and social media. Transl Behav Med. 2015 Sep; 5(3):254-9.
    View on PubMed
  4. Rait MA, Prochaska JJ, Rubinstein ML. Reporting of cigar use among adolescent tobacco smokers. Addict Behav. 2016 Feb; 53:206-9.
    View on PubMed
  5. Rubinstein ML. Scanning the brain for answers about effectiveness of graphic warning labels. Tob Control. 2015 May; 24(3):211-2.
    View on PubMed
  6. Rubinstein ML, Harris DR, Rudy BJ, Kapogiannis BG, Aldrovandi GM, Mulligan K. Exploration of the Effect of Tobacco Smoking on Metabolic Measures in Young People Living with HIV. AIDS Res Treat. 2014; 2014:740545.
    View on PubMed
  7. Rubinstein ML, Rait MA, Prochaska JJ. Frequent marijuana use is associated with greater nicotine addiction in adolescent smokers. Drug Alcohol Depend. 2014 Aug 1; 141:159-62.
    View on PubMed
  8. Rubinstein ML, Rait MA, Sen S, Shiffman S. Characteristics of adolescent intermittent and daily smokers. Addict Behav. 2014 Sep; 39(9):1337-41.
    View on PubMed
  9. Rubinstein ML, Shiffman S, Rait MA, Benowitz NL. Race, gender, and nicotine metabolism in adolescent smokers. Nicotine Tob Res. 2013 Jul; 15(7):1311-5.
    View on PubMed
  10. Rubinstein ML, Shiffman S, Moscicki AB, Rait MA, Sen S, Benowitz NL. Nicotine metabolism and addiction among adolescent smokers. Addiction. 2013 Feb; 108(2):406-12.
    View on PubMed
  11. Rubinstein ML, Luks TL, Dryden WY, Rait MA, Simpson GV. Adolescent smokers show decreased brain responses to pleasurable food images compared with nonsmokers. Nicotine Tob Res. 2011 Aug; 13(8):751-5.
    View on PubMed
  12. Rubinstein ML, Luks TL, Moscicki AB, Dryden W, Rait MA, Simpson GV. Smoking-related cue-induced brain activation in adolescent light smokers. J Adolesc Health. 2011 Jan; 48(1):7-12.
    View on PubMed
  13. Rubinstein ML, Benowitz NL, Auerback GM, Moscicki AB. Withdrawal in adolescent light smokers following 24-hour abstinence. Nicotine Tob Res. 2009 Feb; 11(2):185-9.
    View on PubMed
  14. Rubinstein ML, Benowitz NL, Auerback GM, Moscicki AB. A randomized trial of nicotine nasal spray in adolescent smokers. Pediatrics. 2008 Sep; 122(3):e595-600.
    View on PubMed
  15. Rubinstein ML. Who's Smoking? Cotinine versus self-report in adolescent populations. J Adolesc Health. 2008 Sep; 43(3):205-6.
    View on PubMed
  16. Rubinstein ML, Benowitz NL, Auerback GM, Moscicki AB. Rate of nicotine metabolism and withdrawal symptoms in adolescent light smokers. Pediatrics. 2008 Sep; 122(3):e643-7.
    View on PubMed
  17. Rubinstein ML, Thompson PJ, Benowitz NL, Shiffman S, Moscicki AB. Cotinine levels in relation to smoking behavior and addiction in young adolescent smokers. Nicotine Tob Res. 2007 Jan; 9(1):129-35.
    View on PubMed
  18. Halpern-Felsher BL, Rubinstein ML. Clear the air: adolescents' perceptions of the risks associated with secondhand smoke. Prev Med. 2005 Jul; 41(1):16-22.
    View on PubMed
  19. Halpern-Felsher BL, Biehl M, Kropp RY, Rubinstein ML. Perceived risks and benefits of smoking: differences among adolescents with different smoking experiences and intentions. Prev Med. 2004 Sep; 39(3):559-67.
    View on PubMed
  20. Rubinstein ML, Halpern-Felsher BL, Irwin CE. An evaluation of the use of the transdermal contraceptive patch in adolescents. J Adolesc Health. 2004 May; 34(5):395-401.
    View on PubMed

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