University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Sharanjot Saini, PhD

Sharanjot Saini, PhD

Assistant Adjunct Professor, Department of Urology, UCSF

Cancer Center Program Memberships

Prostate Cancer

Research Summary

My research program is primarily focused on delineating the molecular mechanisms driving progression, recurrence and metastasis of prostate cancer with an objective of identifying novel molecular targets for better diagnostic and therapeutic strategies against advanced disease. Current research interests include understanding the role of microRNAs in tumor progression and metastasis and understanding microRNA-mediated control of prostate cancer stem cells and tumor recurrence. Other focus areas are characterizing the role of extracellular vesicles (EVs) in advanced prostate cancer, delineating EV-mediated molecular mechanisms underlying resistance to androgen pathway inhibitors (APIs) in castration-resistant prostate cancer (CRPC) and developing non-invasive EV-based biomarkers for predicting prostate cancer aggressiveness and response to APIs. Further, we are addressing the underlying mechanisms of resistance for men with metastatic CRPC to APIs by defining the miRNA- mediated signaling pathways associated with progression of CRPC to androgen-independent neuroendocrine states.

Education

Panjab University, Chandigarh, India, BS, 1997, Biochemistry
Panjab University, Chandigarh, India, MS, 1999, Biochemistry
Institute of Microbial Technology and Jawaharlal Nehru University, New Delhi, India, PhD, 2005, Biotechnology, Molecular Biology
University of Massachusetts Medical School, Worcester, Massachusetts, Postdoctoral, 2005, Molecular Biology
University of California, San Francisco/Northern California Institute of Research and Education, Postdoctoral, 2007, Molecular Biology, Cancer Biology


Professional Experience

  • 2010-2014
    Assistant Research Scientist, Department of Urology, NCIRE, San Francisco VA Medical Center
  • 2014-present
    Research Scientist/Principal Investigator, Department of Urology, NCIRE and San Francisco VA Medical Center
  • 2012-present
    Assistant Adjunct Professor, Department of Urology, UCSF

Honors & Awards

  • 2014
    Invited speaker at 4th World Congress on Cancer Science & Therapy, Chicago, USA
  • 2015
    Outstanding abstract selected for oral presentation at Annual Prostate Cancer Program Research Retreat, University of California San Francisco, CA
  • 2015
    Invited speaker at Veterans Affairs Medical Center, San Francisco, CA

Selected Publications

  1. Bhagirath D, Yang TL, Tabatabai ZL, Shahryari V, Majid S, Dahiya R, Tanaka Y, Saini S. Role of a novel race-related tumor suppressor microRNA located in frequently deleted chromosomal locus 8p21 in prostate cancer progression. Carcinogenesis. 2019 Mar 15.
    View on PubMed
  2. Kato T, Hashimoto Y, Wong RK, Mitsui Y, Maekawa S, Chang I, Shahryari V, Yamamura S, Majid S, Saini S, Tabatabai ZL, Dahiya R, Deguchi T, Tanaka Y. Influence of lifestyle choices on risks of CYP1B1 polymorphisms for prostate cancer. J Cell Mol Med. 2018 Oct; 22(10):4676-4687.
    View on PubMed
  3. Kulkarni P, Dasgupta P, Bhat NS, Shahryari V, Shiina M, Hashimoto Y, Majid S, Deng G, Saini S, Tabatabai ZL, Yamamura S, Tanaka Y, Dahiya R. Elevated miR-182-5p Associates with Renal Cancer Cell Mitotic Arrest through Diminished MALAT-1 Expression. Mol Cancer Res. 2018 Nov; 16(11):1750-1760.
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  4. Dasgupta P, Kulkarni P, Majid S, Shahryari V, Hashimoto Y, Bhat NS, Shiina M, Deng G, Saini S, Tabatabai ZL, Yamamura S, Tanaka Y, Dahiya R. MicroRNA-203 Inhibits Long Noncoding RNA HOTAIR and Regulates Tumorigenesis through Epithelial-to-mesenchymal Transition Pathway in Renal Cell Carcinoma. Mol Cancer Ther. 2018 May; 17(5):1061-1069.
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  5. Bhagirath D, Yang TL, Bucay N, Sekhon K, Majid S, Shahryari V, Dahiya R, Tanaka Y, Saini S. microRNA-1246 Is an Exosomal Biomarker for Aggressive Prostate Cancer. Cancer Res. 2018 Apr 01; 78(7):1833-1844.
    View on PubMed
  6. Bhagirath D, Yang TL, Dahiya R, Saini S. MicroRNAs as Regulators of Prostate Cancer Metastasis. Adv Exp Med Biol. 2018; 1095:83-100.
    View on PubMed
  7. Imai-Sumida M, Chiyomaru T, Majid S, Saini S, Nip H, Dahiya R, Tanaka Y, Yamamura S. Silibinin suppresses bladder cancer through down-regulation of actin cytoskeleton and PI3K/Akt signaling pathways. Oncotarget. 2017 Nov 03; 8(54):92032-92042.
    View on PubMed
  8. Bhat NS, Colden M, Dar AA, Saini S, Arora P, Shahryari V, Yamamura S, Tanaka Y, Kato T, Majid S, Dahiya R. MicroRNA-720 Regulates E-cadherin-aE-catenin Complex and Promotes Renal Cell Carcinoma. Mol Cancer Ther. 2017 Dec; 16(12):2840-2848.
    View on PubMed
  9. Bucay N, Bhagirath D, Sekhon K, Yang T, Fukuhara S, Majid S, Shahryari V, Tabatabai Z, Greene KL, Hashimoto Y, Shiina M, Yamamura S, Tanaka Y, Deng G, Dahiya R, Saini S. A novel microRNA regulator of prostate cancer epithelial-mesenchymal transition. Cell Death Differ. 2017 07; 24(7):1263-1274.
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  10. Hashimoto Y, Shiina M, Kato T, Yamamura S, Tanaka Y, Majid S, Saini S, Shahryari V, Kulkarni P, Dasgupta P, Mitsui Y, Sumida M, Deng G, Tabatabai L, Kumar D, Dahiya R. The role of miR-24 as a race related genetic factor in prostate cancer. Oncotarget. 2017 Mar 07; 8(10):16581-16593.
    View on PubMed
  11. Mitsui Y, Shiina H, Kato T, Maekawa S, Hashimoto Y, Shiina M, Imai-Sumida M, Kulkarni P, Dasgupta P, Wong RK, Hiraki M, Arichi N, Fukuhara S, Yamamura S, Majid S, Saini S, Deng G, Dahiya R, Nakajima K, Tanaka Y. Versican Promotes Tumor Progression, Metastasis and Predicts Poor Prognosis in Renal Carcinoma. Mol Cancer Res. 2017 07; 15(7):884-895.
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  12. Shiina M, Hashimoto Y, Kato T, Yamamura S, Tanaka Y, Majid S, Saini S, Varahram S, Kulkarni P, Dasgupta P, Mitsui Y, Sumida M, Tabatabai L, Deng G, Kumar D, Dahiya R. Differential expression of miR-34b and androgen receptor pathway regulate prostate cancer aggressiveness between African-Americans and Caucasians. Oncotarget. 2017 Jan 31; 8(5):8356-8368.
    View on PubMed
  13. Colden M, Dar AA, Saini S, Dahiya PV, Shahryari V, Yamamura S, Tanaka Y, Stein G, Dahiya R, Majid S. MicroRNA-466 inhibits tumor growth and bone metastasis in prostate cancer by direct regulation of osteogenic transcription factor RUNX2. Cell Death Dis. 2017 01 26; 8(1):e2572.
    View on PubMed
  14. Bucay N, Sekhon K, Majid S, Yamamura S, Shahryari V, Tabatabai ZL, Greene K, Tanaka Y, Dahiya R, Deng G, Saini S. Novel tumor suppressor microRNA at frequently deleted chromosomal region 8p21 regulates epidermal growth factor receptor in prostate cancer. Oncotarget. 2016 Oct 25; 7(43):70388-70403.
    View on PubMed
  15. Nip H, Dar AA, Saini S, Colden M, Varahram S, Chowdhary H, Yamamura S, Mitsui Y, Tanaka Y, Kato T, Hashimoto Y, Shiina M, Kulkarni P, Dasgupta P, Imai-Sumida M, Tabatabai ZL, Greene K, Deng G, Dahiya R, Majid S. Oncogenic microRNA-4534 regulates PTEN pathway in prostate cancer. Oncotarget. 2016 Oct 18; 7(42):68371-68384.
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  16. Sekhon K, Bucay N, Majid S, Dahiya R, Saini S. MicroRNAs and epithelial-mesenchymal transition in prostate cancer. Oncotarget. 2016 Oct 11; 7(41):67597-67611.
    View on PubMed
  17. Shahryari V, Nip H, Saini S, Dar AA, Yamamura S, Mitsui Y, Colden M, Bucay N, Tabatabai LZ, Greene K, Deng G, Tanaka Y, Dahiya R, Majid S. Pre-clinical Orthotopic Murine Model of Human Prostate Cancer. J Vis Exp. 2016 Aug 29; (114).
    View on PubMed
  18. Mitsui Y, Chang I, Kato T, Hashimoto Y, Yamamura S, Fukuhara S, Wong DK, Shiina M, Imai-Sumida M, Majid S, Saini S, Shiina H, Nakajima K, Deng G, Dahiya R, Tanaka Y. Functional role and tobacco smoking effects on methylation of CYP1A1 gene in prostate cancer. Oncotarget. 2016 Aug 02; 7(31):49107-49121.
    View on PubMed
  19. Saini S. PSA and beyond: alternative prostate cancer biomarkers. Cell Oncol (Dordr). 2016 Apr; 39(2):97-106.
    View on PubMed
  20. Bucay N, Shahryari V, Majid S, Yamamura S, Mitsui Y, Tabatabai ZL, Greene K, Deng G, Dahiya R, Tanaka Y, Saini S. miRNA Expression Analyses in Prostate Cancer Clinical Tissues. J Vis Exp. 2015 Sep 08; (103).
    View on PubMed

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