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Fred Schaufele, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
schaufele_fred

Associate Adjunct Professor, Department of Medicine (Diabetes Center), UCSF

freds@diabetes.ucsf.edu

Phone: (415) 476-7086 (voice)
Box 0540, UCSF
San Francisco, CA 94143-0540

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Additional Websites


Education

University of Calgary, Calgary, Canada, B.Sc. Honours, 1978-1992, Zoology
University of Zurich, Zurich, Switzerland, Ph.D., 1982-1987, Molecular Biology
University of California, San Francisco, Post-Doc, 1987-1990, Molecular Endocrinology


Professional Experience

  • 1990-1992
    Post-graduate Researcher, University of California, San Francisco
  • 1992-2003
    Assistant Adjunct Professor, University of California, San Francisco
  • 2003-present
    Associate Adjunct Professor, University of California, San Francisco

Selected Publications

  1. Schaufele F. Maximizing the quantitative accuracy and reproducibility of Förster resonance energy transfer measurement for screening by high throughput widefield microscopy. Methods. 2014 Mar 15; 66(2):188-99.
    View on PubMed
  2. Krylova I, Kumar RR, Kofoed EM, Schaufele F. A versatile, bar-coded nuclear marker/reporter for live cell fluorescent and multiplexed high content imaging. PLoS One. 2013; 8(5):e63286.
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  3. Schaufele F. FRET analysis of androgen receptor structure and biochemistry in living cells. Methods Mol Biol. 2011; 776:147-66.
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  4. Kofoed EM, Guerbadot M, Schaufele F. Structure, affinity, and availability of estrogen receptor complexes in the cellular environment. J Biol Chem. 2010 Jan 22; 285(4):2428-37.
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  5. Paruthiyil S, Cvoro A, Zhao X, Wu Z, Sui Y, Staub RE, Baggett S, Herber CB, Griffin C, Tagliaferri M, Harris HA, Cohen I, Bjeldanes LF, Speed TP, Schaufele F, Leitman DC. Drug and cell type-specific regulation of genes with different classes of estrogen receptor beta-selective agonists. PLoS One. 2009; 4(7):e6271.
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  6. Kofoed EM, Guerbadot M, Schaufele F. Dimerization between aequorea fluorescent proteins does not affect interaction between tagged estrogen receptors in living cells. J Biomed Opt. 2008 May-Jun; 13(3):031207.
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  7. Day RN, Schaufele F. Fluorescent protein tools for studying protein dynamics in living cells: a review. J Biomed Opt. 2008 May-Jun; 13(3):031202.
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  8. Kanaani J, Patterson G, Schaufele F, Lippincott-Schwartz J, Baekkeskov S. A palmitoylation cycle dynamically regulates partitioning of the GABA-synthesizing enzyme GAD65 between ER-Golgi and post-Golgi membranes. J Cell Sci. 2008 Feb 15; 121(Pt 4):437-49.
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  9. Liu X, Wu B, Szary J, Kofoed EM, Schaufele F. Functional sequestration of transcription factor activity by repetitive DNA. J Biol Chem. 2007 Jul 20; 282(29):20868-76.
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  10. Cvoro A, Paruthiyil S, Jones JO, Tzagarakis-Foster C, Clegg NJ, Tatomer D, Medina RT, Tagliaferri M, Schaufele F, Scanlan TS, Diamond MI, Cohen I, Leitman DC. Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract. Endocrinology. 2007 Feb; 148(2):538-47.
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  11. Padron A, Li L, Kofoed EM, Schaufele F. Ligand-selective interdomain conformations of estrogen receptor-alpha. Mol Endocrinol. 2007 Jan; 21(1):49-61.
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  12. Schaufele F, Carbonell X, Guerbadot M, Borngraeber S, Chapman MS, Ma AA, Miner JN, Diamond MI. The structural basis of androgen receptor activation: intramolecular and intermolecular amino-carboxy interactions. Proc Natl Acad Sci U S A. 2005 Jul 12; 102(28):9802-7.
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  13. Day RN, Schaufele F. Imaging molecular interactions in living cells. Mol Endocrinol. 2005 Jul; 19(7):1675-86.
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  14. Ross SE, Radomska HS, Wu B, Zhang P, Winnay JN, Bajnok L, Wright WS, Schaufele F, Tenen DG, MacDougald OA. Phosphorylation of C/EBPalpha inhibits granulopoiesis. Mol Cell Biol. 2004 Jan; 24(2):675-86.
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  15. Enwright JF, Kawecki-Crook MA, Voss TC, Schaufele F, Day RN. A PIT-1 homeodomain mutant blocks the intranuclear recruitment of the CCAAT/enhancer binding protein alpha required for prolactin gene transcription. Mol Endocrinol. 2003 Feb; 17(2):209-22.
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  16. Schaufele F, Wang X, Liu X, Day RN. Conformation of CCAAT/enhancer-binding protein alpha dimers varies with intranuclear location in living cells. J Biol Chem. 2003 Mar 21; 278(12):10578-87.
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  17. Day RN, Voss TC, Enwright JF, Booker CF, Periasamy A, Schaufele F. Imaging the localized protein interactions between Pit-1 and the CCAAT/enhancer binding protein alpha in the living pituitary cell nucleus. Mol Endocrinol. 2003 Mar; 17(3):333-45.
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  18. Liu W, Enwright JF, Hyun W, Day RN, Schaufele F. CCAAT/enhancer binding protein alpha uses distinct domains to prolong pituitary cells in the growth 1 and DNA synthesis phases of the cell cycle. BMC Cell Biol. 2002 Mar 21; 3:6.
    View on PubMed
  19. Weatherman RV, Chang CY, Clegg NJ, Carroll DC, Day RN, Baxter JD, McDonnell DP, Scanlan TS, Schaufele F. Ligand-selective interactions of ER detected in living cells by fluorescence resonance energy transfer. Mol Endocrinol. 2002 Mar; 16(3):487-96.
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  20. Schaufele F, Enwright JF, Wang X, Teoh C, Srihari R, Erickson R, MacDougald OA, Day RN. CCAAT/enhancer binding protein alpha assembles essential cooperating factors in common subnuclear domains. Mol Endocrinol. 2001 Oct; 15(10):1665-76.
    View on PubMed

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