John A. Shepherd, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
John A. Shepherd, PhD

Associate Adjunct Professor, Department of Radiology and Biomedical Imaging, UCSF

john.shepherd@ucsf.edu

Phone: (415) 891-7437 (voice)
Box 0628, MRSC, AC122, UCSF
San Francisco, CA 94143-0628

UCSF Profiles

Cancer Center Membership

Program Member » Breast Oncology

Research Summary

John A. Shepherd, PhD, CCD, is a Professor in the Department of Radiology and the Director of the Breast and Bone Density Imaging Group at the University of California, San Francisco. He is an expert in quantitative breast imaging as well as musculoskeletal imaging using x-ray absorptiometry techniques. Dr. Shepherd received his BS in Engineering Physics from Texas Tech University in Lubbock, Texas, and he obtained his PhD in Engineering Physics from the University of Virginia in Charlottesville, Virginia, followed by a postdoctoral fellowship in Biophysics from Princeton University in Princeton, New Jersey.

Dr. Shepherd’s research interests involve quantitative imaging methods for tissue composition using x-rays. His mammographic methods are used extensively for research around the world and in the San Francisco Mammography Registry Program. Dr. Shepherd’s efforts are focused on the technical imaging aspects of the measurements of the body composition and the translation of these measurements into different fields of study. He has present and future research projects in the following areas: breast cancer risk and detection using breast density and tissue texture measures; dual-energy x-ray diagnostic mammography for characterizing compositional signatures of cancer lesions; total body protein measures, body shape analysis and metabolic diseases; statistics of quality assurance and quality control for quantitative measurements.

Education

Texas Tech University, Lubbock, Texas, B.S., 1988, Engineering Physics
University of Virginia, Charlottesville, Virginia, Ph.D., 1993, Engineering Physics
Princeton University, Princeton, NJ, Postdoctoral Fellow, 1993-1996, Biophysics


Professional Experience

  • 9/93 to 1/96
    Postdoctoral Research Assistant, Biophysics Group, Physics Department, Princeton University, Princeton, NJ
  • 1/96 to 1/98
    Senior Scientist, Research and Development Department, Hologic Inc., Waltham, MA
  • 1/98 to 1/99
    Principal Scientist, Research and Development Department, Hologic Inc., Waltham, MA
  • 1/98 to 1/99
    Science Support Coordinator, Research and Development Department Hologic Inc, Waltham, MA
  • 1/99 to present
    Associate Technical Director, Osteoporosis & Arthritis Research Group, Department of Radiology, UCSF, San Francisco, CA
  • 1/99 to 7/03
    Assistant Adjunct Professor, Department of Radiology, University of California San Francisco
  • 6/01 to present
    Faculty Member, Breast Oncology Program, UCSF Cancer Center
  • 10/01 to present
    Faculty Member, Bioengineering Graduate Group, UCSF and UC Berkeley
  • 7/03 to 7/10
    Assistant Professor in Residence, Department of Radiology, University of California San Francisco
  • 7/10 to present
    Associate Adjunct Professor, Department of Radiology and Biomedical Imaging, University of California San Francisco

Honors & Awards

  • 1985
    Sigma Pi Sigma - Physics Honor Society
  • 1987
    C.C. Schmidt Award for Outstanding Underclassman Physics Student, Dept. of Physics, Texas Tech University
  • 1987
    Kappa Mu Epsilon -- Mathematics Honor Society
  • 1987
    Tau Beta Pi -- Engineering Honor Society
  • 1988
    Outstanding Senior Physics Student, Dept. of Physics, Texas Tech University
  • 2000
    Best Poster Presentation (1 of 7 in Technical Category), 14th International Bone Density Workshop, Warnemunde, Germany
  • 2002
    Building Institutional Research Careers in Women's Health (BIRCWH) Scholar
  • 2002
    Co-President, 15th International Bone Density Workshop
  • 2002, 2004, 2006, 2009, 2011
    Co-chair of the Breast Densitometry Workshops
  • 2007
    ISCD John P. Bilezikian Global Leadership Award

Selected Publications

  1. Chesi A, Mitchell JA, Kalkwarf HJ, Bradfield JP, Lappe JM, Cousminer DL, Roy SM, McCormack SE, Gilsanz V, Oberfield SE, Hakonarson H, Shepherd JA, Kelly A, Zemel BS, Grant SF. A Genome-Wide Association Study Identifies Two Sex-specific Loci, at SPTB and IZUMO3, Influencing Pediatric Bone Mineral Density at Multiple Skeletal Sites. J Bone Miner Res. 2017 Feb 09.
    View on PubMed
  2. Cosman F, Krege JH, Looker AC, Schousboe JT, Fan B, Sarafrazi Isfahani N, Shepherd JA, Krohn KD, Steiger P, Wilson KE, Genant HK. Spine fracture prevalence in a nationally representative sample of US women and men aged =40 years: results from the National Health and Nutrition Examination Survey (NHANES) 2013-2014. Osteoporos Int. 2017 Feb 07.
    View on PubMed
  3. Lewiecki EM, Bilezikian JP, Bukata SV, Camacho P, Clarke BL, McClung MR, Miller PD, Shepherd J. Proceedings of the 2016 Santa Fe Bone Symposium: New Concepts in the Management of Osteoporosis and Metabolic Bone Diseases. J Clin Densitom. 2017 Feb 06.
    View on PubMed
  4. Engmann NJ, Scott C, Jensen MR, Ma L, Brandt KR, Mahmoudzadeh A, Malkov S, Whaley DH, Hruska C, Wu FF, Winham S, Miglioretti DL, Norman AD, Heine J, Shepherd J, Pankratz VS, Vachon CM, Kerlikowske K. Longitudinal changes in volumetric breast density with tamoxifen and aromatase inhibitors. Cancer Epidemiol Biomarkers Prev. 2017 Feb 01.
    View on PubMed
  5. Pereira A, Garmendia ML, Uauy R, Neira P, Lopez-Arana S, Malkov S, Shepherd J. Determinants of volumetric breast density in Chilean premenopausal women. Breast Cancer Res Treat. 2017 Jan 28.
    View on PubMed
  6. Malkov S, Shepherd JA, Scott CG, Tamimi RM, Ma L, Bertrand KA, Couch F, Jensen MR, Mahmoudzadeh AP, Fan B, Norman A, Brandt KR, Pankratz VS, Vachon CM, Kerlikowske K. Erratum to: Mammographic texture and risk of breast cancer by tumor type and estrogen receptor status. Breast Cancer Res. 2017 Jan 04; 19(1):1.
    View on PubMed
  7. Malkov S, Shepherd JA, Scott CG, Tamimi RM, Ma L, Bertrand KA, Couch F, Jensen MR, Mahmoudzadeh AP, Fan B, Norman A, Brandt KR, Pankratz VS, Vachon CM, Kerlikowske K. Mammographic texture and risk of breast cancer by tumor type and estrogen receptor status. Breast Cancer Res. 2016 Dec 06; 18(1):122.
    View on PubMed
  8. Shepherd JA, Sommer MJ, Fan B, Powers C, Stranix-Chibanda L, Zadzilka A, Basar M, George K, Mukwasi-Kahari C, Siberry G. Advanced Analysis Techniques Improve Infant Bone and Body Composition Measures by Dual-Energy X-Ray Absorptiometry. J Pediatr. 2016 Nov 18.
    View on PubMed
  9. Strand F, Humphreys K, Cheddad A, Törnberg S, Azavedo E, Shepherd J, Hall P, Czene K. Novel mammographic image features differentiate between interval and screen-detected breast cancer: a case-case study. Breast Cancer Res. 2016 Oct 05; 18(1):100.
    View on PubMed
  10. Strand F, Humphreys K, Eriksson M, Li J, Andersson TM, Törnberg S, Azavedo E, Shepherd J, Hall P, Czene K. Longitudinal fluctuation in mammographic percent density differentiates between interval and screen-detected breast cancer. Int J Cancer. 2016 Sep 12.
    View on PubMed
  11. Felix AS, Lenz P, Pfeiffer RM, Hewitt SM, Morris J, Patel DA, Geller B, Vacek PM, Weaver DL, Chicoine RE, Shepherd J, Mahmoudzadeh AP, Wang J, Fan B, Malkov S, Herschorn SD, Johnson JM, Cora RL, Brinton LA, Sherman ME, Gierach GL. Relationships between mammographic density, tissue microvessel density, and breast biopsy diagnosis. Breast Cancer Res. 2016; 18(1):88.
    View on PubMed
  12. McCormack SE, Chesi A, Mitchell JA, Roy SM, Cousminer DL, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Mahboubi S, Winer KK, Kelly A, Grant SF, Zemel BS. Relative Skeletal Maturation and Population Ancestry in Non-Obese Children and Adolescents. J Bone Miner Res. 2016 Jul 15.
    View on PubMed
  13. Ng BK, Hinton BJ, Fan B, Kanaya AM, Shepherd JA. Clinical anthropometrics and body composition from 3D whole-body surface scans. Eur J Clin Nutr. 2016 Jun 22.
    View on PubMed
  14. Mitchell JA, Chesi A, Elci O, McCormack SE, Roy SM, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Kelly A, Grant SF, Zemel BS. Physical Activity Benefits the Skeleton of Children Genetically Predisposed to Lower Bone Density in Adulthood. J Bone Miner Res. 2016 May 12.
    View on PubMed
  15. Avila JI, Ng BK, Kotowski L, Hinton BJ, Shepherd J. Can Racial Differences in Resting Metabolic Rate be Explained by Body Composition? Obesity (Silver Spring). 2016 Jun; 24(6):1203.
    View on PubMed
  16. Oh H, Khodr ZG, Sherman ME, Palakal M, Pfeiffer RM, Linville L, Geller BM, Vacek PM, Weaver DL, Chicoine RE, Falk RT, Horne HN, Papathomas D, Patel DA, Xiang J, Xu X, Veenstra T, Hewitt SM, Shepherd JA, Brinton LA, Figueroa JD, Gierach GL. Relation of Serum Estrogen Metabolites with Terminal Duct Lobular Unit Involution Among Women Undergoing Diagnostic Image-Guided Breast Biopsy. Horm Cancer. 2016 May 2.
    View on PubMed
  17. Shepherd JA, Heymsfield SB, Norris SA, Redman LM, Ward LC, Slater C. Measuring body composition in low-resource settings across the life course. Obesity (Silver Spring). 2016 May; 24(5):985-8.
    View on PubMed
  18. Mitchell JA, Chesi A, McCormack SE, Roy SM, Cousminer DL, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Kelly A, Zemel BS, Grant SF. Rare EN1 Variants and Pediatric Bone Mass. J Bone Miner Res. 2016 Mar 11.
    View on PubMed
  19. Looker AC, Sarafrazi Isfahani N, Fan B, Shepherd JA. Trabecular bone scores and lumbar spine bone mineral density of US adults: comparison of relationships with demographic and body size variables. Osteoporos Int. 2016 Aug; 27(8):2467-75.
    View on PubMed
  20. Horne HN, Sherman ME, Pfeiffer RM, Figueroa JD, Khodr ZG, Falk RT, Pollak M, Patel DA, Palakal MM, Linville L, Papathomas D, Geller B, Vacek PM, Weaver DL, Chicoine R, Shepherd J, Mahmoudzadeh AP, Wang J, Fan B, Malkov S, Herschorn S, Hewitt SM, Brinton LA, Gierach GL. Circulating insulin-like growth factor-I, insulin-like growth factor binding protein-3 and terminal duct lobular unit involution of the breast: a cross-sectional study of women with benign breast disease. Breast Cancer Res. 2016; 18(1):24.
    View on PubMed

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