John A. Shepherd, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
John A. Shepherd, PhD

Associate Adjunct Professor, Department of Radiology and Biomedical Imaging, UCSF

john.shepherd@ucsf.edu

Phone: (415) 891-7437 (voice)
Box 0628, MRSC, AC122, UCSF
San Francisco, CA 94143-0628

UCSF Profiles

Cancer Center Membership

Program Member » Breast Oncology

Research Summary

John A. Shepherd, PhD, CCD, is a Professor in the Department of Radiology and the Director of the Breast and Bone Density Imaging Group at the University of California, San Francisco. He is an expert in quantitative breast imaging as well as musculoskeletal imaging using x-ray absorptiometry techniques. Dr. Shepherd received his BS in Engineering Physics from Texas Tech University in Lubbock, Texas, and he obtained his PhD in Engineering Physics from the University of Virginia in Charlottesville, Virginia, followed by a postdoctoral fellowship in Biophysics from Princeton University in Princeton, New Jersey.

Dr. Shepherd’s research interests involve quantitative imaging methods for tissue composition using x-rays. His mammographic methods are used extensively for research around the world and in the San Francisco Mammography Registry Program. Dr. Shepherd’s efforts are focused on the technical imaging aspects of the measurements of the body composition and the translation of these measurements into different fields of study. He has present and future research projects in the following areas: breast cancer risk and detection using breast density and tissue texture measures; dual-energy x-ray diagnostic mammography for characterizing compositional signatures of cancer lesions; total body protein measures, body shape analysis and metabolic diseases; statistics of quality assurance and quality control for quantitative measurements.

Education

Texas Tech University, Lubbock, Texas, B.S., 1988, Engineering Physics
University of Virginia, Charlottesville, Virginia, Ph.D., 1993, Engineering Physics
Princeton University, Princeton, NJ, Postdoctoral Fellow, 1993-1996, Biophysics


Professional Experience

  • 9/93 to 1/96
    Postdoctoral Research Assistant, Biophysics Group, Physics Department, Princeton University, Princeton, NJ
  • 1/96 to 1/98
    Senior Scientist, Research and Development Department, Hologic Inc., Waltham, MA
  • 1/98 to 1/99
    Principal Scientist, Research and Development Department, Hologic Inc., Waltham, MA
  • 1/98 to 1/99
    Science Support Coordinator, Research and Development Department Hologic Inc, Waltham, MA
  • 1/99 to present
    Associate Technical Director, Osteoporosis & Arthritis Research Group, Department of Radiology, UCSF, San Francisco, CA
  • 1/99 to 7/03
    Assistant Adjunct Professor, Department of Radiology, University of California San Francisco
  • 6/01 to present
    Faculty Member, Breast Oncology Program, UCSF Cancer Center
  • 10/01 to present
    Faculty Member, Bioengineering Graduate Group, UCSF and UC Berkeley
  • 7/03 to 7/10
    Assistant Professor in Residence, Department of Radiology, University of California San Francisco
  • 7/10 to present
    Associate Adjunct Professor, Department of Radiology and Biomedical Imaging, University of California San Francisco

Honors & Awards

  • 1985
    Sigma Pi Sigma - Physics Honor Society
  • 1987
    C.C. Schmidt Award for Outstanding Underclassman Physics Student, Dept. of Physics, Texas Tech University
  • 1987
    Kappa Mu Epsilon -- Mathematics Honor Society
  • 1987
    Tau Beta Pi -- Engineering Honor Society
  • 1988
    Outstanding Senior Physics Student, Dept. of Physics, Texas Tech University
  • 2000
    Best Poster Presentation (1 of 7 in Technical Category), 14th International Bone Density Workshop, Warnemunde, Germany
  • 2002
    Building Institutional Research Careers in Women's Health (BIRCWH) Scholar
  • 2002
    Co-President, 15th International Bone Density Workshop
  • 2002, 2004, 2006, 2009, 2011
    Co-chair of the Breast Densitometry Workshops
  • 2007
    ISCD John P. Bilezikian Global Leadership Award

Selected Publications

  1. McCormack SE, Chesi A, Mitchell JA, Roy SM, Cousminer DL, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Mahboubi S, Winer KK, Kelly A, Grant SF, Zemel BS. Relative Skeletal Maturation and Population Ancestry in Non-Obese Children and Adolescents. J Bone Miner Res. 2016 Jul 15.
    View on PubMed
  2. Ng BK, Hinton BJ, Fan B, Kanaya AM, Shepherd JA. Clinical anthropometrics and body composition from 3D whole-body surface scans. Eur J Clin Nutr. 2016 Jun 22.
    View on PubMed
  3. Mitchell JA, Chesi A, Elci O, McCormack SE, Roy SM, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Kelly A, Grant SF, Zemel BS. Physical Activity Benefits the Skeleton of Children Genetically Predisposed to Lower Bone Density in Adulthood. J Bone Miner Res. 2016 May 12.
    View on PubMed
  4. Avila JI, Ng BK, Kotowski L, Hinton BJ, Shepherd J. Can Racial Differences in Resting Metabolic Rate be Explained by Body Composition? Obesity (Silver Spring). 2016 Jun; 24(6):1203.
    View on PubMed
  5. Oh H, Khodr ZG, Sherman ME, Palakal M, Pfeiffer RM, Linville L, Geller BM, Vacek PM, Weaver DL, Chicoine RE, Falk RT, Horne HN, Papathomas D, Patel DA, Xiang J, Xu X, Veenstra T, Hewitt SM, Shepherd JA, Brinton LA, Figueroa JD, Gierach GL. Relation of Serum Estrogen Metabolites with Terminal Duct Lobular Unit Involution Among Women Undergoing Diagnostic Image-Guided Breast Biopsy. Horm Cancer. 2016 May 2.
    View on PubMed
  6. Shepherd JA, Heymsfield SB, Norris SA, Redman LM, Ward LC, Slater C. Measuring body composition in low-resource settings across the life course. Obesity (Silver Spring). 2016 May; 24(5):985-8.
    View on PubMed
  7. Mitchell JA, Chesi A, McCormack SE, Roy SM, Cousminer DL, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Kelly A, Zemel BS, Grant SF. Rare EN1 Variants and Pediatric Bone Mass. J Bone Miner Res. 2016 Mar 11.
    View on PubMed
  8. Looker AC, Sarafrazi Isfahani N, Fan B, Shepherd JA. Trabecular bone scores and lumbar spine bone mineral density of US adults: comparison of relationships with demographic and body size variables. Osteoporos Int. 2016 Aug; 27(8):2467-75.
    View on PubMed
  9. Brandt KR, Scott CG, Ma L, Mahmoudzadeh AP, Jensen MR, Whaley DH, Wu FF, Malkov S, Hruska CB, Norman AD, Heine J, Shepherd J, Pankratz VS, Kerlikowske K, Vachon CM. Comparison of Clinical and Automated Breast Density Measurements: Implications for Risk Prediction and Supplemental Screening. Radiology. 2016 Jun; 279(3):710-9.
    View on PubMed
  10. Mitchell JA, Chesi A, Elci O, McCormack SE, Roy SM, Kalkwarf HJ, Lappe JM, Gilsanz V, Oberfield SE, Shepherd JA, Kelly A, Grant SF, Zemel BS. Genetic Risk Scores Implicated in Adult Bone Fragility Associate With Pediatric Bone Density. J Bone Miner Res. 2016 Apr; 31(4):789-95.
    View on PubMed
  11. Gierach GL, Patel DA, Pfeiffer RM, Figueroa JD, Linville L, Papathomas D, Johnson JM, Chicoine RE, Herschorn SD, Shepherd JA, Wang J, Malkov S, Vacek PM, Weaver DL, Fan B, Mahmoudzadeh AP, Palakal M, Xiang J, Oh H, Horne HN, Sprague BL, Hewitt SM, Brinton LA, Sherman ME. Relationship of Terminal Duct Lobular Unit Involution of the Breast with Area and Volume Mammographic Densities. Cancer Prev Res (Phila). 2016 Feb; 9(2):149-58.
    View on PubMed
  12. Bodelon C, Heaphy CM, Meeker AK, Geller B, Vacek PM, Weaver DL, Chicoine RE, Shepherd JA, Mahmoudzadeh AP, Patel DA, Brinton LA, Sherman ME, Gierach GL. Leukocyte telomere length and its association with mammographic density and proliferative diagnosis among women undergoing diagnostic image-guided breast biopsy. BMC Cancer. 2015; 15(1):823.
    View on PubMed
  13. Setiawan VW, Lim U, Lipworth L, Lu SC, Shepherd J, Ernst T, Wilkens LR, Henderson BE, Le Marchand L. Sex and Ethnic Differences in the Association of Obesity With Risk of Hepatocellular Carcinoma. Clin Gastroenterol Hepatol. 2016 Feb; 14(2):309-16.
    View on PubMed
  14. Xie B, Avila JI, Ng BK, Fan B, Loo V, Gilsanz V, Hangartner T, Kalkwarf HJ, Lappe J, Oberfield S, Winer K, Zemel B, Shepherd JA. Accurate body composition measures from whole-body silhouettes. Med Phys. 2015 Aug; 42(8):4668-77.
    View on PubMed
  15. Medina-Gómez C, Chesi A, Heppe DH, Zemel BS, Yin JL, Kalkwarf HJ, Hofman A, Lappe JM, Kelly A, Kayser M, Oberfield SE, Gilsanz V, Uitterlinden AG, Shepherd JA, Jaddoe VW, Grant SF, Lao O, Rivadeneira F. BMD Loci Contribute to Ethnic and Developmental Differences in Skeletal Fragility across Populations: Assessment of Evolutionary Selection Pressures. Mol Biol Evol. 2015 Nov; 32(11):2961-72.
    View on PubMed
  16. Bertrand KA, Baer HJ, Orav EJ, Klifa C, Shepherd JA, Van Horn L, Snetselaar L, Stevens VJ, Hylton NM, Dorgan JF. Body fatness during childhood and adolescence and breast density in young women: a prospective analysis. Breast Cancer Res. 2015; 17:95.
    View on PubMed
  17. Engelke K, Lang T, Khosla S, Qin L, Zysset P, Leslie WD, Shepherd JA, Schousboe JT. Clinical Use of Quantitative Computed Tomography (QCT) of the Hip in the Management of Osteoporosis in Adults: the 2015 ISCD Official Positions-Part I. J Clin Densitom. 2015 Jul-Sep; 18(3):338-58.
    View on PubMed
  18. Zysset P, Qin L, Lang T, Khosla S, Leslie WD, Shepherd JA, Schousboe JT, Engelke K. Clinical Use of Quantitative Computed Tomography-Based Finite Element Analysis of the Hip and Spine in the Management of Osteoporosis in Adults: the 2015 ISCD Official Positions-Part II. J Clin Densitom. 2015 Jul-Sep; 18(3):359-92.
    View on PubMed
  19. Silva BC, Broy SB, Boutroy S, Schousboe JT, Shepherd JA, Leslie WD. Fracture Risk Prediction by Non-BMD DXA Measures: the 2015 ISCD Official Positions Part 2: Trabecular Bone Score. J Clin Densitom. 2015 Jul-Sep; 18(3):309-30.
    View on PubMed
  20. Engelke K, Lang T, Khosla S, Qin L, Zysset P, Leslie WD, Shepherd JA, Shousboe JT. Clinical Use of Quantitative Computed Tomography-Based Advanced Techniques in the Management of Osteoporosis in Adults: the 2015 ISCD Official Positions-Part III. J Clin Densitom. 2015 Jul-Sep; 18(3):393-407.
    View on PubMed

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