University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
David A. Solomon, MD, PhD

David A. Solomon, MD, PhD

Director of Molecular Neuro-Oncology, UCSF Clinical Cancer Genomics Laboratory; Assistant Professor, Department of Pathology, UCSF

Cancer Center Program Memberships

Cancer Genetics

Research Summary

The Solomon laboratory studies the molecular mechanisms governing human cancer development and progression. We recently discovered frequent inactivating mutations of the cohesin complex gene STAG2 in a spectrum of cancers including glioblastoma, urothelial carcinoma, Ewing sarcoma, and acute myeloid leukemia, which define molecular subgroups of these tumors with distinct clinical outcomes. The cohesin complex is responsible for sister chromatid cohesion following DNA replication and helps ensure faithful chromosome segregation during mitosis, but has also been implicated in additional cellular processes such as regulation of chromatin architecture and gene transcription. We are currently working to determine the function of cohesin during tumorigenesis and to identify therapeutic vulnerabilities in the many cancers harboring cohesin gene alterations. Other ongoing research is focused on identifying the recurrent genetic alterations that drive the many different brain tumor variants including glioblastoma, astrocytoma, oligodendroglioma, ependymoma, other gliomas, medulloblastoma, neurocytoma, meningioma, choroid plexus tumors, and pineal parenchymal tumors.

My clinical interests focus on diagnostic neuropathology, particularly tumors of the central nervous system. Accurate pathologic classification of brain tumors is increasingly dependent on integration of histologic features together with specific genetic alterations that molecularly define the many CNS tumor subtypes. I have thus been working with the Clinical Cancer Genomics Laboratory to advance molecular diagnostic testing for brain tumors at UCSF, where I function as the Director of Molecular Neuro-Oncology responsible for supervising and interpreting all genomic testing performed on CNS tumors at UCSF Medical Center.

Education

College of William and Mary, B.S., 1998-2002
University of Cincinnati College of Medicine, post-bac research, 2002-2004
Georgetown University School of Medicine, MD, PhD, 2004-2012
University of California San Francisco, Anatomic Pathology Residency, 2012-2014
University of California San Francisco, Neuropathology Fellowship, 2014-2016


Professional Experience

  • 2016-present
    Assistant Professor (tenure-track), Department of Pathology, UCSF
  • 2016-present
    Member, UCSF Helen Diller Family Comprehensive Cancer Center
  • 2016-present
    Faculty member, UCSF Biomedical Sciences Graduate Program
  • 2018-present
    Principal Investigator, UCSF Brain Tumor Research Center
  • 2018-present
    Director of Molecular Neuro-Oncology, UCSF Clinical Cancer Genomics Laboratory

Honors & Awards

  • 2016-2021
    UCSF Physician-Scientist Scholar Program
  • 2015-2020
    NIH Director's Early Independence Award (DP5)
  • 2015-2016
    Career Development Research Award, UCSF Brain Tumor SPORE
  • 2015
    Hans Popper Hepatopathology Society Award
  • 2014
    Stowell-Orbison Award, United States & Canada Academy of Pathology
  • 2014
    International Society of Bone & Soft Tissue Pathology Young Investigator Award
  • 2013
    Julius R. Krevans Award, San Francisco General Hospital
  • 2013
    Stowell-Orbison Award, United States & Canada Academy of Pathology
  • 2012
    Harold Weintraub Graduate Student Award, Fred Hutchinson Cancer Research Center
  • 2012
    Future Leaders in Basic Cancer Research, American Association for Cancer Research
  • 2004-2012
    Strauss Physician-Scientist Training Fellowship, Georgetown University School of Medicine

Selected Publications

  1. Pekmezci M, Villanueva-Meyer JE, Goode B, Van Ziffle J, Onodera C, Grenert JP, Bastian BC, Chamyan G, Maher OM, Khatib Z, Kleinschmidt-DeMasters BK, Samuel D, Mueller S, Banerjee A, Clarke JL, Cooney T, Torkildson J, Gupta N, Theodosopoulos P, Chang EF, Berger M, Bollen AW, Perry A, Tihan T, Solomon DA. The genetic landscape of ganglioglioma. Acta Neuropathol Commun. 2018 Jun 07; 6(1):47.
    View on PubMed
  2. North JP, Golovato J, Vaske CJ, Sanborn JZ, Nguyen A, Wu W, Goode B, Stevers M, McMullen K, Perez White BE, Collisson EA, Bloomer M, Solomon DA, Benz SC, Cho RJ. Cell of origin and mutation pattern define three clinically distinct classes of sebaceous carcinoma. Nat Commun. 2018 May 14; 9(1):1894.
    View on PubMed
  3. Waszak SM, Northcott PA, Buchhalter I, Robinson GW, Sutter C, Groebner S, Grund KB, Brugières L, Jones DTW, Pajtler KW, Morrissy AS, Kool M, Sturm D, Chavez L, Ernst A, Brabetz S, Hain M, Zichner T, Segura-Wang M, Weischenfeldt J, Rausch T, Mardin BR, Zhou X, Baciu C, Lawerenz C, Chan JA, Varlet P, Guerrini-Rousseau L, Fults DW, Grajkowska W, Hauser P, Jabado N, Ra YS, Zitterbart K, Shringarpure SS, De La Vega FM, Bustamante CD, Ng HK, Perry A, MacDonald TJ, Hernáiz Driever P, Bendel AE, Bowers DC, McCowage G, Chintagumpala MM, Cohn R, Hassall T, Fleischhack G, Eggen T, Wesenberg F, Feychting M, Lannering B, Schüz J, Johansen C, Andersen TV, Röösli M, Kuehni CE, Grotzer M, Kjaerheim K, Monoranu CM, Archer TC, Duke E, Pomeroy SL, Shelagh R, Frank S, Sumerauer D, Scheurlen W, Ryzhova MV, Milde T, Kratz CP, Samuel D, Zhang J, Solomon DA, Marra M, Eils R, Bartram CR, von Hoff K, Rutkowski S, Ramaswamy V, Gilbertson RJ, Korshunov A, Taylor MD, Lichter P, Malkin D, Gajjar A, Korbel JO, Pfister SM. Spectrum and prevalence of genetic predisposition in medulloblastoma: a retrospective genetic study and prospective validation in a clinical trial cohort. Lancet Oncol. 2018 May 09.
    View on PubMed
  4. Ding S, Diep J, Feng N, Ren L, Li B, Ooi YS, Wang X, Brulois KF, Yasukawa LL, Li X, Kuo CJ, Solomon DA, Carette JE, Greenberg HB. STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection. Nat Commun. 2018 Apr 16; 9(1):1485.
    View on PubMed
  5. Hayes J, Yu Y, Jalbert LE, Mazor T, Jones LE, Wood MD, Walsh KM, Bengtsson H, Hong C, Oberndorfer S, Roetzer T, Smirnov IV, Clarke JL, Aghi MK, Chang SM, Nelson SJ, Woehrer A, Phillips JJ, Solomon DA, Costello JF. Genomic analysis of the origins and evolution of multicentric diffuse lower-grade gliomas. Neuro Oncol. 2018 Apr 09; 20(5):632-641.
    View on PubMed
  6. Goode B, Mondal G, Hyun M, Ruiz DG, Lin YH, Van Ziffle J, Joseph NM, Onodera C, Talevich E, Grenert JP, Hewedi IH, Snuderl M, Brat DJ, Kleinschmidt-DeMasters BK, Rodriguez FJ, Louis DN, Yong WH, Lopes MB, Rosenblum MK, Butowski N, Tihan T, Bollen AW, Phillips JJ, Wiita AP, Yeh I, Jacobson MP, Bastian BC, Perry A, Solomon DA. A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle. Nat Commun. 2018 02 23; 9(1):810.
    View on PubMed
  7. Iorgulescu JB, Van Ziffle J, Stevers M, Grenert JP, Bastian BC, Chavez L, Stichel D, Buchhalter I, Samuel D, Nicolaides T, Banerjee A, Mueller S, Gupta N, Tihan T, Bollen AW, Northcott PA, Kool M, Pfister S, Korshunov A, Perry A, Solomon DA. Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation. Acta Neuropathol. 2018 Apr; 135(4):635-638.
    View on PubMed
  8. Pekmezci M, Stevers M, Phillips JJ, Van Ziffle J, Bastian BC, Tsankova NM, Kleinschmidt-DeMasters BK, Rosenblum MK, Tihan T, Perry A, Solomon DA. Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway. Acta Neuropathol. 2018 Mar; 135(3):485-488.
    View on PubMed
  9. Paret C, Russo A, Otto H, Mayer A, Zahnreich S, Wagner W, Samuel D, Scharnhorst D, Solomon DA, Dhall G, Wong K, Bender H, Alt F, Wingerter A, Neu MA, Beck O, Prawitt D, Eder S, Henninger N, El Malki K, Lehmann N, Backes N, Roth L, Seidmann L, Sommer C, Brockmann MA, Staatz G, Schmidberger H, Faber J. Personalized therapy: CNS HGNET-BCOR responsiveness to arsenic trioxide combined with radiotherapy. Oncotarget. 2017 Dec 26; 8(69):114210-114225.
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  10. Goode B, Joseph NM, Stevers M, Van Ziffle J, Onodera C, Talevich E, Grenert JP, Yeh I, Bastian BC, Phillips JJ, Garg K, Rabban JT, Zaloudek C, Solomon DA. Adenomatoid tumors of the male and female genital tract are defined by TRAF7 mutations that drive aberrant NF-kB pathway activation. Mod Pathol. 2018 Apr; 31(4):660-673.
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  11. Wood MD, Tihan T, Perry A, Chacko G, Turner C, Pu C, Payne C, Yu A, Bannykh SI, Solomon DA. Multimodal molecular analysis of astroblastoma enables reclassification of most cases into more specific molecular entities. Brain Pathol. 2018 03; 28(2):192-202.
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  12. Lopez GY, Oberheim Bush NA, Phillips JJ, Bouffard JP, Moshel YA, Jaeckle K, Kleinschmidt-DeMasters BK, Rosenblum MK, Perry A, Solomon DA. Diffuse midline gliomas with subclonal H3F3A K27M mutation and mosaic H3.3 K27M mutant protein expression. Acta Neuropathol. 2017 Dec; 134(6):961-963.
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  13. Chan AK, Han SJ, Choy W, Beleford D, Aghi MK, Berger MS, Shieh JT, Bollen AW, Perry A, Phillips JJ, Butowski N, Solomon DA. Familial melanoma-astrocytoma syndrome: synchronous diffuse astrocytoma and pleomorphic xanthoastrocytoma in a patient with germline CDKN2A/B deletion and a significant family history. Clin Neuropathol. 2017 Sep/Oct; 36(5):213-221.
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  14. Graham RP, Yeh MM, Lam-Himlin D, Roberts LR, Terracciano L, Cruise MW, Greipp PT, Zreik RT, Jain D, Zaid N, Salaria SN, Jin L, Wang X, Rustin JG, Kerr SE, Sukov WR, Solomon DA, Kakar S, Waterhouse E, Gill RM, Ferrell L, Alves VA, Nart D, Yilmaz F, Roessler S, Longerich T, Schirmacher P, Torbenson MS. Molecular testing for the clinical diagnosis of fibrolamellar carcinoma. Mod Pathol. 2018 Jan; 31(1):141-149.
    View on PubMed
  15. Kline CN, Packer RJ, Hwang EI, Raleigh DR, Braunstein S, Raffel C, Bandopadhayay P, Solomon DA, Aboian M, Cha S, Mueller S. Case-based review: pediatric medulloblastoma. Neurooncol Pract. 2017 Sep; 4(3):138-150.
    View on PubMed
  16. Chan E, Bollen AW, Sirohi D, Van Ziffle J, Grenert JP, Kline CN, Tihan T, Perry A, Gupta N, Solomon DA. Angiocentric glioma with MYB-QKI fusion located in the brainstem, rather than cerebral cortex. Acta Neuropathol. 2017 Oct; 134(4):671-673.
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  17. Sorge C, Li R, Singh S, Reddy AT, Solomon DA, Perry A, Friedman GK. Complete durable response of a pediatric anaplastic oligodendroglioma to temozolomide alone: Case report and review of literature. Pediatr Blood Cancer. 2017 Dec; 64(12).
    View on PubMed
  18. Ferris SP, Hofmann JW, Solomon DA, Perry A. Characterization of gliomas: from morphology to molecules. Virchows Arch. 2017 Aug; 471(2):257-269.
    View on PubMed
  19. Dahlin LB, Scherman P, Besjakov J, Lindberg E, Solomon DA, Horvai AE, Perry A. Intraneural glomus tumor of "uncertain malignant potential" and with BRAF mutation in the median nerve - an unusual case. Clin Neuropathol. 2017 Jul/Aug; 36(4):164-170.
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  20. Krings G, Joseph NM, Bean GR, Solomon D, Onodera C, Talevich E, Yeh I, Grenert JP, Hosfield E, Crawford ED, Jordan RC, van Zante A, Zaloudek C, Shin SJ, Chen YY. Genomic profiling of breast secretory carcinomas reveals distinct genetics from other breast cancers and similarity to mammary analog secretory carcinomas. Mod Pathol. 2017 Aug; 30(8):1086-1099.
    View on PubMed

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