David Abram Solomon, MD, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
David Abram Solomon, MD, PhD

Clinical Fellow, Department of Pathology, UCSF

David.Solomon@ucsf.edu

Phone: (415) 353-1613
Box 0102, UCSF
San Francisco, CA 94143-0102

UCSF Profiles

Cancer Center Membership

Member » Neurologic Oncology» Cancer Genetics

Research Summary

Starting early in my education, I have been very interested in complex biological systems with relevance to human disease. During my four years at the College of William & Mary, I performed research in the lab of Dr. Margaret Saha defining the spatiotemporal development of neurotransmitter systems within the amphibian brain. I spent my summers during my undergraduate training in the multiple sclerosis lab of Dr. Timothy Vartanian at Harvard Medical School studying the regulation of oligodendrocyte myelination in the developing central nervous system. After completion of my undergraduate degree, I worked for two years at the University of Cincinnati College of Medicine in the lab of Dr. Erik Knudsen studying the regulation of cell growth by the retinoblastoma tumor suppressor, which led to several first-author publications, the most prominent of which describes the discovery of a novel oncogenic splice variant of cyclin D1 which we termed cyclin D1b and published in the Journal of Biological Chemistry in 2003.

Thereafter, I completed my medical and graduate training in the MD/PhD program at Georgetown University School of Medicine with my thesis research “Identification and Therapeutic Targeting of Novel Transforming Pathways in Human Glioblastoma Multiforme” performed in the lab of Dr. Todd Waldman. During my time at Georgetown, I gained expertise in the genetics of brain tumors and sought an opportunity to apply this knowledge in the field of diagnostic and translational neuropathology. I then entered a combined Anatomic Pathology Residency and Neuropathology Fellowship at UCSF, where I am currently in the final year of training devoted to neuropathology research with minimal clinical responsibilities. I am very interested in the application of molecular diagnostics for cancer pathology and the use of personalized targeted therapeutics based on the genetic profile of individual tumor specimens. I aspire to be an academic physician-scientist both attending as a neuropathologist and molecular pathologist, as well as continuing my research on the genetics of cancer.

During my graduate training, I made an important discovery in the field of cancer biology by identifying mutational inactivation of the STAG2 gene as one of the first common genetic causes of aneuploidy in human cancer (Solomon et al., Science, 2011). Moreover, I have subsequently discovered frequent truncating mutations of this cohesin complex gene STAG2 in urothelial bladder carcinoma (Solomon et al., Nature Genetics, 2013) and Ewing’s sarcoma (Brohl and Solomon et al., PLoS Genetics, 2014) which define a molecular subgroup of these tumors with distinct clinical outcomes. I now aim to define the role of cohesin gene inactivation in cancer pathogenesis and develop effective targeted therapies for the many patients whose tumors harbor cohesin mutations.

Education

College of William and Mary, Williamsburg, VA B.S., 2002, Molecular Cell Biology
University of Cincinnati College of Medicine, OH post-bac research, 2004, Cancer Biology
Georgetown University, Washington, DC, M.D., Ph.D. 08/04-05/12 Medicine, Tumor Biology
University of California, San Francisco, CA, Residency 07/12-06/14 Anatomic Pathology
University of California, San Francisco, CA, Fellowship 07/14-06/16 Neuropathology


Professional Experience

  • 07/2016
    Assistant Professor, Department of Pathology, University of California, San Francisco

Honors & Awards

  • 2015-2020
    NIH Director’s Early Independence Award, funded from the NIH Common Fund's High-Risk, High-Reward Program to support early independence of exceptional early career scientists
  • 2015-2016
    Career Development Research Award, UCSF Brain Tumor SPORE
  • 2015
    Hans Popper Hepatopathology Society Award, best abstract presentation by a trainee at the 2015 United States & Canada Academy of Pathology Annual Meeting, Boston
  • 2014
    Stowell-Orbison Award, one of three recipients of award presented at the 2014 U.S. & Canada Academy of Pathology Annual Meeting for best abstract presentation by a trainee, San Diego
  • 2014
    International Society of Bone & Soft Tissue Pathology Young Investigator Award, best abstract presentation by a trainee at the 2014 U.S. & Canada Academy of Pathology Annual Meeting
  • 2013
    Outstanding Resident Research Award, recipient of annual award from The Resident Research Training Program, UCSF
  • 2013
    Julius R. Krevans Award, recipient of annual award presented for clinical excellence to a UCSF intern in each specialty at San Francisco General Hospital
  • 2013
    Stowell-Orbison Award, one of four recipients of award presented at the 2013 U.S. & Canada Academy of Pathology Annual Meeting for best abstract presentation by a trainee, Baltimore
  • 2012
    Harold Weintraub Graduate Student Award, one of twelve recipients of award presented at the 2012 Weintraub Memorial Symposium at the Fred Hutchinson Cancer Research Center, Seattle
  • 2012
    Future Leaders in Basic Cancer Research, one of four recipients of award presented at the 2012 American Association for Cancer Research Annual Meeting, Chicago

Selected Publications

  1. López G, Oberheim Bush NA, Berger MS, Perry A, Solomon DA. Diffuse non-midline glioma with H3F3A K27M mutation: a prognostic and treatment dilemma. Acta Neuropathol Commun. 2017 May 15; 5(1):38.
    View on PubMed
  2. Kline CN, Joseph NM, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh DR, Braunstein S, Torkildson J, Samuel D, Bloomer M, Campomanes AGA, Banerjee A, Butowski N, Raffel C, Tihan T, Bollen AW, Phillips JJ, Korn WM, Yeh I, Bastian BC, Gupta N, Mueller S, Perry A, Nicolaides T, Solomon DA. Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy. Neuro Oncol. 2017 May 01; 19(5):699-709.
    View on PubMed
  3. Dahlin LB, Scherman P, Besjakov J, Lindberg E, Solomon DA, Horvai AE, Perry A. Intraneural glomus tumor of "uncertain malignant potential" and with BRAF mutation in the median nerve - an unusual case. Clin Neuropathol. 2017 Apr 25.
    View on PubMed
  4. Erwood AA, Velazquez-Vega JE, Neill S, Solomon DA, Butowski N, Nowlan A, Dunbar E, Brat DJ. Chordoid glioma of the third ventricle: report of a rapidly progressive case. J Neurooncol. 2017 Mar 18.
    View on PubMed
  5. Cuevas-Ocampo AK, Bollen AW, Goode B, Pajtler KW, Chavez L, Sharma T, Dai SC, McDermott M, Perry A, Korshunov A, Solomon DA. Genetic confirmation that ependymoma can arise as part of multiple endocrine neoplasia type 1 (MEN1) syndrome. Acta Neuropathol. 2017 Feb 25.
    View on PubMed
  6. Aboian MS, Solomon DA, Felton E, Mabray MC, Villanueva-Meyer JE, Mueller S, Cha S. Imaging Characteristics of Pediatric Diffuse Midline Gliomas with Histone H3 K27M Mutation. AJNR Am J Neuroradiol. 2017 Feb 09.
    View on PubMed
  7. Lee J, Solomon DA, Tihan T. The role of histone modifications and telomere alterations in the pathogenesis of diffuse gliomas in adults and children. J Neurooncol. 2017 Jan 07.
    View on PubMed
  8. Joseph NM, Chen YY, Nasr A, Yeh I, Talevich E, Onodera C, Bastian BC, Rabban JT, Garg K, Zaloudek C, Solomon DA. Genomic profiling of malignant peritoneal mesothelioma reveals recurrent alterations in epigenetic regulatory genes BAP1, SETD2, and DDX3X. Mod Pathol. 2016 Nov 04.
    View on PubMed
  9. Phillips JJ, Gong H, Chen K, Joseph NM, van Ziffle J, Jin LW, Bastian BC, Bollen AW, Perry A, Nicolaides T, Solomon DA, Shieh JT. Activating NRF1-BRAF and ATG7-RAF1 fusions in anaplastic pleomorphic xanthoastrocytoma without BRAF p.V600E mutation. Acta Neuropathol. 2016 Sep 13.
    View on PubMed
  10. Cohen JN, Solomon DA, Horvai AE, Kakar S. Pancreatic Involvement by Mesenchymal Chondrosarcoma Harboring the HEY1-NCOA2 Gene Fusion. Hum Pathol. 2016 Aug 17.
    View on PubMed
  11. Hale G, Liu X, Hu J, Xu Z, Che L, Solomon D, Tsokos C, Shafizadeh N, Chen X, Gill R, Kakar S. Correlation of exon 3 ß-catenin mutations with glutamine synthetase staining patterns in hepatocellular adenoma and hepatocellular carcinoma. Mod Pathol. 2016 Jul 29.
    View on PubMed
  12. Raleigh DR, Solomon DA, Lloyd SA, Lazar A, Garcia MA, Sneed PK, Clarke JL, McDermott MW, Berger MS, Tihan T, Haas-Kogan DA. Histopathologic review of pineal parenchymal tumors identifies novel morphologic subtypes and prognostic factors for outcome. Neuro Oncol. 2016 Jun 9.
    View on PubMed
  13. Ferris SP, Goode B, Joseph NM, Kline CN, Samuel D, Gupta N, Bollen A, Perry A, Mueller S, Solomon DA. IDH1 mutation can be present in diffuse astrocytomas and giant cell glioblastomas of young children under 10 years of age. Acta Neuropathol. 2016 Jul; 132(1):153-5.
    View on PubMed
  14. Garcia MA, Solomon DA, Haas-Kogan DA. Exploiting molecular biology for diagnosis and targeted management of pediatric low-grade gliomas. Future Oncol. 2016 Jun; 12(12):1493-506.
    View on PubMed
  15. Kline CN, Joseph NM, Grenert JP, van Ziffle J, Yeh I, Bastian BC, Mueller S, Solomon DA. Inactivating MUTYH germline mutations in pediatric patients with high-grade midline gliomas. Neuro Oncol. 2016 May; 18(5):752-3.
    View on PubMed
  16. Joseph NM, Solomon DA, Frizzell N, Rabban JT, Zaloudek C, Garg K. Morphology and Immunohistochemistry for 2SC and FH Aid in Detection of Fumarate Hydratase Gene Aberrations in Uterine Leiomyomas From Young Patients. Am J Surg Pathol. 2015 Nov; 39(11):1529-39.
    View on PubMed
  17. Solomon DA, Wood MD, Tihan T, Bollen AW, Gupta N, Phillips JJ, Perry A. Diffuse Midline Gliomas with Histone H3-K27M Mutation: A Series of 47 Cases Assessing the Spectrum of Morphologic Variation and Associated Genetic Alterations. Brain Pathol. 2015 Oct 30.
    View on PubMed
  18. Mabray MC, Glastonbury CM, Mamlouk MD, Punch GE, Solomon DA, Cha S. Direct Cranial Nerve Involvement by Gliomas: Case Series and Review of the Literature. AJNR Am J Neuroradiol. 2015 Jul; 36(7):1349-54.
    View on PubMed
  19. Solomon DA, Brohl AS, Khan J, Miettinen M. Clinicopathologic features of a second patient with Ewing-like sarcoma harboring CIC-FOXO4 gene fusion. Am J Surg Pathol. 2014 Dec; 38(12):1724-5.
    View on PubMed
  20. Hashizume R, Andor N, Ihara Y, Lerner R, Gan H, Chen X, Fang D, Huang X, Tom MW, Ngo V, Solomon D, Mueller S, Paris PL, Zhang Z, Petritsch C, Gupta N, Waldman TA, James CD. Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma. Nat Med. 2014 Dec; 20(12):1394-6.
    View on PubMed

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