Didier Stainier, PhD

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Additional Websites

• Lab Website

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Education

Brandeis University, Waltham, MA, B.A. (summa cum laude), 1984, Biology
Harvard University, Cambridge, MA, Ph.D., 1990, Biochemistry and Molecular Biology
Massachusetts General Hospital and Harvard Medical School, Boston, MA, Postdoc, 1994

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Professional Experience

• 1982-84
  Undergraduate research with Erik Selsing at Brandeis University
• 1984-90
  Doctoral research with Walter Gilbert at Harvard University
• 1990-94
  Postdoctoral research with Mark C. Fishman at the Massachusetts General Hospital, Harvard Medical School
• 1995-2000
  Assistant Professor, Department of Biochemistry and Biophysics, University of California, San Francisco
• 2000-2003
  Associate Professor, Department of Biochemistry and Biophysics, University of California, San Francisco
• 2003-present
  Professor, Department of Biochemistry and Biophysics, University of California, San Francisco

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Honors & Awards

• 1982-84
  Wien International Scholarship, Brandeis University
• 1983
  Elihu A. Silver Prize for undergraduate research in Science, Brandeis University
• 1984
  Dr. Joseph Garrison Parker Prize in Biology, Brandeis University
• 1984
  Phi Beta Kappa, Brandeis Chapter
• 1991-94
  Helen Hay Whitney Foundation Postdoctoral Fellowship
• 1995
  Louis N. Katz Basic Science Research Prize Finalist, American Heart Association
• 1995
  Packard Foundation Fellow in Science and Engineering
• 1996
  Basil O'Connor Scholar, March of Dimes Foundation
• 2000-2003
  American Heart Association Established Investigator
• 2002
  Mossman Developmental Biologist Award, American Association of Anatomists
• 2002
  Annual Byers Award in Basic Science, UCSF
• 2003
  Outstanding Faculty Mentorship Award, UCSF

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Selected Publications

1. Yin C, Evason KJ, Asahina K, Stainier DY. Hepatic stellate cells in liver development, regeneration, and cancer. J Clin Invest. 2013 May 1; 123(5):1902-10.
   View on PubMed
2. Boglev Y, Badrock AP, Trotter AJ, Du Q, Richardson EJ, Parslow AC, Markmiller SJ, Hall NE, de Jong-Curtain TA, Ng AY, Verkade H, Ober EA, Field HA, Shin D, Shin CH, Hannan KM, Hannan RD, Pearson RB, Kim SH, Ess KC, Lieschke GJ, Stainier DY, Heath JK. Autophagy induction is a tor- and tp53-independent cell survival response in a zebrafish model of disrupted ribosome biogenesis. PLoS Genet. 2013 Feb; 9(2):e1003279.
   View on PubMed
3. Mugoni V, Postel R, Catanzaro V, De Luca E, Turco E, Digilio G, Silengo L, Murphy MP, Medana C, Stainier DY, Bakkers J, Santoro MM. Ubiad1 Is an Antioxidant Enzyme that Regulates eNOS Activity by CoQ10 Synthesis. Cell. 2013 Jan 31; 152(3):504-18.
   View on PubMed
4. Gut P, Baeza-Raja B, Andersson O, Hasenkamp L, Hsiao J, Hesselson D, Akassoglou K, Verdin E, Hirschey MD, Stainier DY. Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism. Nat Chem Biol. 2013 Feb; 9(2):97-104.
   View on PubMed
5. Yin C, Evason KJ, Maher JJ, Stainier DY. The basic helix-loop-helix transcription factor, heart and neural crest derivatives expressed transcript 2, marks hepatic stellate cells in zebrafish: Analysis of stellate cell entry into the developing liver. Hepatology. 2012 Nov; 56(5):1958-70.
   View on PubMed
6. Hassel D, Cheng P, White MP, Ivey KN, Kroll J, Augustin HG, Katus HA, Stainier DY, Srivastava D. MicroRNA-10 Regulates the Angiogenic Behavior of Zebrafish and Human Endothelial Cells by Promoting Vascular Endothelial Growth Factor Signaling. Circ Res. 2012 Nov 9; 111(11):1421-33.
   View on PubMed
7. Staudt D, Stainier D. Uncovering the molecular and cellular mechanisms of heart development using the zebrafish. Annu Rev Genet. 2012 Dec 15; 46:397-418.
   View on PubMed
8. Woo S, Housley MP, Weiner OD, Stainier DY. Nodal signaling regulates endodermal cell motility and actin dynamics via Rac1 and Prex1. J Cell Biol. 2012 Sep 3; 198(5):941-52.
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9. Herbert SP, Cheung JY, Stainier DY. Determination of Endothelial Stalk versus Tip Cell Potential during Angiogenesis by H2.0-like Homeobox-1. Curr Biol. 2012 Oct 9; 22(19):1789-94.
   View on PubMed
10. Ni TT, Lu J, Zhu M, Maddison LA, Boyd KL, Huskey L, Ju B, Hesselson D, Zhong TP, Page-McCaw PS, Stainier DY, Chen W. Conditional control of gene function by an invertible gene trap in zebrafish. Proc Natl Acad Sci U S A. 2012 Sep 18; 109(38):15389-94.
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11. Mellman K, Huisken J, Dinsmore C, Hoppe C, Stainier DY. Fibrillin-2b regulates endocardial morphogenesis in zebrafish. Dev Biol. 2012 Dec 1; 372(1):111-9.
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12. Delous M, Yin C, Shin D, Ninov N, Debrito Carten J, Pan L, Ma TP, Farber SA, Moens CB, Stainier DY. Sox9b is a key regulator of pancreaticobiliary ductal system development. PLoS Genet. 2012; 8(6):e1002754.
    View on PubMed
13. Andersson O, Adams BA, Yoo D, Ellis GC, Gut P, Anderson RM, German MS, Stainier DY. Adenosine signaling promotes regeneration of pancreatic ß cells in vivo. Cell Metab. 2012 Jun 6; 15(6):885-94.
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14. Ninov N, Borius M, Stainier DY. Different levels of Notch signaling regulate quiescence, renewal and differentiation in pancreatic endocrine progenitors. Development. 2012 May; 139(9):1557-67.
    View on PubMed
15. Liu J, Stainier DY. Zebrafish in the study of early cardiac development. Circ Res. 2012 Mar 16; 110(6):870-4.
    View on PubMed
16. Hugo SE, Cruz-Garcia L, Karanth S, Anderson RM, Stainier DY, Schlegel A. A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fasting. Genes Dev. 2012 Feb 1; 26(3):282-93.
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17. Shin D, Weidinger G, Moon RT, Stainier DY. Intrinsic and extrinsic modifiers of the regulative capacity of the developing liver. Mech Dev. 2012 Jan-Feb; 128(11-12):525-35.
    View on PubMed
18. Kirchmaier BC, Poon KL, Schwerte T, Huisken J, Winkler C, Jungblut B, Stainier DY, Brand T. The Popeye domain containing 2 (popdc2) gene in zebrafish is required for heart and skeletal muscle development. Dev Biol. 2012 Mar 15; 363(2):438-50.
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19. Schaub M, Nussbaum J, Verkade H, Ober EA, Stainier DY, Sakaguchi TF. Mutation of zebrafish Snapc4 is associated with loss of the intrahepatic biliary network. Dev Biol. 2012 Mar 1; 363(1):128-37.
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20. Balczerski B, Matsutani M, Castillo P, Osborne N, Stainier DY, Crump JG. Analysis of sphingosine-1-phosphate signaling mutants reveals endodermal requirements for the growth but not dorsoventral patterning of jaw skeletal precursors. Dev Biol. 2012 Feb 15; 362(2):230-41.
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