Osamu Tetsu, MD, PhD

---

Education

Chiba University, School of Medicine, M.D., 1989, Medicine
Chiba University, Graduate School of Medicine, Ph.D., 1997, Surgery and Immunology
Chiba University Hospital, Department of Surgery, Residency, 1990-1997, General Surgery
University of California, San Francisco, Postdoc, 1997-2002, Cancer Biology

---

Professional Experience

• 1990-1997
  Resident, Department of Surgery, Chiba University Hospital
• 1997-1999
  Visiting Postdoctoral Fellow, Dr. Frank McCormick Lab, Cancer Research Institute, University of California, San Francisco
• 1999-2002
  Assistant Research Biochemist, Dr. Frank McCormick Lab, Cancer Research Institute, University of California, San Francisco
• 2002-2005
  Assistant Adjunct Professor, Cancer Research Institute and Department of Surgery, University of California, San Francisco
• 2005-2007
  Assistant Adjunct Professor, Department of Pathology, University of California, San Francisco
• 2007- 2008
  Assistant Adjunct Professor, Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco
• 2008-present
  Assistant Professor In-Residence, Department of Otolaryngology - Head and Neck Surgery, University of California, San Francisco

---

Honors & Awards

• 1990
  Chiba University Hospital, 6th Isono Prize (1st place) for the Best Resident's Presentation
• 1993-1997
  The Japan Scholarship Foundation, Graduate School Student Fellowship
• 2000
  The Uehara Memorial Foundation, Research Fellowship Award
• 2003
  American Cancer Society, Institutional Individual Research Award
• 2004
  UCSF Research-Evaluation and Allocation Committee (REAC), New Junior Faculty Award
• 2004
  Chiba University School of Medicine Alumni Association, Outstanding Academic Achievement Award
• 2004
  The Concern Foundation, Young Investigator Award
• 2005
  The V Foundation for Cancer Research, V Scholar Award
• 2009-2010
  UC Cancer Research Coordinating Committee Award

---

Selected Publications

1. Tetsu O, Phuchareon J, Chou A, Cox DP, Eisele DW, Jordan RC. Mutations in the c-Kit gene disrupt mitogen-activated protein kinase signaling during tumor development in adenoid cystic carcinoma of the salivary glands. Neoplasia. 2010 Sep; 12(9):708-17.
   View on PubMed
2. Phuchareon J, Ohta Y, Woo JM, Eisele DW, Tetsu O. Genetic profiling reveals cross-contamination and misidentification of 6 adenoid cystic carcinoma cell lines: ACC2, ACC3, ACCM, ACCNS, ACCS and CAC2. PLoS One. 2009; 4(6):e6040.
   View on PubMed
3. Senawong T, Phuchareon J, Ohara O, McCormick F, Rauen KA, Tetsu O. Germline mutations of MEK in cardio-facio-cutaneous syndrome are sensitive to MEK and RAF inhibition: implications for therapeutic options. Hum Mol Genet. 2008 Feb 1; 17(3):419-30.
   View on PubMed
4. Okabe H, Lee SH, Phuchareon J, Albertson DG, McCormick F, Tetsu O. A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation. PLoS One. 2006; 1:e128.
   View on PubMed
5. Rodriguez-Viciana P, Tetsu O, Tidyman WE, Estep AL, Conger BA, Cruz MS, McCormick F, Rauen KA. Germline mutations in genes within the MAPK pathway cause cardio-facio-cutaneous syndrome. Science. 2006 Mar 3; 311(5765):1287-90.
   View on PubMed
6. Rodriguez-Viciana P, Tetsu O, Oda K, Okada J, Rauen K, McCormick F. Cancer targets in the Ras pathway. Cold Spring Harb Symp Quant Biol. 2005; 70:461-7.
   View on PubMed
7. Tetsu O, McCormick F. Proliferation of cancer cells despite CDK2 inhibition. Cancer Cell. 2003 Mar; 3(3):233-45.
   View on PubMed
8. Wakita K, McCormick F, Tetsu O. Method for screening ecdysone-inducible stable cell lines. Biotechniques. 2001 Aug; 31(2):414-8.
   View on PubMed
9. Wakita K, Tetsu O, McCormick F. A mammalian two-hybrid system for adenomatous polyposis coli-mutated colon cancer therapeutics. Cancer Res. 2001 Feb 1; 61(3):854-8.
   View on PubMed
10. Tetsu O, McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature. 1999 Apr 1; 398(6726):422-6.
    View on PubMed
11. Tetsu O, Ishihara H, Kanno R, Kamiyasu M, Inoue H, Tokuhisa T, Taniguchi M, Kanno M. mel-18 negatively regulates cell cycle progression upon B cell antigen receptor stimulation through a cascade leading to c-myc/cdc25. Immunity. 1998 Oct; 9(4):439-48.
    View on PubMed
12. Hasegawa M, Tetsu O, Kanno R, Inoue H, Ishihara H, Kamiyasu M, Taniguchi M, Kanno M. Mammalian Polycomb group genes are categorized as a new type of early response gene induced by B-cell receptor cross-linking. Mol Immunol. 1998 Jun; 35(9):559-63.
    View on PubMed
13. Kenmochi T, Asano T, Nakagori T, Kaneko K, Nakajima K, Tetsu O, Jingu K, Iwashita C, Kainuma O, Tokoro Y, Sugamoto Y, Sakamoto K, Hatakeyama E, Yamada K, Isono K. Successful gene transfer into murine pancreatic islets using polyamine transfection reagents. Transplant Proc. 1998 Mar; 30(2):470-2.
    View on PubMed
14. Akasaka T, Tsuji K, Kawahira H, Kanno M, Harigaya K, Hu L, Ebihara Y, Nakahata T, Tetsu O, Taniguchi M, Koseki H. The role of mel-18, a mammalian Polycomb group gene, during IL-7-dependent proliferation of lymphocyte precursors. Immunity. 1997 Jul; 7(1):135-46.
    View on PubMed
15. Tetsu O, Kanno R, Isono K, Taniguchi M, Kanno M. Cloning and characterization of two transcripts generated from the mel-13 gene positioned adjacent to the mammalian Polycomb group-related gene mel-18. Biochim Biophys Acta. 1996 Mar 1; 1305(3):109-12.
    View on PubMed
16. Furukawa H, Hara T, Taniguchi T, Tetsu O. A case of spontaneous intramural hematoma of the esophagus. Gastroenterol Jpn. 1993 Feb; 28(1):81-7.
    View on PubMed

View on UCSF Profiles