Osamu Tetsu, MD, PhD
Associate Professor, Department of Otolaryngology - Head and Neck Surgery, UCSF
Cancer Center Program MembershipsExperimental Therapeutics
Research SummaryOsamu Tetsu, MD, PhD, is an Associate Professor and Director of the Head and Neck Cancer Research Laboratory in the Department of Otolaryngology – Head and Neck Surgery (OHNS) at the University of California, San Francisco. He received his MD from Chiba University, Japan and he completed his residency program from the Chiba University Hospital in Japan. Dr. Tetsu obtained his PhD in molecular immunology at Chiba University, and this was following by a postdoctoral in cancer biology at UCSF.
Dr. Tetsu’s research focus is to understand the molecular mechanism of head and neck cancer, especially salivary gland tumors, and to identify novel therapeutic approaches to the treatment of various types of neoplasm in the head and neck. His laboratory is interested in molecular mechanism underlying initiation and progression of head and neck cancers and other malignancies. They have exploited the cell signaling pathways that make cancers different from normal tissues.
Chiba University, School of Medicine, M.D., 1989, Medicine
Chiba University, Graduate School of Medicine, Ph.D., 1997, Surgery and Immunology
Chiba University Hospital, Department of Surgery, Residency, 1990-1997, General Surgery
University of California, San Francisco, Postdoc, 1997-2002, Cancer Biology
1990 - 1997
Resident, Department of Surgery, Chiba University Hospital
1997 - 1999
Visiting Postdoctoral Fellow, Dr. Frank McCormick Lab, Cancer Research Institute, University of California, San Francisco
1999 - 2002
Assistant Research Biochemist, Dr. Frank McCormick Lab, Cancer Research Institute, University of California, San Francisco
2002 - 2005
Assistant Adjunct Professor, Cancer Research Institute and Department of Surgery, University of California, San Francisco
2005 - 2007
Assistant Adjunct Professor, Department of Pathology, University of California, San Francisco
Assistant Adjunct Professor, Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco
2008 - 2016
Assistant Professor In-Residence, Department of Otolaryngology - Head and Neck Surgery, University of California, San Francisco
2016 - present
Associate Professor In-Residence, Department of Otolaryngology - Head and Neck Surgery, University of California, San Francisco
Honors & Awards
Chiba University Hospital, 6th Isono Prize (1st place) for the Best Resident's Presentation
The Japan Scholarship Foundation, Graduate School Student Fellowship
The Uehara Memorial Foundation, Research Fellowship Award
American Cancer Society, Institutional Individual Research Award
UCSF Research-Evaluation and Allocation Committee (REAC), New Junior Faculty Award
Chiba University School of Medicine Alumni Association, Outstanding Academic Achievement Award
The Concern Foundation, Young Investigator Award
The V Foundation for Cancer Research, V Scholar Award
UC Cancer Research Coordinating Committee Award
- Tetsu O, Kanno R, Isono K, Taniguchi M, Kanno M. Cloning and characterization of two transcripts generated from the mel-13 gene positioned adjacent to the mammalian Polycomb group-related gene mel-18. Biochim Biophys Acta. 1996; 1305:109-12.
- Hasegawa M, Tetsu O, Kanno R, Inoue H, Ishihara H, Kamiyasu M, Taniguchi M, Kanno M. Mammalian Polycomb group genes are categorized as a new type of early response gene induced by B-cell receptor cross-linking. Mol Immunol. 1998; 35:559-63.
- Tetsu O, Ishihara H, Kanno R, Kamiyasu M, Inoue H, Tokuhisa T, Taniguchi M, Kanno M. mel-18 negatively regulates cell cycle progression upon B cell antigen receptor stimulation through a cascade leading to c-myc/cdc25. Immunity. 1998; 9:439-48.
- Tetsu O, McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature. 1999; 398:422-6.
- Wakita K, Tetsu O, McCormick F. A mammalian two-hybrid system for adenomatous polyposis coli-mutated colon cancer therapeutics. Cancer Res. 2001; 61:854-8.
- Wakita K, McCormick F, Tetsu O. Method for screening ecdysone-inducible stable cell lines. Biotechniques. 2001; 31:414-8.
- Tetsu O, McCormick F. Proliferation of cancer cells despite CDK2 inhibition. Cancer Cell. 2003; 3:233-45.
- Rodriguez-Viciana P*, Tetsu O*, Tidyman WE, Estep AL, Conger BA, Santa Cruz M, McCormick F, Rauen KA. Germline Mutations in Genes within the MAPK Pathway Cause Cardio-facio-cutaneous Syndrome. Science. 2006 Jan 26; [Epub ahead of print] (*co-first author)
- Okabe H, Lee SH, Phuchareon J, Albertson DG, McCormick F, Tetsu O. (2006). A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation. PLoS ONE 1 e128, 1-12.
- Senawong T, Phuchareon J, Ohara O, McCormick F, Rauen KA, Tetsu O. (2008). Germline mutations of MEK in cardio-facio-cutaneous syndrome are sensitive to MEK and RAF inhibition: Implications for therapeutic options. Hum Mol Genet. 17: 419-30. (2007 Nov 2; [Epub ahead of print])
- Phuchareon J, Ohta Y, Woo JM, Eisele DW, Tetsu O. (2009). Genetic profiling reveals cross-contamination and misidentification of 6 adenoid cystic carcinoma cell lines: ACC2, ACC3, ACCM, ACCNS, ACCS and CAC2. PLoS One. 2009 Jun 25; 4(6):e6040.