University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Tarik Tihan, MD, PhD

Tarik Tihan, MD, PhD

Associate Professor, Department of Pathology, UCSF

Cancer Center Program Memberships

Neurologic Oncology

Education

University of Istanbul, School of Medicine, MD, 1979-85, Medicine
University of Istanbul/Univ. Of Vienna, PhD, 1986-89, Biochemistry


Professional Experience

  • 1985-1986
    Kahramanmaras State Hospital, Department of Critical Care, Turkey. House Officer.
  • 1986-1989
    University of Istanbul, Istanbul Medical School, Department of Clinical Biochemistry. Clinical Instructor and Research Assistant.
  • 1988-1989
    University of Vienna, Department of Medical Chemistry, Austria. Research Assistant. Research Grant from the Austrian government, Ministry of Education, (Bundesministerium fuer Auswaertige Angelegenheiten).
  • 1989
    Doctorate, University of Istanbul, Department of Clinical Biochemistry. Diplomate of the Ministry of Health and Social Aid for the medical doctorate in Clinical Biochemistry.
  • 1989-1990
    University of South Florida, Department of Internal Medicine & H. Lee Moffitt Cancer Center. Research Associate.
  • 1991-1992
    Beth Israel Medical Center, Department of Neurosurgery. Manager of the Recanati Research Laboratory.
  • 1992-1994
    Beth Israel Medical Center, Department of Pathology, Resident
  • 1994-1995
    Memorial Sloan-Kettering Cancer Center, Department of Pathology. Fellow in Oncologic Pathology.
  • 1996
    American Board of Pathology Certificate of Anatomic Pathology.
  • 1995-1997
    State University of New York at Stony Brook, Department of Pathology. Fellow in Neuropathology.
  • 1997-2000
    Johns Hopkins Medical Institutions, Department of Pathology, Clinical Instructor. Johns Hopkins Bayview Medical Center, Department of Pathology. Attending Pathologist in Anatomic Pathology and Cytopathology.
  • 2000-2002
    Johns Hopkins Medical Institutions, Department of Pathology, Assistant Professor
  • 2002-present
    UCSF School of Medicine, Department of Pathology, Neuropathology Unit, Associate Professor
  • 2002-present
    Principal Investigator, Brain Tumor Research Center, Department of Neurological Surgery

Honors & Awards

  • 2001-2003
    John Hopkins W. Barry Wood Jr, Award in excellence in teaching
  • 2003
    USCF Department of Pathology Teaching Excellence Award
  • 2003, 2005
    UCSF Department of Neurological Surgery Teaching Excellence in Basic Science Award

Selected Publications

  1. Sloan EA, Hilz S, Gupta R, Cadwell C, Ramani B, Hofmann J, Kline CN, Banerjee A, Reddy A, Oberheim Bush NA, Chang S, Braunstein S, Chang EF, Raffel C, Gupta N, Sun PP, Kim JYH, Moes G, Alva E, Li R, Bruggers CS, Alashari M, Wetmore C, Garg S, Dishop M, Van Ziffle J, Onodera C, Devine P, Grenert JP, Lee JC, Phillips JJ, Pekmezci M, Tihan T, Bollen AW, Berger MS, Costello JF, Perry A, Solomon DA. Gliomas arising in the setting of Li-Fraumeni syndrome stratify into two molecular subgroups with divergent clinicopathologic features. Acta Neuropathol. 2020 Mar 10.
    View on PubMed
  2. Payabvash S, Aboian M, Tihan T, Cha S. Machine Learning Decision Tree Models for Differentiation of Posterior Fossa Tumors Using Diffusion Histogram Analysis and Structural MRI Findings. Front Oncol. 2020; 10:71.
    View on PubMed
  3. Pekmezci M, Phillips JJ, Dirilenoglu F, Atasever-Rezanko T, Tihan T, Solomon D, Bollen A, Perry A. Loss of H3K27 trimethylation by immunohistochemistry is frequent in oligodendroglioma, IDH-mutant and 1p/19q-codeleted, but is neither a sensitive nor a specific marker. Acta Neuropathol. 2020 Mar; 139(3):597-600.
    View on PubMed
  4. Lee JC, Villanueva-Meyer JE, Ferris SP, Cham EM, Zucker J, Cooney T, Gilani A, Kleinschmidt-DeMasters BK, Trembath D, Mafra M, Chiang J, Ellison DW, Cho SJ, Horvai AE, Van Ziffle J, Onodera C, Devine P, Grenert JP, de Voijs CMA, van Blokland WTM, de Leng WWJ, Ploegmakers MJ, Flucke U, Pekmezci M, Bollen AW, Tihan T, Koelsche C, von Deimling A, Wesseling P, Solomon DA, Perry A. Clinicopathologic and molecular features of intracranial desmoplastic small round cell tumors. Brain Pathol. 2019 Dec 14.
    View on PubMed
  5. Lucas CG, Villanueva-Meyer JE, Whipple N, Oberheim Bush NA, Cooney T, Chang S, McDermott M, Berger M, Cham E, Sun PP, Putnam A, Zhou H, Bollo R, Cheshier S, Poppe MM, Fung KM, Sung S, Glenn C, Fan X, Bannykh S, Hu J, Danielpour M, Li R, Alva E, Johnston J, Van Ziffle J, Onodera C, Devine P, Grenert JP, Lee JC, Pekmezci M, Tihan T, Bollen AW, Perry A, Solomon DA. Myxoid glioneuronal tumor, PDGFRA p.K385-mutant: clinical, radiologic, and histopathologic features. Brain Pathol. 2019 Oct 14.
    View on PubMed
  6. Sloan EA, Cooney T, Oberheim Bush NA, Buerki R, Taylor J, Clarke JL, Torkildson J, Kline C, Reddy A, Mueller S, Banerjee A, Butowski N, Chang S, Mummaneni PV, Chou D, Tan L, Theodosopoulos P, McDermott M, Berger M, Raffel C, Gupta N, Sun PP, Li Y, Shah V, Cha S, Braunstein S, Raleigh DR, Samuel D, Scharnhorst D, Fata C, Guo H, Moes G, Kim JYH, Koschmann C, Van Ziffle J, Onodera C, Devine P, Grenert JP, Lee JC, Pekmezci M, Phillips JJ, Tihan T, Bollen AW, Perry A, Solomon DA. Recurrent non-canonical histone H3 mutations in spinal cord diffuse gliomas. Acta Neuropathol. 2019 11; 138(5):877-881.
    View on PubMed
  7. Mandel-Brehm C, Retallack H, Knudsen GM, Yamana A, Hajj-Ali RA, Calabrese LH, Tihan T, Sample HA, Zorn KC, Gorman MP, Madan Cohen J, Sreih AG, Marcus JF, Josephson SA, Douglas VC, Gelfand JM, Wilson MR, DeRisi JL. Exploratory proteomic analysis implicates the alternative complement cascade in primary CNS vasculitis. Neurology. 2019 07 30; 93(5):e433-e444.
    View on PubMed
  8. Ferris SP, Velazquez Vega J, Aboian M, Lee JC, Van Ziffle J, Onodera C, Grenert JP, Saunders T, Chen YY, Banerjee A, Kline CN, Gupta N, Raffel C, Samuel D, Ruiz-Diaz I, Magaki S, Wilson D, Neltner J, Al-Hajri Z, Phillips JJ, Pekmezci M, Bollen AW, Tihan T, Schniederjan M, Cha S, Perry A, Solomon DA. High-grade neuroepithelial tumor with BCOR exon 15 internal tandem duplication-a comprehensive clinical, radiographic, pathologic, and genomic analysis. Brain Pathol. 2020 01; 30(1):46-62.
    View on PubMed
  9. Yousef A, Rutkowski MJ, Yalcin CE, Eren OC, Caliskan I, Tihan T. Sporadic and Von-Hippel Lindau disease-associated spinal hemangioblastomas: institutional experience on their similarities and differences. J Neurooncol. 2019 Jul; 143(3):547-552.
    View on PubMed
  10. Kulac I, Tihan T. Pilomyxoid astrocytomas: a short review. Brain Tumor Pathol. 2019 Apr; 36(2):52-55.
    View on PubMed
  11. Lee JC, Mazor T, Lao R, Wan E, Diallo AB, Hill NS, Thangaraj N, Wendelsdorf K, Samuel D, Kline CN, Banerjee A, Auguste K, Raffel C, Gupta N, Berger M, Raleigh DR, Shai A, Phillips JJ, Bollen AW, Tihan T, Perry A, Costello J, Solomon DA. Recurrent KBTBD4 small in-frame insertions and absence of DROSHA deletion or DICER1 mutation differentiate pineal parenchymal tumor of intermediate differentiation (PPTID) from pineoblastoma. Acta Neuropathol. 2019 05; 137(5):851-854.
    View on PubMed
  12. Lee JC, Sharifai N, Dahiya S, Kleinschmidt-DeMasters BK, Rosenblum MK, Reis GF, Samuel D, Siongco AM, Santi M, Storm PB, Ferris SP, Bollen AW, Pekmezci M, Solomon DA, Tihan T, Perry A. Clinicopathologic features of anaplastic myxopapillary ependymomas. Brain Pathol. 2019 01; 29(1):75-84.
    View on PubMed
  13. Çakir E, Oran G, Yüksek GE, Ding C, Tihan T. Intraoperative Consultations of Central Nervous System Tumors: A Review for Practicing Pathologists and Testing of an Algorithmic Approach. Turk Patoloji Derg. 2019; 35(3):173-184.
    View on PubMed
  14. Winkler EA, Birk H, Burkhardt JK, Chen X, Yue JK, Guo D, Rutledge WC, Lasker GF, Partow C, Tihan T, Chang EF, Su H, Kim H, Walcott BP, Lawton MT. Reductions in brain pericytes are associated with arteriovenous malformation vascular instability. J Neurosurg. 2018 12 01; 129(6):1464-1474.
    View on PubMed
  15. Phillips JJ, Gong H, Chen K, Joseph NM, van Ziffle J, Bastian BC, Grenert JP, Kline CN, Mueller S, Banerjee A, Nicolaides T, Gupta N, Berger MS, Lee HS, Pekmezci M, Tihan T, Bollen AW, Perry A, Shieh JTC, Solomon DA. The genetic landscape of anaplastic pleomorphic xanthoastrocytoma. Brain Pathol. 2019 01; 29(1):85-96.
    View on PubMed
  16. Safaee MM, Jonzzon S, López GY, Asaikar S, Tihan T, Glenn OA, Gupta N. Perilesional edema associated with an intracranial calcifying pseudoneoplasm of the neuraxis in a child: case report and review of imaging features. J Neurosurg Pediatr. 2018 Nov 01; 22(5):528-531.
    View on PubMed
  17. Payabvash S, Tihan T, Cha S. Volumetric voxelwise apparent diffusion coefficient histogram analysis for differentiation of the fourth ventricular tumors. Neuroradiol J. 2018 Dec; 31(6):554-564.
    View on PubMed
  18. López GY, Van Ziffle J, Onodera C, Grenert JP, Yeh I, Bastian BC, Clarke J, Oberheim Bush NA, Taylor J, Chang S, Butowski N, Banerjee A, Mueller S, Kline C, Torkildson J, Samuel D, Siongco A, Raffel C, Gupta N, Kunwar S, Mummaneni P, Aghi M, Theodosopoulos P, Berger M, Phillips JJ, Pekmezci M, Tihan T, Bollen AW, Perry A, Solomon DA. The genetic landscape of gliomas arising after therapeutic radiation. Acta Neuropathol. 2019 01; 137(1):139-150.
    View on PubMed
  19. Payabvash S, Tihan T, Cha S. Differentiation of Cerebellar Hemisphere Tumors: Combining Apparent Diffusion Coefficient Histogram Analysis and Structural MRI Features. J Neuroimaging. 2018 11; 28(6):656-665.
    View on PubMed
  20. Ding C, Tihan T. Recent Progress in the Pathology and Genetics of Pilocytic and Pilomyxoid Astrocytomas Balkan Med J. 2019 01 01; 36(1):3-11.
    View on PubMed

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