Tarik Tihan, MD, PhD

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Additional Websites

• Physician Referral Directory

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Education

University of Istanbul, School of Medicine, MD, 1979-85, Medicine
University of Istanbul/Univ. Of Vienna, PhD, 1986-89, Biochemistry

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Professional Experience

• 1985-1986
  Kahramanmaras State Hospital, Department of Critical Care, Turkey. House Officer.
• 1986-1989
  University of Istanbul, Istanbul Medical School, Department of Clinical Biochemistry. Clinical Instructor and Research Assistant.
• 1988-1989
  University of Vienna, Department of Medical Chemistry, Austria. Research Assistant. Research Grant from the Austrian government, Ministry of Education, (Bundesministerium fuer Auswaertige Angelegenheiten).
• 1989
  Doctorate, University of Istanbul, Department of Clinical Biochemistry. Diplomate of the Ministry of Health and Social Aid for the medical doctorate in Clinical Biochemistry.
• 1989-1990
  University of South Florida, Department of Internal Medicine & H. Lee Moffitt Cancer Center. Research Associate.
• 1991-1992
  Beth Israel Medical Center, Department of Neurosurgery. Manager of the Recanati Research Laboratory.
• 1992-1994
  Beth Israel Medical Center, Department of Pathology, Resident
• 1994-1995
  Memorial Sloan-Kettering Cancer Center, Department of Pathology. Fellow in Oncologic Pathology.
• 1996
  American Board of Pathology Certificate of Anatomic Pathology.
• 1995-1997
  State University of New York at Stony Brook, Department of Pathology. Fellow in Neuropathology.
• 1997-2000
  Johns Hopkins Medical Institutions, Department of Pathology, Clinical Instructor. Johns Hopkins Bayview Medical Center, Department of Pathology. Attending Pathologist in Anatomic Pathology and Cytopathology.
• 2000-2002
  Johns Hopkins Medical Institutions, Department of Pathology, Assistant Professor
• 2002-present
  UCSF School of Medicine, Department of Pathology, Neuropathology Unit, Associate Professor
• 2002-present
  Principal Investigator, Brain Tumor Research Center, Department of Neurological Surgery

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Honors & Awards

• 2001-2003
  John Hopkins W. Barry Wood Jr, Award in excellence in teaching
• 2003
  USCF Department of Pathology Teaching Excellence Award
• 2003, 2005
  UCSF Department of Neurological Surgery Teaching Excellence in Basic Science Award

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Selected Publications

1. Venneti S, Felicella MM, Coyne T, Phillips JJ, Gorovets D, Huse JT, Kofler J, Lu C, Tihan T, Sullivan LM, Santi M, Judkins AR, Perry A, Thompson CB. Histone 3 lysine 9 trimethylation is differentially associated with isocitrate dehydrogenase mutations in oligodendrogliomas and high-grade astrocytomas. J Neuropathol Exp Neurol. 2013 Apr; 72(4):298-306.
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2. Shchors K, Persson AI, Rostker F, Tihan T, Lyubynska N, Li N, Swigart LB, Berger MS, Hanahan D, Weiss WA, Evan GI. Using a preclinical mouse model of high-grade astrocytoma to optimize p53 restoration therapy. Proc Natl Acad Sci U S A. 2013 Apr 16; 110(16):E1480-9.
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3. Mukherjee A, Bylund Q, Prasanna M, Margalit Y, Tihan T. Spectroscopic imaging of serum proteins using quantum cascade lasers. J Biomed Opt. 2013 Mar; 18(3):36011.
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4. Scott BJ, Douglas VC, Tihan T, Rubenstein JL, Josephson SA. A systematic approach to the diagnosis of suspected central nervous system lymphoma. JAMA Neurol. 2013 Mar 1; 70(3):311-9.
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5. Rice T, Zheng S, Decker PA, Walsh KM, Bracci P, Xiao Y, McCoy LS, Smirnov I, Patoka JS, Hansen HM, Hsuang G, Wiemels JL, Tihan T, Pico AR, Prados MD, Chang SM, Berger MS, Caron A, Fink S, Kollmeyer T, Rynearson A, Voss J, Kosel ML, Fridley BL, Lachance DH, Eckel-Passow JE, Sicotte H, O'Neill BP, Giannini C, Wiencke JK, Jenkins RB, Wrensch MR. Inherited variant on chromosome 11q23 increases susceptibility to IDH-mutated but not IDH-normal gliomas regardless of grade or histology. Neuro Oncol. 2013 Feb 7.
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6. Chen W, Guo Y, Walker EJ, Shen F, Jun K, Oh SP, Degos V, Lawton MT, Tihan T, Davalos D, Akassoglou K, Nelson J, Pile-Spellman J, Su H, Young WL. Reduced Mural Cell Coverage and Impaired Vessel Integrity After Angiogenic Stimulation in the Alk1-deficient Brain. Arterioscler Thromb Vasc Biol. 2013 Feb; 33(2):305-10.
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7. Wang DD, Deans AE, Barkovich AJ, Tihan T, Barbaro NM, Garcia PA, Chang EF. Transmantle sign in focal cortical dysplasia: a unique radiological entity with excellent prognosis for seizure control. J Neurosurg. 2013 Feb; 118(2):337-44.
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8. Safaee M, Oh MC, Bloch O, Sun MZ, Kaur G, Auguste KI, Tihan T, Parsa AT. Choroid plexus papillomas: advances in molecular biology and understanding of tumorigenesis. Neuro Oncol. 2013 Mar; 15(3):255-67.
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9. Joseph NM, Phillips J, Dahiya S, M Felicella M, Tihan T, Brat DJ, Perry A. Diagnostic implications of IDH1-R132H and OLIG2 expression patterns in rare and challenging glioblastoma variants. Mod Pathol. 2013 Mar; 26(3):315-26.
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10. Jenkins RB, Xiao Y, Sicotte H, Decker PA, Kollmeyer TM, Hansen HM, Kosel ML, Zheng S, Walsh KM, Rice T, Bracci P, McCoy LS, Smirnov I, Patoka JS, Hsuang G, Wiemels JL, Tihan T, Pico AR, Prados MD, Chang SM, Berger MS, Caron AA, Fink SR, Halder C, Rynearson AL, Fridley BL, Buckner JC, O'Neill BP, Giannini C, Lachance DH, Wiencke JK, Eckel-Passow JE, Wrensch MR. A low-frequency variant at 8q24.21 is strongly associated with risk of oligodendroglial tumors and astrocytomas with IDH1 or IDH2 mutation. Nat Genet. 2012 Oct; 44(10):1122-5.
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11. Oh MC, Tihan T, Kunwar S, Blevins L, Aghi MK. Clinical management of pituitary carcinomas. Neurosurg Clin N Am. 2012 Oct; 23(4):595-606.
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12. Huang X, Dubuc AM, Hashizume R, Berg J, He Y, Wang J, Chiang C, Cooper MK, Northcott PA, Taylor MD, Barnes MJ, Tihan T, Chen J, Hackett CS, Weiss WA, James CD, Rowitch DH, Shuman MA, Jan YN, Jan LY. Voltage-gated potassium channel EAG2 controls mitotic entry and tumor growth in medulloblastoma via regulating cell volume dynamics. Genes Dev. 2012 Aug 15; 26(16):1780-96.
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13. Baia GS, Caballero OL, Orr BA, Lal A, Ho JS, Cowdrey C, Tihan T, Mawrin C, Riggins GJ. Yes-associated protein 1 is activated and functions as an oncogene in meningiomas. Mol Cancer Res. 2012 Jul; 10(7):904-13.
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14. Xiao Y, Decker PA, Rice T, McCoy LS, Smirnov I, Patoka JS, Hansen HM, Wiemels JL, Tihan T, Prados MD, Chang SM, Berger MS, Kosel ML, Fridley BL, Lachance DH, O'Neill BP, Buckner JC, Thompson RC, Nabors LB, Olson JJ, Brem S, Madden MH, Browning JE, Wiencke JK, Egan KM, Jenkins RB, Wrensch MR. SSBP2 variants are associated with survival in glioblastoma patients. Clin Cancer Res. 2012 Jun 1; 18(11):3154-62.
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15. Schoenfeld A, Pekmezci M, Barnes MJ, Tihan T, Gupta N, Lamborn KR, Banerjee A, Mueller S, Chang S, Berger MS, Haas-Kogan D. The superiority of conservative resection and adjuvant radiation for craniopharyngiomas. J Neurooncol. 2012 May; 108(1):133-9.
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16. Guo Y, Saunders T, Su H, Kim H, Akkoc D, Saloner DA, Hetts SW, Hess C, Lawton MT, Bollen AW, Pourmohamad T, McCulloch CE, Tihan T, Young WL. Silent intralesional microhemorrhage as a risk factor for brain arteriovenous malformation rupture. Stroke. 2012 May; 43(5):1240-6.
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17. Tihan T, Ersen A, Qaddoumi I, Sughayer MA, Tolunay S, Al-Hussaini M, Phillips J, Gupta N, Goldhoff P, Baneerjee A. Pathologic characteristics of pediatric intracranial pilocytic astrocytomas and their impact on outcome in 3 countries: a multi-institutional study. Am J Surg Pathol. 2012 Jan; 36(1):43-55.
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18. Barrows BD, Rutkowski MJ, Gültekin SH, Parsa AT, Tihan T. Evidence of ambiguous differentiation and mTOR pathway dysregulation in subependymal giant cell astrocytoma. Turk Patoloji Derg. 2012; 28(2):95-103.
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19. Ekmekçi S, Nacar OA, Tihan T. Who owns these tissues? General principles on the use of material submitted to pathology departments for healthcare, education and research purposes. Turk Patoloji Derg. 2012; 28(3):189-94.
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20. Rutkowski MJ, Bloch O, Jian BJ, Chen C, Sughrue ME, Tihan T, Barani IJ, Berger MS, McDermott MW, Parsa AT. Management of recurrent intracranial hemangiopericytoma. J Clin Neurosci. 2011 Nov; 18(11):1500-4.
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