University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Tarik Tihan, MD, PhD

Tarik Tihan, MD, PhD

Associate Professor, Department of Pathology, UCSF

Cancer Center Program Memberships

Neurologic Oncology

Education

University of Istanbul, School of Medicine, MD, 1979-85, Medicine
University of Istanbul/Univ. Of Vienna, PhD, 1986-89, Biochemistry


Professional Experience

  • 1985-1986
    Kahramanmaras State Hospital, Department of Critical Care, Turkey. House Officer.
  • 1986-1989
    University of Istanbul, Istanbul Medical School, Department of Clinical Biochemistry. Clinical Instructor and Research Assistant.
  • 1988-1989
    University of Vienna, Department of Medical Chemistry, Austria. Research Assistant. Research Grant from the Austrian government, Ministry of Education, (Bundesministerium fuer Auswaertige Angelegenheiten).
  • 1989
    Doctorate, University of Istanbul, Department of Clinical Biochemistry. Diplomate of the Ministry of Health and Social Aid for the medical doctorate in Clinical Biochemistry.
  • 1989-1990
    University of South Florida, Department of Internal Medicine & H. Lee Moffitt Cancer Center. Research Associate.
  • 1991-1992
    Beth Israel Medical Center, Department of Neurosurgery. Manager of the Recanati Research Laboratory.
  • 1992-1994
    Beth Israel Medical Center, Department of Pathology, Resident
  • 1994-1995
    Memorial Sloan-Kettering Cancer Center, Department of Pathology. Fellow in Oncologic Pathology.
  • 1996
    American Board of Pathology Certificate of Anatomic Pathology.
  • 1995-1997
    State University of New York at Stony Brook, Department of Pathology. Fellow in Neuropathology.
  • 1997-2000
    Johns Hopkins Medical Institutions, Department of Pathology, Clinical Instructor. Johns Hopkins Bayview Medical Center, Department of Pathology. Attending Pathologist in Anatomic Pathology and Cytopathology.
  • 2000-2002
    Johns Hopkins Medical Institutions, Department of Pathology, Assistant Professor
  • 2002-present
    UCSF School of Medicine, Department of Pathology, Neuropathology Unit, Associate Professor
  • 2002-present
    Principal Investigator, Brain Tumor Research Center, Department of Neurological Surgery

Honors & Awards

  • 2001-2003
    John Hopkins W. Barry Wood Jr, Award in excellence in teaching
  • 2003
    USCF Department of Pathology Teaching Excellence Award
  • 2003, 2005
    UCSF Department of Neurological Surgery Teaching Excellence in Basic Science Award

Selected Publications

  1. Safaee MM, Jonzzon S, López GY, Asaikar S, Tihan T, Glenn OA, Gupta N. Perilesional edema associated with an intracranial calcifying pseudoneoplasm of the neuraxis in a child: case report and review of imaging features. J Neurosurg Pediatr. 2018 Aug 17; 1-4.
    View on PubMed
  2. Payabvash S, Tihan T, Cha S. Differentiation of Cerebellar Hemisphere Tumors: Combining Apparent Diffusion Coefficient Histogram Analysis and Structural MRI Features. J Neuroimaging. 2018 Aug 01.
    View on PubMed
  3. Phillips JJ, Gong H, Chen K, Joseph NM, van Ziffle J, Bastian BC, Grenert JP, Kline CN, Mueller S, Banerjee A, Nicolaides T, Gupta N, Berger MS, Lee HS, Pekmezci M, Tihan T, Bollen AW, Perry A, Shieh JTC, Solomon DA. The genetic landscape of anaplastic pleomorphic xanthoastrocytoma. Brain Pathol. 2018 Jul 27.
    View on PubMed
  4. Ding C, Tihan T. Recent Progress in Pathology and Genetics of Pilocytic and Pilomyxoid Astrocytomas. Balkan Med J. 2018 Jul 09.
    View on PubMed
  5. Pekmezci M, Villanueva-Meyer JE, Goode B, Van Ziffle J, Onodera C, Grenert JP, Bastian BC, Chamyan G, Maher OM, Khatib Z, Kleinschmidt-DeMasters BK, Samuel D, Mueller S, Banerjee A, Clarke JL, Cooney T, Torkildson J, Gupta N, Theodosopoulos P, Chang EF, Berger M, Bollen AW, Perry A, Tihan T, Solomon DA. The genetic landscape of ganglioglioma. Acta Neuropathol Commun. 2018 Jun 07; 6(1):47.
    View on PubMed
  6. Winkler EA, Rutledge C, Ward M, Tihan T, Sneed PK, Barbaro N, Garcia P, McDermott M, Chang EF. Radiation-induced Cavernous Malformation as a Late Sequelae of Stereotactic Radiosurgery for Epilepsy. Cureus. 2018 Mar 11; 10(3):e2308.
    View on PubMed
  7. Goode B, Mondal G, Hyun M, Ruiz DG, Lin YH, Van Ziffle J, Joseph NM, Onodera C, Talevich E, Grenert JP, Hewedi IH, Snuderl M, Brat DJ, Kleinschmidt-DeMasters BK, Rodriguez FJ, Louis DN, Yong WH, Lopes MB, Rosenblum MK, Butowski N, Tihan T, Bollen AW, Phillips JJ, Wiita AP, Yeh I, Jacobson MP, Bastian BC, Perry A, Solomon DA. A recurrent kinase domain mutation in PRKCA defines chordoid glioma of the third ventricle. Nat Commun. 2018 02 23; 9(1):810.
    View on PubMed
  8. Iorgulescu JB, Van Ziffle J, Stevers M, Grenert JP, Bastian BC, Chavez L, Stichel D, Buchhalter I, Samuel D, Nicolaides T, Banerjee A, Mueller S, Gupta N, Tihan T, Bollen AW, Northcott PA, Kool M, Pfister S, Korshunov A, Perry A, Solomon DA. Deep sequencing of WNT-activated medulloblastomas reveals secondary SHH pathway activation. Acta Neuropathol. 2018 Apr; 135(4):635-638.
    View on PubMed
  9. Pekmezci M, Stevers M, Phillips JJ, Van Ziffle J, Bastian BC, Tsankova NM, Kleinschmidt-DeMasters BK, Rosenblum MK, Tihan T, Perry A, Solomon DA. Multinodular and vacuolating neuronal tumor of the cerebrum is a clonal neoplasm defined by genetic alterations that activate the MAP kinase signaling pathway. Acta Neuropathol. 2018 Mar; 135(3):485-488.
    View on PubMed
  10. Winkler EA, Birk H, Burkhardt JK, Chen X, Yue JK, Guo D, Rutledge WC, Lasker GF, Partow C, Tihan T, Chang EF, Su H, Kim H, Walcott BP, Lawton MT. Reductions in brain pericytes are associated with arteriovenous malformation vascular instability. J Neurosurg. 2018 Jan 05; 1-11.
    View on PubMed
  11. Villanueva-Meyer JE, Wood MD, Choi BS, Mabray MC, Butowski NA, Tihan T, Cha S. MRI Features and IDH Mutational Status of Grade II Diffuse Gliomas: Impact on Diagnosis and Prognosis. AJR Am J Roentgenol. 2018 Mar; 210(3):621-628.
    View on PubMed
  12. Lee JC, Pekmezci M, Lavezo JL, Vogel H, Katznelson L, Fraenkel M, Harsh G, Dulai M, Perry A, Tihan T. Utility of Pit-1 Immunostaining in Distinguishing Pituitary Adenomas of Primitive Differentiation from Null Cell Adenomas. Endocr Pathol. 2017 Dec; 28(4):287-292.
    View on PubMed
  13. Tan YL, Kim H, Lee S, Tihan T, Ver Hoef L, Mueller SG, Barkovich AJ, Xu D, Knowlton R. Quantitative surface analysis of combined MRI and PET enhances detection of focal cortical dysplasias. Neuroimage. 2018 Feb 01; 166:10-18.
    View on PubMed
  14. Wood MD, Tihan T, Perry A, Chacko G, Turner C, Pu C, Payne C, Yu A, Bannykh SI, Solomon DA. Multimodal molecular analysis of astroblastoma enables reclassification of most cases into more specific molecular entities. Brain Pathol. 2018 03; 28(2):192-202.
    View on PubMed
  15. Chen X, Cooke DL, Saloner D, Nelson J, Su H, Lawton MT, Hess C, Tihan T, Zhao Y, Kim H. Higher Flow Is Present in Unruptured Arteriovenous Malformations With Silent Intralesional Microhemorrhages. Stroke. 2017 10; 48(10):2881-2884.
    View on PubMed
  16. Tremblay MA, Villanueva-Meyer JE, Cha S, Tihan T, Gelfand JM. Clinical and imaging correlation in patients with pathologically confirmed tumefactive demyelinating lesions. J Neurol Sci. 2017 Oct 15; 381:83-87.
    View on PubMed
  17. Chan E, Bollen AW, Sirohi D, Van Ziffle J, Grenert JP, Kline CN, Tihan T, Perry A, Gupta N, Solomon DA. Angiocentric glioma with MYB-QKI fusion located in the brainstem, rather than cerebral cortex. Acta Neuropathol. 2017 Oct; 134(4):671-673.
    View on PubMed
  18. Kline CN, Joseph NM, Grenert JP, van Ziffle J, Talevich E, Onodera C, Aboian M, Cha S, Raleigh DR, Braunstein S, Torkildson J, Samuel D, Bloomer M, Campomanes AGA, Banerjee A, Butowski N, Raffel C, Tihan T, Bollen AW, Phillips JJ, Korn WM, Yeh I, Bastian BC, Gupta N, Mueller S, Perry A, Nicolaides T, Solomon DA. Targeted next-generation sequencing of pediatric neuro-oncology patients improves diagnosis, identifies pathogenic germline mutations, and directs targeted therapy. Neuro Oncol. 2017 05 01; 19(5):699-709.
    View on PubMed
  19. Tamrazi B, Pekmezci M, Aboian M, Tihan T, Glastonbury CM. Apparent diffusion coefficient and pituitary macroadenomas: pre-operative assessment of tumor atypia. Pituitary. 2017 Apr; 20(2):195-200.
    View on PubMed
  20. Pekmezci M, Rice T, Molinaro AM, Walsh KM, Decker PA, Hansen H, Sicotte H, Kollmeyer TM, McCoy LS, Sarkar G, Perry A, Giannini C, Tihan T, Berger MS, Wiemels JL, Bracci PM, Eckel-Passow JE, Lachance DH, Clarke J, Taylor JW, Luks T, Wiencke JK, Jenkins RB, Wrensch MR. Adult infiltrating gliomas with WHO 2016 integrated diagnosis: additional prognostic roles of ATRX and TERT. Acta Neuropathol. 2017 Jun; 133(6):1001-1016.
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