University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Anatoly Urisman, MD, PhD

Anatoly Urisman, MD, PhD

Assistant Professor, Department of Pathology, UCSF

Cancer Center Program Memberships

Experimental Therapeutics

Research Summary

My research is focused on understanding regulation of cell signaling by post-tranlational modifications in cancer cells. Specifically, we are using targeted proteomic techniques to study phosphorylation dynamics in key signaling networks such as EGFR, RAS/ERK, and AKT/mTOR. The studies are aimed at identifying key regulatory phosphorylation sites relevant to tumor development, progression, response to targeted therapies, and development of resistance. As part of this effort, we are working on novel approaches for quantifying site-specific phosphorylation of low-abundance proteins, such as transcription factors and other nuclear targets of the intracellular signal transduction pathways.

Education

University of California, Berkeley, B.A., 05/1999, Molecular and Cell Biology
University of California, San Francisco, PhD, 06/2006, Biomedical Sciences
University of California, San Francisco, MD, 05/2008, Medicine, Medical Scientist Training Program
University of California, San Francisco, Residency, 7/08-6/10, Anatomic Pathology
University of California, San Francisco, Fellowship, 7/10-6/11, Pulmonary and Surgical Pathology
University of California, San Francisco, Chief Resident, 7/10-6/11, Anatomic Pathology
University of California, San Francisco, Post-doc, 7/11-6/16, Biology of lung cancer
University of California, San Francisco, Post-doc, 7/11-6/16, Proteomics of signaling


Professional Experience

  • 2008 – 2010
    Resident, Anatomic Pathology, UCSF
  • 2010 – 2011
    Chief Resident, Anatomic Pathology, UCSF
  • 2010 – 2011
    Pulmonary Pathology Fellow, Dept. of Pathology, UCSF
  • 2011 – 2014
    Research Fellow, Department of Pathology, UCSF
  • 2014 – pres.
    Clinical Instructor, Department of Pathology, UCSF
  • 2015 – pres.
    Staff Pathologist, San Francisco Veteran’s Administration Medical Center, San Francisco, CA