Ying Wei, MD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Ying Wei, MD

Assistant Adjunct Professor, Department of Medicine, UCSF

ying.wei@ucsf.edu

Phone: (415) 514-3435 (voice)
Box 0130, UCSF
San Francisco, CA 94143-0130

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Cancer Center Membership

Associate Member » Breast Oncology

Education

1988, B.Sc. in Pharmacy, Shanghai Medical University
1991, M.D. in Medicine, Shanghai Medical University
1991-1993, Research Assistant in Molecular Biology and Cell Biology, Shanghai Institute of Cell Biology, Academia Sinica
1993-1997, Postdoctoral Fellow in Medicine, Respiratory Division, Brigham and Womens Hospital, Harvard Medical School


Professional Experience

  • 1997-2001
    Instructor in Medicine, Brigham and Women's Hospital, Harvard Medical School
  • 2001-present
    Assistant Adjunct Professor in Medicine, University of California, San Francisco

Honors & Awards

  • 1983-1988
    College Dean's List (every year)
  • 1991
    Rong-Ling's Scholarship (the highest honor for exceptional graduating students)

Selected Publications

  1. Suppression of tumor invasion and metastasis by concurrent inhibition of c-Met and VEGF signaling in pancreatic neuroendocrine tumors. Cancer Discov. 2012 Mar; 2(3):270-87.
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  2. Axin pathway activity regulates in vivo pY654-ß-catenin accumulation and pulmonary fibrosis. J Biol Chem. 2012 Feb 10; 287(7):5164-72.
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  3. Integrin a6ß4 identifies an adult distal lung epithelial population with regenerative potential in mice. J Clin Invest. 2011 Jul; 121(7):2855-62.
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  4. Antagonistic anti-urokinase plasminogen activator receptor (uPAR) antibodies significantly inhibit uPAR-mediated cellular signaling and migration. J Biol Chem. 2010 Aug 27; 285(35):26878-88.
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  5. Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial Smad signaling to cell contacts. J Cell Biol. 2009 Jan 26; 184(2):309-22.
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  6. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest. 2009 Jan; 119(1):213-24.
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  7. Signaling through urokinase and urokinase receptor in lung cancer cells requires interactions with beta1 integrins. J Cell Sci. 2008 Nov 15; 121(Pt 22):3747-56.
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  8. Urokinase receptors are required for alpha 5 beta 1 integrin-mediated signaling in tumor cells. J Biol Chem. 2007 Feb 9; 282(6):3929-39.
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  9. Functional relevance of urinary-type plasminogen activator receptor-alpha3beta1 integrin association in proteinase regulatory pathways. J Biol Chem. 2006 May 12; 281(19):13021-9.
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  10. Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding. J Cell Biol. 2005 Jan 31; 168(3):501-11.
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  11. Distinct ligand binding sites in integrin alpha3beta1 regulate matrix adhesion and cell-cell contact. J Cell Biol. 2003 Oct 13; 163(1):177-88.
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  12. Urokinase receptor and integrin interactions. Curr Pharm Des. 2003; 9(19):1565-74.
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  13. Urokinase receptors promote beta1 integrin function through interactions with integrin alpha3beta1. Mol Biol Cell. 2001 Oct; 12(10):2975-86.
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  14. Identification of a urokinase receptor-integrin interaction site. Promiscuous regulator of integrin function. J Biol Chem. 2000 Apr 7; 275(14):10228-34.
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  15. A role for caveolin and the urokinase receptor in integrin-mediated adhesion and signaling. J Cell Biol. 1999 Mar 22; 144(6):1285-94.
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  16. Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin. J Clin Invest. 1997 Jul 1; 100(1):58-67.
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  17. Mac-1 (CD11b/CD18) and the urokinase receptor (CD87) form a functional unit on monocytic cells. Blood. 1996 Oct 15; 88(8):3185-94.
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  18. Regulation of integrin function by the urokinase receptor. Science. 1996 Sep 13; 273(5281):1551-5.
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  19. Identification of the urokinase receptor as an adhesion receptor for vitronectin. J Biol Chem. 1994 Dec 23; 269(51):32380-8.
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