University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Jonathan Weissman, PhD

Jonathan Weissman, PhD

Professor, Dept. of Cellular Molecular Pharmacology, UCSF

Cancer Center Program Memberships

Experimental Therapeutics

Education

Harvard College, A.B., 06/1988, Physics
Massachusetts Institute of Technology, Ph.D., 05/1993, Physics


Professional Experience

  • 1993-1996
    Postdoctoral Fellow, Structural/Biochemical Studies of GroEL, Yale University 
  • 1996-2000
    Assistant Professor, Departments of Cellular & Molecular Pharmacology, and Biochemistry & Biophysics, UCSF
  • 2000-2003
    Associate Professor, Departments of Cellular & Molecular Pharmacology, and Biochemistry & Biophysics, UCSF 
  • 2000-present
    Investigator, Howard Hughes Medical Institute, San Francisco, CA
  • 2003-present
    Professor, Department of Cellular & Molecular Pharmacology, UCSF
  • 2010-present
    Vice-chair of Department of Cellular and Molecular Pharmacology, UCSF
  • 2014-present
    Co-Director of Innovative Genomics Initiative of Berkeley and UCSF
  • 2016-present
    Presidents Advisory Committee of the Chan-Zuckerberg Biohub

Honors & Awards

  • 1988
    Summa cum laude in Physics, Harvard University
  • 1988
    NSF Pre-doctoral Fellowship
  • 1996
    David and Lucile Packard Fellowship
  • 1997
    Searle Scholars Program Fellowship
  • 2004
    Protein Society’s Irving Sigal Young Investigator’s Award
  • 2008
    Raymond & Beverly Sackler International Prize in Biophysics
  • 2009
    Member National Academy of Sciences USA
  • 2009
    David Perlman Award Lecturer of the ACS
  • 2009
    Fellow American Academy of Microbiology
  • 2013
    Marshall Nirenberg Lecturer, National Institutes of Health
  • 2013
    Bashour Distinguished Lecturer, University of Texas Southwestern Medical Center
  • 2014
    Max Planck Distinguished Seminar, Max Planck Institute (MPI) for Developmental Biology
  • 2014
    Cedars-Sinai Medical Center Research Day 2014 Lecturer, Academic Senate Faculty Research Lecturer in Basic Science, UCSF
  • 2015
    National Academy of Sciences Award for Scientific Discovery
  • 2015
    12th Annual Albert L. Lehninger Lecturer, Johns Hopkins University
  • 2015
    Keith R. Porter Lecture Award, American Society for Cell Biology
  • 2016
    Frank H. Westheimer Prize Lecture, Harvard University

Selected Publications

  1. Kostova KK, Hickey KL, Osuna BA, Hussmann JA, Frost A, Weinberg DE, Weissman JS. CAT-tailing as a fail-safe mechanism for efficient degradation of stalled nascent polypeptides. Science. 2017 Jul 28; 357(6349):414-417.
    View on PubMed
  2. Sood A, Meyer CP, Abdollah F, Sammon JD, Sun M, Lipsitz SR, Hollis M, Weissman JS, Menon M, Trinh QD. Minimally invasive surgery and its impact on 30-day postoperative complications, unplanned readmissions and mortality. Br J Surg. 2017 Sep; 104(10):1372-1381.
    View on PubMed
  3. Kruth KA, Fang M, Shelton DN, Abu-Halawa O, Mahling R, Yang H, Weissman JS, Loh ML, Müschen M, Tasian SK, Bassik MC, Kampmann M, Pufall MA. Suppression of B-cell development genes is key to glucocorticoid efficacy in treatment of acute lymphoblastic leukemia. Blood. 2017 Jun 01; 129(22):3000-3008.
    View on PubMed
  4. Burkhardt DH, Rouskin S, Zhang Y, Li GW, Weissman JS, Gross CA. Operon mRNAs are organized into ORF-centric structures that predict translation efficiency. Elife. 2017 Jan 31; 6.
    View on PubMed
  5. Sendoel A, Dunn JG, Rodriguez EH, Naik S, Gomez NC, Hurwitz B, Levorse J, Dill BD, Schramek D, Molina H, Weissman JS, Fuchs E. Translation from unconventional 5' start sites drives tumour initiation. Nature. 2017 01 26; 541(7638):494-499.
    View on PubMed
  6. Dixit A, Parnas O, Li B, Chen J, Fulco CP, Jerby-Arnon L, Marjanovic ND, Dionne D, Burks T, Raychowdhury R, Adamson B, Norman TM, Lander ES, Weissman JS, Friedman N, Regev A. Perturb-Seq: Dissecting Molecular Circuits with Scalable Single-Cell RNA Profiling of Pooled Genetic Screens. Cell. 2016 Dec 15; 167(7):1853-1866.e17.
    View on PubMed
  7. Adamson B, Norman TM, Jost M, Cho MY, Nuñez JK, Chen Y, Villalta JE, Gilbert LA, Horlbeck MA, Hein MY, Pak RA, Gray AN, Gross CA, Dixit A, Parnas O, Regev A, Weissman JS. A Multiplexed Single-Cell CRISPR Screening Platform Enables Systematic Dissection of the Unfolded Protein Response. Cell. 2016 Dec 15; 167(7):1867-1882.e21.
    View on PubMed
  8. Besnard E, Hakre S, Kampmann M, Lim HW, Hosmane NN, Martin A, Bassik MC, Verschueren E, Battivelli E, Chan J, Svensson JP, Gramatica A, Conrad RJ, Ott M, Greene WC, Krogan NJ, Siliciano RF, Weissman JS, Verdin E. The mTOR Complex Controls HIV Latency. Cell Host Microbe. 2016 Dec 14; 20(6):785-797.
    View on PubMed
  9. Aviram N, Ast T, Costa EA, Arakel EC, Chuartzman SG, Jan CH, Haßdenteufel S, Dudek J, Jung M, Schorr S, Zimmermann R, Schwappach B, Weissman JS, Schuldiner M. The SND proteins constitute an alternative targeting route to the endoplasmic reticulum. Nature. 2016 11 30; 540(7631):134-138.
    View on PubMed
  10. Dunn JG, Weissman JS. Plastid: nucleotide-resolution analysis of next-generation sequencing and genomics data. BMC Genomics. 2016 Nov 22; 17(1):958.
    View on PubMed
  11. Stewart-Ornstein J, Chen S, Bhatnagar R, Weissman JS, El-Samad H. Model-guided optogenetic study of PKA signaling in budding yeast. Mol Biol Cell. 2017 Jan 01; 28(1):221-227.
    View on PubMed
  12. Zubradt M, Gupta P, Persad S, Lambowitz AM, Weissman JS, Rouskin S. DMS-MaPseq for genome-wide or targeted RNA structure probing in vivo. Nat Methods. 2017 Jan; 14(1):75-82.
    View on PubMed
  13. Schrader JM, Li GW, Childers WS, Perez AM, Weissman JS, Shapiro L, McAdams HH. Dynamic translation regulation in Caulobacter cell cycle control. Proc Natl Acad Sci U S A. 2016 Nov 01; 113(44):E6859-E6867.
    View on PubMed
  14. Horlbeck MA, Gilbert LA, Villalta JE, Adamson B, Pak RA, Chen Y, Fields AP, Park CY, Corn JE, Kampmann M, Weissman JS. Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation. Elife. 2016 Sep 23; 5.
    View on PubMed
  15. Sabnis AJ, Guerriero CJ, Olivas V, Sayana A, Shue J, Flanagan J, Asthana S, Paton AW, Paton JC, Gestwicki JE, Walter P, Weissman JS, Wipf P, Brodsky JL, Bivona TG. Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma. Proc Natl Acad Sci U S A. 2016 Aug 09; 113(32):9015-20.
    View on PubMed
  16. Nguyen DP, Miyaoka Y, Gilbert LA, Mayerl SJ, Lee BH, Weissman JS, Conklin BR, Wells JA. Ligand-binding domains of nuclear receptors facilitate tight control of split CRISPR activity. Nat Commun. 2016 Jul 01; 7:12009.
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  17. Liu YC, Fujimori DG, Weissman JS. Htm1p-Pdi1p is a folding-sensitive mannosidase that marks N-glycoproteins for ER-associated protein degradation. Proc Natl Acad Sci U S A. 2016 Jul 12; 113(28):E4015-24.
    View on PubMed
  18. Braun CJ, Bruno PM, Horlbeck MA, Gilbert LA, Weissman JS, Hemann MT. Versatile in vivo regulation of tumor phenotypes by dCas9-mediated transcriptional perturbation. Proc Natl Acad Sci U S A. 2016 07 05; 113(27):E3892-900.
    View on PubMed
  19. Leonetti MD, Sekine S, Kamiyama D, Weissman JS, Huang B. A scalable strategy for high-throughput GFP tagging of endogenous human proteins. Proc Natl Acad Sci U S A. 2016 06 21; 113(25):E3501-8.
    View on PubMed
  20. Peters JM, Colavin A, Shi H, Czarny TL, Larson MH, Wong S, Hawkins JS, Lu CHS, Koo BM, Marta E, Shiver AL, Whitehead EH, Weissman JS, Brown ED, Qi LS, Huang KC, Gross CA. A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria. Cell. 2016 Jun 02; 165(6):1493-1506.
    View on PubMed

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