Joseph L. Wiemels, PhD

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Joseph L. Wiemels, PhD

Associate Professor, Department of Epidemiology and Biostatistics, UCSF

joe.wiemels@ucsf.edu

Phone: (415) 514-0577 (voice)
Box 0520, 1450 3rd Street
San Francisco, CA 94158

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Cancer Center Membership

Program Member » Neurologic Oncology» Pediatric Malignancies

Research Summary

I am a trained molecular epidemiologist with a strong focus on immunologic and genetic approaches at understanding disease etiology, particularly in childhood immune development and leukemia. I currently hold a primary appointment in the Department of Epidemiology and Biostatistics, with a secondary appointment in Neurological Surgery, and am the co-President of the Brain Tumor Epidemiology Consortium. This combination of expertise makes me well suited to serve as a HDFCCC Member in the Programs of Pediatric Malignancies and Neurological Oncology. I have worked on cancer etiology for more than 18 years for both hematologic cancers and brain cancers. Discovering the etiology and preventive modalities for cancer, particularly brain and hematologic ones in both children and adults, is my life’s work.

Education

Kenyon College, BA, 1988, Biology
University of California Berkeley, PhD, 1997, Environmental Health Science/Toxicology


Professional Experience

  • 1988-90
    Science Teacher, St. Johns College, Levuka, Fiji
  • 1992-97
    Graduate Student Researcher, University of California Berkeley
  • 1997-99
    Postdoctoral Fellow, Leukaemia Research Fund Centre, Institute of Cancer Research, London
  • 1999-2000
    Assistant Research Molecular Epidemiologist, University of California San Francisco
  • 2001-2002
    Assistant Adjunct Professor, University of California San Francisco
  • 2002-2006
    Assistant Professor in Residence, University of California San Francisco
  • 2006-present
    Associate Professor, University of California San Francisco

Honors & Awards

  • 1986
    Maxwell Elliot Power Prize, Kenyon College
  • 1988
    Phi Beta Kappa, Kenyon College
  • 1993
    Public Health Alumni Scholarship, University of California Berkeley
  • 1993
    National Science Foundation Predoctoral Fellowship in Toxicology awarded
  • 1993-97
    Postdoctoral Fellow, Howard Hughes Medical Institute, University of California Berkeley
  • 2002
    Scholar, Leukemia and Lymphoma Society of America

Selected Publications

  1. New insights into childhood leukemia etiology. Eur J Epidemiol. 2015 Dec; 30(12):1225-7.
    View on PubMed
  2. Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors. N Engl J Med. 2015 Jun 25; 372(26):2499-508.
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  3. Whole-genome fingerprint of the DNA methylome during human B cell differentiation. Nat Genet. 2015 Jul; 47(7):746-56.
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  4. Telomere maintenance and the etiology of adult glioma. Neuro Oncol. 2015 May 25.
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  5. Rising rates of acute lymphoblastic leukemia in Hispanic children: trends in incidence from 1992 to 2011. Blood. 2015 May 7; 125(19):3033-4.
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  6. What causes leukemia? Pediatr Blood Cancer. 2015 Jul; 62(7):1123-4.
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  7. Excess winter deaths caused by cardiovascular diseases are associated with both mild winter temperature and socio-economic inequalities in the U.S. Int J Cardiol. 2015 May 6; 187:642-4.
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  8. Association of genetic variation in IKZF1, ARID5B, and CEBPE and surrogates for early-life infections with the risk of acute lymphoblastic leukemia in Hispanic children. Cancer Causes Control. 2015 Apr; 26(4):609-19.
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  9. Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures. Nucleic Acids Res. 2015 Mar 11; 43(5):2590-602.
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  10. Serum macrophage-derived chemokine/CCL22 levels are associated with glioma risk, CD4 T cell lymphopenia and survival time. Int J Cancer. 2015 Aug 15; 137(4):826-36.
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  11. Survival and low-grade glioma: the emergence of genetic information. Neurosurg Focus. 2015 Jan; 38(1):E6.
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  12. Brain Tumor Epidemiology - A Hub within Multidisciplinary Neuro-oncology. Report on the 15th Brain Tumor Epidemiology Consortium (BTEC) Annual Meeting, Vienna, 2014. Clin Neuropathol. 2015 Jan-Feb; 34(1):40-6.
    View on PubMed
  13. Integrative Bayesian variable selection with gene-based informative priors for genome-wide association studies. BMC Genet. 2014; 15(1):130.
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  14. Global characteristics of childhood acute promyelocytic leukemia. Blood Rev. 2015 Mar; 29(2):101-25.
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  15. Variants near TERT and TERC influencing telomere length are associated with high-grade glioma risk. Nat Genet. 2014 Jul; 46(7):731-5.
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  16. Genomic ancestry and somatic alterations correlate with age at diagnosis in Hispanic children with B-cell acute lymphoblastic leukemia. Am J Hematol. 2014 Jul; 89(7):721-5.
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  17. Serum immunoglobulin e and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiol Biomarkers Prev. 2014 Jul; 23(7):1414-20.
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  18. Mode of delivery and risk of childhood leukemia. Cancer Epidemiol Biomarkers Prev. 2014 May; 23(5):876-81.
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  19. PTPRG inhibition by DNA methylation and cooperation with RAS gene activation in childhood acute lymphoblastic leukemia. Int J Cancer. 2014 Sep 1; 135(5):1101-9.
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  20. The role of KIR genes and their cognate HLA class I ligands in childhood acute lymphoblastic leukemia. Blood. 2014 Apr 17; 123(16):2497-503.
    View on PubMed

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