University of California San Francisco
Helen Diller Family Comprehensive Cancer Center
Joseph L. Wiemels, PhD

Joseph L. Wiemels, PhD

Associate Professor, Department of Epidemiology and Biostatistics, UCSF

Cancer Center Program Memberships

Neurologic Oncology | Pediatric Malignancies

Research Summary

I am a trained molecular epidemiologist with a strong focus on immunologic and genetic approaches at understanding disease etiology, particularly in childhood immune development and leukemia. I currently hold a primary appointment in the Department of Epidemiology and Biostatistics, with a secondary appointment in Neurological Surgery, and am the co-President of the Brain Tumor Epidemiology Consortium. This combination of expertise makes me well suited to serve as a HDFCCC Member in the Programs of Pediatric Malignancies and Neurological Oncology. I have worked on cancer etiology for more than 18 years for both hematologic cancers and brain cancers. Discovering the etiology and preventive modalities for cancer, particularly brain and hematologic ones in both children and adults, is my life’s work.

Education

Kenyon College, BA, 1988, Biology
University of California Berkeley, PhD, 1997, Environmental Health Science/Toxicology


Professional Experience

  • 1988-90
    Science Teacher, St. Johns College, Levuka, Fiji
  • 1992-97
    Graduate Student Researcher, University of California Berkeley
  • 1997-99
    Postdoctoral Fellow, Leukaemia Research Fund Centre, Institute of Cancer Research, London
  • 1999-2000
    Assistant Research Molecular Epidemiologist, University of California San Francisco
  • 2001-2002
    Assistant Adjunct Professor, University of California San Francisco
  • 2002-2006
    Assistant Professor in Residence, University of California San Francisco
  • 2006-present
    Associate Professor, University of California San Francisco

Honors & Awards

  • 1986
    Maxwell Elliot Power Prize, Kenyon College
  • 1988
    Phi Beta Kappa, Kenyon College
  • 1993
    Public Health Alumni Scholarship, University of California Berkeley
  • 1993
    National Science Foundation Predoctoral Fellowship in Toxicology awarded
  • 1993-97
    Postdoctoral Fellow, Howard Hughes Medical Institute, University of California Berkeley
  • 2002
    Scholar, Leukemia and Lymphoma Society of America

Selected Publications

  1. Bazyka D, Finch SC, Ilienko IM, Lyaskivska O, Dyagil I, Trotsiuk N, Gudzenko N, Chumak VV, Walsh KM, Wiemels J, Little MP, Zablotska LB. Buccal mucosa micronuclei counts in relation to exposure to low dose-rate radiation from the Chornobyl nuclear accident and other medical and occupational radiation exposures. Environ Health. 2017 Jun 23; 16(1):70.
    View on PubMed
  2. Wang R, Metayer C, Morimoto L, Wiemels JL, DeWan AT, Kang A, Ma X. Parental age and risk of pediatric cancer in the offspring: a population-based record-linkage study in California. Am J Epidemiol. 2017 May 23.
    View on PubMed
  3. Breton CV, Marsit CJ, Faustman E, Nadeau K, Goodrich JM, Dolinoy DC, Herbstman J, Holland N, LaSalle JM, Schmidt R, Yousefi P, Perera F, Joubert BR, Wiemels J, Taylor M, Yang IV, Chen R, Hew KM, Freeland DM, Miller R, Murphy SK. Small-Magnitude Effect Sizes in Epigenetic End Points are Important in Children's Environmental Health Studies: The Children's Environmental Health and Disease Prevention Research Center's Epigenetics Working Group. Environ Health Perspect. 2017 Apr; 125(4):511-526.
    View on PubMed
  4. Pekmezci M, Rice T, Molinaro AM, Walsh KM, Decker PA, Hansen H, Sicotte H, Kollmeyer TM, McCoy LS, Sarkar G, Perry A, Giannini C, Tihan T, Berger MS, Wiemels JL, Bracci PM, Eckel-Passow JE, Lachance DH, Clarke J, Taylor JW, Luks T, Wiencke JK, Jenkins RB, Wrensch MR. Adult infiltrating gliomas with WHO 2016 integrated diagnosis: additional prognostic roles of ATRX and TERT. Acta Neuropathol. 2017 Mar 02.
    View on PubMed
  5. de Smith AJ, Kaur M, Gonseth S, Endicott AA, Selvin S, Zhang L, Roy R, Shao X, Hansen HM, Kang AY, Walsh KM, Dahl GV, McKean-Cowdin R, Metayer C, Wiemels JL. Correlates of prenatal and early-life tobacco smoke exposure and frequency of common gene deletions in childhood acute lymphoblastic leukemia. Cancer Res. 2017 Feb 15.
    View on PubMed
  6. Wiencke JK, Koestler DC, Salas LA, Wiemels JL, Roy RP, Hansen HM, Rice T, McCoy LS, Bracci PM, Molinaro AM, Kelsey KT, Wrensch MR, Christensen BC. Immunomethylomic approach to explore the blood neutrophil lymphocyte ratio (NLR) in glioma survival. Clin Epigenetics. 2017; 9:10.
    View on PubMed
  7. Wang R, Wiemels JL, Metayer C, Morimoto L, Francis SS, Kadan-Lottick N, DeWan AT, Zhang Y, Ma X. Cesarean Section and Risk of Childhood Acute Lymphoblastic Leukemia in a Population-Based, Record-Linkage Study in California. Am J Epidemiol. 2016 Dec 16.
    View on PubMed
  8. Francis SS, Wallace AD, Wendt GA, Li L, Liu F, Riley LW, Kogan S, Walsh KM, de Smith AJ, Dahl GV, Ma X, Delwart E, Metayer C, Wiemels JL. In utero cytomegalovirus infection and development of childhood acute lymphoblastic leukemia. Blood. 2016 Dec 15.
    View on PubMed
  9. Endicott AA, Morimoto LM, Kline CN, Wiemels JL, Metayer C, Walsh KM. Perinatal factors associated with clinical presentation of osteosarcoma in children and adolescents. Pediatr Blood Cancer. 2016 Nov 10.
    View on PubMed
  10. Triebwasser C, Wang R, DeWan AT, Metayer C, Morimoto L, Wiemels JL, Kadan-Lottick N, Ma X. Birth weight and risk of paediatric Hodgkin lymphoma: Findings from a population-based record linkage study in California. Eur J Cancer. 2016 Nov 1; 69:19-27.
    View on PubMed
  11. Metayer C, Dahl G, Wiemels J, Miller M. Childhood Leukemia: A Preventable Disease. Pediatrics. 2016 Nov; 138(Suppl 1):S45-S55.
    View on PubMed
  12. Kaur M, de Smith AJ, Selvin S, Zhang L, Cunningham M, Kang MW, Hansen HM, Cooper RM, McKean-Cowdin R, Wiemels JL, Metayer C. Tobacco Smoke and Ras Mutations Among Latino and Non-Latino Children with Acute Lymphoblastic Leukemia. Arch Med Res. 2016 Nov; 47(8):677-683.
    View on PubMed
  13. Barrington-Trimis JL, Cockburn M, Metayer C, Gauderman WJ, Wiemels J, McKean-Cowdin R. Trends in Childhood Leukemia Incidence Over Two Decades from 1992-2013. Int J Cancer. 2016 Oct 25.
    View on PubMed
  14. Whitehead TP, Metayer C, Wiemels JL, Singer AW, Miller MD. Childhood Leukemia and Primary Prevention. Curr Probl Pediatr Adolesc Health Care. 2016 Oct; 46(10):317-352.
    View on PubMed
  15. de Smith AJ, Ojha J, Francis SS, Sanders E, Endicott AA, Hansen HM, Smirnov I, Termuhlen AM, Walsh KM, Metayer C, Wiemels JL. Clonal and microclonal mutational heterogeneity in high hyperdiploid acute lymphoblastic leukemia. Oncotarget. 2016 Sep 24.
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  16. Johnson KJ, Hainfellner JA, Lau CC, Scheurer ME, Woehrer A, Wiemels J. Immune factors and viral interactions in brain cancer etiology and outcomes, The 2016 Brain Tumor Epidemiology Consortium Meeting report. Clin Neuropathol. 2016 Sep-Oct; 35(5):280-6.
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  17. Gonseth S, de Smith AJ, Roy R, Zhou M, Lee ST, Shao X, Ohja J, Wrensch MR, Walsh KM, Metayer C, Wiemels JL. Genetic contribution to variation in DNA methylation at maternal smoking sensitive loci in exposed neonates. Epigenetics. 2016 Jul 12; 0.
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  18. Sapru A, Liu KD, Wiemels J, Hansen H, Pawlikowska L, Poon A, Jorgenson E, Witte JS, Calfee CS, Ware LB, Matthay MA. Association of common genetic variation in the protein C pathway genes with clinical outcomes in acute respiratory distress syndrome. Crit Care. 2016; 20(1):151.
    View on PubMed
  19. Ojha J, Codd V, Nelson CP, Samani NJ, Smirnov IV, Madsen NR, Hansen HM, de Smith AJ, Bracci PM, Wiencke JK, Wrensch MR, Wiemels JL, Walsh KM. Genetic Variation Associated with Longer Telomere Length Increases Risk of Chronic Lymphocytic Leukemia. Cancer Epidemiol Biomarkers Prev. 2016 Jul; 25(7):1043-9.
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  20. Walsh KM, Whitehead TP, de Smith AJ, Smirnov IV, Park M, Endicott AA, Francis SS, Codd V. Common genetic variants associated with telomere length confer risk for neuroblastoma and other childhood cancers. Carcinogenesis. 2016 Jun; 37(6):576-82.
    View on PubMed

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