Professor, Department of Pediatrics, and Division Chief, Pediatric Medical Genetics, UCSF
Additional Websites
Education
Franklin and Marshall College, Lancaster, PA, BA, 1977, Biology
Case Western Reserve University, Cleveland, OH, PhD, 1984, Biochemistry
Case Western Reserve University, Cleveland, OH, MD, 1987, Medicine
Rainbow Babies and Children’s Hosp.Cleveland, OH, Pediatrics, 1989, Pediatrics Residency
Harvard Medical School, Boston MA, Research, 1994, Research Fellowship
Professional Experience
-
1989-1994
Fellow in Genetics, The Children's Hospital, Boston, MA
-
1991-1994
Physician Research Fellow, Howard Hughes Medical Institute
-
1994-1999
Unit Head, Mouse Models Section, GDRB/NHGRI/NIH, Bethesda, MD
-
1996-1999
Director, Animal Core Facility, GDRB/NHGRI/NIH, Bethesda, MD
-
1999-2002
Assistant Professor, Pediatrics and Medicine, UCSD School of Medicine, La Jolla, CA
-
2002-2004
Associate Professor, Pediatrics and Medicine, UCSD School of Medicine, La Jolla, CA
-
2003-2007
Chief, Division of Genetics, Department of Pediatrics, UCSD School of Medicine
-
2004-2007
Professor, Pediatrics and Medicine, UCSD School of Medicine, La Jolla, CA
-
2004-2007
Director, Center for Human Genetics and Genomics
-
2006-2007
Vice Chair for Research, Department of Pediatrics
-
2007-present
Charles J. Epstein Professor in Human Genetics and Pediatrics, UCSF School of Medicine 2007-present
Chief, Division of Genetics, Department of Pediatrics, UCSF School of Medicine
Honors & Awards
- 1987
Alpha Omega Alpha, Case Western Reserve University School of Medicine - 1987
The Martin Wahl Memorial Fund Award, CWRU School of Medicine - 1987
Science Day Award, Department of Pediatrics, Rainbow Babies and Children's Hospital - 1995
Special Achievement Award, NCHGR/NIH - 1997
NIH Director's Award - 2000-2003
EJLB Foundation Research Scholars Program Fellowship - 2002
Election to American Society of Clinical Investigation - 2007
Election to Association of American Physicians - 2008
Election to American Pediatric Society
Selected Publications
- Toba S, Tamura Y, Kumamoto K, Yamada M, Takao K, Hattori S, Miyakawa T, Kataoka Y, Azuma M, Hayasaka K, Amamoto M, Tominaga K, Wynshaw-Boris A, Wanibuchi H, Oka Y, Sato M, Kato M, Hirotsune S. Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly. Sci Rep. 2013; 3:1224.
View on PubMed - Huang X, McGann JC, Liu BY, Hannoush RN, Lill JR, Pham V, Newton K, Kakunda M, Liu J, Yu C, Hymowitz SG, Hongo JA, Wynshaw-Boris A, Polakis P, Harland RM, Dixit VM. Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling. Science. 2013 Mar 22; 339(6126):1441-5.
View on PubMed - Sebe JY, Bershteyn M, Hirotsune S, Wynshaw-Boris A, Baraban SC. ALLN rescues an in vitro excitatory synaptic transmission deficit in Lis1 mutant mice. J Neurophysiol. 2013 Jan; 109(2):429-36.
View on PubMed - Kosaka Y, Cieslik KA, Li L, Lezin G, Maguire CT, Saijoh Y, Toyo-Oka K, Gambello MJ, Vatta M, Wynshaw-Boris A, Baldini A, Yost HJ, Brunelli L. 14-3-3{varepsilon} Plays a Role in Cardiac Ventricular Compaction by Regulating the Cardiomyocyte Cell Cycle. Mol Cell Biol. 2012 Dec; 32(24):5089-102.
View on PubMed - Takitoh T, Kumamoto K, Wang CC, Sato M, Toba S, Wynshaw-Boris A, Hirotsune S. Activation of Aurora-A is essential for neuronal migration via modulation of microtubule organization. J Neurosci. 2012 Aug 8; 32(32):11050-66.
View on PubMed - Sinha T, Wang B, Evans S, Wynshaw-Boris A, Wang J. Disheveled mediated planar cell polarity signaling is required in the second heart field lineage for outflow tract morphogenesis. Dev Biol. 2012 Oct 1; 370(1):135-44.
View on PubMed - Wang J, Sinha T, Wynshaw-Boris A. Wnt signaling in mammalian development: lessons from mouse genetics. Cold Spring Harb Perspect Biol. 2012 May; 4(5).
View on PubMed - Chow ML, Pramparo T, Winn ME, Barnes CC, Li HR, Weiss L, Fan JB, Murray S, April C, Belinson H, Fu XD, Wynshaw-Boris A, Schork NJ, Courchesne E. Age-dependent brain gene expression and copy number anomalies in autism suggest distinct pathological processes at young versus mature ages. PLoS Genet. 2012; 8(3):e1002592.
View on PubMed - Kawabata I, Kashiwagi Y, Obashi K, Ohkura M, Nakai J, Wynshaw-Boris A, Yanagawa Y, Okabe S. LIS1-dependent retrograde translocation of excitatory synapses in developing interneuron dendrites. Nat Commun. 2012; 3:722.
View on PubMed - Chow ML, Winn ME, Li HR, April C, Wynshaw-Boris A, Fan JB, Fu XD, Courchesne E, Schork NJ. Preprocessing and Quality Control Strategies for Illumina DASL Assay-Based Brain Gene Expression Studies with Semi-Degraded Samples. Front Genet. 2012; 3:11.
View on PubMed - Wynshaw-Boris A. Dishevelled: in vivo roles of a multifunctional gene family during development. Curr Top Dev Biol. 2012; 101:213-35.
View on PubMed - Chow ML, Li HR, Winn ME, April C, Barnes CC, Wynshaw-Boris A, Fan JB, Fu XD, Courchesne E, Schork NJ. Genome-wide expression assay comparison across frozen and fixed postmortem brain tissue samples. BMC Genomics. 2011; 12:449.
View on PubMed - Wynshaw-Boris A, Risch N, Motulsky A. Charles Joseph Epstein, M.D., 1933–2011, in memoriam. Am J Hum Genet. 2011 Jun 10; 88(6):684-8.
View on PubMed - Pramparo T, Libiger O, Jain S, Li H, Youn YH, Hirotsune S, Schork NJ, Wynshaw-Boris A. Global developmental gene expression and pathway analysis of normal brain development and mouse models of human neuronal migration defects. PLoS Genet. 2011 Mar; 7(3):e1001331.
View on PubMed - Hippenmeyer S, Youn YH, Moon HM, Miyamichi K, Zong H, Wynshaw-Boris A, Luo L. Genetic mosaic dissection of Lis1 and Ndel1 in neuronal migration. Neuron. 2010 Nov 18; 68(4):695-709.
View on PubMed - Wynshaw-Boris A, Pramparo T, Youn YH, Hirotsune S. Lissencephaly: mechanistic insights from animal models and potential therapeutic strategies. Semin Cell Dev Biol. 2010 Oct; 21(8):823-30.
View on PubMed - Yamada M, Hirotsune S, Wynshaw-Boris A. A novel strategy for therapeutic intervention for the genetic disease: preventing proteolytic cleavage using small chemical compound. Int J Biochem Cell Biol. 2010 Sep; 42(9):1401-7.
View on PubMed - Yamada M, Hirotsune S, Wynshaw-Boris A. The essential role of LIS1, NDEL1 and Aurora-A in polarity formation and microtubule organization during neurogensis. Cell Adh Migr. 2010 Apr-Jun; 4(2):180-4.
View on PubMed - Pramparo T, Youn YH, Yingling J, Hirotsune S, Wynshaw-Boris A. Novel embryonic neuronal migration and proliferation defects in Dcx mutant mice are exacerbated by Lis1 reduction. J Neurosci. 2010 Feb 24; 30(8):3002-12.
View on PubMed - Hashimoto M, Shinohara K, Wang J, Ikeuchi S, Yoshiba S, Meno C, Nonaka S, Takada S, Hatta K, Wynshaw-Boris A, Hamada H. Planar polarization of node cells determines the rotational axis of node cilia. Nat Cell Biol. 2010 Feb; 12(2):170-6.
View on PubMed
View on UCSF Profiles
