Zhidong Xu, PhD


Assistant Adjunct Professor, Department of Surgery, UCSF


Phone: (415) 502-0555 (voice)
Box 0875, UCSF, San Francisco, CA 94143-0875

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Shanghai Fisheries University, B.S., 1982, Marine Aquaculture
Western Illinois University, M.S., 1986, Biology/Cytogenetics
The University of Texas Medical Branch, Galveston, Ph.D., 1992, Molecular Mutagenesis

Professional Experience

  • 1986-1988
    Research Assistant, The University of Texas Medical Branch, Galveston, Texas
  • 1989-1991
    Co-principal Investigator, Laboratories for Genetic Services, Inc., Houston, Texas
  • 1986-1992
    Pre-doctoral Fellow, The University of Texas Medical Branch, Galveston, Texas
  • 1992-1993
    Postdoctoral Fellow, Human Genome mapping Center, UCSF
  • 1993-1998
    Post-graduate Molecular Biologist, Cardiovascular Research Institute, UCSF
  • 1998-2001
    Assistant Researcher, Department of Surgery, UCSF
  • 2001-present
    Assistant Adjunct Professor, Department of Surgery, UCSF

Honors & Awards

  • 1989
    Alexander Hollander Student Travel Award, Environmental Mutagen Society
  • 1987-1990
    Scholarships from American Lung Association/San Jacinto Area, Houston, Texas
  • 1992
    James E. Beall II Memorial Scholarship, The University of Texas Medical Branch
  • 1992
    The Doctor Edward Storrs Reynolds, Jr. Memorial Award, The University of Texas Medical Branch, Galveston, Texas
  • 1993
    Walter Travel Fund from American Lung Association, San Francisco

Selected Publications

  1. Yang YL, Hung MS, Wang Y, Ni J, Mao JH, Hsieh D, Au A, Kumar A, Quigley D, Fang LT, Yeh CC, Xu Z, Jablons DM, You L. Lung tumourigenesis in a conditional Cul4A transgenic mouse model. J Pathol. 2014 Jun; 233(2):113-23.
    View on PubMed
  2. Hung MS, Xu Z, Chen Y, Smith E, Mao JH, Hsieh D, Lin YC, Yang CT, Jablons DM, You L. Hematein, a casein kinase II inhibitor, inhibits lung cancer tumor growth in a murine xenograft model. Int J Oncol. 2013 Nov; 43(5):1517-22.
    View on PubMed
  3. Liu S, Hsieh D, Yang YL, Xu Z, Peto C, Jablons DM, You L. Coumestrol from the national cancer Institute's natural product library is a novel inhibitor of protein kinase CK2. BMC Pharmacol Toxicol. 2013; 14:36.
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  4. Bravo DT, Yang YL, Kuchenbecker K, Hung MS, Xu Z, Jablons DM, You L. Frizzled-8 receptor is activated by the Wnt-2 ligand in non-small cell lung cancer. BMC Cancer. 2013; 13:316.
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  5. Zhang S, Long H, Yang YL, Wang Y, Hsieh D, Li W, Au A, Stoppler HJ, Xu Z, Jablons DM, You L. Inhibition of CK2a down-regulates Notch1 signalling in lung cancer cells. J Cell Mol Med. 2013 Jul; 17(7):854-62.
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  6. Zhang S, Wang Y, Mao JH, Hsieh D, Kim IJ, Hu LM, Xu Z, Long H, Jablons DM, You L. Inhibition of CK2a down-regulates Hedgehog/Gli signaling leading to a reduction of a stem-like side population in human lung cancer cells. PLoS One. 2012; 7(6):e38996.
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  7. Kratz JR, He J, Van Den Eeden SK, Zhu ZH, Gao W, Pham PT, Mulvihill MS, Ziaei F, Zhang H, Su B, Zhi X, Quesenberry CP, Habel LA, Deng Q, Wang Z, Zhou J, Li H, Huang MC, Yeh CC, Segal MR, Ray MR, Jones KD, Raz DJ, Xu Z, Jahan TM, Berryman D, He B, Mann MJ, Jablons DM. A practical molecular assay to predict survival in resected non-squamous, non-small-cell lung cancer: development and international validation studies. Lancet. 2012 Mar 3; 379(9818):823-32.
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  8. Li T, Hung MS, Wang Y, Mao JH, Tan JL, Jahan K, Roos H, Xu Z, Jablons DM, You L. Transgenic mice for cre-inducible overexpression of the Cul4A gene. Genesis. 2011 Mar; 49(3):134-41.
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  9. Hung MS, Mao JH, Xu Z, Yang CT, Yu JS, Harvard C, Lin YC, Bravo DT, Jablons DM, You L. Cul4A is an oncogene in malignant pleural mesothelioma. J Cell Mol Med. 2011 Feb; 15(2):350-8.
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  10. Li T, Li H, Wang Y, Harvard C, Tan JL, Au A, Xu Z, Jablons DM, You L. The expression of CXCR4, CXCL12 and CXCR7 in malignant pleural mesothelioma. J Pathol. 2011 Mar; 223(4):519-30.
    View on PubMed
  11. Hung MS, Lin YC, Mao JH, Kim IJ, Xu Z, Yang CT, Jablons DM, You L. Functional polymorphism of the CK2alpha intronless gene plays oncogenic roles in lung cancer. PLoS One. 2010; 5(7):e11418.
    View on PubMed
  12. More SS, Li S, Yee SW, Chen L, Xu Z, Jablons DM, Giacomini KM. Organic cation transporters modulate the uptake and cytotoxicity of picoplatin, a third-generation platinum analogue. Mol Cancer Ther. 2010 Apr; 9(4):1058-69.
    View on PubMed
  13. Hung MS, Xu Z, Lin YC, Mao JH, Yang CT, Chang PJ, Jablons DM, You L. Identification of hematein as a novel inhibitor of protein kinase CK2 from a natural product library. BMC Cancer. 2009; 9:135.
    View on PubMed
  14. Chou J, Lin YC, Kim J, You L, Xu Z, He B, Jablons DM. Nasopharyngeal carcinoma--review of the molecular mechanisms of tumorigenesis. Head Neck. 2008 Jul; 30(7):946-63.
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  15. You L, Xu Z, Punchihewa C, Jablons DM, Fujii N. Evaluation of a chemical library of small-molecule Dishevelled antagonists that suppress tumor growth by down-regulating T-cell factor-mediated transcription. Mol Cancer Ther. 2008 Jun; 7(6):1633-8.
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  16. Ko AH, Dito E, Schillinger B, Venook AP, Xu Z, Bergsland EK, Wong D, Scott J, Hwang J, Tempero MA. A phase II study evaluating bevacizumab in combination with fixed-dose rate gemcitabine and low-dose cisplatin for metastatic pancreatic cancer: is an anti-VEGF strategy still applicable? Invest New Drugs. 2008 Oct; 26(5):463-71.
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  17. Clément G, Guilleret I, He B, Yagui-Beltrán A, Lin YC, You L, Xu Z, Shi Y, Okamoto J, Benhattar J, Jablons D. Epigenetic alteration of the Wnt inhibitory factor-1 promoter occurs early in the carcinogenesis of Barrett's esophagus. Cancer Sci. 2008 Jan; 99(1):46-53.
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  18. Shi Y, He B, Kuchenbecker KM, You L, Xu Z, Mikami I, Yagui-Beltran A, Clement G, Lin YC, Okamoto J, Bravo DT, Jablons DM. Inhibition of Wnt-2 and galectin-3 synergistically destabilizes beta-catenin and induces apoptosis in human colorectal cancer cells. Int J Cancer. 2007 Sep 15; 121(6):1175-81.
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  19. Lin YC, You L, Xu Z, He B, Yang CT, Chen JK, Mikami I, Clément G, Shi Y, Kuchenbecker K, Okamoto J, Kashani-Sabet M, Jablons DM. Wnt inhibitory factor-1 gene transfer inhibits melanoma cell growth. Hum Gene Ther. 2007 Apr; 18(4):379-86.
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  20. Kim J, You L, Xu Z, Kuchenbecker K, Raz D, He B, Jablons D. Wnt inhibitory factor inhibits lung cancer cell growth. J Thorac Cardiovasc Surg. 2007 Mar; 133(3):733-7.
    View on PubMed

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